iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062913

UUCD1 version

UUC-MoD-00894

Ensembl Protein ID

ENSMODP00000009538.3

UniProt Accession

F7FNF3; F7FNF3_MONDO

Protein Name

Apoptotic protease-activating factor 1

Gene Name

APAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000007679.3	ENSMODT00000009726.3	ENSMODP00000009538.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.60e-69	224.8	740	774
UBD/Beta-Prp	2.50e-98	329.1	1004	1237

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtg 33
           gH +sv+ ++f +d t+l+s+s Dgt+k+WD+++ 
   Q: 740  GHMNSVNHCQFsPDdTHLASCSADGTLKLWDVSSA 774
           89**********777****************9875 PP

UBD/Beta-Prp

   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghe 94
           h+k+v + v+f+pd++ l+++s+d+t++vw+++++ +   l+ h+++v++ ++ +++  l+t s D+t+kvw++ tgk    ++ h+
   Q: 1004 HEKAVRR-VQFTPDGRTLISSSDDSTVQVWNWQSEEF-VFLKAHQEPVKDFRLLQNS-RLLTWSFDGTVKVWNILTGKVEKDFTCHQ 1087
           6666655.**************************888.889***************8.9**************************** PP
   S: 95   dsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl...... 175
            +vls+++sp+  k+ s+s+d+t+++w+ e+   l+  l+gh+g v+c v+++d+ ll++G +++ +r+W++++g ll+        
   Q: 1088 GTVLSCDVSPNATKFSSTSADKTAKIWNFESSFPLH-ELRGHEGCVRCSVFSGDNALLATGDDNGEIRIWSVSSGGLLHSClpltve 1173
           ************************************.*******************************************99****8 PP
   S: 176  ..tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvs 239
             +    + v+ l f+++g+ lvs++  g++k wd+ tge ++t+    +n k +++sp    +v+
   Q: 1174 egEATYGGWVTDLHFSPDGRMLVSAG--GYLKWWDVDTGESLQTFYTNGTNLKTIHVSPSFRAYVT 1237
           77555678888888********9986..9****************************976665555 PP

Organism

Monodelphis domestica

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

MDAKARNCLL QHKEALERDI KTSYLMDHMI SDQVLSLSEE EKIRNEPTQK KRAALLITVL 60
LGKDNNSYIS FYNALLHEGY KDLAFLLQKG LPLSSYNGKD PVDGVTSYVK TVLCEGGVPQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTTTAAGA CCTTCAAAGA ACTTTCCACT CAAGATCCCT AGGATGTAAT TTGTCCAAAT 60
ATCCCCGTTT TACAGATGAG GAAAAGAGAA TTTTTTGTCT GCAAGGTATG CTTTTGCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR003143--Cyt_cd1_C
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR023302--Pept_S9A_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

KEGG

mdo:100013051

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	79.12	0.00e+00	2072.00
IUUC-Apl-004201	Anas platyrhynchos	68.96	0.00e+00	1806.00
IUUC-Aca-004638	Anolis carolinensis	67.04	0.00e+00	1777.00
IUUC-Afu-008928	Aspergillus fumigatus	26.90	8.00e-59	223.00
IUUC-Ani-009285	Aspergillus nidulans	26.43	1.00e-70	262.00
IUUC-Ame-011062	Astyanax mexicanus	55.66	0.00e+00	1398.00
IUUC-Bta-012865	Bos taurus	78.99	0.00e+00	2088.00
IUUC-Cja-018815	Callithrix jacchus	71.70	0.00e+00	1839.00
IUUC-Cfa-020222	Canis familiaris	75.10	0.00e+00	1940.00
IUUC-Cpo-021524	Cavia porcellus	78.59	0.00e+00	2055.00
IUUC-Csa-023861	Chlorocebus sabaeus	79.07	0.00e+00	2085.00
IUUC-Cho-024484	Choloepus hoffmanni	69.09	0.00e+00	1074.00
IUUC-Dre-028006	Danio rerio	54.20	0.00e+00	1281.00
IUUC-Dno-029591	Dasypus novemcinctus	79.94	0.00e+00	2131.00
IUUC-Dor-030237	Dipodomys ordii	66.34	0.00e+00	964.00
IUUC-Ete-032620	Echinops telfairi	74.68	0.00e+00	962.00
IUUC-Eca-033569	Equus caballus	79.71	0.00e+00	2085.00
IUUC-Eeu-035354	Erinaceus europaeus	57.23	4.00e-158	552.00
IUUC-Fca-036337	Felis catus	79.33	0.00e+00	2106.00
IUUC-Fal-037077	Ficedula albicollis	68.94	0.00e+00	1804.00
IUUC-Gmo-039687	Gadus morhua	51.21	0.00e+00	936.00
IUUC-Ggr-039828	Gaeumannomyces graminis	24.74	5.00e-45	177.00
IUUC-Gga-040299	Gallus gallus	68.98	0.00e+00	1825.00
IUUC-Gac-041762	Gasterosteus aculeatus	53.07	0.00e+00	1280.00
IUUC-Ggo-045563	Gorilla gorilla	79.15	0.00e+00	2087.00
IUUC-Hsa-046771	Homo sapiens	79.07	0.00e+00	2087.00
IUUC-Lch-050200	Latimeria chalumnae	64.34	0.00e+00	1635.00
IUUC-Loc-052090	Lepisosteus oculatus	59.81	0.00e+00	1530.00
IUUC-Laf-053861	Loxodonta africana	79.81	0.00e+00	2097.00
IUUC-Mcc-055543	Macaca mulatta	79.47	0.00e+00	2093.00
IUUC-Meu-056688	Macropus eugenii	90.65	0.00e+00	2330.00
IUUC-Mga-059243	Meleagris gallopavo	69.11	0.00e+00	1833.00
IUUC-Mmr-061134	Microcebus murinus	74.93	0.00e+00	1769.00
IUUC-Mmu-063811	Mus musculus	78.04	0.00e+00	2075.00
IUUC-Mpu-066780	Mustela putorius furo	79.17	0.00e+00	2062.00
IUUC-Mlu-067276	Myotis lucifugus	79.17	0.00e+00	2096.00
IUUC-Nle-069129	Nomascus leucogenys	78.51	0.00e+00	2068.00
IUUC-Opr-071007	Ochotona princeps	59.00	0.00e+00	993.00
IUUC-Ont-071348	Oreochromis niloticus	55.72	0.00e+00	1407.00
IUUC-Oan-072717	Ornithorhynchus anatinus	78.04	0.00e+00	2071.00
IUUC-Ocu-074286	Oryctolagus cuniculus	79.55	0.00e+00	1777.00
IUUC-Ola-086895	Oryzias latipes	51.36	0.00e+00	1224.00
IUUC-Oga-088678	Otolemur garnettii	78.99	0.00e+00	2070.00
IUUC-Oar-089359	Ovis aries	78.12	0.00e+00	2064.00
IUUC-Ptr-091062	Pan troglodytes	78.99	0.00e+00	2085.00
IUUC-Pan-092528	Papio anubis	82.53	0.00e+00	1256.00
IUUC-Psi-093430	Pelodiscus sinensis	72.23	0.00e+00	1899.00
IUUC-Pma-094690	Petromyzon marinus	40.39	3.00e-157	548.00
IUUC-Pfo-097204	Poecilia formosa	55.51	0.00e+00	1395.00
IUUC-Pab-097690	Pongo abelii	79.15	0.00e+00	2094.00
IUUC-Pca-100778	Procavia capensis	62.19	0.00e+00	1046.00
IUUC-Pva-102870	Pteropus vampyrus	77.50	0.00e+00	1885.00
IUUC-Rno-104889	Rattus norvegicus	77.80	0.00e+00	2031.00
IUUC-Sha-107465	Sarcophilus harrisii	89.39	0.00e+00	2357.00
IUUC-Sar-113268	Sorex araneus	76.92	1.00e-169	590.00
IUUC-Ssc-115654	Sus scrofa	78.91	0.00e+00	2097.00
IUUC-Tgu-117302	Taeniopygia guttata	69.34	0.00e+00	1820.00
IUUC-Tru-118363	Takifugu rubripes	55.41	0.00e+00	1389.00
IUUC-Tsy-119007	Tarsius syrichta	76.12	0.00e+00	1989.00
IUUC-Tni-120910	Tetraodon nigroviridis	53.77	0.00e+00	1336.00
IUUC-Tbe-127413	Tupaia belangeri	67.11	0.00e+00	1242.00
IUUC-Ttr-129213	Tursiops truncatus	72.92	0.00e+00	1895.00
IUUC-Vpa-130146	Vicugna pacos	74.06	0.00e+00	1440.00
IUUC-Xtr-132559	Xenopus tropicalis	60.46	0.00e+00	1565.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence