iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027408

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-specific peptidase 18

Genbank Nucleotide ID

CU571169

Gene Name

usp18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000088078.2	ENSDART00000124085.2	ENSDARP00000104564.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.30e-54	184.6	30	331

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl N g +C +N++LQ+ s+++el + l++ ++++        ++ ++  +l++ + ++  + +++   + +l++l + a  +  y qq
   Q: 30   GLFNDGLSCCVNALLQSFSATTELLDILNKWNPSD------GIEQSNIPLQLRNTLLSV-RDPSHSAPHKGFLDCLYRHA--ICRYTQQ 109
           99**************************9933333......345668*********988.55555666666*****8776..669**** PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da E ++++l+   +++                          ++ +  + i  l+ +++++q++c +c  +    ++ ++l+l +++ 
   Q: 110  DADEIFHMILNLSLKQM--------------------------PDHELAQEIRSLYTIEVETQVTCMDCTFIHRLPNSYFSLPLVIHEG 172
           ***********999999..........................556677889*********************8888888888888887 PP
   S: 180  eetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctsp 268
           e+    +l++c++sf+k+++le ++k++c++c+kkq +  + kl +lP++L++hLkRf  ++e +  +k+++kv+fp++L++s f + +
   Q: 173  EN----TLESCIKSFFKKQKLEVSEKFFCDRCEKKQPCAYEQKLVSLPQILCVHLKRF--RNEHGLIKKLDSKVTFPETLKISVFAAGQ 255
           75....8***************************************************..8899*******************999997 PP
   S: 269  eekqke...kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg..staYvlfYkrr 338
           +e+ ++   +  Y+L+av+vH Gs+  GHY+a++++++++ W++ +Ds+V++ ++++v+ + +  +taY+l+Y+++
   Q: 256  SENAASdspQADYSLFAVIVHIGSAMFGHYTAFIRQTQDQmWYYANDSRVNQATWKDVQDTYKgrETAYLLLYRKK 331
           77766577799*************************99999*******************8889*********985 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MGDYWSKMAY HRRYIRSSSW SSNRGYEVRG LFNDGLSCCV NALLQSFSAT TELLDILNKW 60
NPSDGIEQSN IPLQLRNTLL SVRDPSHSAP HKGFLDCLYR HAICRYTQQD ADEIFHMILN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAAACTCTG GGTAGCTACG AGTAAAACGA GAGTGCTAGT ATCTTGATAT GACTTAAACG 60
AACAGGTTTT CAGAAGAAGA GAAAAAAAAC AGAAGGTTTT GCTATCAATA TATGTGTGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dre:100334535

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001615	Ailuropoda melanoleuca	32.26	5.00e-43	168.00
IUUC-Apl-004006	Anas platyrhynchos	36.08	3.00e-47	182.00
IUUC-Aca-005088	Anolis carolinensis	33.33	6.00e-40	158.00
IUUC-Ame-010606	Astyanax mexicanus	52.66	2.00e-97	349.00
IUUC-Bta-013036	Bos taurus	33.44	3.00e-44	172.00
IUUC-Cja-019052	Callithrix jacchus	32.18	2.00e-37	149.00
IUUC-Cfa-020554	Canis familiaris	33.13	5.00e-46	178.00
IUUC-Cpo-022421	Cavia porcellus	34.15	7.00e-46	177.00
IUUC-Csa-023737	Chlorocebus sabaeus	35.50	5.00e-29	120.00
IUUC-Cho-024807	Choloepus hoffmanni	32.98	2.00e-22	100.00
IUUC-Dor-030532	Dipodomys ordii	33.33	3.00e-43	169.00
IUUC-Ete-032254	Echinops telfairi	32.82	4.00e-44	172.00
IUUC-Eca-033482	Equus caballus	34.71	1.00e-47	183.00
IUUC-Eeu-034451	Erinaceus europaeus	32.06	6.00e-28	117.00
IUUC-Fca-036313	Felis catus	33.12	1.00e-44	173.00
IUUC-Fal-037216	Ficedula albicollis	35.85	1.00e-45	177.00
IUUC-Gmo-038649	Gadus morhua	44.86	3.00e-67	248.00
IUUC-Gga-041082	Gallus gallus	34.38	2.00e-41	162.00
IUUC-Gac-042439	Gasterosteus aculeatus	47.17	2.00e-76	278.00
IUUC-Ggo-044957	Gorilla gorilla	29.96	1.00e-31	130.00
IUUC-Hsa-046381	Homo sapiens	31.66	7.00e-43	167.00
IUUC-Itr-047918	Ictidomys tridecemlineatus	33.13	7.00e-45	174.00
IUUC-Loc-052688	Lepisosteus oculatus	42.90	2.00e-65	242.00
IUUC-Laf-054109	Loxodonta africana	33.74	3.00e-47	182.00
IUUC-Mcc-054814	Macaca mulatta	32.31	4.00e-43	168.00
IUUC-Meu-056253	Macropus eugenii	31.45	1.00e-31	130.00
IUUC-Mmr-061613	Microcebus murinus	34.97	1.00e-46	180.00
IUUC-Mdo-061890	Monodelphis domestica	32.09	4.00e-37	148.00
IUUC-Mmu-064329	Mus musculus	33.64	7.00e-42	164.00
IUUC-Mpu-066342	Mustela putorius furo	34.15	7.00e-48	184.00
IUUC-Mlu-067010	Myotis lucifugus	32.11	1.00e-43	170.00
IUUC-Nle-069148	Nomascus leucogenys	31.07	9.00e-43	167.00
IUUC-Ont-072039	Oreochromis niloticus	44.51	3.00e-73	268.00
IUUC-Ocu-074498	Oryctolagus cuniculus	33.76	6.00e-40	158.00
IUUC-Ola-086753	Oryzias latipes	48.91	2.00e-72	265.00
IUUC-Oga-088497	Otolemur garnettii	34.42	5.00e-45	175.00
IUUC-Oar-089505	Ovis aries	33.44	5.00e-45	174.00
IUUC-Ptr-091656	Pan troglodytes	31.66	2.00e-43	170.00
IUUC-Pan-092498	Papio anubis	32.31	4.00e-43	169.00
IUUC-Psi-093409	Pelodiscus sinensis	33.13	1.00e-40	160.00
IUUC-Pfo-096507	Poecilia formosa	46.71	7.00e-79	287.00
IUUC-Pab-097828	Pongo abelii	30.91	3.00e-41	162.00
IUUC-Pva-102972	Pteropus vampyrus	32.80	8.00e-43	167.00
IUUC-Rno-105738	Rattus norvegicus	35.28	5.00e-49	188.00
IUUC-Sha-107309	Sarcophilus harrisii	32.80	6.00e-39	154.00
IUUC-Sar-112983	Sorex araneus	33.46	8.00e-35	141.00
IUUC-Ssc-116049	Sus scrofa	34.62	1.00e-46	180.00
IUUC-Tgu-117115	Taeniopygia guttata	35.83	2.00e-44	172.00
IUUC-Tru-118022	Takifugu rubripes	40.29	1.00e-65	243.00
IUUC-Tni-120306	Tetraodon nigroviridis	41.67	2.00e-65	243.00
IUUC-Ttr-128686	Tursiops truncatus	33.12	1.00e-44	173.00
IUUC-Xtr-132032	Xenopus tropicalis	33.65	9.00e-38	150.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence