iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088743

Ensembl Protein ID

ENSOGAP00000010251.2

UniProt Accession

H0X4U4; H0X4U4_OTOGA

Genbank Protein ID

ENSOGAP00000010251

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AAQR03181135

Gene Name

NSD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000011442.2	ENSOGAT00000011452.2	ENSOGAP00000010251.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.10e-16	60.7	1357	1397

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC egg+    l++C+ C  +fH +Cl++      p+ + w+C++C+
   Q: 1357 WCFVCSEGGS----LLCCDSCPAAFHRECLNID----IPEGN-WYCNDCK 1397
           8*********....*******************....99996.******8 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

VSNRRPYRQY YVEAFGDPSE RAWVAGKAIV MFEGRHQFEE LPVLRRRGKQ KEKGYRHKVP 60
QKILSKWEAS VGLAEQYDVP RGSKSRKCVT SSIKLDSEED VLFEDCTNDP ESEHDLLLNG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTCCAACC GGAGGCCGTA TCGGCAGTAC TACGTGGAGG CTTTTGGAGA CCCTTCTGAG 60
AGAGCCTGGG TGGCTGGAAA AGCAATCGTC ATGTTTGAAG GCAGACATCA ATTTGAAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0046975--F:histone methyltransferase activity (H3-K36 specific)
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0008270--F:zinc ion binding
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000414--P:regulation of histone H3-K36 methylation
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1903025--P:regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001795	Ailuropoda melanoleuca	88.82	0.00e+00	4012.00
IUUC-Apl-003953	Anas platyrhynchos	56.72	0.00e+00	2142.00
IUUC-Aca-005339	Anolis carolinensis	60.22	0.00e+00	1533.00
IUUC-Ame-011932	Astyanax mexicanus	62.61	0.00e+00	922.00
IUUC-Bta-012966	Bos taurus	88.01	0.00e+00	4035.00
IUUC-Bol-016001	Brassica oleracea	30.05	1.00e-16	82.80
IUUC-Bra-017864	Brassica rapa	29.51	2.00e-15	79.30
IUUC-Cja-018780	Callithrix jacchus	88.55	0.00e+00	3750.00
IUUC-Cfa-020975	Canis familiaris	88.08	0.00e+00	4018.00
IUUC-Cpo-021331	Cavia porcellus	87.39	0.00e+00	2678.00
IUUC-Csa-024226	Chlorocebus sabaeus	88.84	0.00e+00	3989.00
IUUC-Cho-024464	Choloepus hoffmanni	73.77	0.00e+00	1360.00
IUUC-Dre-028152	Danio rerio	63.27	0.00e+00	1259.00
IUUC-Dno-029230	Dasypus novemcinctus	84.82	0.00e+00	3799.00
IUUC-Dor-031016	Dipodomys ordii	81.15	0.00e+00	1311.00
IUUC-Dme-032193	Drosophila melanogaster	36.70	1.00e-122	434.00
IUUC-Eca-033591	Equus caballus	88.80	0.00e+00	4063.00
IUUC-Fca-035791	Felis catus	88.39	0.00e+00	4132.00
IUUC-Fal-037378	Ficedula albicollis	58.20	0.00e+00	2048.00
IUUC-Gmo-038919	Gadus morhua	71.68	0.00e+00	940.00
IUUC-Gga-040881	Gallus gallus	56.16	0.00e+00	2075.00
IUUC-Gac-041378	Gasterosteus aculeatus	78.19	0.00e+00	1075.00
IUUC-Hsa-046436	Homo sapiens	89.27	0.00e+00	4032.00
IUUC-Itr-048194	Ictidomys tridecemlineatus	87.82	0.00e+00	4043.00
IUUC-Lch-049684	Latimeria chalumnae	50.84	0.00e+00	1541.00
IUUC-Lpe-051661	Leersia perrieri	28.72	5.00e-12	67.00
IUUC-Laf-054046	Loxodonta africana	87.18	0.00e+00	4005.00
IUUC-Mcc-055593	Macaca mulatta	88.71	0.00e+00	3995.00
IUUC-Mga-059756	Meleagris gallopavo	56.80	0.00e+00	2149.00
IUUC-Mmr-061182	Microcebus murinus	91.23	0.00e+00	4222.00
IUUC-Mdo-061984	Monodelphis domestica	67.48	0.00e+00	2878.00
IUUC-Mmu-063605	Mus musculus	80.36	0.00e+00	3655.00
IUUC-Mpu-066446	Mustela putorius furo	88.39	0.00e+00	4080.00
IUUC-Mlu-067261	Myotis lucifugus	86.75	0.00e+00	3923.00
IUUC-Nle-069818	Nomascus leucogenys	89.27	0.00e+00	4029.00
IUUC-Opr-070842	Ochotona princeps	83.02	0.00e+00	2341.00
IUUC-Ont-072448	Oreochromis niloticus	75.22	0.00e+00	1149.00
IUUC-Oan-073496	Ornithorhynchus anatinus	74.29	0.00e+00	1638.00
IUUC-Ocu-074918	Oryctolagus cuniculus	88.27	0.00e+00	4086.00
IUUC-Obr-076753	Oryza brachyantha	54.84	8.00e-08	53.50
IUUC-Olo-080702	Oryza longistaminata	39.91	3.00e-43	170.00
IUUC-Opu-083371	Oryza punctata	41.15	7.00e-45	176.00
IUUC-Ola-087518	Oryzias latipes	76.21	0.00e+00	1056.00
IUUC-Oar-090265	Ovis aries	87.88	0.00e+00	4023.00
IUUC-Ptr-090521	Pan troglodytes	89.57	0.00e+00	4058.00
IUUC-Psi-093245	Pelodiscus sinensis	59.61	0.00e+00	1986.00
IUUC-Pfo-096066	Poecilia formosa	62.28	0.00e+00	1222.00
IUUC-Pab-098644	Pongo abelii	88.97	0.00e+00	3994.00
IUUC-Pva-103094	Pteropus vampyrus	83.99	0.00e+00	2007.00
IUUC-Rno-105803	Rattus norvegicus	81.52	0.00e+00	3679.00
IUUC-Sha-107278	Sarcophilus harrisii	68.24	0.00e+00	2908.00
IUUC-Sar-113402	Sorex araneus	76.63	0.00e+00	2528.00
IUUC-Sbi-114400	Sorghum bicolor	36.54	5.00e-13	66.20
IUUC-Ssc-116193	Sus scrofa	87.69	0.00e+00	3919.00
IUUC-Tgu-116532	Taeniopygia guttata	90.15	0.00e+00	1256.00
IUUC-Tru-117988	Takifugu rubripes	75.52	0.00e+00	1204.00
IUUC-Tsy-118830	Tarsius syrichta	88.37	0.00e+00	3517.00
IUUC-Tca-121456	Theobroma cacao	30.33	1.00e-19	91.70

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence