iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-022073

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02039365

Gene Name

Itch

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000013787.3	ENSCPOT00000013927.2	ENSCPOP00000012422.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.70e-136	454.4	529	861

Active Site

Position(s)	Description	Evidence
830	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 529  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 616
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle++dpe+y+sl ++ken   +iee+gl++ fsv++eilge+k+++Lkp+G ni Vt+eNkeeY++ v+e
   Q: 617  GFSLPFYKRILNKQVGLKDLESIDPEFYNSLIWVKEN---NIEECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAE 702
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ yt++s++i+wFw++++e+++e+r ++LqFv
   Q: 703  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YTRTSKQIIWFWQFVKEIDNEKRMRLLQFV 790
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 791  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 861
           *********************************************************************96 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MSDSGSQPGS MGSLTMKSQL QITVISAKLK ENKKNWFGPS PYVEVTVDGQ SKKTEKCNNT 60
NSPKWKQPLT VIVTPVSKLQ FRVWSHQTLK SDVLLGTAAL DIYETLKSNN MKLEEVVVTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTGACA GTGGATCACA ACCTGGTTCA ATGGGTAGCC TGACCATGAA ATCACAGCTG 60
CAGATCACTG GTAAGGTTTG AAAAGATCCA CTATTTTACT CTTCCTATAC CTAAGATTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	96.93	0.00e+00	1622.00
IUUC-Apl-003752	Anas platyrhynchos	83.85	0.00e+00	1459.00
IUUC-Aca-005338	Anolis carolinensis	81.75	0.00e+00	1441.00
IUUC-Ago-007742	Ashbya gossypii	49.05	2.00e-162	566.00
IUUC-Ame-010601	Astyanax mexicanus	88.07	0.00e+00	1121.00
IUUC-Bta-012782	Bos taurus	96.64	0.00e+00	1589.00
IUUC-Cja-018899	Callithrix jacchus	93.13	0.00e+00	1570.00
IUUC-Cfa-020648	Canis familiaris	95.77	0.00e+00	1588.00
IUUC-Csa-023252	Chlorocebus sabaeus	97.10	0.00e+00	1639.00
IUUC-Cho-024695	Choloepus hoffmanni	90.03	0.00e+00	1621.00
IUUC-Cne-026849	Cryptococcus neoformans	47.64	2.00e-159	556.00
IUUC-Dre-028451	Danio rerio	75.83	0.00e+00	1306.00
IUUC-Dno-029884	Dasypus novemcinctus	96.40	0.00e+00	1664.00
IUUC-Eca-033793	Equus caballus	97.33	0.00e+00	1647.00
IUUC-Eeu-034716	Erinaceus europaeus	92.58	0.00e+00	885.00
IUUC-Fca-035605	Felis catus	97.05	0.00e+00	1652.00
IUUC-Fal-037126	Ficedula albicollis	83.90	0.00e+00	1461.00
IUUC-Gmo-038596	Gadus morhua	81.13	0.00e+00	1013.00
IUUC-Gga-040832	Gallus gallus	83.65	0.00e+00	1479.00
IUUC-Gac-041658	Gasterosteus aculeatus	86.82	0.00e+00	1125.00
IUUC-Ggo-044535	Gorilla gorilla	94.08	0.00e+00	1602.00
IUUC-Hsa-046564	Homo sapiens	93.47	0.00e+00	1630.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	96.52	0.00e+00	1572.00
IUUC-Kpa-049273	Komagataella pastoris	49.40	8.00e-164	570.00
IUUC-Lch-050454	Latimeria chalumnae	77.75	0.00e+00	1405.00
IUUC-Loc-052647	Lepisosteus oculatus	74.42	0.00e+00	1358.00
IUUC-Laf-054383	Loxodonta africana	97.80	0.00e+00	1652.00
IUUC-Mcc-055532	Macaca mulatta	97.10	0.00e+00	1640.00
IUUC-Mga-059661	Meleagris gallopavo	83.54	0.00e+00	1466.00
IUUC-Mmr-061135	Microcebus murinus	97.45	0.00e+00	1669.00
IUUC-Mdo-062505	Monodelphis domestica	87.57	0.00e+00	1509.00
IUUC-Mmu-063375	Mus musculus	95.72	0.00e+00	1601.00
IUUC-Mpu-066203	Mustela putorius furo	97.29	0.00e+00	1627.00
IUUC-Mlu-067837	Myotis lucifugus	96.87	0.00e+00	1643.00
IUUC-Nle-069244	Nomascus leucogenys	96.41	0.00e+00	1622.00
IUUC-Opr-070585	Ochotona princeps	90.92	0.00e+00	1584.00
IUUC-Ont-071798	Oreochromis niloticus	88.10	0.00e+00	1143.00
IUUC-Ocu-074298	Oryctolagus cuniculus	97.57	0.00e+00	1637.00
IUUC-Ola-086526	Oryzias latipes	85.74	0.00e+00	1125.00
IUUC-Oga-088167	Otolemur garnettii	90.41	0.00e+00	1520.00
IUUC-Oar-090316	Ovis aries	80.42	0.00e+00	1202.00
IUUC-Ptr-090819	Pan troglodytes	92.68	0.00e+00	1592.00
IUUC-Pan-092454	Papio anubis	97.10	0.00e+00	1639.00
IUUC-Psi-093319	Pelodiscus sinensis	82.60	0.00e+00	1435.00
IUUC-Pfo-097346	Poecilia formosa	84.51	0.00e+00	1108.00
IUUC-Pab-097580	Pongo abelii	86.71	0.00e+00	1470.00
IUUC-Pca-100923	Procavia capensis	78.65	0.00e+00	1359.00
IUUC-Pva-103209	Pteropus vampyrus	95.71	0.00e+00	1586.00
IUUC-Rno-104924	Rattus norvegicus	95.37	0.00e+00	1608.00
IUUC-Sha-107175	Sarcophilus harrisii	88.62	0.00e+00	1506.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	44.96	2.00e-160	559.00
IUUC-Spo-108171	Schizosaccharomyces pombe	51.06	5.00e-163	568.00
IUUC-Sar-113761	Sorex araneus	86.23	0.00e+00	1486.00
IUUC-Tgu-116632	Taeniopygia guttata	80.80	0.00e+00	1340.00
IUUC-Tru-118442	Takifugu rubripes	89.10	0.00e+00	1122.00
IUUC-Tsy-119198	Tarsius syrichta	90.60	0.00e+00	1530.00
IUUC-Tni-120168	Tetraodon nigroviridis	86.88	0.00e+00	1059.00
IUUC-Tbe-127756	Tupaia belangeri	78.07	0.00e+00	1310.00
IUUC-Ttr-128504	Tursiops truncatus	90.67	0.00e+00	1192.00
IUUC-Vpa-130103	Vicugna pacos	82.52	0.00e+00	1396.00
IUUC-Xtr-132885	Xenopus tropicalis	76.24	0.00e+00	1380.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence