iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013338

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

DCN1-like protein 3; DCUN1 domain-containing protein 3; Defective in cullin neddylation protein 1-like protein 3

Genbank Nucleotide ID

BT020819

Gene Name

DCUN1D3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000032260.2	ENSBTAT00000045756.2	ENSBTAP00000043119.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/DCUN1	1.00e-84	283.5	87	278

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/DCUN1

   S: 2    skkkleelferYkdpqedligieglekfcedlgvdpediavLvlawkleaatlcefsreefldgltalgcdsieklqeklktleselkd 90
           s ++leelf+rYkd++ed+i++eg+e+fc+dl+vdp++++vL+lawk++aat+c+f+r+ef+dg++a+++dsi+++++++++l +e+k+
   Q: 87   SLQRLEELFRRYKDEREDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSIDGICARFPSLLTEAKQ 175
           679************************************************************************************** PP
   S: 91   eqkfkdiYrfafnfakd..kgqksldldtaialwkLllaerefklldawlkfLeee..kkksiskDtWnllLefskviakdlsnYdeeg 175
           e+kfkd+Yrf+f+f++d  +gq+sl++++aialwkL+++++++++ld+wl+fL+e+  ++k+is+DtWn++L+f++vi +dlsnY+e++
   Q: 176  EDKFKDLYRFTFQFGLDseEGQRSLHREIAIALWKLVFTQNNPPVLDQWLNFLTENpsGIKGISRDTWNMFLNFTQVIGPDLSNYSEDE 264
           ***************998899**********************************9889****************************** PP
   S: 176  aWPvliDefveylk 189
           aWP+l+D+fve+++
   Q: 265  AWPSLFDTFVEWEM 278
           ************85 PP

Organism

Bos taurus

Functional Description
(View)

Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane.

Protein Sequence
(Fasta)

MGQCVTKCKN PSSTLGSKNG DRDPSSKSHG RRSASHREEQ LPTCGKPGGD ILVNGTKKAE 60
AAPEACQLPT SSGDAGREPK SNAEESSLQR LEELFRRYKD EREDAILEEG MERFCNDLCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAAGAGGCG GCGGCGGCGG CGGCGGAGGG GGTAGGGAAC CTGGAAACGC GAGCGGGGAT 60
GGTAGGTGTT TTGGACCCGC CGGGCCGCCG TCGTTTCCAG AAAGGGTTTG ACTGGAGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0519--Myristate
KW-1185--Reference proteome

Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom

PROSITE

PS51229--DCUN1

Pfam

PF03556--Cullin_binding

Gene Ontology

GO:0005737--C:cytoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0030308--P:negative regulation of cell growth
GO:0043065--P:positive regulation of apoptotic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation
GO:0010332--P:response to gamma radiation
GO:0009314--P:response to radiation
GO:0010225--P:response to UV-C

KEGG

bta:504926

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001689	Ailuropoda melanoleuca	97.37	2.00e-166	578.00
IUUC-Apl-003497	Anas platyrhynchos	82.24	8.00e-143	499.00
IUUC-Aca-004961	Anolis carolinensis	81.58	1.00e-148	518.00
IUUC-Ani-009241	Aspergillus nidulans	34.98	2.00e-23	102.00
IUUC-Aor-009902	Aspergillus oryzae	33.83	2.00e-11	60.80
IUUC-Ame-011413	Astyanax mexicanus	63.25	4.00e-101	360.00
IUUC-Cja-019458	Callithrix jacchus	97.04	1.00e-166	578.00
IUUC-Cfa-020160	Canis familiaris	97.70	3.00e-167	580.00
IUUC-Cpo-021835	Cavia porcellus	96.38	7.00e-157	546.00
IUUC-Csa-023328	Chlorocebus sabaeus	97.37	3.00e-167	580.00
IUUC-Cho-024888	Choloepus hoffmanni	95.03	7.00e-164	569.00
IUUC-Cin-025134	Ciona intestinalis	52.24	5.00e-60	224.00
IUUC-Csv-025904	Ciona savignyi	50.41	2.00e-32	130.00
IUUC-Dre-027780	Danio rerio	64.39	3.00e-97	347.00
IUUC-Dno-028866	Dasypus novemcinctus	96.71	2.00e-164	571.00
IUUC-Dor-030387	Dipodomys ordii	95.72	1.00e-163	568.00
IUUC-Dme-032081	Drosophila melanogaster	47.17	3.00e-48	185.00
IUUC-Eca-033857	Equus caballus	96.71	2.00e-166	578.00
IUUC-Eeu-034825	Erinaceus europaeus	89.80	2.00e-151	527.00
IUUC-Fca-036130	Felis catus	97.37	5.00e-167	579.00
IUUC-Fal-037296	Ficedula albicollis	81.58	3.00e-140	491.00
IUUC-Gmo-039626	Gadus morhua	65.48	3.00e-98	351.00
IUUC-Ggr-039959	Gaeumannomyces graminis	26.64	4.00e-15	76.60
IUUC-Gga-040741	Gallus gallus	81.58	3.00e-139	487.00
IUUC-Gac-042271	Gasterosteus aculeatus	67.27	4.00e-92	330.00
IUUC-Ggo-044727	Gorilla gorilla	97.37	3.00e-167	580.00
IUUC-Hsa-046288	Homo sapiens	97.04	7.00e-167	579.00
IUUC-Itr-049054	Ictidomys tridecemlineatus	97.37	2.00e-176	610.00
IUUC-Lch-050289	Latimeria chalumnae	78.88	2.00e-132	465.00
IUUC-Loc-052455	Lepisosteus oculatus	71.58	1.00e-108	385.00
IUUC-Laf-054369	Loxodonta africana	95.07	4.00e-157	546.00
IUUC-Mcc-055413	Macaca mulatta	78.57	6.00e-122	429.00
IUUC-Meu-056535	Macropus eugenii	87.83	5.00e-154	536.00
IUUC-Mga-059290	Meleagris gallopavo	82.89	8.00e-143	499.00
IUUC-Mmr-060689	Microcebus murinus	97.04	9.00e-167	578.00
IUUC-Mdo-062128	Monodelphis domestica	87.50	5.00e-149	520.00
IUUC-Mmu-064396	Mus musculus	96.05	3.00e-174	603.00
IUUC-Mpu-065926	Mustela putorius furo	97.37	2.00e-166	578.00
IUUC-Mlu-067044	Myotis lucifugus	95.07	6.00e-172	596.00
IUUC-Nle-069346	Nomascus leucogenys	97.37	3.00e-167	580.00
IUUC-Opr-070682	Ochotona princeps	96.71	2.00e-155	541.00
IUUC-Ont-071772	Oreochromis niloticus	67.74	9.00e-101	359.00
IUUC-Oan-072765	Ornithorhynchus anatinus	83.88	5.00e-145	506.00
IUUC-Ocu-074272	Oryctolagus cuniculus	92.74	2.00e-119	421.00
IUUC-Ola-087561	Oryzias latipes	68.75	6.00e-106	376.00
IUUC-Oga-088440	Otolemur garnettii	78.04	5.00e-123	433.00
IUUC-Oar-089403	Ovis aries	99.34	8.00e-171	592.00
IUUC-Ptr-091384	Pan troglodytes	97.37	3.00e-167	580.00
IUUC-Pan-092650	Papio anubis	97.37	3.00e-167	580.00
IUUC-Psi-093806	Pelodiscus sinensis	83.55	9.00e-136	476.00
IUUC-Pma-094196	Petromyzon marinus	53.02	4.00e-88	317.00
IUUC-Pfo-096584	Poecilia formosa	70.71	3.00e-104	371.00
IUUC-Pab-098605	Pongo abelii	97.37	3.00e-167	580.00
IUUC-Pca-100933	Procavia capensis	78.62	2.00e-116	411.00
IUUC-Pva-102172	Pteropus vampyrus	92.51	6.00e-161	559.00
IUUC-Rno-105406	Rattus norvegicus	97.04	8.00e-176	608.00
IUUC-Sha-106531	Sarcophilus harrisii	88.16	3.00e-154	537.00
IUUC-Sar-113051	Sorex araneus	76.64	4.00e-116	410.00
IUUC-Ssc-115555	Sus scrofa	97.70	5.00e-168	583.00
IUUC-Tgu-117178	Taeniopygia guttata	82.57	2.00e-143	501.00
IUUC-Tru-117876	Takifugu rubripes	67.48	4.00e-105	374.00
IUUC-Tsy-118790	Tarsius syrichta	95.36	3.00e-134	470.00
IUUC-Tni-119673	Tetraodon nigroviridis	66.23	1.00e-105	376.00
IUUC-Tbe-127429	Tupaia belangeri	97.04	6.00e-167	579.00
IUUC-Ttr-128467	Tursiops truncatus	98.36	4.00e-169	586.00
IUUC-Vpa-130376	Vicugna pacos	67.64	4.00e-96	343.00
IUUC-Xtr-132134	Xenopus tropicalis	80.36	3.00e-123	434.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence