iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003486

Ensembl Protein ID

ENSAPLP00000015182.1

UniProt Accession

U3J6Q5; U3J6Q5_ANAPL

Genbank Protein ID

ENSAPLP00000015182

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01058970

Gene Name

USP47

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000015288.1	ENSAPLT00000015975.1	ENSAPLP00000015182.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.90e-75	253.9	175	549

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +Gl N+  tCY+NS+LQ+L+++pe+r++l +    +++e++ ++p +++  +lq+lf  l++skk+a++++++++++++ ++e    +q
   Q: 175  VGLVNQAMTCYLNSLLQTLFMTPEFRNALYK---WEFEESE-EDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSE--AWQQ 257
           6******************************...5555443.5899*********************************9998..9*** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +D+qE++++++d+le++                           k++++ +li++l+qg+lk+ ++clec+ +  r ++ ld++l ++ 
   Q: 258  HDVQELCRVMFDALEQKW--------------------------KQTEQADLINQLYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRP 320
           ******************..........................678999*************************************95 PP
   S: 179  k.eetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfct 266
             ++++  s++++L++f ++e l+g n+y+ce+ckkk++a+k l++ ++P  L+l+LkRf f+ ++++r+k+n++++fp+eLd+s f  
   Q: 321  YgSNQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSIFID 409
           41334678*****************************************************************************9998 PP
   S: 267  speekqke.....................................................kkkYeLiavvvHsGslssGHYvayvkn. 301
            ++ek+ +                                                     +  YeL++v+vHsGs+ +GHY+a++k+ 
   Q: 410  VEDEKSPQtesctdsgaenegschsdqmsndfsnddgvdegiclesnsaaeriskvgseknSLLYELFSVMVHSGSAAGGHYYACIKSf 498
           86666655777778888888888888888888888888888888888888888888888889**************************5 PP
   S: 302  ekgkWllfdDskVtevkeeevleetg................staYvlfYk 336
           ++++W+ f+D++V+++++e+++++ g                ++aY+l+Y+
   Q: 499  SDDQWYSFNDQHVSKITQEDIKKTYGgssgsrgyyssafassTNAYMLIYR 549
           5666*******************888************************8 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

DMFWSCRQSI FAEMKKKFSQ VESAAEEPRV LCIIQDTTNS KTVNERVTLN LPASTLLKKL 60
FEDVASKVGY VNGTFDLVWG NGDNVTDTTP IDQNSDKTIL DAGFEPGKKN FLHLTDKDGE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATATGTTTT GGAGTTGCAG ACAGAGTATC TTTGCTGAAA TGAAGAAGAA ATTTTCACAG 60
GTAGACAGAT GAAATCAACT TTATTTAATA ACTAAGATAC ATAGTAACAG CATGAGGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF14560--Ubiquitin_2
PF00443--UCH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006284--P:base-excision repair
GO:0034644--P:cellular response to UV
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010972--P:negative regulation of G2/M transition of mitotic cell cycle
GO:1902230--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0030307--P:positive regulation of cell growth
GO:0042493--P:response to drug
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002228	Ailuropoda melanoleuca	88.57	0.00e+00	2331.00
IUUC-Aca-005061	Anolis carolinensis	90.68	0.00e+00	2441.00
IUUC-Ame-011206	Astyanax mexicanus	80.92	0.00e+00	2124.00
IUUC-Bta-012942	Bos taurus	89.79	0.00e+00	2383.00
IUUC-Cel-018600	Caenorhabditis elegans	37.47	9.00e-122	431.00
IUUC-Cja-018950	Callithrix jacchus	90.77	0.00e+00	2229.00
IUUC-Cfa-020299	Canis familiaris	90.51	0.00e+00	2363.00
IUUC-Cpo-021943	Cavia porcellus	89.94	0.00e+00	2373.00
IUUC-Csa-023285	Chlorocebus sabaeus	90.69	0.00e+00	2351.00
IUUC-Cho-025006	Choloepus hoffmanni	82.79	0.00e+00	2051.00
IUUC-Cin-025145	Ciona intestinalis	41.54	0.00e+00	714.00
IUUC-Csv-025839	Ciona savignyi	49.47	6.00e-163	568.00
IUUC-Dre-027959	Danio rerio	81.58	0.00e+00	2058.00
IUUC-Dno-030023	Dasypus novemcinctus	87.77	0.00e+00	2273.00
IUUC-Dor-030994	Dipodomys ordii	88.40	0.00e+00	874.00
IUUC-Dme-031604	Drosophila melanogaster	48.53	2.00e-145	510.00
IUUC-Ete-032596	Echinops telfairi	75.89	0.00e+00	771.00
IUUC-Eca-033913	Equus caballus	90.17	0.00e+00	2395.00
IUUC-Eeu-034518	Erinaceus europaeus	83.20	0.00e+00	1989.00
IUUC-Fca-035997	Felis catus	90.17	0.00e+00	2378.00
IUUC-Fal-037088	Ficedula albicollis	95.23	0.00e+00	2219.00
IUUC-Gmo-038920	Gadus morhua	77.77	0.00e+00	2012.00
IUUC-Gga-040953	Gallus gallus	96.99	0.00e+00	2527.00
IUUC-Gac-042400	Gasterosteus aculeatus	78.56	0.00e+00	2006.00
IUUC-Ggo-044820	Gorilla gorilla	88.62	0.00e+00	2309.00
IUUC-Hsa-046634	Homo sapiens	90.38	0.00e+00	2379.00
IUUC-Lch-050440	Latimeria chalumnae	86.26	0.00e+00	2310.00
IUUC-Loc-051904	Lepisosteus oculatus	84.92	0.00e+00	2237.00
IUUC-Laf-053760	Loxodonta africana	89.58	0.00e+00	2405.00
IUUC-Mcc-054637	Macaca mulatta	90.53	0.00e+00	2385.00
IUUC-Meu-056904	Macropus eugenii	90.44	0.00e+00	1615.00
IUUC-Mga-059556	Meleagris gallopavo	95.67	0.00e+00	2499.00
IUUC-Mmr-061192	Microcebus murinus	90.53	0.00e+00	2380.00
IUUC-Mdo-061929	Monodelphis domestica	90.68	0.00e+00	2399.00
IUUC-Mmu-063726	Mus musculus	87.53	0.00e+00	2344.00
IUUC-Mpu-066014	Mustela putorius furo	90.48	0.00e+00	2353.00
IUUC-Mlu-067232	Myotis lucifugus	89.82	0.00e+00	2365.00
IUUC-Nle-069619	Nomascus leucogenys	90.54	0.00e+00	2347.00
IUUC-Opr-070224	Ochotona princeps	85.93	0.00e+00	1055.00
IUUC-Ont-071384	Oreochromis niloticus	80.46	0.00e+00	2066.00
IUUC-Oan-073208	Ornithorhynchus anatinus	86.01	0.00e+00	2293.00
IUUC-Ocu-074285	Oryctolagus cuniculus	90.23	0.00e+00	2377.00
IUUC-Ola-087051	Oryzias latipes	79.03	0.00e+00	1988.00
IUUC-Oga-088928	Otolemur garnettii	90.16	0.00e+00	2373.00
IUUC-Oar-090215	Ovis aries	89.89	0.00e+00	2391.00
IUUC-Ptr-091035	Pan troglodytes	90.46	0.00e+00	2383.00
IUUC-Pan-092377	Papio anubis	90.01	0.00e+00	2361.00
IUUC-Pfo-096722	Poecilia formosa	79.61	0.00e+00	2045.00
IUUC-Pab-098723	Pongo abelii	90.46	0.00e+00	2383.00
IUUC-Pca-100105	Procavia capensis	85.61	0.00e+00	2176.00
IUUC-Pva-102514	Pteropus vampyrus	90.42	0.00e+00	888.00
IUUC-Rno-105384	Rattus norvegicus	88.55	0.00e+00	2325.00
IUUC-Sha-106982	Sarcophilus harrisii	88.83	0.00e+00	2362.00
IUUC-Sar-113723	Sorex araneus	82.65	0.00e+00	894.00
IUUC-Ssc-115671	Sus scrofa	91.14	0.00e+00	1917.00
IUUC-Tgu-116722	Taeniopygia guttata	94.79	0.00e+00	2463.00
IUUC-Tru-118380	Takifugu rubripes	77.87	0.00e+00	2043.00
IUUC-Tsy-119646	Tarsius syrichta	83.92	0.00e+00	2165.00
IUUC-Tni-120762	Tetraodon nigroviridis	78.22	0.00e+00	2055.00
IUUC-Tbe-127861	Tupaia belangeri	88.12	0.00e+00	2199.00
IUUC-Ttr-129254	Tursiops truncatus	83.86	0.00e+00	1331.00
IUUC-Vpa-130141	Vicugna pacos	90.32	0.00e+00	1103.00
IUUC-Xtr-132700	Xenopus tropicalis	82.10	0.00e+00	2198.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence