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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046377
UUCD1 version UUC-HoS-01258
Ensembl Protein ID ENSP00000451235.1
UniProt Accession Q5TAQ9; D3DVE6; Q12839; Q4QQI6; Q53F14; Q66K50; Q68CS7; Q96E00; DCAF8_HUMAN
Genbank Protein ID AAA16607.1; BAD97195.1; CAH18661.1; CAI15993.1; EAW52731.1; EAW52732.1; AAH13107.1; AAH80597.1; AAH98271.1; AAH99709.1; AAH99846.1; AAI11064.1
Protein Name DDB1- and CUL4-associated factor 8; WD repeat-containing protein 42A
Genbank Nucleotide ID U06631; AK223475; CR749801; AL139011; CH471121; CH471121; BC013107; BC080597; BC098271; BC099709; BC099846; BC111063
Gene Name DCAF8; H326; WDR42A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000258465.6 ENST00000556710.5 ENSP00000451235.1
ENSG00000258465.6 ENST00000485079.1 ENSP00000450870.1
Annotation
Cancer Mutation
ICGCCOSMICIntOGen
mRNA Expression
ArrayExpressTHPA
DNA & RNA Element
UTRdbCircNetTargetScanRepTar
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtmUbiSiDa
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.90e-21 76.9 345 376
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDl 30
           gHt+ v+ l+f   +t l+sGsdD ++ vWD+
   Q: 345  GHTGCVNTLHFnqRGTWLASGSDDLKVVVWDW 376
           8**********86559***************7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
 May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Protein Sequence
(Fasta)
MSEEELTKAM EGLGMDEGDG EGNILPIMQS IMQNLLSKDV LYPSLKEITE KYPEWLQSHR 60
ESLPPEQFEK YQEQHSVMCK ICEQFEAETP TDSETTQKAR FEMVLDLMQQ LQDLGHPPKE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046377|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCAAGATGG CCGCCGCTGA GGAAGGCTGT AGTGTCGGGG CCGAAGCGGA CAGGGAATTG 60
GAGGAGCTTC TGGAAAGTAA GAGCCCATAG TGGGAAAGGC CCGAAGAGGG CACGTGTGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046377|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0488--Methylation
KW-0523--Neurodegeneration
KW-0622--Neuropathy
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016567--P:protein ubiquitination
KEGG hsa:50717
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000985 Aegilops tauschii 40.93 3.00e-83 302.00
IUUC-Aml-001810 Ailuropoda melanoleuca 95.87 0.00e+00 1287.00
IUUC-Atr-002578 Amborella trichopoda 43.37 6.00e-82 298.00
IUUC-Apl-003872 Anas platyrhynchos 66.88 3.00e-159 554.00
IUUC-Aca-004853 Anolis carolinensis 79.84 0.00e+00 1102.00
IUUC-Aly-005505 Arabidopsis lyrata 41.04 3.00e-79 289.00
IUUC-Ath-007629 Arabidopsis thaliana 41.55 2.00e-77 283.00
IUUC-Ame-011615 Astyanax mexicanus 62.83 0.00e+00 694.00
IUUC-Bta-013549 Bos taurus 97.82 0.00e+00 1082.00
IUUC-Bdi-014538 Brachypodium distachyon 40.46 1.00e-74 273.00
IUUC-Cja-018802 Callithrix jacchus 98.99 0.00e+00 1085.00
IUUC-Cfa-020535 Canis familiaris 98.49 0.00e+00 1078.00
IUUC-Cpo-022216 Cavia porcellus 96.31 0.00e+00 1075.00
IUUC-Csa-023095 Chlorocebus sabaeus 99.50 0.00e+00 1090.00
IUUC-Cin-025683 Ciona intestinalis 57.72 7.00e-144 503.00
IUUC-Csv-026331 Ciona savignyi 57.52 1.00e-125 443.00
IUUC-Dre-027731 Danio rerio 63.70 0.00e+00 675.00
IUUC-Dno-029192 Dasypus novemcinctus 96.31 0.00e+00 1045.00
IUUC-Dse-031250 Dothistroma septosporum 49.43 1.00e-23 105.00
IUUC-Dme-032115 Drosophila melanogaster 42.66 3.00e-83 303.00
IUUC-Ete-032932 Echinops telfairi 88.10 0.00e+00 894.00
IUUC-Eca-034100 Equus caballus 98.83 0.00e+00 1083.00
IUUC-Fca-036138 Felis catus 97.65 0.00e+00 1075.00
IUUC-Fal-037132 Ficedula albicollis 96.46 2.00e-55 206.00
IUUC-Gmo-038895 Gadus morhua 77.89 0.00e+00 631.00
IUUC-Gga-040447 Gallus gallus 88.46 0.00e+00 934.00
IUUC-Gac-041796 Gasterosteus aculeatus 77.51 0.00e+00 674.00
IUUC-Gma-044062 Glycine max 40.41 2.00e-74 273.00
IUUC-Ggo-045613 Gorilla gorilla 100.00 0.00e+00 1065.00
IUUC-Hvu-047687 Hordeum vulgare 42.74 5.00e-85 308.00
IUUC-Itr-048599 Ictidomys tridecemlineatus 91.62 0.00e+00 969.00
IUUC-Lch-050050 Latimeria chalumnae 67.08 0.00e+00 637.00
IUUC-Lpe-051191 Leersia perrieri 41.85 5.00e-81 295.00
IUUC-Laf-053407 Loxodonta africana 96.98 0.00e+00 1022.00
IUUC-Mcc-055604 Macaca mulatta 95.47 0.00e+00 1291.00
IUUC-Meu-056043 Macropus eugenii 90.19 0.00e+00 857.00
IUUC-Mtr-057813 Medicago truncatula 40.89 3.00e-81 295.00
IUUC-Mga-059697 Meleagris gallopavo 88.10 3.00e-171 594.00
IUUC-Mmr-061338 Microcebus murinus 97.35 0.00e+00 1342.00
IUUC-Mdo-062689 Monodelphis domestica 97.12 0.00e+00 986.00
IUUC-Mmu-063993 Mus musculus 95.48 0.00e+00 1055.00
IUUC-Mac-064558 Musa acuminata 40.30 5.00e-82 298.00
IUUC-Mpu-066622 Mustela putorius furo 97.32 0.00e+00 1073.00
IUUC-Mlu-067235 Myotis lucifugus 94.66 0.00e+00 1261.00
IUUC-Nle-069048 Nomascus leucogenys 99.50 0.00e+00 1090.00
IUUC-Opr-070489 Ochotona princeps 80.06 2.00e-140 492.00
IUUC-Ont-072060 Oreochromis niloticus 77.16 0.00e+00 687.00
IUUC-Ocu-074684 Oryctolagus cuniculus 97.99 0.00e+00 1043.00
IUUC-Oba-075746 Oryza barthii 41.39 6.00e-84 305.00
IUUC-Obr-076629 Oryza brachyantha 41.96 6.00e-86 311.00
IUUC-Ogl-077243 Oryza glaberrima 43.12 1.00e-85 310.00
IUUC-Ogu-078029 Oryza glumaepatula 43.12 1.00e-85 310.00
IUUC-Oin-080109 Oryza indica 39.09 2.00e-73 269.00
IUUC-Olo-080308 Oryza longistaminata 41.97 5.00e-83 301.00
IUUC-Ome-081126 Oryza meridionalis 43.05 4.00e-83 301.00
IUUC-Oni-083114 Oryza nivara 43.12 6.00e-86 311.00
IUUC-Opu-083288 Oryza punctata 42.25 3.00e-83 302.00
IUUC-Oru-084724 Oryza rufipogon 43.12 1.00e-85 310.00
IUUC-Osa-085895 Oryza sativa 43.12 1.00e-85 310.00
IUUC-Olu-087847 Ostreococcus lucimarinus 29.86 4.00e-35 142.00
IUUC-Oga-088849 Otolemur garnettii 98.83 0.00e+00 1084.00
IUUC-Oar-089474 Ovis aries 94.97 0.00e+00 1028.00
IUUC-Ptr-091235 Pan troglodytes 100.00 0.00e+00 1097.00
IUUC-Pan-092895 Papio anubis 99.50 0.00e+00 1090.00
IUUC-Psi-093973 Pelodiscus sinensis 87.17 0.00e+00 1148.00
IUUC-Ppa-095764 Physcomitrella patens 42.20 6.00e-85 308.00
IUUC-Pfo-097275 Poecilia formosa 77.83 0.00e+00 687.00
IUUC-Pab-098299 Pongo abelii 97.44 0.00e+00 1115.00
IUUC-Pop-099784 Populus trichocarpa 41.94 3.00e-79 288.00
IUUC-Pca-100729 Procavia capensis 93.63 0.00e+00 1002.00
IUUC-Ppe-101712 Prunus persica 40.47 4.00e-79 288.00
IUUC-Pva-103030 Pteropus vampyrus 98.99 0.00e+00 1085.00
IUUC-Rno-105416 Rattus norvegicus 96.98 0.00e+00 1070.00
IUUC-Sha-106545 Sarcophilus harrisii 94.58 0.00e+00 1217.00
IUUC-Smo-109128 Selaginella moellendorffii 46.37 1.00e-90 326.00
IUUC-Sit-110823 Setaria italica 40.92 2.00e-84 306.00
IUUC-Sly-111605 Solanum lycopersicum 38.61 1.00e-75 277.00
IUUC-Stu-111978 Solanum tuberosum 40.65 3.00e-81 295.00
IUUC-Sbi-114455 Sorghum bicolor 41.01 2.00e-79 289.00
IUUC-Ssc-115612 Sus scrofa 98.49 0.00e+00 1079.00
IUUC-Tru-117708 Takifugu rubripes 77.40 0.00e+00 690.00
IUUC-Tsy-119579 Tarsius syrichta 89.20 0.00e+00 743.00
IUUC-Tni-120739 Tetraodon nigroviridis 70.19 0.00e+00 696.00
IUUC-Tca-121555 Theobroma cacao 42.03 9.00e-80 291.00
IUUC-Tae-125509 Triticum aestivum 44.23 2.00e-86 313.00
IUUC-Tur-126617 Triticum urartu 41.53 3.00e-73 269.00
IUUC-Tbe-128115 Tupaia belangeri 95.42 0.00e+00 714.00
IUUC-Ttr-128231 Tursiops truncatus 93.47 0.00e+00 1004.00
IUUC-Vpa-130377 Vicugna pacos 81.24 0.00e+00 870.00
IUUC-Vvi-131540 Vitis vinifera 41.36 3.00e-79 289.00
IUUC-Xtr-131860 Xenopus tropicalis 77.78 0.00e+00 826.00
IUUC-Xma-133371 Xiphophorus maculatus 77.64 0.00e+00 688.00
Created Date 25-Jun-2017

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