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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106221
Ensembl Protein ID YDR320C
UniProt Accession Q06677; D6VSV1; SWA2_YEAST
Genbank Protein ID AAB64756.1; DAA12161.1
Protein Name Auxilin-like clathrin uncoating factor SWA2; Bud site selection protein 24; DnaJ-related protein SWA2; Synthetic lethal with ARF1 protein 2
Genbank Nucleotide ID U32517; BK006938
Gene Name SWA2; AUX1; BUD24; YDR320C; D9798.10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YDR320C YDR320C YDR320C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
PHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 12672455; 14997574; 16687570; 18948116
Reviewed
Classification
Family Identity E-value Score Source Orthology
UBD/Alpha-Helix/UBA 30.90 1.00e-40 162.00 IUUC-Spo-108127
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Cofactor for the uncoating of clathrin-coated vesicles (CCVs) by Hsp70-type chaperones (SSA1/2/3 and SSB1/2). Coat disassembly is important for fusion of vesicles with target membranes and for recycling components of clathrin coats to the cytoplasm for further rounds of vesicle formation. Binds to assembled clathrin and recruits the ATP-activated chaperone to CCVs. Stimulates the ATPase activity of the clathrin-associated Hsp70-type chaperone SSA1, which then disrupts clathrin-clathrin interactions, leading to release of the clathrin coat. In addition, prevents unproductive clathrin assembly in the cell. Also required for cortical endoplasmic reticulum inheritance.
 Cofactor for the uncoating of clathrin-coated vesicles (CCVs) by Hsp70-type chaperones (SSA1/2/3 and SSB1/2). Coat disassembly is important for fusion of vesicles with target membranes and for recycling components of clathrin coats to the cytoplasm for further rounds of vesicle formation. Binds to assembled clathrin and recruits the ATP-activated chaperone to CCVs. Stimulates the ATPase activity of the clathrin-associated Hsp70-type chaperone SSA1, which then disrupts clathrin-clathrin interactions, leading to release of the clathrin coat. In addition, prevents unproductive clathrin assembly in the cell. Also required for cortical endoplasmic reticulum inheritance.
Protein Sequence
(Fasta)
MSDPFAHLLT SLKNKDSASA SKETTPQSSN SPSITGSAVA DVARTDKSPN DSLHSISAPP 60
LIPSPKVDFS APPLVPTNST TKSNTANNTP PSALANTDDD FNQLFGMGTV TTTDTIQKPD 120
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Protein Fasta Sequence


>IUUC-Sce-106221|UBD,UBA|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGTCAGATC CATTTGCACA TTTACTGACT TCTTTGAAGA ATAAGGACTC TGCATCTGCA 60
TCCAAGGAAA CAACTCCTCA GAGCAGCAAT TCGCCTTCCA TTACTGGTTC CGCTGTTGCA 120
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Nucleotide Fasta Sequence


>IUUC-Sce-106221|UBD,UBA|Saccharomyces cerevisiae
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
Interpro

IPR001623--DnaJ_domain
IPR015228--SWA2_UBA
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
IPR009060--UBA-like
PROSITE

PS50293--TPR_REGION
Pfam

PF09145--Ubiq-assoc
SMART

SM00028--TPR
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0031982--C:vesicle
GO:0030276--F:clathrin binding
GO:0043130--F:ubiquitin binding
GO:0072318--P:clathrin coat disassembly
GO:0048309--P:endoplasmic reticulum inheritance
GO:0032781--P:positive regulation of ATPase activity
GO:0006898--P:receptor-mediated endocytosis
KEGG sce:YDR320C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000572 Aegilops tauschii 33.33 2.00e-12 65.90
IUUC-Aml-001602 Ailuropoda melanoleuca 39.78 8.00e-13 64.70
IUUC-Atr-002902 Amborella trichopoda 32.20 5.00e-12 63.50
IUUC-Apl-003319 Anas platyrhynchos 39.13 5.00e-12 64.70
IUUC-Aca-004679 Anolis carolinensis 40.22 1.00e-11 63.90
IUUC-Aly-006371 Arabidopsis lyrata 35.19 4.00e-15 75.10
IUUC-Ath-007132 Arabidopsis thaliana 35.19 5.00e-15 74.70
IUUC-Ago-007899 Ashbya gossypii 30.27 1.00e-69 255.00
IUUC-Acl-008209 Aspergillus clavatus 31.82 9.00e-38 150.00
IUUC-Afl-008687 Aspergillus flavus 30.72 9.00e-40 156.00
IUUC-Afu-009038 Aspergillus fumigatus 30.99 1.00e-43 169.00
IUUC-Ani-009386 Aspergillus nidulans 31.01 5.00e-43 167.00
IUUC-Ang-009793 Aspergillus niger 31.41 1.00e-41 162.00
IUUC-Aor-009993 Aspergillus oryzae 30.38 8.00e-40 156.00
IUUC-Ate-010348 Aspergillus terreus 32.48 5.00e-43 167.00
IUUC-Ame-011836 Astyanax mexicanus 40.22 8.00e-12 63.90
IUUC-Bgr-012104 Blumeria graminis 32.04 1.00e-37 149.00
IUUC-Bta-012737 Bos taurus 40.22 7.00e-12 63.90
IUUC-Bci-013716 Botrytis cinerea 33.44 1.00e-40 159.00
IUUC-Bdi-014164 Brachypodium distachyon 40.91 2.00e-14 72.40
IUUC-Bol-015627 Brassica oleracea 42.05 3.00e-15 74.30
IUUC-Bra-017031 Brassica rapa 40.00 3.00e-15 74.30
IUUC-Cel-018193 Caenorhabditis elegans 37.63 3.00e-09 55.50
IUUC-Cja-019196 Callithrix jacchus 39.13 1.00e-11 63.50
IUUC-Cfa-020198 Canis familiaris 39.13 1.00e-11 63.50
IUUC-Cpo-022425 Cavia porcellus 39.13 8.00e-12 63.90
IUUC-Cre-022715 Chlamydomonas reinhardtii 33.71 5.00e-08 49.30
IUUC-Csa-023487 Chlorocebus sabaeus 40.22 8.00e-12 63.90
IUUC-Cho-024924 Choloepus hoffmanni 40.22 8.00e-12 64.30
IUUC-Cin-025341 Ciona intestinalis 35.85 1.00e-09 56.60
IUUC-Csv-026368 Ciona savignyi 37.74 7.00e-11 60.10
IUUC-Cgl-026441 Colletotrichum gloeosporioides 27.65 1.00e-29 123.00
IUUC-Cne-027019 Cryptococcus neoformans 25.16 1.00e-20 92.80
IUUC-Cme-027261 Cyanidioschyzon merolae 30.00 6.00e-06 43.90
IUUC-Dre-027719 Danio rerio 40.22 7.00e-12 64.30
IUUC-Dno-029249 Dasypus novemcinctus 40.22 9.00e-12 63.90
IUUC-Dor-030705 Dipodomys ordii 39.13 1.00e-11 63.20
IUUC-Dse-031381 Dothistroma septosporum 30.92 2.00e-37 149.00
IUUC-Ete-032360 Echinops telfairi 40.22 9.00e-12 63.90
IUUC-Eca-033503 Equus caballus 40.22 7.00e-12 64.30
IUUC-Fca-036367 Felis catus 27.36 1.20e-02 32.30
IUUC-Fal-036665 Ficedula albicollis 27.84 1.60e-01 31.60
IUUC-Fox-038054 Fusarium oxysporum 35.60 7.00e-45 173.00
IUUC-Fso-038394 Fusarium solani 33.66 8.00e-43 166.00
IUUC-Gmo-038798 Gadus morhua 39.13 3.00e-11 62.40
IUUC-Ggr-040006 Gaeumannomyces graminis 33.33 3.00e-41 161.00
IUUC-Gga-040208 Gallus gallus 40.22 4.00e-12 65.10
IUUC-Gac-041725 Gasterosteus aculeatus 40.22 5.00e-12 64.70
IUUC-Gma-042986 Glycine max 39.77 2.00e-14 72.80
IUUC-Ggo-044959 Gorilla gorilla 40.22 7.00e-12 64.30
IUUC-Hsa-046253 Homo sapiens 40.22 7.00e-12 64.30
IUUC-Hvu-047859 Hordeum vulgare 35.19 1.00e-14 73.60
IUUC-Itr-048009 Ictidomys tridecemlineatus 40.22 1.00e-11 63.50
IUUC-Kpa-049310 Komagataella pastoris 39.74 2.00e-58 218.00
IUUC-Lch-049852 Latimeria chalumnae 39.13 3.00e-11 62.40
IUUC-Lpe-050789 Leersia perrieri 35.19 2.00e-14 72.80
IUUC-Loc-052500 Lepisosteus oculatus 39.13 7.00e-12 63.90
IUUC-Lma-053081 Leptosphaeria maculans 30.26 1.00e-35 143.00
IUUC-Laf-053442 Loxodonta africana 40.22 8.00e-12 63.90
IUUC-Mcc-055357 Macaca mulatta 40.22 8.00e-12 63.90
IUUC-Meu-055902 Macropus eugenii 45.90 1.00e-09 56.60
IUUC-Mor-057010 Magnaporthe oryzae 32.90 2.00e-43 169.00
IUUC-Mpo-057447 Magnaporthe poae 41.51 2.00e-27 115.00
IUUC-Mtr-058569 Medicago truncatula 39.77 2.00e-14 72.40
IUUC-Mla-059090 Melampsora laricipopulina 27.51 9.00e-22 97.10
IUUC-Mga-059288 Meleagris gallopavo 40.22 3.00e-12 65.50
IUUC-Mvi-060375 Microbotryum violaceum 25.37 1.00e-19 90.10
IUUC-Mmr-060617 Microcebus murinus 40.22 8.00e-12 63.90
IUUC-Mdo-062466 Monodelphis domestica 39.13 1.00e-11 63.50
IUUC-Mmu-063266 Mus musculus 39.13 1.00e-11 63.90
IUUC-Mac-065191 Musa acuminata 35.19 2.00e-14 72.80
IUUC-Mpu-066264 Mustela putorius furo 39.13 1.00e-11 63.50
IUUC-Mlu-067016 Myotis lucifugus 40.22 5.00e-12 64.70
IUUC-Nfi-068286 Neosartorya fischeri 30.67 5.00e-42 164.00
IUUC-Ncr-068716 Neurospora crassa 34.21 1.00e-47 183.00
IUUC-Nle-069934 Nomascus leucogenys 40.22 7.00e-12 64.30
IUUC-Ont-072687 Oreochromis niloticus 40.22 6.00e-12 64.30
IUUC-Oan-073279 Ornithorhynchus anatinus 32.26 2.00e-03 35.80
IUUC-Ocu-074760 Oryctolagus cuniculus 40.22 5.00e-12 64.30
IUUC-Oba-075068 Oryza barthii 39.77 5.00e-14 70.90
IUUC-Obr-076494 Oryza brachyantha 40.91 3.00e-14 72.40
IUUC-Ogl-077765 Oryza glaberrima 39.77 4.00e-14 71.60
IUUC-Ogu-078409 Oryza glumaepatula 34.26 3.00e-14 72.00
IUUC-Oin-079736 Oryza indica 39.77 4.00e-14 71.60
IUUC-Olo-080973 Oryza longistaminata 38.10 2.00e-11 62.00
IUUC-Ome-081515 Oryza meridionalis 40.91 3.00e-14 72.40
IUUC-Oni-083001 Oryza nivara 34.26 4.00e-14 71.60
IUUC-Opu-083298 Oryza punctata 40.91 5.00e-14 71.20
IUUC-Oru-085233 Oryza rufipogon 40.91 4.00e-14 71.60
IUUC-Osa-085672 Oryza sativa 39.77 4.00e-14 71.60
IUUC-Ola-086849 Oryzias latipes 40.22 9.00e-12 63.90
IUUC-Olu-087759 Ostreococcus lucimarinus 31.25 2.00e-09 55.10
IUUC-Oga-088457 Otolemur garnettii 39.13 9.00e-12 63.90
IUUC-Oar-089865 Ovis aries 47.54 1.00e-09 57.00
IUUC-Ptr-091246 Pan troglodytes 40.22 7.00e-12 64.30
IUUC-Pan-092688 Papio anubis 40.22 7.00e-12 63.90
IUUC-Psi-093294 Pelodiscus sinensis 39.13 7.00e-12 64.30
IUUC-Pma-094391 Petromyzon marinus 43.55 1.00e-08 53.10
IUUC-Pno-095073 Phaeosphaeria nodorum 31.65 4.00e-37 147.00
IUUC-Ppa-095294 Physcomitrella patens 41.38 4.00e-14 71.60
IUUC-Pfo-096387 Poecilia formosa 40.22 7.00e-12 64.30
IUUC-Pab-097705 Pongo abelii 40.22 5.00e-12 64.30
IUUC-Pop-098982 Populus trichocarpa 40.00 5.00e-16 77.00
IUUC-Pca-100190 Procavia capensis 40.22 6.00e-12 64.30
IUUC-Ppe-101744 Prunus persica 38.64 5.00e-14 71.60
IUUC-Pva-102358 Pteropus vampyrus 45.90 1.00e-09 56.60
IUUC-Pgr-103508 Puccinia graminis 25.50 2.00e-15 76.30
IUUC-Ptt-104005 Puccinia triticina 43.24 1.00e-13 69.70
IUUC-Pte-104104 Pyrenophora teres 31.61 8.00e-34 137.00
IUUC-Pyt-104479 Pyrenophora triticirepentis 50.98 2.00e-25 108.00
IUUC-Rno-105923 Rattus norvegicus 39.13 1.00e-11 63.50
IUUC-Sha-106749 Sarcophilus harrisii 39.13 1.00e-11 63.50
IUUC-Sja-107998 Schizosaccharomyces japonicus 30.77 6.00e-42 163.00
IUUC-Spo-108127 Schizosaccharomyces pombe 31.97 4.00e-44 171.00
IUUC-Smo-108804 Selaginella moellendorffii 36.04 2.00e-15 76.60
IUUC-Sit-109875 Setaria italica 40.91 2.00e-14 72.80
IUUC-Sly-111651 Solanum lycopersicum 42.05 4.00e-15 75.10
IUUC-Stu-111986 Solanum tuberosum 38.64 3.00e-14 72.00
IUUC-Sar-113634 Sorex araneus 40.22 1.00e-11 63.50
IUUC-Sbi-114708 Sorghum bicolor 35.19 5.00e-15 74.70
IUUC-Sre-115214 Sporisorium reilianum 22.74 5.00e-15 74.70
IUUC-Ssc-115636 Sus scrofa 39.13 1.00e-11 63.20
IUUC-Tgu-116847 Taeniopygia guttata 39.13 6.00e-12 64.30
IUUC-Tru-117730 Takifugu rubripes 38.26 3.00e-12 65.50
IUUC-Tsy-119269 Tarsius syrichta 35.87 2.00e-08 52.80
IUUC-Tni-120061 Tetraodon nigroviridis 38.26 2.00e-12 65.90
IUUC-Tca-121218 Theobroma cacao 36.11 9.00e-15 73.90
IUUC-Tre-121980 Trichoderma reesei 32.91 7.00e-42 163.00
IUUC-Tvi-122538 Trichoderma virens 32.39 8.00e-41 160.00
IUUC-Tae-124301 Triticum aestivum 35.19 7.00e-15 73.90
IUUC-Tur-126241 Triticum urartu 35.19 8.00e-15 73.60
IUUC-Tme-127081 Tuber melanosporum 35.18 3.00e-41 161.00
IUUC-Tbe-128130 Tupaia belangeri 40.22 6.00e-12 64.30
IUUC-Uma-129632 Ustilago maydis 23.49 3.00e-18 85.50
IUUC-Vda-129786 Verticillium dahliae 32.21 1.00e-41 163.00
IUUC-Vpa-130526 Vicugna pacos 39.13 1.00e-11 63.90
IUUC-Vvi-131028 Vitis vinifera 38.71 1.00e-14 72.40
IUUC-Xtr-132049 Xenopus tropicalis 36.13 3.00e-12 65.10
IUUC-Xma-133859 Xiphophorus maculatus 26.32 4.20e-01 30.80
IUUC-Yli-134359 Yarrowia lipolytica 34.74 2.00e-42 165.00
IUUC-Zma-135446 Zea mays 40.91 2.00e-14 72.80
Created Date 25-Jun-2017

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