iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-061913

UUCD1 version

UUC-MoD-00556

Ensembl Protein ID

ENSMODP00000023088.2

UniProt Accession

F7AGR4; F7AGR4_MONDO

Protein Name

Uncharacterized protein

Gene Name

FBXO18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000018516.3	ENSMODT00000023500.2	ENSMODP00000023088.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	69.75	0.00e+00	1387.00	IUUC-Hsa-046650
E3 adaptor/Cullin RING/SCF/F-box	29.55	6.00e-41	164.00	IUUC-Spo-108147

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MAQSGSTDEN NTAADEMAFA CALPQEHEGE SKVESLGSVA TSRKRCLSFD QEGNEVTERS 60
QCGSVAKKNL TEQLPVSSTD LEEVKWEVNC FFQVPKDPKQ NKQEDEENGP EPDPYYGLLG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGGAGAGA AGTAAATGCC TTGTATTTTT CTTTTACGTT TCCCATCAAC TTTGCCTACA 60
TAATACACCA AGTAGGCACC CCAAAGCAGT CATTTATTTG TCCTGTTTAC TTGCCAGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR014017--DNA_helicase_UvrD-like_C
IPR000212--DNA_helicase_UvrD/REP
IPR001810--F-box_dom
IPR027417--P-loop_NTPase

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like
PF13361--UvrD_C

SMART

SM00256--FBOX

Gene Ontology

GO:0000785--C:chromatin
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0043138--F:3'-5' DNA helicase activity
GO:0005524--F:ATP binding
GO:0004003--F:ATP-dependent DNA helicase activity
GO:0015616--F:DNA translocase activity
GO:0003690--F:double-stranded DNA binding
GO:0003697--F:single-stranded DNA binding
GO:0008219--P:cell death
GO:0006974--P:cellular response to DNA damage stimulus
GO:0000737--P:DNA catabolic process, endonucleolytic
GO:0035562--P:negative regulation of chromatin binding
GO:2000042--P:negative regulation of double-strand break repair via homologous recombination
GO:1902231--P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0001934--P:positive regulation of protein phosphorylation
GO:0016567--P:protein ubiquitination
GO:0031297--P:replication fork processing
GO:0048478--P:replication fork protection
GO:0072429--P:response to intra-S DNA damage checkpoint signaling

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000424	Aegilops tauschii	45.65	3.00e-04	41.20
IUUC-Aml-001396	Ailuropoda melanoleuca	69.65	0.00e+00	1366.00
IUUC-Atr-002826	Amborella trichopoda	39.44	5.00e-03	37.40
IUUC-Apl-003317	Anas platyrhynchos	51.83	0.00e+00	893.00
IUUC-Aca-004498	Anolis carolinensis	52.42	0.00e+00	918.00
IUUC-Ani-009226	Aspergillus nidulans	33.70	6.00e-05	43.50
IUUC-Ate-010526	Aspergillus terreus	39.13	4.00e-04	40.80
IUUC-Ame-011808	Astyanax mexicanus	57.25	6.00e-131	460.00
IUUC-Bta-013250	Bos taurus	68.72	0.00e+00	1353.00
IUUC-Cja-019638	Callithrix jacchus	69.86	0.00e+00	1396.00
IUUC-Cfa-020195	Canis familiaris	70.27	0.00e+00	1413.00
IUUC-Cpo-022269	Cavia porcellus	67.70	0.00e+00	1315.00
IUUC-Cre-022611	Chlamydomonas reinhardtii	33.33	9.00e-08	52.80
IUUC-Csa-024060	Chlorocebus sabaeus	69.86	0.00e+00	1332.00
IUUC-Cho-025003	Choloepus hoffmanni	72.73	1.00e-171	597.00
IUUC-Cin-025694	Ciona intestinalis	29.25	1.00e-29	124.00
IUUC-Dre-028083	Danio rerio	48.58	0.00e+00	839.00
IUUC-Dno-029203	Dasypus novemcinctus	67.76	0.00e+00	1273.00
IUUC-Dor-030477	Dipodomys ordii	78.77	0.00e+00	662.00
IUUC-Ete-032861	Echinops telfairi	69.35	0.00e+00	1348.00
IUUC-Eca-033205	Equus caballus	70.37	0.00e+00	1413.00
IUUC-Eeu-034784	Erinaceus europaeus	71.31	0.00e+00	1033.00
IUUC-Fca-035797	Felis catus	69.61	0.00e+00	1369.00
IUUC-Gmo-038855	Gadus morhua	46.03	4.00e-123	435.00
IUUC-Gga-040326	Gallus gallus	52.76	0.00e+00	903.00
IUUC-Gac-042240	Gasterosteus aculeatus	45.90	0.00e+00	723.00
IUUC-Ggo-045050	Gorilla gorilla	66.70	0.00e+00	1264.00
IUUC-Hsa-046650	Homo sapiens	69.44	0.00e+00	1348.00
IUUC-Itr-047965	Ictidomys tridecemlineatus	77.52	0.00e+00	638.00
IUUC-Lch-050231	Latimeria chalumnae	47.07	4.00e-153	535.00
IUUC-Loc-051884	Lepisosteus oculatus	53.73	0.00e+00	962.00
IUUC-Lma-053267	Leptosphaeria maculans	25.07	2.00e-03	38.50
IUUC-Laf-053843	Loxodonta africana	70.16	0.00e+00	1387.00
IUUC-Mcc-055570	Macaca mulatta	69.75	0.00e+00	1367.00
IUUC-Meu-056798	Macropus eugenii	77.78	0.00e+00	631.00
IUUC-Mtr-057915	Medicago truncatula	39.13	3.00e-04	41.60
IUUC-Mga-059648	Meleagris gallopavo	55.50	0.00e+00	874.00
IUUC-Mmr-060757	Microcebus murinus	67.66	0.00e+00	1319.00
IUUC-Mmu-064337	Mus musculus	68.83	0.00e+00	1368.00
IUUC-Mpu-066483	Mustela putorius furo	68.52	0.00e+00	1373.00
IUUC-Mlu-068204	Myotis lucifugus	66.80	0.00e+00	1315.00
IUUC-Ncr-068735	Neurospora crassa	38.46	2.00e-03	38.90
IUUC-Nle-070053	Nomascus leucogenys	69.96	0.00e+00	1332.00
IUUC-Opr-070588	Ochotona princeps	65.64	0.00e+00	1299.00
IUUC-Ont-072655	Oreochromis niloticus	46.12	0.00e+00	741.00
IUUC-Oan-073351	Ornithorhynchus anatinus	63.66	0.00e+00	1207.00
IUUC-Ocu-074465	Oryctolagus cuniculus	68.65	0.00e+00	1308.00
IUUC-Oin-079176	Oryza indica	23.78	5.00e-05	42.40
IUUC-Olu-087831	Ostreococcus lucimarinus	30.90	8.00e-60	226.00
IUUC-Oga-089088	Otolemur garnettii	67.83	0.00e+00	1326.00
IUUC-Oar-089870	Ovis aries	68.52	0.00e+00	1347.00
IUUC-Ptr-090957	Pan troglodytes	69.72	0.00e+00	1334.00
IUUC-Pan-092632	Papio anubis	69.89	0.00e+00	1333.00
IUUC-Psi-093035	Pelodiscus sinensis	53.77	0.00e+00	1013.00
IUUC-Ppa-095660	Physcomitrella patens	37.66	3.00e-03	38.10
IUUC-Pfo-096902	Poecilia formosa	44.10	0.00e+00	674.00
IUUC-Pab-098206	Pongo abelii	69.98	0.00e+00	1259.00
IUUC-Pop-098801	Populus trichocarpa	38.57	6.00e-04	40.00
IUUC-Pca-100238	Procavia capensis	65.74	0.00e+00	1286.00
IUUC-Ppe-101748	Prunus persica	36.76	1.10e-02	36.20
IUUC-Pva-103182	Pteropus vampyrus	67.31	0.00e+00	1334.00
IUUC-Pte-104033	Pyrenophora teres	34.29	1.50e-02	35.40
IUUC-Pyt-104599	Pyrenophora triticirepentis	34.29	1.30e-02	35.40
IUUC-Rno-105141	Rattus norvegicus	68.83	0.00e+00	1366.00
IUUC-Sce-106341	Saccharomyces cerevisiae	34.92	3.10e-02	33.90
IUUC-Sha-106827	Sarcophilus harrisii	88.37	0.00e+00	1799.00
IUUC-Sja-107882	Schizosaccharomyces japonicus	30.64	7.00e-43	169.00
IUUC-Spo-108147	Schizosaccharomyces pombe	29.55	2.00e-41	164.00
IUUC-Ssl-108584	Sclerotinia sclerotiorum	25.23	7.00e-04	39.70
IUUC-Sly-111170	Solanum lycopersicum	39.39	4.50e-02	33.10
IUUC-Sre-115025	Sporisorium reilianum	32.39	1.00e-37	152.00
IUUC-Ssc-116188	Sus scrofa	74.73	0.00e+00	1031.00
IUUC-Tgu-116612	Taeniopygia guttata	56.43	3.00e-158	551.00
IUUC-Tsy-119560	Tarsius syrichta	68.55	2.00e-96	347.00
IUUC-Tni-120734	Tetraodon nigroviridis	45.88	0.00e+00	702.00
IUUC-Tca-121338	Theobroma cacao	34.78	3.00e-02	34.70
IUUC-Tre-122089	Trichoderma reesei	32.84	3.00e-03	37.00
IUUC-Tme-127009	Tuber melanosporum	26.94	4.00e-04	40.80
IUUC-Tbe-127431	Tupaia belangeri	68.06	0.00e+00	1135.00
IUUC-Ttr-128744	Tursiops truncatus	66.77	0.00e+00	1314.00
IUUC-Uma-129536	Ustilago maydis	33.54	3.00e-38	154.00
IUUC-Vpa-130123	Vicugna pacos	50.28	4.00e-40	159.00
IUUC-Vvi-131025	Vitis vinifera	37.68	4.00e-03	37.40
IUUC-Xtr-132902	Xenopus tropicalis	54.56	0.00e+00	951.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence