iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012422

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

DAAA02017014

Gene Name

HERC5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000020538.5	ENSBTAT00000052811.2	ENSBTAP00000052996.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.50e-89	298.2	638	959

Active Site

Position(s)	Description	Evidence
929	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl+++l+v+f+gE g + gGv  ef+++l++e+ +p++g+f+y e+ +++++p + ++    e+ ++F f+G l+g++l++ ++ d+
   Q: 638  NEDLRRELMVSFSGEIGYNFGGVRAEFFYCLFQEMTRPEYGMFTYPEEASYMWFPVRPKF----EKKSYF-FFGLLCGLSLFNCNVADI 721
           6899*******************************************************9....567888.99**************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           p++ +++k+ll++  sledl+e+ p l +sl+ +++ + +d+ee      f+++ ++  + ++++L+p+G+++ V ++Nk++Yv+++v+
   Q: 722  PFPLALFKKLLDQTPSLEDLKELSPVLGESLQTLLDDDGDDLEEV-----FHIHFNVHWDKNDVDLIPDGSHVIVDQTNKRDYVSKYVN 805
           ***********************************8855555554.....555555677889999************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           y+++ ++k  +e+f++Gf++v+++e+++ F++e+l+ +i G++++d+e+++k++ y++gy +++p+i +Fw++l++++ ee+k+fL F+
   Q: 806  YIFNISVKAVYEEFQRGFYKVCDKEIIEFFHPEQLKDVIIGNTDYDWETFEKNAHYEHGYDSSHPTIVMFWKALHKLTLEEKKKFLVFL 894
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg++r+ ++G++++k   f ++++ ++++ ++++TCf++L LP+Ys++e ++e L++Ai++++gF+
   Q: 895  TGTDRIQVKGLKNMK-ITFHCPENLNEKDPIRAQTCFSVLYLPKYSTMERVEEALQAAINNKRGFG 959
           ***************.55777777999*************************************96 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MEGRPRRRSR GGARPVPGRV SESRPPPASR PSATVPAVSW GAKLWLFPSA AGLRSALSKR 60
PEATRQMCCT RRRLAVLERG GAGVEVHQLP AGSDGARKPK CIKLGKKMKI HSMDQGEEHM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGGGA GGCCACGGAG GAGGTCGCGG GGCGGCGCAC GCCCGGTACC CGGGCGGGTC 60
TCCGAGTCCC GACCCCCCGC GTCCCGACCC CCCGCGTCCC GGCCCTCCGC GACAGTGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0042296--F:ISG15 transferase activity
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0050688--P:regulation of defense response to virus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001676	Ailuropoda melanoleuca	82.45	0.00e+00	916.00
IUUC-Aca-005342	Anolis carolinensis	36.57	5.00e-165	575.00
IUUC-Cja-018751	Callithrix jacchus	66.11	0.00e+00	1261.00
IUUC-Dno-029795	Dasypus novemcinctus	74.16	0.00e+00	879.00
IUUC-Dor-030862	Dipodomys ordii	68.37	0.00e+00	744.00
IUUC-Ete-032585	Echinops telfairi	55.73	0.00e+00	709.00
IUUC-Eca-034358	Equus caballus	74.79	0.00e+00	1370.00
IUUC-Eeu-035282	Erinaceus europaeus	57.88	6.00e-168	584.00
IUUC-Fca-036505	Felis catus	74.59	0.00e+00	1412.00
IUUC-Ggo-045445	Gorilla gorilla	66.11	0.00e+00	1203.00
IUUC-Hsa-046342	Homo sapiens	67.89	0.00e+00	1274.00
IUUC-Laf-053921	Loxodonta africana	69.41	0.00e+00	1318.00
IUUC-Mmr-060783	Microcebus murinus	62.19	0.00e+00	1062.00
IUUC-Mpu-066123	Mustela putorius furo	76.88	0.00e+00	1514.00
IUUC-Nle-069986	Nomascus leucogenys	67.37	0.00e+00	1249.00
IUUC-Opr-070513	Ochotona princeps	74.44	0.00e+00	816.00
IUUC-Ocu-074305	Oryctolagus cuniculus	64.29	0.00e+00	1157.00
IUUC-Oga-088858	Otolemur garnettii	73.94	0.00e+00	1319.00
IUUC-Oar-089456	Ovis aries	84.24	0.00e+00	1562.00
IUUC-Ptr-091216	Pan troglodytes	66.36	0.00e+00	1066.00
IUUC-Pan-091706	Papio anubis	73.37	0.00e+00	857.00
IUUC-Pca-100320	Procavia capensis	64.42	0.00e+00	1247.00
IUUC-Pva-102646	Pteropus vampyrus	73.74	0.00e+00	1398.00
IUUC-Sar-113605	Sorex araneus	79.04	2.00e-153	536.00
IUUC-Ssc-116076	Sus scrofa	84.02	0.00e+00	637.00
IUUC-Tsy-119240	Tarsius syrichta	56.16	0.00e+00	970.00
IUUC-Ttr-128191	Tursiops truncatus	74.97	0.00e+00	1424.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence