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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046170
Ensembl Protein ID ENSP00000364929.3
UniProt Accession Q9UK53; O00532; O43658; Q53ZR3; Q5T9G8; Q5T9G9; Q5T9H0; Q5T9H1; Q9H007; Q9HD98; Q9HD99; Q9NS83; Q9P0U6; Q9UBC6; Q9UIJ1; Q9UIJ2; Q9UIJ3; Q9UIJ4; Q9UK52; ING1_HUMAN
Genbank Protein ID AAF07920.1; AAF07921.1; AAB60879.1; AAC00501.1; AAF37421.1; AAF37422.1; AAF37423.1; AAG02578.1; AAG02578.1; AAG02579.1; AAG02579.1; BAB08101.1; BAB08102.1; BAB08103.1; BAB20992.2; BAA83496.1; BAA82886.1; BAA82887.1; BAA82888.1; BAA82889.1; BAA83462.1; BAA82890.1; CAC38067.1; AAG12174.1; AAG12175.1; AAG12175.1; BAG63679.1; CAI16972.1; CAI16973.1; CAI16974.1; CAI16975.1; EAX09127.1; EAX09130.1; AAH93942.1; AAH93944.1
Protein Name Inhibitor of growth protein 1
Genbank Nucleotide ID AF181849; AF181850; AF001954; AF044076; AF149721; AF149722; AF149723; AF167551; AF167550; AF167551; AF167549; AB037387; AB037387; AB037387; AB037594; AB031269; AB024401; AB024402; AB024403; AB024404; AB024404; AB024405; AJ310392; AF078835; AF078837; AF078836; AK302353; AL157820; AL157820; AL157820; AL157820; CH471085; CH471085; BC093942; BC093944
Gene Name ING1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000153487.12 ENST00000338450.7 ENSP00000345202.7
ENSG00000153487.12 ENST00000333219.8 ENSP00000328436.7
ENSG00000153487.12 ENST00000375774.3 ENSP00000364929.3
ENSG00000153487.12 ENST00000464141.1 ENSP00000480985.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACmiRecordsRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPHOSIDABioGRID
DNA Methylation
MethyCancerTCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Other/Other UBD/Other/Other 21731648
Classification
Family E-value Score Start End
E3 activity/RING/PHD 2.50e-08 35.6 354 401
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C +C + + +e  ++ C++  C  ewfH+ C++l+    +p+ + w+CpkCr 
   Q: 354  TYC-LCNQVSYGE--MIGCDNdeCPiEWFHFSCVGLN---HKPKGK-WYCPKCRG 401
           69*.*******99..******9**99***********...999997.******85 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
 Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
Protein Sequence
(Fasta)
MSFVECPYHS PAERLVAEAD EGGPSAITGM GLCFRCLLFS FSGRSGVEGG RVDLNVFGSL 60
GLQPWIGSSR CWGGPCSSAL RCGWFSSWPP PSKSAIPIGG GSRGAGRVSR WPPPHWLEAW 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046170|UBD,UBD/Other/Other;E3,PHD|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCTCCGAGAA CGGTGTCCAT GACACAGGGC GGGAAGAGAT AAGGCCTAGG GAAGGCGCCC 60
CTCGGGCCTA TCCACCTCTT CTGGGGCTCG GCACTAGGAA GCAGCTTCCC TCTCAGGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046170|UBD,UBD/Other/Other;E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0043--Tumor suppressor
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR028643--ING1
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF12998--ING
SMART

SM01408--ING
SM00249--PHD
Gene Ontology

GO:0005634--C:nucleus
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0010941--P:regulation of cell death
KEGG hsa:3621
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001945 Ailuropoda melanoleuca 87.71 2.00e-98 352.00
IUUC-Apl-003910 Anas platyrhynchos 87.66 3.00e-96 344.00
IUUC-Aca-004874 Anolis carolinensis 86.44 6.00e-95 340.00
IUUC-Ame-011262 Astyanax mexicanus 67.21 1.00e-75 276.00
IUUC-Bta-013507 Bos taurus 87.18 7.00e-88 316.00
IUUC-Cja-018925 Callithrix jacchus 98.31 3.00e-109 387.00
IUUC-Cfa-020947 Canis familiaris 87.29 3.00e-97 347.00
IUUC-Cpo-022286 Cavia porcellus 71.39 8.00e-109 386.00
IUUC-Csa-023825 Chlorocebus sabaeus 97.88 8.00e-109 386.00
IUUC-Cho-024577 Choloepus hoffmanni 88.84 7.00e-96 343.00
IUUC-Cne-027005 Cryptococcus neoformans 45.95 7.00e-16 78.20
IUUC-Dno-029834 Dasypus novemcinctus 88.14 1.00e-98 352.00
IUUC-Dor-030315 Dipodomys ordii 67.30 3.00e-126 445.00
IUUC-Ete-032408 Echinops telfairi 66.59 3.00e-120 425.00
IUUC-Eca-034244 Equus caballus 87.61 9.00e-97 345.00
IUUC-Fca-035391 Felis catus 87.61 7.00e-89 320.00
IUUC-Fal-036838 Ficedula albicollis 86.86 7.00e-96 343.00
IUUC-Gga-040619 Gallus gallus 86.44 2.00e-95 342.00
IUUC-Gac-041996 Gasterosteus aculeatus 64.29 1.00e-73 270.00
IUUC-Ggo-045481 Gorilla gorilla 97.39 0.00e+00 699.00
IUUC-Itr-048440 Ictidomys tridecemlineatus 90.17 9.00e-99 352.00
IUUC-Lch-050397 Latimeria chalumnae 83.05 8.00e-94 336.00
IUUC-Loc-052038 Lepisosteus oculatus 72.22 2.00e-76 278.00
IUUC-Laf-054126 Loxodonta africana 88.98 3.00e-99 354.00
IUUC-Mcc-055031 Macaca mulatta 89.90 9.00e-175 606.00
IUUC-Meu-056248 Macropus eugenii 71.20 2.00e-96 345.00
IUUC-Mga-059217 Meleagris gallopavo 86.70 2.00e-93 335.00
IUUC-Mmr-061581 Microcebus murinus 88.56 4.00e-98 350.00
IUUC-Mdo-062452 Monodelphis domestica 87.29 1.00e-96 345.00
IUUC-Mmu-063412 Mus musculus 87.71 4.00e-97 347.00
IUUC-Mpu-066479 Mustela putorius furo 88.46 2.00e-97 349.00
IUUC-Mlu-067723 Myotis lucifugus 87.71 3.00e-97 347.00
IUUC-Nle-069122 Nomascus leucogenys 98.31 3.00e-109 387.00
IUUC-Opr-070835 Ochotona princeps 84.12 2.00e-82 298.00
IUUC-Oan-073023 Ornithorhynchus anatinus 86.44 4.00e-93 334.00
IUUC-Ocu-073779 Oryctolagus cuniculus 86.75 2.00e-88 318.00
IUUC-Ola-086891 Oryzias latipes 63.14 2.00e-75 275.00
IUUC-Oga-087954 Otolemur garnettii 87.71 1.00e-96 345.00
IUUC-Oar-090006 Ovis aries 86.02 1.00e-93 335.00
IUUC-Ptr-090589 Pan troglodytes 98.73 1.00e-109 389.00
IUUC-Pan-091896 Papio anubis 93.35 0.00e+00 681.00
IUUC-Psi-093266 Pelodiscus sinensis 87.29 1.00e-96 346.00
IUUC-Pma-094265 Petromyzon marinus 76.39 4.00e-32 130.00
IUUC-Pab-098253 Pongo abelii 98.31 4.00e-109 387.00
IUUC-Pva-102753 Pteropus vampyrus 70.24 5.00e-109 387.00
IUUC-Rno-105964 Rattus norvegicus 87.61 8.00e-88 316.00
IUUC-Sha-107270 Sarcophilus harrisii 86.86 2.00e-95 342.00
IUUC-Tgu-116822 Taeniopygia guttata 88.14 3.00e-97 347.00
IUUC-Tvi-122341 Trichoderma virens 61.40 1.00e-15 75.50
IUUC-Ttr-128672 Tursiops truncatus 86.53 9.00e-97 346.00
Created Date 25-Jun-2017

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