iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004634

UUCD1 version

UUC-AnC-01025

Ensembl Protein ID

ENSACAP00000004324.3

UniProt Accession

G1KCT7; G1KCT7_ANOCA

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000004318.3	ENSACAT00000004424.3	ENSACAP00000004324.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.70e-57	195.1	409	936
UBD/Alpha-Helix/UBA	2.50e-18	65.5	803	840

Active Site

Position(s)	Description	Evidence
418	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
899	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tGlkNlgN+CY+NSvLQ+L+nipe+++++  + ++ ++ + p +p++++ ++++kl + l                      +k +++ 
   Q: 409  TGLKNLGNSCYVNSVLQALFNIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMAKLGHGLlsgqyskppmkseiieqvmkeeQKPQHNG 496
           7******************************788777765.79*****************8888888888888877765544477788* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDa+Ef+ +l++ +e++                               +++  sd+F++ ++++++c
   Q: 497  ISPRMFKALVSKGHPEFSSNRQQDAHEFFLHLINLIERNH-----------------------------IGSENPSDVFRFLVEERTQC 556
           **************************************99.............................688899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  ++k                             ++ cL++f++++++e+   ++++  ++k+  +
   Q: 557  CQSRKVRYTERVDYLMQLPVAMEAASNKDeliayelkrreaeaarrpppelvrakiPFSACLQAFSEPDNVED---FWSSALQAKSAGV 642
           9999999999999999999999998777799*****************************************7...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + + ++k++ ++++p+ Ld+++  ++                                        
   Q: 643  KTSRFASFPEYLVVQIKKFTFGLD-WIPKKLDVSIDMPELLDINHLRATglqpgeeelpdisppiiipedpkdgttnhfmespdidess 730
           *********************997.*******************988888999999999999999999988888888888888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 731  vmqlaemgfpleacrkavyytgnmgaevafnwiiahmeepdfaepllipgyagaafpgadkpgfagldnqppeemvaiiasmgfqrnia 819
           88888888877777777777777777777777777777777777777777777777777777777777777766666666666666666 PP
   S: 268  .......................peekqke..................................kkkYeLiavvvHsG.slssGHYvay 298
                                  p     e                                  + +YeL++ ++H+G s+ sGHYv++
   Q: 820  lralratnnnlehaldwifshpeP-----EeaneasseamdienhvnanllaesdpegprvkdgSGRYELFGFISHMGtSTMSGHYVCH 903
           666666666666666666555551.....05555667777777888888888888888888888************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            k+ +g+W+ ++D kV ++  e+  +   + +Y++fY+r
   Q: 904  LKK-EGRWVIYNDLKVCAS--ERPPR---ELGYIYFYRR 936
           ***.9***********999..56666...78******97 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ + +MGF r+ al+aLra+nnnle A+++++++
   Q: 803  EEMVAIIASMGFQRNIALRALRATNNNLEHALDWIFSH 840
           89999999****************************97 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MCRVHILSPP PLPRGPGGGL GGRGWSLCAS FWAAAAPSAL PPSPAGLKIA SLLLLLLVRP 60
GGLSVCLPVC LSGAMERAAL LGSGREAGSA VAMAGDVGEL LVPYMPTVRV PKTGDRVYKA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAATAGTCTC ACTTATCCAA CATAAACGGG CCGGTAGAAC GTTGGATAAG CGAATATGTT 60
GGATAATAAG GAGGGATTAA GGAAAAGTCT ATTAAACATC AAATTACATT ATGATTTTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	83.51	0.00e+00	1412.00
IUUC-Atr-002580	Amborella trichopoda	42.43	0.00e+00	654.00
IUUC-Apl-003712	Anas platyrhynchos	87.79	0.00e+00	1434.00
IUUC-Ame-011470	Astyanax mexicanus	76.11	0.00e+00	1313.00
IUUC-Bta-013349	Bos taurus	83.20	0.00e+00	1434.00
IUUC-Cja-019021	Callithrix jacchus	82.85	0.00e+00	1399.00
IUUC-Cfa-020614	Canis familiaris	83.51	0.00e+00	1412.00
IUUC-Cpo-022484	Cavia porcellus	84.58	0.00e+00	1345.00
IUUC-Csa-024078	Chlorocebus sabaeus	83.55	0.00e+00	1414.00
IUUC-Cho-024522	Choloepus hoffmanni	70.99	0.00e+00	1071.00
IUUC-Cme-027335	Cyanidioschyzon merolae	24.86	3.00e-47	183.00
IUUC-Dre-027651	Danio rerio	76.72	0.00e+00	1380.00
IUUC-Dno-028975	Dasypus novemcinctus	83.47	0.00e+00	1411.00
IUUC-Dor-030130	Dipodomys ordii	62.64	0.00e+00	902.00
IUUC-Ete-032251	Echinops telfairi	70.86	0.00e+00	1123.00
IUUC-Eca-033568	Equus caballus	84.94	0.00e+00	1348.00
IUUC-Eeu-034612	Erinaceus europaeus	68.48	0.00e+00	1030.00
IUUC-Fca-036280	Felis catus	84.65	0.00e+00	1341.00
IUUC-Fal-036610	Ficedula albicollis	86.89	0.00e+00	1401.00
IUUC-Gmo-038906	Gadus morhua	73.51	0.00e+00	1263.00
IUUC-Gga-041215	Gallus gallus	86.14	0.00e+00	1489.00
IUUC-Gac-042441	Gasterosteus aculeatus	72.20	0.00e+00	1287.00
IUUC-Ggo-044446	Gorilla gorilla	83.78	0.00e+00	1424.00
IUUC-Hsa-046546	Homo sapiens	83.66	0.00e+00	1421.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	79.65	0.00e+00	1299.00
IUUC-Lch-050425	Latimeria chalumnae	78.89	0.00e+00	1380.00
IUUC-Loc-052072	Lepisosteus oculatus	76.00	0.00e+00	1304.00
IUUC-Laf-053909	Loxodonta africana	82.22	0.00e+00	1395.00
IUUC-Mcc-054686	Macaca mulatta	83.78	0.00e+00	1418.00
IUUC-Meu-056361	Macropus eugenii	76.95	0.00e+00	1292.00
IUUC-Mga-059972	Meleagris gallopavo	83.39	0.00e+00	1353.00
IUUC-Mmr-060916	Microcebus murinus	83.43	0.00e+00	1412.00
IUUC-Mdo-062302	Monodelphis domestica	86.29	0.00e+00	1508.00
IUUC-Mmu-063639	Mus musculus	83.83	0.00e+00	1424.00
IUUC-Mpu-066533	Mustela putorius furo	83.62	0.00e+00	1414.00
IUUC-Mlu-067786	Myotis lucifugus	80.12	0.00e+00	1323.00
IUUC-Nle-069997	Nomascus leucogenys	84.64	0.00e+00	1336.00
IUUC-Ont-071859	Oreochromis niloticus	73.21	0.00e+00	1291.00
IUUC-Oan-072959	Ornithorhynchus anatinus	84.52	3.00e-126	443.00
IUUC-Ocu-074265	Oryctolagus cuniculus	84.64	0.00e+00	1415.00
IUUC-Ola-087344	Oryzias latipes	72.64	0.00e+00	1297.00
IUUC-Oga-088734	Otolemur garnettii	84.19	0.00e+00	1387.00
IUUC-Oar-089636	Ovis aries	84.20	0.00e+00	1363.00
IUUC-Ptr-090982	Pan troglodytes	83.78	0.00e+00	1423.00
IUUC-Pan-091991	Papio anubis	83.66	0.00e+00	1416.00
IUUC-Psi-093509	Pelodiscus sinensis	89.13	0.00e+00	1558.00
IUUC-Pfo-096029	Poecilia formosa	75.55	0.00e+00	1350.00
IUUC-Pab-098672	Pongo abelii	80.07	0.00e+00	1330.00
IUUC-Pca-100860	Procavia capensis	65.44	0.00e+00	904.00
IUUC-Pva-102545	Pteropus vampyrus	77.98	0.00e+00	1299.00
IUUC-Rno-105210	Rattus norvegicus	83.47	0.00e+00	1399.00
IUUC-Sar-113733	Sorex araneus	84.65	0.00e+00	704.00
IUUC-Tgu-116591	Taeniopygia guttata	85.20	0.00e+00	1486.00
IUUC-Tru-118627	Takifugu rubripes	72.61	0.00e+00	1315.00
IUUC-Tsy-119278	Tarsius syrichta	76.51	0.00e+00	1208.00
IUUC-Tni-120804	Tetraodon nigroviridis	74.77	0.00e+00	1334.00
IUUC-Tbe-127699	Tupaia belangeri	69.51	0.00e+00	749.00
IUUC-Ttr-128295	Tursiops truncatus	76.85	0.00e+00	1290.00
IUUC-Vpa-130170	Vicugna pacos	75.06	0.00e+00	1170.00
IUUC-Xtr-132809	Xenopus tropicalis	74.97	0.00e+00	1312.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence