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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046787
Ensembl Protein ID ENSP00000447224.1
UniProt Accession Q149M9; C9J021; Q68CT3; NWD1_HUMAN
Genbank Protein ID CAH18655.1; AAI17699.1
Protein Name NACHT domain- and WD repeat-containing protein 1
Genbank Nucleotide ID CR749794; AC008737
Gene Name NWD1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000188039.13 ENST00000518676.5 ENSP00000428224.1
ENSG00000188039.13 ENST00000524140.6 ENSP00000428579.2
ENSG00000188039.13 ENST00000549814.5 ENSP00000447548.1
ENSG00000188039.13 ENST00000438489.6 ENSP00000400248.2
ENSG00000188039.13 ENST00000552788.1 ENSP00000447224.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.80e-22 80.1 908 942
UBD/Beta-Prp 5.20e-49 168.7 862 1075
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtcla.f.sdtllvsGsdDgtikvWDlrtg 33
           gHt++v+c++ f  +tl  s+s D t+++W+l +g
   Q: 908  GHTGEVRCVKiFaKGTLANSASKDYTLHLWNLLSG 942
           8********9558669***************9776 PP
   

   UBD/Beta-Prp
   S: 46   rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.... 131
           ++lsg+ +++ta+ +  ++k+lv g +D++  vwd++    +h l+gh+ +v++++++++g    s+s+d t+++w+l +gq+  +    
   Q: 862  ATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEKFTiwdg 951
           799********************************************************999999******************9999999 PP
   S: 132  .tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlng 220
             +++ +  ++ ++v++  +++ s+s  ++++ W+l+t++ + +  g+  d+  ++++  ++  l+++s+dg v lw+  tg+   +++ 
   Q: 952  gSKNPAEPQIWNLHVDEAHKVVYSAS-GSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGKLQGKQHM 1040
           98888998999999999776666665.478999*********999999********************************9999888877 PP
   S: 221  ht...dnvksvrfspnderlvsgssDgsiriWdlr 252
            +   +++++    +++  lv+g s gsi++  ++
   Q: 1041 SSikeETPTCAVSVQKQGKLVTGFSNGSISLVSSK 1075
           65666566665555688889999999999876444 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May play a role in the control of androgen receptor (AR) protein steady-state levels.
 May play a role in the control of androgen receptor (AR) protein steady-state levels.
Protein Sequence
(Fasta)
MQRGKPCRAL PTLKCQTFCQ RHGLMFEVVD LRWGIRNIEA TDHLTTELCL EEVDRCWKTS 60
IGPAFVALIG DQYGPCLIPS RIDEKEWEVL RDHLTARPSD LELVARYFQR DENAFPPTYV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046787|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGGAGTCTA AATTGGTCGT TCAACTACCA GCAAAGGCTA AAGAGAGGCT GGAGCCCCCA 60
GGACAGCCAG AACGCTGACA CTGCAAAGGG CCTCTGTCCT TACTGGGGAA GCCCAGTCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046787|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR024977--Apc4_WD40_dom
IPR027417--P-loop_NTPase
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005829--C:cytosol
GO:0071011--C:precatalytic spliceosome
GO:0005682--C:U5 snRNP
GO:0005524--F:ATP binding
GO:0008380--P:RNA splicing
KEGG hsa:284434
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001525 Ailuropoda melanoleuca 82.46 0.00e+00 2545.00
IUUC-Apl-003467 Anas platyrhynchos 58.80 2.00e-81 295.00
IUUC-Ame-011400 Astyanax mexicanus 36.85 0.00e+00 973.00
IUUC-Bta-013223 Bos taurus 82.18 0.00e+00 2202.00
IUUC-Cel-018404 Caenorhabditis elegans 29.13 2.00e-95 345.00
IUUC-Cja-018773 Callithrix jacchus 89.40 0.00e+00 1695.00
IUUC-Cfa-020334 Canis familiaris 83.28 0.00e+00 2545.00
IUUC-Cpo-022316 Cavia porcellus 65.66 0.00e+00 1930.00
IUUC-Csa-023631 Chlorocebus sabaeus 94.56 0.00e+00 2929.00
IUUC-Cin-025646 Ciona intestinalis 32.14 3.00e-131 463.00
IUUC-Csv-026191 Ciona savignyi 24.68 1.00e-25 110.00
IUUC-Dre-028241 Danio rerio 36.73 0.00e+00 939.00
IUUC-Dno-029990 Dasypus novemcinctus 75.45 0.00e+00 668.00
IUUC-Dor-030869 Dipodomys ordii 62.08 2.00e-174 607.00
IUUC-Ete-033059 Echinops telfairi 83.59 0.00e+00 853.00
IUUC-Eca-033718 Equus caballus 78.39 0.00e+00 2432.00
IUUC-Fca-035748 Felis catus 81.43 0.00e+00 2356.00
IUUC-Gac-041507 Gasterosteus aculeatus 34.55 0.00e+00 732.00
IUUC-Ggo-044551 Gorilla gorilla 94.13 0.00e+00 2913.00
IUUC-Itr-048104 Ictidomys tridecemlineatus 70.45 0.00e+00 1313.00
IUUC-Lch-049578 Latimeria chalumnae 47.13 0.00e+00 1428.00
IUUC-Loc-052039 Lepisosteus oculatus 40.85 0.00e+00 1197.00
IUUC-Laf-054240 Loxodonta africana 81.57 0.00e+00 2583.00
IUUC-Mcc-054657 Macaca mulatta 86.30 0.00e+00 2536.00
IUUC-Meu-056591 Macropus eugenii 62.35 0.00e+00 1147.00
IUUC-Mmr-061577 Microcebus murinus 80.00 0.00e+00 2467.00
IUUC-Mdo-062895 Monodelphis domestica 61.20 0.00e+00 1752.00
IUUC-Mmu-063866 Mus musculus 76.89 0.00e+00 2352.00
IUUC-Mpu-066510 Mustela putorius furo 82.14 0.00e+00 2547.00
IUUC-Mlu-067855 Myotis lucifugus 81.50 0.00e+00 2450.00
IUUC-Nle-069557 Nomascus leucogenys 90.34 0.00e+00 2756.00
IUUC-Opr-071196 Ochotona princeps 63.65 0.00e+00 638.00
IUUC-Ont-072070 Oreochromis niloticus 35.09 0.00e+00 782.00
IUUC-Oan-073437 Ornithorhynchus anatinus 56.79 0.00e+00 1238.00
IUUC-Ocu-074941 Oryctolagus cuniculus 79.09 7.00e-51 193.00
IUUC-Ola-086624 Oryzias latipes 32.92 0.00e+00 687.00
IUUC-Oga-088313 Otolemur garnettii 84.41 0.00e+00 2368.00
IUUC-Oar-090123 Ovis aries 81.11 0.00e+00 2507.00
IUUC-Ptr-090552 Pan troglodytes 98.17 0.00e+00 1301.00
IUUC-Psi-093963 Pelodiscus sinensis 53.36 0.00e+00 1583.00
IUUC-Pfo-096197 Poecilia formosa 34.29 0.00e+00 781.00
IUUC-Pab-097755 Pongo abelii 95.36 0.00e+00 1077.00
IUUC-Pca-100809 Procavia capensis 80.31 0.00e+00 1246.00
IUUC-Pva-102554 Pteropus vampyrus 79.05 0.00e+00 2189.00
IUUC-Rno-105174 Rattus norvegicus 69.98 0.00e+00 2056.00
IUUC-Sha-107304 Sarcophilus harrisii 60.92 0.00e+00 1922.00
IUUC-Sar-113168 Sorex araneus 65.19 0.00e+00 1361.00
IUUC-Tru-118251 Takifugu rubripes 35.52 0.00e+00 671.00
IUUC-Tsy-119276 Tarsius syrichta 76.17 7.00e-117 416.00
Created Date 25-Jun-2017

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