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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063241
UUCD1 version UUC-MuM-01189
Ensembl Protein ID ENSMUSP00000033383.2
UniProt Accession Q99K46; B1AXB2; Q3TLG5; UBP11_MOUSE
Genbank Protein ID BAE38827.1; CAM23095.1; EDL00740.1; AAH05470.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 11; Deubiquitinating enzyme 11; Ubiquitin thioesterase 11; Ubiquitin-specific-processing protease 11
Genbank Nucleotide ID AK166523; AL807240; CH466625; BC005470
Gene Name Usp11
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031066.10 ENSMUST00000033383.2 ENSMUSP00000033383.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.90e-111 373.7 257 889
Active Site
Position(s) Description Evidence
266 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
847 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl+NlgNtC+mNS+LQcLsn+p+l+e++l+ ++ e+ln +np ++kgel++++++l+++ w++ ++++ p+ ++++++++a++f gy+
   Q: 257  CGLTNLGNTCFMNSALQCLSNVPQLTEYFLNnRYLEELNFRNPLGMKGELAEAYADLVKQTWSGYHRSIVPNVFKNKVGHFASQFLGYQ 345
           7******************************99******************************************************** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeed...kselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
           q+D+qE+l+flld+l+e+l++ k+k++ e+++ +   + e  +ea++++k++n+s+i+d+F+g +ks+++c++c+nvs++++pf++ls+
   Q: 346  QHDSQELLSFLLDGLHEDLNRVKKKEYVELCNGAgrpDLEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSV 434
           *****************************998761113455666********************************************* PP
   S: 175  pvpgkeetkke.............................................................................. 185
           p+p  + + +e                                                                              
   Q: 435  PLPVCSRRVLEvffvpmdprrkpeqhrvvvpkkgnisdlcvalsthtsvapdkmivadvfshrfyklyqledplsgildrddifvyevt 523
           ****9998888****************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 524  griepvegsrddivvpvylrertpsrdynnsyyglilfghpllvsvprdrfsweglynilmyrlsryvtkptsdeddgdekvdededed 612
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 613  veddssseeekeemsaptvndgtreaeqeqagtssgvtercpslldnslrasqwpprrrrkqlftlqtvnsngtsdrttspeemqtqpy 701
           ***************************************************************************************** PP
   S: 186  .....................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRf 237
                                                +l++c++ ft+ e+le+en +yc++ck++q a+kkl+l+ lPevLi+hLkRf
   Q: 702  iamdwepdmkrryydeveaegyvkhdcvgymlkkspvQLKECIKLFTTVETLEKENPWYCSSCKQHQLATKKLDLWMLPEVLIIHLKRF 790
           ***************************************************************************************** PP
   S: 238  sfseeqksrekinkkvefple.Ldlspfctspeekqke.kkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevl 323
           sfs+   srek+++ v+fp++ Ld s+f+++p+++++   +kY+Liav +H+G+++ GHY++++ n ++g+W +fdD++V++v+e++++
   Q: 791  SFSK--ISREKLDTLVQFPIRdLDFSEFVIKPKNESSPdLYKYDLIAVSNHYGGMRDGHYTTFACNkDSGQWHYFDDNSVSPVNENQIE 877
           9987..6999******************9999877654489*********************988834566****************** PP
   S: 324  eetgstaYvlfYkrr 338
           +   + aYvlfY+r+
   Q: 878  S---KAAYVLFYQRQ 889
           *...*********96 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex.
 Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex.
Protein Sequence
(Fasta)
MAAVAADPAA AAVPASAEDR DTQPEAMPDL DEQWRQIGNG RERPLRAGES WFLVEKHWYK 60
QWEVYVKGGD QDASTFPGCI NNAGLFEDQI SWHLRERLLE GDDYVLLPAP AWNYMVSWYG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063241|DUB,USP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCAGTTGAG GGTCGTCTTC CTATCTTCAG TTGCGTCGGC AGTTGGAGGA GGACAGACGG 60
TGATGGCGGC GGTCGCAGCG GACCCAGCTG CAGCTGCCGT CCCGGCCTCT GCTGAGGACC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063241|DUB,USP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH
SMART

SM00695--DUSP
Gene Ontology

GO:0005694--C:chromosome
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:236733
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001760 Ailuropoda melanoleuca 75.67 0.00e+00 1403.00
IUUC-Aca-004532 Anolis carolinensis 62.39 0.00e+00 1099.00
IUUC-Bta-013284 Bos taurus 75.08 0.00e+00 1390.00
IUUC-Bdi-014523 Brachypodium distachyon 33.37 5.00e-121 429.00
IUUC-Cja-019746 Callithrix jacchus 81.61 0.00e+00 1488.00
IUUC-Cfa-020134 Canis familiaris 76.65 0.00e+00 1427.00
IUUC-Cpo-022535 Cavia porcellus 81.70 0.00e+00 1527.00
IUUC-Csa-023828 Chlorocebus sabaeus 81.95 0.00e+00 1510.00
IUUC-Dre-027398 Danio rerio 60.78 0.00e+00 732.00
IUUC-Dno-028853 Dasypus novemcinctus 76.49 0.00e+00 1214.00
IUUC-Dor-030384 Dipodomys ordii 84.56 0.00e+00 1540.00
IUUC-Eca-033271 Equus caballus 77.05 0.00e+00 1395.00
IUUC-Fca-036012 Felis catus 75.99 0.00e+00 1438.00
IUUC-Gac-042574 Gasterosteus aculeatus 53.12 0.00e+00 867.00
IUUC-Hsa-046551 Homo sapiens 82.07 0.00e+00 1512.00
IUUC-Itr-048915 Ictidomys tridecemlineatus 84.42 0.00e+00 1533.00
IUUC-Kpa-049332 Komagataella pastoris 33.85 1.00e-73 271.00
IUUC-Laf-054561 Loxodonta africana 73.60 0.00e+00 1395.00
IUUC-Mcc-054881 Macaca mulatta 81.61 0.00e+00 1507.00
IUUC-Meu-056749 Macropus eugenii 75.19 0.00e+00 862.00
IUUC-Mla-058848 Melampsora laricipopulina 42.42 3.00e-69 257.00
IUUC-Mvi-060324 Microbotryum violaceum 31.62 6.00e-79 290.00
IUUC-Mmr-061400 Microcebus murinus 82.39 0.00e+00 1511.00
IUUC-Mpu-066507 Mustela putorius furo 76.04 0.00e+00 1441.00
IUUC-Mlu-066961 Myotis lucifugus 71.21 0.00e+00 1310.00
IUUC-Nle-069284 Nomascus leucogenys 82.07 0.00e+00 1514.00
IUUC-Ont-071847 Oreochromis niloticus 55.78 0.00e+00 954.00
IUUC-Oan-073387 Ornithorhynchus anatinus 67.52 0.00e+00 1145.00
IUUC-Ocu-074066 Oryctolagus cuniculus 82.57 0.00e+00 1501.00
IUUC-Obr-076301 Oryza brachyantha 33.14 2.00e-113 404.00
IUUC-Oga-088424 Otolemur garnettii 82.75 0.00e+00 1518.00
IUUC-Oar-089732 Ovis aries 75.77 0.00e+00 1367.00
IUUC-Pan-092292 Papio anubis 80.40 0.00e+00 1511.00
IUUC-Pab-098779 Pongo abelii 74.66 0.00e+00 1300.00
IUUC-Pca-100851 Procavia capensis 77.38 0.00e+00 831.00
IUUC-Pva-103244 Pteropus vampyrus 74.89 0.00e+00 1384.00
IUUC-Ptt-103847 Puccinia triticina 36.73 2.00e-62 234.00
IUUC-Rno-105100 Rattus norvegicus 96.35 0.00e+00 1721.00
IUUC-Sha-107502 Sarcophilus harrisii 73.97 0.00e+00 851.00
IUUC-Ssc-116345 Sus scrofa 75.79 0.00e+00 1445.00
IUUC-Tsy-119414 Tarsius syrichta 74.79 0.00e+00 1066.00
IUUC-Tbe-128081 Tupaia belangeri 83.80 0.00e+00 952.00
IUUC-Ttr-128502 Tursiops truncatus 74.01 0.00e+00 1355.00
Created Date 25-Jun-2017

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