iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066255

Ensembl Protein ID

ENSMPUP00000013274.1

UniProt Accession

M3YPL6; M3YPL6_MUSPF

Genbank Protein ID

ENSMPUP00000013274

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01051057

Gene Name

UBA7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000013373.1	ENSMPUT00000013486.1	ENSMPUP00000013274.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.60e-196	652.7	415	889

Active Site

Position(s)	Description	Evidence
599	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G+  qekl+++++llvGag++GcEllK ++l+G+     g +tv Dmd++e snl+rqFLfr +d+g++KAevaaea ++l
   Q: 415  YDGQIAVFGAGFQEKLSRQHYLLVGAGAIGCELLKGFALMGLgagdsGGVTVADMDHIERSNLSRQFLFRTQDIGRPKAEVAAEATRRL 503
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dpp 167
           n++ +v++ + ++++++e+i+   Ff+++d+V++ald+++ar +v+ +c+++ +pl+++gt G+ G++ v+++++t  y+ ++     +
   Q: 504  NSHLQVTPLTHPLDPTTEHIYednFFSNVDGVAAALDSFQARHYVAARCTHYLKPLLDAGTQGTSGHAYVFVPHVTDVYRVPPsglAAE 592
           ***********************************************************************************9*999* PP
   S: 168  qktiPfctlketpnaaehtiewa........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakt 248
             t+P+ctl+ +p+ +eht++wa        +l +++++ ++++ + l+++d  + ++ +++v   l++ +++++++++ +a+ +++++
   Q: 593  GATYPVCTLRYFPSSVEHTLQWArdefeglfHLSAETINRHQEALTSLAETDGPQVLTLLEEVLGVLRQ-RPQTWQDCVVWALGHWQRR 680
           ***************************************************************666555.7****************** PP
   S: 249  tinsikqllksfecdivtkskspfwv................................................sfcsnaealqvpekv 289
           ++++i+qll++f++d+v ++++ fw+                                                +  ++   +   +  
   Q: 681  FHYGIRQLLSHFPPDKVLEDGTLFWLgrkqcpkplefdasqdthllyvlaaanlyaqmhglpgsrdqtalrellESLPLPVPQALAPIS 769
           ***********************************999999999999999999999999999998888777777666666666666777 PP
   S: 290  ekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiat 371
            +d e   asa+     l+ l ++l+ ++  + ++p  l+fekd ds  +vd+v+aaa+lra+++gi+p +++++ k+i+g+iipaiat
   Q: 770  PSDLELAGASAEfgpeqLKKLHQVLKVWNRSPPLEP--LKFEKDNDSnfHVDFVAAAASLRAQNYGIPP-ASRSQSKRIVGQIIPAIAT 855
           77777777777788888999**************99..9*******99*********************.******************* PP
   S: 372  tnavvgGlaaqEviKvvsg..kfeplknfflfda 403
           t+a+v+Gl+ +E++Kvv g  +  ++++ +l++a
   Q: 856  TTAAVAGLVGLELYKVVGGprPLRAFRHSYLHLA 889
           ******************9666667777777665 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MGVLETAKLL DEQLYSRQLY VLDLPAMQRI QGAKVLLSGL QGLGAEVAKN LVLMGVGSLT 60
LHDPHPTCWS DLAAQFFLSE KDLKKSRAEA SQEPLAKLNG AVQVCVHTGY ITEELLLDFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGTGTCC TGGAGACCGC CAAGCTGCTA GATGAGCAGC TGTACTCACG GCAGCTGTGA 60
GGCCCGAGGT GGGGAAGGGA GTGGGATGGC CTCCTGACTT CTGGCCTCCC ACTGCCTACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	85.93	0.00e+00	1638.00
IUUC-Bta-012665	Bos taurus	75.15	0.00e+00	1350.00
IUUC-Cja-019047	Callithrix jacchus	76.82	0.00e+00	1474.00
IUUC-Cfa-021225	Canis familiaris	84.32	0.00e+00	1637.00
IUUC-Cpo-022336	Cavia porcellus	69.80	0.00e+00	1298.00
IUUC-Csa-023462	Chlorocebus sabaeus	80.57	0.00e+00	1485.00
IUUC-Cho-024436	Choloepus hoffmanni	78.48	8.00e-102	364.00
IUUC-Dno-029347	Dasypus novemcinctus	78.60	0.00e+00	1459.00
IUUC-Dor-030997	Dipodomys ordii	71.99	0.00e+00	1329.00
IUUC-Ete-033124	Echinops telfairi	73.38	0.00e+00	950.00
IUUC-Eca-033929	Equus caballus	80.87	0.00e+00	1600.00
IUUC-Eeu-034717	Erinaceus europaeus	69.44	0.00e+00	984.00
IUUC-Fca-036564	Felis catus	85.50	0.00e+00	1645.00
IUUC-Ggo-044480	Gorilla gorilla	79.82	0.00e+00	1474.00
IUUC-Hsa-046498	Homo sapiens	79.68	0.00e+00	1449.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	76.01	0.00e+00	1421.00
IUUC-Laf-054119	Loxodonta africana	77.42	0.00e+00	1505.00
IUUC-Mcc-055597	Macaca mulatta	79.04	0.00e+00	1421.00
IUUC-Mdo-063058	Monodelphis domestica	57.13	0.00e+00	1034.00
IUUC-Mmu-063578	Mus musculus	68.86	0.00e+00	1327.00
IUUC-Mlu-067814	Myotis lucifugus	75.27	0.00e+00	1354.00
IUUC-Nle-069193	Nomascus leucogenys	79.49	0.00e+00	1468.00
IUUC-Opr-070715	Ochotona princeps	70.51	0.00e+00	1342.00
IUUC-Oan-073306	Ornithorhynchus anatinus	53.49	0.00e+00	741.00
IUUC-Ocu-074162	Oryctolagus cuniculus	76.71	0.00e+00	1419.00
IUUC-Oga-088895	Otolemur garnettii	75.80	0.00e+00	1384.00
IUUC-Oar-089579	Ovis aries	75.15	0.00e+00	1351.00
IUUC-Ptr-090581	Pan troglodytes	80.10	0.00e+00	1421.00
IUUC-Pan-092458	Papio anubis	80.87	0.00e+00	1481.00
IUUC-Pab-098653	Pongo abelii	75.25	0.00e+00	1392.00
IUUC-Pca-100578	Procavia capensis	72.34	0.00e+00	857.00
IUUC-Pva-102914	Pteropus vampyrus	79.24	0.00e+00	1234.00
IUUC-Rno-106066	Rattus norvegicus	70.97	0.00e+00	1384.00
IUUC-Sha-107368	Sarcophilus harrisii	59.96	0.00e+00	1127.00
IUUC-Ssc-115743	Sus scrofa	80.08	0.00e+00	1516.00
IUUC-Tbe-127587	Tupaia belangeri	74.00	0.00e+00	1230.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence