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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046493
Ensembl Protein ID ENSP00000266458.5
UniProt Accession Q9H0R8; B4E0Y7; Q6FIE6; GBRL1_HUMAN
Genbank Protein ID AAK55962.1; AAK20399.1; AEZ06294.1; CAB66611.1; BAG64599.1; CAG38511.1; EAW96164.1; AAH09309.1; AAH28315.1
Protein Name Gamma-aminobutyric acid receptor-associated protein-like 1; Early estrogen-regulated protein; GABA(A) receptor-associated protein-like 1; Glandular epithelial cell protein 1
Genbank Nucleotide ID AF287012; AF087847; JN663881; AL136676; AK303581; CR533480; AC115676; BC009309; BC028315
Gene Name GABARAPL1; GEC1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000139112.10 ENST00000539408.5 ENSP00000443122.1
ENSG00000139112.10 ENST00000266458.9 ENSP00000266458.5
ENSG00000139112.10 ENST00000421801.6 ENSP00000411256.2
ENSG00000139112.10 ENST00000545047.5 ENSP00000441165.1
ENSG00000139112.10 ENST00000541960.5 ENSP00000445709.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACmiRWalkTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UBL/ATG8 ATG8 19533740; 23721406
Classification
Family E-value Score Start End
ULD/UBL/ATG8 5.10e-53 179.3 14 116
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UBL/ATG8
   S: 2    rkeevekirdkfpdkiPvivekakkekipeldkkkylvPsdltvgqlvkiirkrlqlraedalfllvnnslvsvsatlaeiyeeekdedgfl 93
           rk+e+ekir+k+pd++Pviveka+k+++p+ldk+kylvPsdltvgq++++irkr++lr+edalf++vnn+++++sat++++ye++++ed+fl
   Q: 14   RKKEGEKIRKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEEDYFL 105
           89****************************************************************************************** PP
   S: 94   yvayaseetfG 104
           yvay++e+++G
   Q: 106  YVAYSDESVYG 116
           **********9 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
 Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
Protein Sequence
(Fasta)
MKFQYKEDHP FEYRKKEGEK IRKKYPDRVP VIVEKAPKAR VPDLDKRKYL VPSDLTVGQF 60
YFLIRKRIHL RPEDALFFFV NNTIPPTSAT MGQLYEDNHE EDYFLYVAYS DESVYGK 117
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046493|ULD,ATG8|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGGGCAGCGG AACGCGCAGA GGGCACGGTG CAAGCACGGG ACAGCTCTGC ATTGGCCAAA 60
GGGATCCCAG GAGGCCTGGC CCTCTTTTCT CCTGAGGCTG GATCCCAACC AGCAGGAAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046493|ULD,ATG8|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0493--Microtubule
KW-1185--Reference proteome
Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom
Pfam

PF02991--Atg8
Gene Ontology

GO:0005776--C:autophagosome
GO:0000421--C:autophagosome membrane
GO:0044297--C:cell body
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005829--C:cytosol
GO:0032839--C:dendrite cytoplasm
GO:0032590--C:dendrite membrane
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0005622--C:intracellular
GO:0005874--C:microtubule
GO:0048487--F:beta-tubulin binding
GO:0050811--F:GABA receptor binding
GO:0030957--F:Tat protein binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0097352--P:autophagosome maturation
GO:0016236--P:macroautophagy
KEGG hsa:23710
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002173 Ailuropoda melanoleuca 100.00 7.00e-65 238.00
IUUC-Apl-003994 Anas platyrhynchos 100.00 1.00e-64 237.00
IUUC-Aca-004544 Anolis carolinensis 94.87 4.00e-60 222.00
IUUC-Bta-012584 Bos taurus 100.00 6.00e-65 238.00
IUUC-Cja-019701 Callithrix jacchus 100.00 6.00e-65 238.00
IUUC-Cfa-020883 Canis familiaris 100.00 6.00e-65 238.00
IUUC-Cpo-022522 Cavia porcellus 100.00 6.00e-65 238.00
IUUC-Csa-024162 Chlorocebus sabaeus 100.00 6.00e-65 238.00
IUUC-Cho-025008 Choloepus hoffmanni 95.73 9.00e-62 228.00
IUUC-Dno-030014 Dasypus novemcinctus 100.00 3.00e-65 239.00
IUUC-Eca-033464 Equus caballus 100.00 6.00e-65 238.00
IUUC-Eeu-034826 Erinaceus europaeus 76.92 2.00e-46 176.00
IUUC-Fca-036435 Felis catus 100.00 2.00e-64 237.00
IUUC-Fal-037143 Ficedula albicollis 100.00 1.00e-64 237.00
IUUC-Gga-040919 Gallus gallus 100.00 6.00e-65 238.00
IUUC-Gma-044021 Glycine max 57.39 4.00e-38 149.00
IUUC-Ggo-044931 Gorilla gorilla 100.00 6.00e-65 238.00
IUUC-Itr-048838 Ictidomys tridecemlineatus 100.00 1.00e-64 237.00
IUUC-Laf-054083 Loxodonta africana 100.00 5.00e-65 239.00
IUUC-Mcc-055410 Macaca mulatta 100.00 6.00e-65 238.00
IUUC-Meu-056010 Macropus eugenii 100.00 6.00e-65 238.00
IUUC-Mga-060108 Meleagris gallopavo 100.00 1.00e-64 237.00
IUUC-Mmr-060690 Microcebus murinus 100.00 6.00e-65 238.00
IUUC-Mdo-062279 Monodelphis domestica 100.00 2.00e-65 240.00
IUUC-Mmu-063624 Mus musculus 100.00 6.00e-65 238.00
IUUC-Mpu-066745 Mustela putorius furo 100.00 6.00e-65 238.00
IUUC-Oan-073612 Ornithorhynchus anatinus 98.85 7.00e-47 177.00
IUUC-Ocu-073934 Oryctolagus cuniculus 100.00 5.00e-65 238.00
IUUC-Oga-088360 Otolemur garnettii 100.00 6.00e-65 238.00
IUUC-Oar-089396 Ovis aries 100.00 1.00e-64 238.00
IUUC-Ptr-091136 Pan troglodytes 94.87 1.00e-60 224.00
IUUC-Psi-093055 Pelodiscus sinensis 100.00 6.00e-65 238.00
IUUC-Pfo-096947 Poecilia formosa 61.54 6.00e-32 129.00
IUUC-Pva-103103 Pteropus vampyrus 100.00 6.00e-65 238.00
IUUC-Rno-105347 Rattus norvegicus 100.00 6.00e-65 238.00
IUUC-Sha-106802 Sarcophilus harrisii 100.00 4.00e-65 239.00
IUUC-Ssc-115683 Sus scrofa 99.15 1.00e-64 237.00
IUUC-Tgu-116669 Taeniopygia guttata 100.00 7.00e-65 238.00
IUUC-Tsy-118919 Tarsius syrichta 100.00 6.00e-65 238.00
IUUC-Tca-121335 Theobroma cacao 58.26 7.00e-34 136.00
IUUC-Tbe-128099 Tupaia belangeri 76.92 2.00e-46 176.00
IUUC-Ttr-128712 Tursiops truncatus 100.00 6.00e-65 238.00
IUUC-Vpa-130227 Vicugna pacos 100.00 3.00e-47 179.00
Created Date 25-Jun-2017

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