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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105653
UUCD1 version UUC-RaN-00307
Ensembl Protein ID ENSRNOP00000044089.3
UniProt Accession D3ZVM4; LIN41_RAT
Protein Name E3 ubiquitin-protein ligase TRIM71; Protein lin-41 homolog; RING-type E3 ubiquitin transferase TRIM71; Tripartite motif-containing protein 71
Gene Name Trim71; Lin41
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000030098.3 ENSRNOT00000047198.3 ENSRNOP00000044089.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 6.40e-06 27.0 12 94
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf.................................kdgplvlpCgHvfhadCl..qkw...pglknssskefrCPlCr 46
           C++C+e++                                 ++ ++vlpC H+f++ Cl  +++    g    +  + rCP+C+
   Q: 12   CLLCKEMCgspaplsssssasssssqtstssaggggpgaaaRR-LHVLPCLHAFCRPCLeaHRLpapGGAGPAEALKLRCPVCD 94
           9999888888888888888888888777777777777777444.***************5555599855555589999*****5 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1.
 E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1.
Protein Sequence
(Fasta)
MASFPETDFQ ICLLCKEMCG SPAPLSSSSS ASSSSSQTST SSAGGGGPGA AARRLHVLPC 60
LHAFCRPCLE AHRLPAPGGA GPAEALKLRC PVCDQKVVLA EAAGMDALPS SAFLLSNLLD 120
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Protein Fasta Sequence


>IUUC-Rno-105653|E3,RING|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
ATGGCTTCGT TCCCTGAGAC CGACTTCCAG ATCTGCCTGC TGTGCAAGGA GATGTGCGGC 60
TCGCCCGCGC CTCTCTCCTC CAGCTCGTCC GCCTCTTCAT CGTCCTCGCA GACGTCCACG 120
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Nucleotide Fasta Sequence


>IUUC-Rno-105653|E3,RING|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0943--RNA-mediated gene silencing
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR017868--Filamin/ABP280_repeat-like
IPR001298--Filamin/ABP280_rpt
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR001258--NHL_repeat
IPR013017--NHL_repeat_subgr
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50194--FILAMIN_REPEAT
PS51125--NHL
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00630--Filamin
PF01436--NHL
PF00643--zf-B_box
SMART

SM00336--BBOX
SM00557--IG_FLMN
SM00184--RING
Gene Ontology

GO:0000932--C:P-body
GO:0035198--F:miRNA binding
GO:0030371--F:translation repressor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0061158--P:3'-UTR-mediated mRNA destabilization
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035278--P:miRNA mediated inhibition of translation
GO:0010586--P:miRNA metabolic process
GO:0001843--P:neural tube closure
GO:0021915--P:neural tube development
GO:2000637--P:positive regulation of gene silencing by miRNA
GO:0051865--P:protein autoubiquitination
GO:0060964--P:regulation of gene silencing by miRNA
GO:2000177--P:regulation of neural precursor cell proliferation
GO:0072089--P:stem cell proliferation
KEGG rno:301042
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001234 Ailuropoda melanoleuca 93.02 0.00e+00 1153.00
IUUC-Apl-003905 Anas platyrhynchos 91.10 0.00e+00 1123.00
IUUC-Aca-004326 Anolis carolinensis 84.12 0.00e+00 1190.00
IUUC-Ani-009171 Aspergillus nidulans 27.27 3.40e-02 33.10
IUUC-Ame-011573 Astyanax mexicanus 70.50 0.00e+00 1182.00
IUUC-Bta-013395 Bos taurus 93.98 0.00e+00 1285.00
IUUC-Cel-018188 Caenorhabditis elegans 35.52 6.00e-107 382.00
IUUC-Cja-019863 Callithrix jacchus 95.98 0.00e+00 1289.00
IUUC-Cfa-020285 Canis familiaris 93.60 0.00e+00 1272.00
IUUC-Cpo-021879 Cavia porcellus 89.38 0.00e+00 1444.00
IUUC-Csa-024271 Chlorocebus sabaeus 95.98 0.00e+00 1286.00
IUUC-Cho-024376 Choloepus hoffmanni 95.38 0.00e+00 1149.00
IUUC-Cin-025406 Ciona intestinalis 49.63 0.00e+00 653.00
IUUC-Cne-027010 Cryptococcus neoformans 26.00 3.90e-02 30.40
IUUC-Dre-027699 Danio rerio 71.96 0.00e+00 1199.00
IUUC-Dno-029022 Dasypus novemcinctus 94.53 0.00e+00 1145.00
IUUC-Dor-031072 Dipodomys ordii 96.16 0.00e+00 1306.00
IUUC-Dme-031997 Drosophila melanogaster 47.45 5.00e-69 256.00
IUUC-Ete-032228 Echinops telfairi 94.51 0.00e+00 795.00
IUUC-Eca-033373 Equus caballus 96.50 0.00e+00 1027.00
IUUC-Eeu-034463 Erinaceus europaeus 93.29 0.00e+00 1103.00
IUUC-Fca-036184 Felis catus 93.66 0.00e+00 1163.00
IUUC-Fal-036918 Ficedula albicollis 81.56 0.00e+00 1160.00
IUUC-Fox-038003 Fusarium oxysporum 32.20 4.00e-03 35.40
IUUC-Gmo-039415 Gadus morhua 70.74 0.00e+00 877.00
IUUC-Gga-040379 Gallus gallus 88.48 0.00e+00 1238.00
IUUC-Gac-042330 Gasterosteus aculeatus 66.12 0.00e+00 1054.00
IUUC-Gma-043819 Glycine max 23.18 3.00e-12 67.80
IUUC-Ggo-045208 Gorilla gorilla 95.98 0.00e+00 1284.00
IUUC-Hsa-045988 Homo sapiens 96.13 0.00e+00 1287.00
IUUC-Itr-048371 Ictidomys tridecemlineatus 96.07 0.00e+00 1162.00
IUUC-Kpa-049184 Komagataella pastoris 24.69 5.90e-02 31.20
IUUC-Lch-050324 Latimeria chalumnae 76.63 0.00e+00 1265.00
IUUC-Loc-052322 Lepisosteus oculatus 71.88 0.00e+00 1249.00
IUUC-Laf-054272 Loxodonta africana 92.24 0.00e+00 1229.00
IUUC-Mcc-055125 Macaca mulatta 95.98 0.00e+00 1284.00
IUUC-Meu-055934 Macropus eugenii 82.39 0.00e+00 1117.00
IUUC-Mga-059930 Meleagris gallopavo 90.77 0.00e+00 1117.00
IUUC-Mmr-060662 Microcebus murinus 94.07 0.00e+00 1278.00
IUUC-Mdo-062918 Monodelphis domestica 87.16 0.00e+00 1259.00
IUUC-Mmu-064351 Mus musculus 97.66 0.00e+00 1461.00
IUUC-Mpu-066325 Mustela putorius furo 95.53 0.00e+00 1022.00
IUUC-Mlu-067171 Myotis lucifugus 89.60 0.00e+00 1215.00
IUUC-Nle-069692 Nomascus leucogenys 95.98 0.00e+00 1286.00
IUUC-Opr-070354 Ochotona princeps 93.84 0.00e+00 1141.00
IUUC-Ont-072125 Oreochromis niloticus 67.97 0.00e+00 1151.00
IUUC-Oan-073079 Ornithorhynchus anatinus 92.99 0.00e+00 1135.00
IUUC-Ocu-073910 Oryctolagus cuniculus 93.75 0.00e+00 1269.00
IUUC-Ola-087162 Oryzias latipes 68.33 0.00e+00 1129.00
IUUC-Oga-088523 Otolemur garnettii 85.69 0.00e+00 1163.00
IUUC-Oar-090009 Ovis aries 94.49 0.00e+00 667.00
IUUC-Ptr-091173 Pan troglodytes 96.13 0.00e+00 1288.00
IUUC-Pan-091750 Papio anubis 95.84 0.00e+00 1282.00
IUUC-Psi-093053 Pelodiscus sinensis 87.01 0.00e+00 1060.00
IUUC-Pma-094227 Petromyzon marinus 58.96 1.00e-174 606.00
IUUC-Pfo-096980 Poecilia formosa 65.78 0.00e+00 1109.00
IUUC-Pab-098189 Pongo abelii 95.83 0.00e+00 1284.00
IUUC-Pva-103126 Pteropus vampyrus 93.04 0.00e+00 1265.00
IUUC-Sce-106389 Saccharomyces cerevisiae 25.64 4.70e-02 32.00
IUUC-Sha-107178 Sarcophilus harrisii 91.77 0.00e+00 1126.00
IUUC-Sar-113613 Sorex araneus 82.33 0.00e+00 946.00
IUUC-Tgu-116963 Taeniopygia guttata 90.60 0.00e+00 1117.00
IUUC-Tru-117942 Takifugu rubripes 68.93 0.00e+00 1135.00
IUUC-Tsy-119075 Tarsius syrichta 86.82 0.00e+00 1031.00
IUUC-Tni-120704 Tetraodon nigroviridis 80.38 0.00e+00 1001.00
IUUC-Tbe-128141 Tupaia belangeri 76.11 0.00e+00 793.00
IUUC-Ttr-128908 Tursiops truncatus 90.27 0.00e+00 694.00
IUUC-Xtr-132272 Xenopus tropicalis 73.83 0.00e+00 1226.00
Created Date 25-Jun-2017

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