iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-036015

Ensembl Protein ID

ENSFCAP00000013796.3

UniProt Accession

M3WLI4; M3WLI4_FELCA

Genbank Protein ID

ENSFCAP00000013796

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AANG02050573

Gene Name

BLK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000014872.3	ENSFCAT00000014876.3	ENSFCAP00000013796.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.90e-13	50.2	55	112

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++ v ++ydy+++nd +L++ kG++++++   ++ ++W+ + +  +g++G +P+nFv+++e
   Q: 55   EHFVVAQYDYTSVNDRDLQMLKGEKLQIL---KEVGDWWLARSLITGREGYVPSNFVARVE 112
           57799************************...88899**********************97 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MGVVSSKKQV KEKGKGLWSP VKVSTQSQDP PPLPPLVLFN HLAPSPPDMH PDQEEHFVVA 60
QYDYTSVNDR DLQMLKGEKL QILKEVGDWW LARSLITGRE GYVPSNFVAR VETLEVEKWF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGAGTGG TGAGCAGCAA AAAGCAGGTG AAGGAGAAAG GTAAGGGCCT CTGGAGCCCT 60
GTGAAGGTCA GCACCCAGAG CCAAGATCCC CCACCACTGC CTCCCCTGGT GAGTGATGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0050853--P:B cell receptor signaling pathway
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0032024--P:positive regulation of insulin secretion
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

fca:101084104

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002133	Ailuropoda melanoleuca	94.40	0.00e+00	941.00
IUUC-Apl-003307	Anas platyrhynchos	74.11	0.00e+00	723.00
IUUC-Aca-004357	Anolis carolinensis	67.94	0.00e+00	662.00
IUUC-Ame-010642	Astyanax mexicanus	69.11	0.00e+00	677.00
IUUC-Bta-012400	Bos taurus	89.82	0.00e+00	914.00
IUUC-Cja-019717	Callithrix jacchus	82.84	0.00e+00	681.00
IUUC-Cfa-021056	Canis familiaris	93.60	0.00e+00	954.00
IUUC-Cpo-021779	Cavia porcellus	86.20	0.00e+00	871.00
IUUC-Csa-023557	Chlorocebus sabaeus	86.93	0.00e+00	896.00
IUUC-Dre-027517	Danio rerio	69.26	0.00e+00	690.00
IUUC-Eca-034218	Equus caballus	90.68	0.00e+00	907.00
IUUC-Eeu-035095	Erinaceus europaeus	68.60	0.00e+00	674.00
IUUC-Fal-036946	Ficedula albicollis	74.61	0.00e+00	718.00
IUUC-Gga-040822	Gallus gallus	74.39	0.00e+00	726.00
IUUC-Ggo-044608	Gorilla gorilla	90.38	0.00e+00	822.00
IUUC-Hsa-046719	Homo sapiens	86.93	0.00e+00	895.00
IUUC-Itr-048323	Ictidomys tridecemlineatus	88.80	0.00e+00	897.00
IUUC-Lch-050114	Latimeria chalumnae	72.20	0.00e+00	696.00
IUUC-Loc-052326	Lepisosteus oculatus	71.15	0.00e+00	702.00
IUUC-Laf-053387	Loxodonta africana	88.60	0.00e+00	906.00
IUUC-Mcc-055026	Macaca mulatta	87.13	0.00e+00	896.00
IUUC-Mga-059427	Meleagris gallopavo	73.72	0.00e+00	714.00
IUUC-Mmr-061660	Microcebus murinus	87.80	0.00e+00	893.00
IUUC-Mdo-062318	Monodelphis domestica	76.34	0.00e+00	796.00
IUUC-Mmu-063325	Mus musculus	87.20	0.00e+00	909.00
IUUC-Mpu-066582	Mustela putorius furo	93.80	0.00e+00	935.00
IUUC-Nle-069624	Nomascus leucogenys	89.42	0.00e+00	877.00
IUUC-Opr-070656	Ochotona princeps	83.20	0.00e+00	819.00
IUUC-Ont-072266	Oreochromis niloticus	65.13	0.00e+00	677.00
IUUC-Ocu-073907	Oryctolagus cuniculus	86.00	0.00e+00	869.00
IUUC-Oga-088057	Otolemur garnettii	87.82	0.00e+00	901.00
IUUC-Oar-089332	Ovis aries	85.43	0.00e+00	877.00
IUUC-Ptr-091551	Pan troglodytes	85.80	0.00e+00	855.00
IUUC-Pan-092173	Papio anubis	86.93	0.00e+00	876.00
IUUC-Psi-093895	Pelodiscus sinensis	73.10	0.00e+00	723.00
IUUC-Pab-097598	Pongo abelii	86.53	0.00e+00	860.00
IUUC-Pva-102135	Pteropus vampyrus	91.16	0.00e+00	902.00
IUUC-Rno-104891	Rattus norvegicus	86.40	0.00e+00	884.00
IUUC-Sha-107192	Sarcophilus harrisii	77.14	0.00e+00	809.00
IUUC-Ssc-115696	Sus scrofa	90.62	0.00e+00	936.00
IUUC-Tgu-117056	Taeniopygia guttata	73.20	0.00e+00	709.00
IUUC-Tbe-127520	Tupaia belangeri	88.92	0.00e+00	682.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence