iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000013753.3	ENSMMUT00000019315.3	ENSMMUP00000018086.3
ENSMMUG00000013753.3	ENSMMUT00000019314.3	ENSMMUP00000018085.3
ENSMMUG00000013753.3	ENSMMUT00000055579.1	ENSMMUP00000042534.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.70e-84	284.4	1587	1986

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle................kkkeklneenp............................. 42
           +GlkN g+tCYmNSv+Q+L++ip++r+ +l                 k         +                             
   Q: 1587 VGLKNAGATCYMNSVIQQLYMIPSIRNGILAiegtgsdvdddmsgdeK---------Qdnesnvdprddvfgypqqfedkpalskte 1664
           6******************************88888877666654331.........033334456677777777777777777777 PP
   S: 43   ..kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedksels 127
             ke +  +l++lq +f +l  s+ +++ pr ++k+++ + e ++  eq+Da Ef++ l+d+l+e+l                    
   Q: 1665 drKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEAL-------------------- 1731
           6677777************************************************************.................... PP
   S: 128  deaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkk 214
                 k   ++ ++s++++g++ +q +c+ c ++++ ee+f++l++++++++     +l d+Le+++k + leg+n+y+cekc+kk
   Q: 1732 ------KALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQ-----NLLDSLEQYVKGDLLEGANAYHCEKCNKK 1807
           ......67999******************************************.....9**************************** PP
   S: 215  qeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts......................peekqke..... 274
           ++++k+l +kklP+vL ++LkRf ++ e+++ +k+n+++efp+eLd++p+++                       +     e     
   Q: 1808 VDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAgvaklegdnvnpesqliqqseqS-----Esetag 1889
           *****************************************************89989888888888887665543.....144555 PP
   S: 275  kkkYeLiavvvHsGslssGHYvayvknekgk......WllfdDskVtevkeeevleetg...........................s 328
           ++kY+L++v+vHsG++s+GHY++y+ +++g+      W++fdD  Vte+k+++ +e+++                           +
   Q: 1890 STKYRLVGVLVHSGQASGGHYYSYIIQRNGGdgernrWYKFDDGDVTECKMDDDEEMKNqcfggeymgevfdhmmkrmsyrrqkrwW 1976
           ***************************5444555556*******************9999*************************** PP
   S: 329  taYvlfYkrr 338
           +aY+lfY+r+
   Q: 1977 NAYILFYERM 1986
           ********96 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MTATTRGSPV GGNDNQGQAP DGQSQPPLQQ NQTSSPDSSN ENSPATPPDE QGQGDAPPQL 60
EDEEPAFPHT DLAKLDDMIN RPRWVVPVLP KGELEVLLEA AIDLSKKGLD VKSEACQRFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGCCGCCT TAGCGCCCGG TGCTTGGGTC GGCGCCGGGA GCTAGGAGAG AGCTGTTGCA 60
AAGCCACCAG GCCCGGAACG GGGACAGAGG CGGCGACTAG GGGAAGGTGA AGCCGTCGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0030426--C:growth cone
GO:0016020--C:membrane
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0048675--P:axon extension
GO:0030509--P:BMP signaling pathway
GO:0001764--P:neuron migration
GO:0016579--P:protein deubiquitination
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001640	Ailuropoda melanoleuca	97.83	0.00e+00	5006.00
IUUC-Apl-003592	Anas platyrhynchos	94.16	0.00e+00	4833.00
IUUC-Aca-004939	Anolis carolinensis	93.85	0.00e+00	4791.00
IUUC-Ame-011772	Astyanax mexicanus	87.30	0.00e+00	4542.00
IUUC-Bta-012775	Bos taurus	97.60	0.00e+00	4965.00
IUUC-Cja-019464	Callithrix jacchus	98.07	0.00e+00	4912.00
IUUC-Cfa-020569	Canis familiaris	97.41	0.00e+00	3235.00
IUUC-Csa-023405	Chlorocebus sabaeus	98.84	0.00e+00	4987.00
IUUC-Cho-024524	Choloepus hoffmanni	93.07	0.00e+00	797.00
IUUC-Cin-025551	Ciona intestinalis	63.75	6.00e-143	500.00
IUUC-Csv-025956	Ciona savignyi	53.08	0.00e+00	2487.00
IUUC-Dre-028329	Danio rerio	87.50	0.00e+00	4565.00
IUUC-Dno-028936	Dasypus novemcinctus	97.76	0.00e+00	5002.00
IUUC-Dor-030352	Dipodomys ordii	93.81	0.00e+00	2242.00
IUUC-Dme-032160	Drosophila melanogaster	47.42	0.00e+00	2155.00
IUUC-Ete-032287	Echinops telfairi	94.95	0.00e+00	2756.00
IUUC-Eca-033352	Equus caballus	96.50	0.00e+00	4991.00
IUUC-Eeu-034907	Erinaceus europaeus	86.80	0.00e+00	1843.00
IUUC-Fca-035458	Felis catus	97.15	0.00e+00	5024.00
IUUC-Fal-036924	Ficedula albicollis	94.02	0.00e+00	4741.00
IUUC-Gmo-039578	Gadus morhua	88.93	0.00e+00	4474.00
IUUC-Gga-040978	Gallus gallus	94.31	0.00e+00	4837.00
IUUC-Gac-041970	Gasterosteus aculeatus	89.56	0.00e+00	4563.00
IUUC-Ggo-045575	Gorilla gorilla	98.08	0.00e+00	5004.00
IUUC-Hsa-046295	Homo sapiens	98.12	0.00e+00	5005.00
IUUC-Itr-048768	Ictidomys tridecemlineatus	98.14	0.00e+00	5011.00
IUUC-Lch-050493	Latimeria chalumnae	91.54	0.00e+00	4640.00
IUUC-Loc-052667	Lepisosteus oculatus	89.10	0.00e+00	4680.00
IUUC-Laf-054094	Loxodonta africana	97.15	0.00e+00	4996.00
IUUC-Meu-056849	Macropus eugenii	82.72	0.00e+00	1416.00
IUUC-Mga-060159	Meleagris gallopavo	94.31	0.00e+00	4835.00
IUUC-Mmr-060732	Microcebus murinus	98.07	0.00e+00	5031.00
IUUC-Mdo-062274	Monodelphis domestica	94.43	0.00e+00	4904.00
IUUC-Mmu-064056	Mus musculus	97.33	0.00e+00	4984.00
IUUC-Mpu-066669	Mustela putorius furo	97.87	0.00e+00	5010.00
IUUC-Mlu-067516	Myotis lucifugus	96.94	0.00e+00	4960.00
IUUC-Nle-069664	Nomascus leucogenys	98.30	0.00e+00	3680.00
IUUC-Opr-070185	Ochotona princeps	88.68	0.00e+00	804.00
IUUC-Ont-072119	Oreochromis niloticus	88.88	0.00e+00	4573.00
IUUC-Oan-073154	Ornithorhynchus anatinus	94.00	0.00e+00	4882.00
IUUC-Ocu-074485	Oryctolagus cuniculus	97.46	0.00e+00	5044.00
IUUC-Ola-086350	Oryzias latipes	89.24	0.00e+00	4501.00
IUUC-Oga-088328	Otolemur garnettii	96.85	0.00e+00	5046.00
IUUC-Oar-090098	Ovis aries	96.88	0.00e+00	4991.00
IUUC-Pan-091741	Papio anubis	98.50	0.00e+00	3814.00
IUUC-Psi-093040	Pelodiscus sinensis	94.16	0.00e+00	4821.00
IUUC-Pfo-096871	Poecilia formosa	88.07	0.00e+00	4559.00
IUUC-Pab-098374	Pongo abelii	98.72	0.00e+00	4979.00
IUUC-Pca-100801	Procavia capensis	87.80	0.00e+00	2410.00
IUUC-Pva-102992	Pteropus vampyrus	90.98	0.00e+00	2411.00
IUUC-Rno-105377	Rattus norvegicus	97.52	0.00e+00	4990.00
IUUC-Sha-106648	Sarcophilus harrisii	91.80	0.00e+00	4722.00
IUUC-Sar-113729	Sorex araneus	93.08	0.00e+00	3138.00
IUUC-Ssc-116261	Sus scrofa	91.47	0.00e+00	4789.00
IUUC-Tgu-117126	Taeniopygia guttata	94.19	0.00e+00	4834.00
IUUC-Tru-117676	Takifugu rubripes	89.23	0.00e+00	4571.00
IUUC-Tni-120207	Tetraodon nigroviridis	85.47	0.00e+00	2047.00
IUUC-Tbe-128033	Tupaia belangeri	94.06	0.00e+00	1038.00
IUUC-Ttr-128742	Tursiops truncatus	96.05	0.00e+00	4924.00
IUUC-Vpa-130581	Vicugna pacos	94.08	0.00e+00	4786.00
IUUC-Xtr-132145	Xenopus tropicalis	91.77	0.00e+00	4742.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence