iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-061839

UUCD1 version

UUC-MoD-00109

Ensembl Protein ID

ENSMODP00000024013.3

UniProt Accession

F6QU60; F6QU60_MONDO

Protein Name

Uncharacterized protein

Gene Name

HERC6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000019236.3	ENSMODT00000024440.3	ENSMODP00000024013.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-85	287.7	714	1032

Active Site

Position(s)	Description	Evidence
1002	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           +d+kk+l vef gE gld gGv +ef++ ++ke+ +p++g+f+yse+++ +++p +       ++ ++F ++G+l+g+++  g+++ 
   Q: 714  KDFKKELLVEFIGEIGLDFGGVRKEFFYYMFKEMIQPEYGMFVYSETSSLMWFPTNPIL----KKKNYF-LFGILCGLSIASGNVVH 795
           799**************************************************999886....678899.55*************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           lp++ +++k+ll+kk sledl+e+ pe+ ++l+ +++    + +e+++ l fs    i+ + ++++L+p+G++i+V ++Nke++v++
   Q: 796  LPFPLALFKKLLDKKPSLEDLQELTPEMGNNLQLLLDD---NDNEEEFSLCFS----IYWDKEDVNLIPNGSTIHVDKSNKEDFVSR 875
           ************************************88...444444666665....78999************************* PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
            ++y++++++k+ +e+f+ Gf++v+++e+++ F++eel+ ++ G+ ++d+++++k+ ky +gy++++++i +Fw++++++  ee+k+
   Q: 876  CIDYIFNTSVKKIYEEFQMGFYKVCKKEIINFFKPEELKAVTIGNLDYDWKTFEKNSKYCQGYHRSHSTIVMFWDAFHRLPLEEKKK 962
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           fL F+Tgs+r  ++G+ +   + f + +  ++++lP+++TCfn L LP+Ys++e +++ L++ i++++gF 
   Q: 963  FLLFLTGSDRFNPEGISNPGIE-FAYLETLKEEDLPQASTCFNILYLPQYSTMERMEKALQTVIKNNSGFA 1032
           ******************9955.666666999*************************************95 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MYYCWGDNSS GQLGIPAVPR AKARAVRCRR GASLGNQTLL QAACGERHSL LLLSDGTVWS 60
CGNNSCGQLG RKRCQKHGRP AQIQALETQD IVSVSCGKEH SLAICKEGRV FSWGSGSDGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCAAACCAC AAGACGAGTT GGAAGAAGGG AACAATTTTC TTCATTTAGG GCATCTCTAG 60
CGTGGAAGTG GTGGTCCCCA CGGGCAACCC TATTGCTGCT TTTCTGGTCA CAGGATGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation

KEGG

mdo:100024844

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	56.59	0.00e+00	1013.00
IUUC-Aca-004663	Anolis carolinensis	46.67	0.00e+00	845.00
IUUC-Bta-013080	Bos taurus	55.49	0.00e+00	1035.00
IUUC-Cja-018891	Callithrix jacchus	54.42	0.00e+00	1048.00
IUUC-Cfa-020763	Canis familiaris	56.14	0.00e+00	978.00
IUUC-Cpo-022346	Cavia porcellus	53.03	0.00e+00	1028.00
IUUC-Csa-023049	Chlorocebus sabaeus	57.61	0.00e+00	1155.00
IUUC-Cho-025101	Choloepus hoffmanni	47.70	1.00e-128	454.00
IUUC-Dno-029093	Dasypus novemcinctus	57.42	0.00e+00	1108.00
IUUC-Dor-030862	Dipodomys ordii	47.47	2.00e-132	467.00
IUUC-Eca-034098	Equus caballus	56.54	0.00e+00	1026.00
IUUC-Eeu-035028	Erinaceus europaeus	49.51	4.00e-121	429.00
IUUC-Fca-036283	Felis catus	56.78	0.00e+00	1019.00
IUUC-Ggo-045553	Gorilla gorilla	56.03	0.00e+00	1086.00
IUUC-Hsa-046396	Homo sapiens	57.28	0.00e+00	1116.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	42.33	0.00e+00	740.00
IUUC-Loc-052736	Lepisosteus oculatus	40.11	0.00e+00	713.00
IUUC-Laf-054433	Loxodonta africana	53.75	0.00e+00	1082.00
IUUC-Mcc-055014	Macaca mulatta	55.00	0.00e+00	1093.00
IUUC-Mmr-060783	Microcebus murinus	40.42	0.00e+00	649.00
IUUC-Mmu-064378	Mus musculus	52.51	0.00e+00	979.00
IUUC-Mpu-066293	Mustela putorius furo	55.51	0.00e+00	994.00
IUUC-Mlu-067407	Myotis lucifugus	55.39	0.00e+00	1032.00
IUUC-Nle-069978	Nomascus leucogenys	56.74	0.00e+00	1125.00
IUUC-Opr-070190	Ochotona princeps	45.80	6.00e-147	514.00
IUUC-Ocu-074305	Oryctolagus cuniculus	45.15	0.00e+00	800.00
IUUC-Oga-088780	Otolemur garnettii	51.31	0.00e+00	955.00
IUUC-Oar-090307	Ovis aries	57.26	0.00e+00	1066.00
IUUC-Ptr-091567	Pan troglodytes	57.38	0.00e+00	1117.00
IUUC-Pan-091802	Papio anubis	53.37	0.00e+00	1049.00
IUUC-Pab-098024	Pongo abelii	45.73	0.00e+00	816.00
IUUC-Pca-100320	Procavia capensis	44.92	0.00e+00	786.00
IUUC-Pva-102382	Pteropus vampyrus	52.07	0.00e+00	968.00
IUUC-Rno-105768	Rattus norvegicus	49.81	0.00e+00	938.00
IUUC-Sha-106525	Sarcophilus harrisii	65.03	0.00e+00	1337.00
IUUC-Sar-113014	Sorex araneus	51.61	4.00e-129	455.00
IUUC-Tbe-127787	Tupaia belangeri	42.63	0.00e+00	698.00
IUUC-Ttr-128191	Tursiops truncatus	44.50	0.00e+00	775.00
IUUC-Vpa-130214	Vicugna pacos	52.66	0.00e+00	905.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence