iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048976

Ensembl Protein ID

ENSSTOP00000015675.1

UniProt Accession

I3MU80; I3MU80_ICTTR

Genbank Protein ID

ENSSTOP00000015675

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AGTP01103871

Gene Name

SIAH2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000025639.1	ENSSTOT00000020271.1	ENSSTOP00000015675.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	98.45	6.00e-153	537.00	IUUC-Hsa-046179
E3 activity/RING/RING	98.44	2.00e-152	535.00	IUUC-Mmu-063206
E3 activity/RING/RING	98.44	1.00e-152	535.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ictidomys tridecemlineatus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

XVSPQHHELT SLFECPVCFD YVLPPILQCQ AGHLVCNQCR QKLSCCPTCR GALTPSIRNL 60
AMEKVASAVL FPCKYATTGC SLTLHHTEKP EHEDICEYRP YSCPCPGASC KWQGSLEAVM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNC 60
GGTGTCCCCG CAGCACCACG AGCTGACCTC GCTCTTCGAG TGTCCGGTCT GCTTTGACTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	98.45	3.00e-153	533.00
IUUC-Ame-011678	Astyanax mexicanus	91.30	2.00e-140	491.00
IUUC-Bta-012750	Bos taurus	98.04	4.00e-151	526.00
IUUC-Cja-019800	Callithrix jacchus	98.43	2.00e-151	528.00
IUUC-Cfa-020505	Canis familiaris	98.43	3.00e-151	527.00
IUUC-Cpo-021394	Cavia porcellus	97.67	2.00e-151	528.00
IUUC-Csa-023374	Chlorocebus sabaeus	98.43	2.00e-151	528.00
IUUC-Cho-024933	Choloepus hoffmanni	98.43	2.00e-151	527.00
IUUC-Dre-027711	Danio rerio	90.91	3.00e-140	490.00
IUUC-Dno-029260	Dasypus novemcinctus	98.37	8.00e-146	509.00
IUUC-Dor-030489	Dipodomys ordii	94.59	1.00e-105	374.00
IUUC-Ete-032946	Echinops telfairi	97.67	8.00e-153	532.00
IUUC-Eca-033546	Equus caballus	98.06	2.00e-153	533.00
IUUC-Eeu-034861	Erinaceus europaeus	94.57	2.00e-146	511.00
IUUC-Fal-037160	Ficedula albicollis	88.05	2.00e-132	464.00
IUUC-Gmo-039091	Gadus morhua	89.33	1.00e-138	485.00
IUUC-Gga-040252	Gallus gallus	96.89	4.00e-150	523.00
IUUC-Gac-041673	Gasterosteus aculeatus	88.93	1.00e-138	485.00
IUUC-Ggo-044618	Gorilla gorilla	98.43	2.00e-151	528.00
IUUC-Hsa-046179	Homo sapiens	98.43	2.00e-151	528.00
IUUC-Lch-049496	Latimeria chalumnae	94.16	2.00e-147	514.00
IUUC-Loc-052107	Lepisosteus oculatus	92.00	1.00e-140	491.00
IUUC-Laf-054257	Loxodonta africana	98.06	3.00e-151	527.00
IUUC-Mcc-055023	Macaca mulatta	98.43	2.00e-151	528.00
IUUC-Meu-055922	Macropus eugenii	96.08	2.00e-147	514.00
IUUC-Mga-060070	Meleagris gallopavo	95.33	1.00e-146	511.00
IUUC-Mmr-061494	Microcebus murinus	98.43	2.00e-151	528.00
IUUC-Mdo-061971	Monodelphis domestica	97.65	2.00e-150	524.00
IUUC-Mmu-063206	Mus musculus	98.43	9.00e-151	525.00
IUUC-Mpu-066597	Mustela putorius furo	98.43	2.00e-151	528.00
IUUC-Mlu-067199	Myotis lucifugus	98.04	7.00e-151	526.00
IUUC-Nle-069342	Nomascus leucogenys	98.43	2.00e-151	528.00
IUUC-Opr-070341	Ochotona princeps	56.21	1.00e-49	189.00
IUUC-Ont-071906	Oreochromis niloticus	89.33	9.00e-140	489.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.21	2.00e-49	188.00
IUUC-Ocu-073950	Oryctolagus cuniculus	98.05	4.00e-152	530.00
IUUC-Oga-089154	Otolemur garnettii	98.43	2.00e-151	528.00
IUUC-Oar-089446	Ovis aries	98.05	5.00e-152	529.00
IUUC-Ptr-091088	Pan troglodytes	98.43	2.00e-151	528.00
IUUC-Psi-093079	Pelodiscus sinensis	98.06	1.00e-152	531.00
IUUC-Pfo-097007	Poecilia formosa	84.98	1.00e-132	465.00
IUUC-Pab-098092	Pongo abelii	98.43	2.00e-151	528.00
IUUC-Pca-100328	Procavia capensis	95.29	5.00e-146	509.00
IUUC-Pva-102368	Pteropus vampyrus	96.43	1.00e-61	229.00
IUUC-Rno-105477	Rattus norvegicus	98.43	9.00e-151	525.00
IUUC-Sha-107630	Sarcophilus harrisii	98.06	1.00e-152	531.00
IUUC-Ssc-116441	Sus scrofa	98.04	4.00e-151	526.00
IUUC-Tru-118004	Takifugu rubripes	86.56	6.00e-134	469.00
IUUC-Tsy-119548	Tarsius syrichta	86.47	7.00e-65	239.00
IUUC-Tni-120846	Tetraodon nigroviridis	88.14	2.00e-136	477.00
IUUC-Vpa-130799	Vicugna pacos	97.11	8.00e-101	358.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence