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Tag Content
iUUCD ID IUUC-Aca-005014
Ensembl Protein ID ENSACAP00000014121.2
UniProt Accession H9GL05; H9GL05_ANOCA
Protein Name E3 ubiquitin-protein ligase
Gene Name SIAH1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSACAG00000014413.2 ENSACAT00000014411.2 ENSACAP00000014121.2
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 81.96 2.00e-125 445.00 IUUC-Dme-031700
E3 activity/RING/RING 99.65 3.00e-169 591.00 IUUC-Hsa-046357
E3 activity/RING/RING 99.29 3.00e-168 587.00 IUUC-Mmu-064129
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Anolis carolinensis
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Protein Sequence
(Fasta)
YILKKKILPK HYFLAEMSRQ TATALPTGTS KCTPSQRVPA LTGTTASNND LASLFECPVC 60
FDYVLPPILQ CQSGHLVCSN CRPKLTCCPT CRGPLGSIRN LAMEKVANSV LFPCKYASSG 120
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Protein Fasta Sequence


>IUUC-Aca-005014|E3,RING|Anolis carolinensis
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Nucleotide Sequence
(Fasta)
TATATCTTAA AAAAAAAGAT TCTACCTAAA CATTAGGAAG AACTTTCTGA TGGTAAGGGC 60
TGTTCATCAG TGGAATATGT TGTCTCGTAG TTTGGTGGAG TGTCCTTCTG TGAAAGTTTT 120
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Nucleotide Fasta Sequence


>IUUC-Aca-005014|E3,RING|Anolis carolinensis
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH
PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH
Pfam

PF03145--Sina
Gene Ontology

GO:0030877--C:beta-catenin destruction complex
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000061 Aegilops tauschii 37.36 2.00e-44 172.00
IUUC-Aml-001186 Ailuropoda melanoleuca 100.00 2.00e-171 594.00
IUUC-Atr-002857 Amborella trichopoda 36.06 2.00e-44 172.00
IUUC-Apl-003813 Anas platyrhynchos 100.00 1.00e-170 591.00
IUUC-Aly-006207 Arabidopsis lyrata 33.94 1.00e-41 162.00
IUUC-Ath-007049 Arabidopsis thaliana 33.45 8.00e-42 163.00
IUUC-Ame-011196 Astyanax mexicanus 94.24 5.00e-169 586.00
IUUC-Bta-012887 Bos taurus 99.65 8.00e-171 592.00
IUUC-Bdi-014200 Brachypodium distachyon 37.73 4.00e-45 174.00
IUUC-Bol-015523 Brassica oleracea 36.36 6.00e-42 164.00
IUUC-Bra-016910 Brassica rapa 36.82 3.00e-41 162.00
IUUC-Cel-018320 Caenorhabditis elegans 67.15 2.00e-114 405.00
IUUC-Cja-019796 Callithrix jacchus 99.65 2.00e-170 591.00
IUUC-Cfa-020642 Canis familiaris 100.00 2.00e-172 597.00
IUUC-Cpo-022348 Cavia porcellus 99.65 5.00e-170 589.00
IUUC-Csa-023974 Chlorocebus sabaeus 99.65 1.00e-170 591.00
IUUC-Cho-024933 Choloepus hoffmanni 84.92 1.00e-130 458.00
IUUC-Cin-025674 Ciona intestinalis 78.01 5.00e-135 473.00
IUUC-Csv-026233 Ciona savignyi 84.25 3.00e-132 463.00
IUUC-Dre-028041 Danio rerio 94.24 6.00e-169 586.00
IUUC-Dno-029764 Dasypus novemcinctus 100.00 2.00e-171 594.00
IUUC-Dor-030489 Dipodomys ordii 84.70 1.00e-94 338.00
IUUC-Dme-031700 Drosophila melanogaster 83.87 5.00e-120 423.00
IUUC-Ete-032423 Echinops telfairi 99.63 1.00e-160 558.00
IUUC-Eca-033536 Equus caballus 100.00 1.00e-170 591.00
IUUC-Eeu-035314 Erinaceus europaeus 99.25 5.00e-161 560.00
IUUC-Fca-035362 Felis catus 100.00 1.00e-171 594.00
IUUC-Fal-037487 Ficedula albicollis 100.00 2.00e-171 593.00
IUUC-Gmo-039091 Gadus morhua 80.45 8.00e-129 452.00
IUUC-Gga-040269 Gallus gallus 100.00 1.00e-170 591.00
IUUC-Gac-042282 Gasterosteus aculeatus 97.16 6.00e-167 579.00
IUUC-Gma-042926 Glycine max 34.44 1.00e-40 159.00
IUUC-Ggo-045444 Gorilla gorilla 99.65 1.00e-170 591.00
IUUC-Hsa-046357 Homo sapiens 99.65 1.00e-170 591.00
IUUC-Hvu-047574 Hordeum vulgare 37.00 3.00e-44 172.00
IUUC-Itr-048046 Ictidomys tridecemlineatus 99.65 5.00e-170 589.00
IUUC-Lch-049504 Latimeria chalumnae 98.94 3.00e-169 586.00
IUUC-Lpe-050879 Leersia perrieri 40.25 1.00e-42 166.00
IUUC-Loc-052191 Lepisosteus oculatus 96.61 2.00e-171 594.00
IUUC-Laf-053668 Loxodonta africana 100.00 1.00e-170 591.00
IUUC-Mcc-054640 Macaca mulatta 99.65 1.00e-170 591.00
IUUC-Meu-055922 Macropus eugenii 83.33 1.00e-127 448.00
IUUC-Mtr-058747 Medicago truncatula 34.81 3.00e-42 165.00
IUUC-Mga-059503 Meleagris gallopavo 97.28 2.00e-172 597.00
IUUC-Mmr-060794 Microcebus murinus 99.65 5.00e-170 589.00
IUUC-Mdo-061971 Monodelphis domestica 84.92 2.00e-130 457.00
IUUC-Mmu-064129 Mus musculus 99.29 2.00e-169 587.00
IUUC-Mac-065014 Musa acuminata 36.64 6.00e-42 164.00
IUUC-Mpu-066488 Mustela putorius furo 100.00 2.00e-171 593.00
IUUC-Mlu-067207 Myotis lucifugus 99.30 5.00e-172 596.00
IUUC-Nle-069706 Nomascus leucogenys 99.65 1.00e-170 591.00
IUUC-Opr-070341 Ochotona princeps 55.56 3.00e-49 187.00
IUUC-Ont-071849 Oreochromis niloticus 96.50 2.00e-168 584.00
IUUC-Oan-073701 Ornithorhynchus anatinus 52.56 5.00e-49 187.00
IUUC-Ocu-074876 Oryctolagus cuniculus 99.65 2.00e-170 590.00
IUUC-Oba-075454 Oryza barthii 40.66 1.00e-42 166.00
IUUC-Obr-076037 Oryza brachyantha 35.43 3.00e-40 158.00
IUUC-Ogl-077712 Oryza glaberrima 40.66 1.00e-42 166.00
IUUC-Ogu-078910 Oryza glumaepatula 40.83 2.00e-42 166.00
IUUC-Oin-079749 Oryza indica 40.66 1.00e-42 166.00
IUUC-Olo-080244 Oryza longistaminata 35.43 3.00e-40 159.00
IUUC-Ome-081318 Oryza meridionalis 40.66 1.00e-42 166.00
IUUC-Oni-083109 Oryza nivara 40.66 1.00e-42 166.00
IUUC-Opu-084065 Oryza punctata 41.08 6.00e-43 167.00
IUUC-Oru-084785 Oryza rufipogon 40.66 1.00e-42 166.00
IUUC-Osa-085610 Oryza sativa 40.66 1.00e-42 166.00
IUUC-Ola-086814 Oryzias latipes 97.16 6.00e-167 579.00
IUUC-Oga-088399 Otolemur garnettii 99.65 5.00e-170 589.00
IUUC-Oar-089323 Ovis aries 99.65 1.00e-170 592.00
IUUC-Ptr-090692 Pan troglodytes 97.60 2.00e-173 600.00
IUUC-Pan-092012 Papio anubis 99.65 1.00e-170 591.00
IUUC-Psi-093687 Pelodiscus sinensis 100.00 9.00e-172 595.00
IUUC-Pma-094387 Petromyzon marinus 93.73 3.00e-162 563.00
IUUC-Ppa-095212 Physcomitrella patens 36.19 6.00e-41 160.00
IUUC-Pfo-097134 Poecilia formosa 97.16 6.00e-167 579.00
IUUC-Pab-097555 Pongo abelii 99.65 1.00e-170 591.00
IUUC-Pop-099970 Populus trichocarpa 34.90 3.00e-44 171.00
IUUC-Pca-100328 Procavia capensis 83.33 9.00e-127 446.00
IUUC-Ppe-101760 Prunus persica 36.10 4.00e-44 171.00
IUUC-Pva-102368 Pteropus vampyrus 90.00 7.00e-57 213.00
IUUC-Rno-104866 Rattus norvegicus 99.29 2.00e-169 587.00
IUUC-Sha-106547 Sarcophilus harrisii 100.00 1.00e-171 594.00
IUUC-Smo-109412 Selaginella moellendorffii 33.68 3.00e-39 155.00
IUUC-Sit-110595 Setaria italica 37.45 2.00e-41 162.00
IUUC-Sly-111259 Solanum lycopersicum 36.76 2.00e-41 162.00
IUUC-Stu-112571 Solanum tuberosum 36.76 2.00e-41 162.00
IUUC-Sbi-114090 Sorghum bicolor 37.11 3.00e-42 165.00
IUUC-Ssc-116441 Sus scrofa 84.52 3.00e-130 457.00
IUUC-Tgu-116579 Taeniopygia guttata 100.00 1.00e-170 591.00
IUUC-Tru-118250 Takifugu rubripes 92.91 6.00e-159 552.00
IUUC-Tsy-119548 Tarsius syrichta 81.68 8.00e-60 223.00
IUUC-Tni-120488 Tetraodon nigroviridis 96.81 2.00e-163 567.00
IUUC-Tca-121228 Theobroma cacao 33.33 3.00e-41 162.00
IUUC-Tae-123647 Triticum aestivum 37.36 2.00e-44 172.00
IUUC-Tur-126049 Triticum urartu 35.04 7.00e-39 154.00
IUUC-Ttr-129166 Tursiops truncatus 99.17 2.00e-143 501.00
IUUC-Vpa-130799 Vicugna pacos 88.30 1.00e-91 328.00
IUUC-Vvi-131233 Vitis vinifera 34.15 6.00e-43 167.00
IUUC-Xtr-132553 Xenopus tropicalis 98.94 1.00e-169 588.00
IUUC-Xma-133670 Xiphophorus maculatus 97.16 6.00e-167 579.00
Created Date 25-Jun-2017

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