iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.70e-40	135.2	182	220
UBD/Beta-Prp	2.70e-52	179.5	47	270

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+++v +l++ +d +++vsG+ D +ik+WD+r+  + +
   Q: 182  GHSGDVMSLSLaPDgRTFVSGACDASIKLWDVRDSMCRQ 220
           8***********99999****************988866 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee...t 132
           + r+l gh a+++a+ +  d+ +lv++s+D+ + +wd  t   vh++   ++ v+++++ psg++++ G+ d++  ++ l+t++        
   Q: 47   TRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRvsrE 138
           5689*****************************************************************************99877666779 PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdn 224
           l gh+g  +c ++ + +n ++++s D+t+ lWd++tg+    + g h ++v sls+ ++g+ +vsg++d ++klwd++ + c +t++gh++ 
   Q: 139  LPGHTGYLSCCRFLD-DNQIITSSGDTTCALWDIETGQQTVGFAG-HSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESD 228
           *************99.7778999********************99.********************************************** PP
   S: 225  vksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvi 268
           ++ v+f+pn+  + +gs+D + r++dlr ++ l ++++ n  +i
   Q: 229  INAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDN--II 270
           *********************************9999854..55 PP

Organism

Homo sapiens

Functional Description
(View)

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. Interacts with ATXN10. Interacts with SCN8A (PubMed:26900580).

Protein Sequence
(Fasta)

MSELEQLRQE AEQLRNQIRD ARKACGDSTL TQITAGLDPV GRIQMRTRRT LRGHLAKIYA 60
MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV MTCAYAPSGN FVACGGLDNI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCAGTCCCA GAGGGGGGAT GTCTTACTCC TTTCCGTGAA GCAAACCCTT TGAGTACGGT 60
TTGCGTCCAC AAAGCGTAGG GTGAGAACCT TGGGAGCGAC TGGGCCCGTC TTTGCTCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0807--Transducer
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR016346--Guanine_nucleotide-bd_bsu
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0044297--C:cell body
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0005925--C:focal adhesion
GO:0005765--C:lysosomal membrane
GO:0016020--C:membrane
GO:0043209--C:myelin sheath
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0031982--C:vesicle
GO:0005246--F:calcium channel regulator activity
GO:0003924--F:GTPase activity
GO:0051020--F:GTPase binding
GO:0032403--F:protein complex binding
GO:0004871--F:signal transducer activity
GO:0071377--P:cellular response to glucagon stimulus
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006457--P:protein folding

KEGG

hsa:2783

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001395	Ailuropoda melanoleuca	99.07	0.00e+00	658.00
IUUC-Ago-007831	Ashbya gossypii	38.24	4.00e-68	252.00
IUUC-Ame-011124	Astyanax mexicanus	94.12	0.00e+00	637.00
IUUC-Bta-013430	Bos taurus	100.00	0.00e+00	665.00
IUUC-Bol-015759	Brassica oleracea	50.32	3.00e-81	297.00
IUUC-Cel-018704	Caenorhabditis elegans	85.29	7.00e-180	622.00
IUUC-Cja-019794	Callithrix jacchus	100.00	0.00e+00	665.00
IUUC-Cpo-021865	Cavia porcellus	100.00	0.00e+00	665.00
IUUC-Csa-023572	Chlorocebus sabaeus	100.00	0.00e+00	665.00
IUUC-Cin-025309	Ciona intestinalis	80.18	2.00e-169	588.00
IUUC-Csv-026258	Ciona savignyi	80.47	1.00e-169	588.00
IUUC-Cgl-026673	Colletotrichum gloeosporioides	65.50	5.00e-136	477.00
IUUC-Dre-027957	Danio rerio	94.43	0.00e+00	634.00
IUUC-Dno-029001	Dasypus novemcinctus	100.00	0.00e+00	665.00
IUUC-Dor-030322	Dipodomys ordii	88.85	2.00e-166	578.00
IUUC-Eca-034149	Equus caballus	100.00	0.00e+00	665.00
IUUC-Fca-036537	Felis catus	100.00	0.00e+00	665.00
IUUC-Fox-037946	Fusarium oxysporum	65.79	4.00e-131	461.00
IUUC-Fso-038136	Fusarium solani	65.79	4.00e-131	461.00
IUUC-Gmo-039332	Gadus morhua	94.74	0.00e+00	634.00
IUUC-Ggr-039969	Gaeumannomyces graminis	65.20	1.00e-134	473.00
IUUC-Gac-041932	Gasterosteus aculeatus	93.19	0.00e+00	629.00
IUUC-Ggo-044543	Gorilla gorilla	100.00	0.00e+00	665.00
IUUC-Itr-048049	Ictidomys tridecemlineatus	100.00	0.00e+00	686.00
IUUC-Laf-053865	Loxodonta africana	100.00	0.00e+00	665.00
IUUC-Mcc-055781	Macaca mulatta	100.00	0.00e+00	631.00
IUUC-Meu-056902	Macropus eugenii	99.38	0.00e+00	662.00
IUUC-Mor-057188	Magnaporthe oryzae	64.91	6.00e-134	470.00
IUUC-Mpo-057544	Magnaporthe poae	64.91	4.00e-135	474.00
IUUC-Mtr-058752	Medicago truncatula	44.96	4.00e-85	308.00
IUUC-Mla-059086	Melampsora laricipopulina	70.62	3.00e-149	521.00
IUUC-Mmr-061015	Microcebus murinus	100.00	0.00e+00	665.00
IUUC-Mdo-062734	Monodelphis domestica	99.38	0.00e+00	662.00
IUUC-Mmu-063737	Mus musculus	100.00	0.00e+00	665.00
IUUC-Mpu-066784	Mustela putorius furo	99.68	0.00e+00	637.00
IUUC-Mlu-067912	Myotis lucifugus	99.69	0.00e+00	663.00
IUUC-Opr-070866	Ochotona princeps	100.00	0.00e+00	665.00
IUUC-Ont-072526	Oreochromis niloticus	93.50	0.00e+00	629.00
IUUC-Ocu-074344	Oryctolagus cuniculus	100.00	0.00e+00	665.00
IUUC-Oga-089046	Otolemur garnettii	100.00	0.00e+00	665.00
IUUC-Oar-089822	Ovis aries	93.50	5.00e-177	613.00
IUUC-Ptr-091444	Pan troglodytes	100.00	0.00e+00	665.00
IUUC-Pan-092045	Papio anubis	100.00	0.00e+00	665.00
IUUC-Pma-094748	Petromyzon marinus	90.87	5.00e-139	486.00
IUUC-Pab-097601	Pongo abelii	99.07	0.00e+00	660.00
IUUC-Pca-100940	Procavia capensis	100.00	0.00e+00	665.00
IUUC-Pva-102229	Pteropus vampyrus	99.69	0.00e+00	658.00
IUUC-Rno-106104	Rattus norvegicus	100.00	0.00e+00	665.00
IUUC-Sha-107632	Sarcophilus harrisii	99.38	0.00e+00	662.00
IUUC-Ssc-115595	Sus scrofa	100.00	0.00e+00	665.00
IUUC-Tru-118401	Takifugu rubripes	93.19	0.00e+00	628.00
IUUC-Tni-120216	Tetraodon nigroviridis	92.88	0.00e+00	627.00
IUUC-Tre-122156	Trichoderma reesei	65.50	4.00e-135	474.00
IUUC-Tvi-122640	Trichoderma virens	65.50	4.00e-135	474.00
IUUC-Tbe-128132	Tupaia belangeri	99.22	2.00e-148	517.00
IUUC-Ttr-128403	Tursiops truncatus	100.00	0.00e+00	665.00
IUUC-Vda-129855	Verticillium dahliae	70.16	5.00e-129	453.00
IUUC-Vpa-130474	Vicugna pacos	97.79	4.00e-76	278.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence