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Tag Content
UUCD2 ID IUUC-Cfa-020614
UUCD1 version UUC-CaF-01023
Ensembl Protein ID ENSCAFP00000016852.3
UniProt Accession E2R7B0; E2R7B0_CANLF
Genbank Protein ID ENSCAFP00000016852
Protein Name Ubiquitinyl hydrolase 1
Genbank Nucleotide ID AAEX03017257
Gene Name USP13
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCAFG00000011446.3 ENSCAFT00000018199.3 ENSCAFP00000016852.3
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 8.20e-57 193.2 336 860
UBD/Alpha-Helix/UBA 8.50e-20 70.6 730 767
Active Site
Position(s) Description Evidence
345 Nucleophile {ECO:0000256|PIRSR:PIRSR016308-1}
823 Proton acceptor {ECO:0000256|PIRSR:PIRSR016308-1}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tGlkNlgN+CY+ Sv+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       k +++ 
   Q: 336  TGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMTKLGHGLlsgqyskppvkselieqvmkeeHKPQQNG 423
           7******************************788777765.79*****************8888888888888877765543388888* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++i+c
   Q: 424  ISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNR-----------------------------IGSENPSDVFRFLVEERIQC 483
           *************************************998.............................688899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+k                             ++ cL++f+++e++++   ++++  ++k+  +
   Q: 484  CQTRKVRYTERVDYLMQLPVAMEAATNKDeliayeltrreaeanrrplpelvrakiPFSACLQAFSEPENVDD---FWSSALQAKSAGV 569
           ******9999999999999999998887799****************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + ++++k++ ++++p+ Ld+++  ++                                        
   Q: 570  KTSRFASFPEYLVVQIKKFTFGLD-WVPKKFDVSIDMPDLLDINHLRARglqpgeeelpdisppivipddskdrlmnqlidpsdidess 657
           *********************997.*******************999889999999999999999998888888888888888888877 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 658  vmqlaemgfpleacrkavyftgnmgaevafnwiivhmeepdfaepltmpgyggaasagasvfgatgldnqppeeivaiitsmgfhrnqa 746
           77777777777777777777777777777777777777777777777777777777777777777776666666666666666666666 PP
   S: 268  ...........peekqke...........................................kkkYeLiavvvHsG.slssGHYvayvkn 301
                      +     +                                           +  YeL+a ++H+G s+ sGHYv+++k+
   Q: 747  iqalratnnnlE-----RaldwifshpefeedsdfviemennananiiseakpegprvkdgSGMYELFAFISHMGtSTMSGHYVCHIKK 830
           666665555550.....055555555555555555566666666677888888888888889*************************** PP
   S: 302  ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            +g+W+ ++D++V ++  e+  +   + +Y++fY+r
   Q: 831  -EGRWVIYNDHRVCAS--ERPPK---DLGYMYFYHR 860
           .9***********999..78888...89******97 PP
   

   UBD/Alpha-Helix/UBA
   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r++a+qaLra+nnnle+A+++++++
   Q: 730  EEIVAIITSMGFHRNQAIQALRATNNNLERALDWIFSH 767
           899*********************************97 PP
   
Organism Canis familiaris
Protein Sequence
(Fasta)
MQRRGALFGV PGGSGGRKMA AGDVGELLVP HMPTIRVPRS GDRVYKNECA FSYDSPNSEG 60
GLYVCMNTFL AFGREHVERH FRKTGQSVYM HLKRHVREKV RGASGGALPK RRNSKIFLDL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cfa-020614|DUB,USP;UBD,UBA|Canis familiaris
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTCCCCCCC CTCCCCCTGC TCCCCCCCGC CGCCGAGCGC GGTCCGCGCG CAGGGCCCCT 60
CTCCAGCGCC CCCTCCCCGG CGCGCTGCGG CTGGCGCTCC CCGGCGCCCC GCCTGACGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cfa-020614|DUB,USP;UBD,UBA|Canis familiaris
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP
SMART

SM00165--UBA
SM00290--ZnF_UBP
Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG cfa:478640
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001356 Ailuropoda melanoleuca 99.07 0.00e+00 1624.00
IUUC-Apl-003712 Anas platyrhynchos 83.83 0.00e+00 1357.00
IUUC-Aca-004634 Anolis carolinensis 83.28 0.00e+00 1398.00
IUUC-Ame-011470 Astyanax mexicanus 74.74 0.00e+00 1283.00
IUUC-Bta-013349 Bos taurus 97.91 0.00e+00 1651.00
IUUC-Cja-019021 Callithrix jacchus 96.40 0.00e+00 1585.00
IUUC-Cpo-022484 Cavia porcellus 97.91 0.00e+00 1509.00
IUUC-Csa-024078 Chlorocebus sabaeus 98.72 0.00e+00 1627.00
IUUC-Cho-024522 Choloepus hoffmanni 81.02 0.00e+00 1176.00
IUUC-Cme-027335 Cyanidioschyzon merolae 25.45 5.00e-53 203.00
IUUC-Dre-027651 Danio rerio 74.88 0.00e+00 1345.00
IUUC-Dno-028975 Dasypus novemcinctus 98.15 0.00e+00 1620.00
IUUC-Dor-030130 Dipodomys ordii 73.50 0.00e+00 1066.00
IUUC-Ete-032251 Echinops telfairi 82.51 0.00e+00 1278.00
IUUC-Eca-033568 Equus caballus 99.26 0.00e+00 1517.00
IUUC-Eeu-034612 Erinaceus europaeus 79.65 0.00e+00 1150.00
IUUC-Fca-036280 Felis catus 99.88 0.00e+00 1527.00
IUUC-Fal-036610 Ficedula albicollis 84.75 0.00e+00 1334.00
IUUC-Gmo-038906 Gadus morhua 72.80 0.00e+00 1249.00
IUUC-Gga-041215 Gallus gallus 83.45 0.00e+00 1433.00
IUUC-Gac-042441 Gasterosteus aculeatus 72.54 0.00e+00 1270.00
IUUC-Ggo-044446 Gorilla gorilla 98.26 0.00e+00 1622.00
IUUC-Hsa-046546 Homo sapiens 98.49 0.00e+00 1623.00
IUUC-Itr-048147 Ictidomys tridecemlineatus 89.54 0.00e+00 1432.00
IUUC-Lch-050425 Latimeria chalumnae 77.83 0.00e+00 1357.00
IUUC-Loc-052072 Lepisosteus oculatus 77.54 0.00e+00 1307.00
IUUC-Laf-053909 Loxodonta africana 96.07 0.00e+00 1602.00
IUUC-Mcc-054686 Macaca mulatta 98.72 0.00e+00 1628.00
IUUC-Meu-056361 Macropus eugenii 80.52 0.00e+00 1307.00
IUUC-Mga-059972 Meleagris gallopavo 79.33 0.00e+00 1300.00
IUUC-Mmr-060916 Microcebus murinus 97.80 0.00e+00 1616.00
IUUC-Mdo-062302 Monodelphis domestica 89.49 0.00e+00 1513.00
IUUC-Mmu-063639 Mus musculus 95.48 0.00e+00 1603.00
IUUC-Mpu-066533 Mustela putorius furo 99.42 0.00e+00 1638.00
IUUC-Mlu-067786 Myotis lucifugus 92.24 0.00e+00 1477.00
IUUC-Nle-069997 Nomascus leucogenys 98.49 0.00e+00 1493.00
IUUC-Ont-071859 Oreochromis niloticus 72.75 0.00e+00 1273.00
IUUC-Oan-072959 Ornithorhynchus anatinus 88.70 1.00e-128 451.00
IUUC-Ocu-074265 Oryctolagus cuniculus 97.79 0.00e+00 1599.00
IUUC-Ola-087344 Oryzias latipes 71.66 0.00e+00 1277.00
IUUC-Oga-088734 Otolemur garnettii 98.44 0.00e+00 1557.00
IUUC-Oar-089636 Ovis aries 98.14 0.00e+00 1574.00
IUUC-Ptr-090982 Pan troglodytes 98.49 0.00e+00 1625.00
IUUC-Pan-091991 Papio anubis 98.84 0.00e+00 1630.00
IUUC-Psi-093509 Pelodiscus sinensis 86.24 0.00e+00 1459.00
IUUC-Pfo-096029 Poecilia formosa 74.22 0.00e+00 1315.00
IUUC-Pab-098672 Pongo abelii 94.20 0.00e+00 1524.00
IUUC-Pca-100860 Procavia capensis 74.31 0.00e+00 1040.00
IUUC-Pva-102545 Pteropus vampyrus 90.26 0.00e+00 1478.00
IUUC-Rno-105210 Rattus norvegicus 94.66 0.00e+00 1581.00
IUUC-Sar-113733 Sorex araneus 96.29 0.00e+00 774.00
IUUC-Tgu-116591 Taeniopygia guttata 84.70 0.00e+00 1432.00
IUUC-Tru-118627 Takifugu rubripes 71.22 0.00e+00 1286.00
IUUC-Tsy-119278 Tarsius syrichta 89.58 0.00e+00 1353.00
IUUC-Tni-120804 Tetraodon nigroviridis 74.30 0.00e+00 1314.00
IUUC-Tbe-127699 Tupaia belangeri 79.23 0.00e+00 878.00
IUUC-Ttr-128295 Tursiops truncatus 89.80 0.00e+00 1473.00
IUUC-Vpa-130170 Vicugna pacos 87.47 0.00e+00 1336.00
IUUC-Xtr-132809 Xenopus tropicalis 74.25 0.00e+00 1277.00
Created Date 25-Jun-2017

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