iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Csv-025842

UUCD1 version

UUC-CiS-00460

Ensembl Protein ID

ENSCSAVP00000011530.1

UniProt Accession

H2Z1R8; H2Z1R8_CIOSA

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAVG00000006754.1	ENSCSAVT00000011664.1	ENSCSAVP00000011530.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	1.40e-91	307.4	2	378

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqv 94
           +w eLesdPglftllvedfgv+++ qv+e+y+L++      ++ v+g+++lFk+ne  +s+rk+q t+++ + +de+i++++ffa+q+
   Q: 2    GWKELESDPGLFTLLVEDFGVEGV-QVDEIYDLQEAI----NRKVYGFIFLFKWNEAGRSRRKIQSTVDEPFCKDEEIVNKMFFAHQL 84
           7***********************.*********966....899******************************************** PP
   S: 95   igNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqy...tkeafh 179
           ++NsCat+Allsvllnced+  +lG+ + rlk+ t ++spe+k+ a+gn ++l+  h  +ar+e   +   q++ n      t+eafh
   Q: 85   VPNSCATHALLSVLLNCEDV--QLGPLITRLKTDTYKFSPEMKGFAIGNIPELAFSHSKHARPETNPLLDMQNKPNGITstrTMEAFH 170
           ********************..9******************************************98877776655443344****** PP
   S: 180  fvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid.... 259
           + sy +  grl+eldglkpfP+d+g+   +  ++d +++v   + ri  ++ +e    ir+nl+a+v+ +    +++l+ lk d    
   Q: 171  YTSYFPLHGRLFELDGLKPFPIDHGPLPSDGTWHDMARRVV--TSRITAATGGEqchdIRYNLMAVVPCQVQHFKAKLEKLKADytfa 256
           *****************************************..**************************999999***99**99**** PP
   S: 260  ..................................................keLlkLlkdieseeekieaqlddekekrkkfkiddirR 297
                                                               +  + + +e+++ k+  +  + +ekr+k+kid  rR
   Q: 257  kravenllsqtsnsneekinfetgyeledppddnpsslahnnglkndqeiSSIKTMEEFMEALKSKNISEYFESNEKRYKYKIDCARR 344
           ***********************************************5554444455555666666666666789************* PP
   S: 298  tenydeficifikdlaregilrklveetisevre 331
           t+ y+ fi  f+ +l + +il ++v++++  +++
   Q: 345  THDYVPFISLFLAMLEERNILSNIVDKNVQLRKR 378
           *****************************98887 PP

Organism

Ciona savignyi

Protein Sequence
(Fasta)

GGWKELESDP GLFTLLVEDF GVEGVQVDEI YDLQEAINRK VYGFIFLFKW NEAGRSRRKI 60
QSTVDEPFCK DEEIVNKMFF AHQLVPNSCA THALLSVLLN CEDVQLGPLI TRLKTDTYKF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGGGTGGA AAGAATTGGA AAGTGATCCT GGCTTATTCA CGTTGTTGGT TGAAGATTTT 60
GGAGTGGAGG GGGTTCAGGT GGATGAGATA TACGACCTGC AAGAGGCAAT TAACCGGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005622--C:intracellular
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001263	Ailuropoda melanoleuca	58.95	1.00e-88	319.00
IUUC-Aca-004836	Anolis carolinensis	61.00	7.00e-89	320.00
IUUC-Ame-011946	Astyanax mexicanus	63.86	3.00e-92	331.00
IUUC-Bta-013131	Bos taurus	61.76	4.00e-79	287.00
IUUC-Cja-019599	Callithrix jacchus	57.88	2.00e-89	322.00
IUUC-Cfa-021003	Canis familiaris	61.28	1.00e-88	319.00
IUUC-Cpo-022143	Cavia porcellus	59.22	8.00e-89	320.00
IUUC-Csa-023477	Chlorocebus sabaeus	58.95	4.00e-89	320.00
IUUC-Cho-024734	Choloepus hoffmanni	57.33	1.00e-19	90.10
IUUC-Dre-027793	Danio rerio	63.86	3.00e-92	331.00
IUUC-Dno-029253	Dasypus novemcinctus	57.65	9.00e-85	306.00
IUUC-Dor-030891	Dipodomys ordii	49.82	1.00e-71	262.00
IUUC-Dme-031796	Drosophila melanogaster	44.73	3.00e-85	307.00
IUUC-Ete-032646	Echinops telfairi	58.59	5.00e-70	257.00
IUUC-Eca-033805	Equus caballus	57.88	3.00e-89	321.00
IUUC-Eeu-035216	Erinaceus europaeus	48.53	2.00e-31	129.00
IUUC-Fca-035611	Felis catus	60.47	5.00e-84	303.00
IUUC-Fal-037186	Ficedula albicollis	58.95	2.00e-62	231.00
IUUC-Gmo-038824	Gadus morhua	56.33	2.00e-93	335.00
IUUC-Gga-040875	Gallus gallus	62.03	1.00e-94	338.00
IUUC-Gac-042226	Gasterosteus aculeatus	57.04	4.00e-94	337.00
IUUC-Ggo-045122	Gorilla gorilla	58.95	3.00e-89	321.00
IUUC-Hsa-045882	Homo sapiens	58.95	5.00e-89	320.00
IUUC-Itr-048185	Ictidomys tridecemlineatus	61.28	6.00e-89	320.00
IUUC-Lch-049960	Latimeria chalumnae	51.48	8.00e-70	256.00
IUUC-Loc-052408	Lepisosteus oculatus	56.38	3.00e-92	330.00
IUUC-Laf-054187	Loxodonta africana	61.65	3.00e-94	337.00
IUUC-Mcc-055273	Macaca mulatta	55.79	1.00e-80	292.00
IUUC-Meu-056267	Macropus eugenii	58.46	4.00e-85	307.00
IUUC-Mga-059958	Meleagris gallopavo	61.24	1.00e-89	321.00
IUUC-Mmr-061280	Microcebus murinus	61.28	8.00e-89	319.00
IUUC-Mdo-062625	Monodelphis domestica	58.90	6.00e-96	343.00
IUUC-Mmu-063853	Mus musculus	60.90	2.00e-88	318.00
IUUC-Mlu-067771	Myotis lucifugus	57.53	3.00e-89	321.00
IUUC-Opr-070741	Ochotona princeps	61.28	1.00e-88	319.00
IUUC-Ont-072172	Oreochromis niloticus	61.28	7.00e-94	336.00
IUUC-Oan-073167	Ornithorhynchus anatinus	58.90	4.00e-96	343.00
IUUC-Ocu-074176	Oryctolagus cuniculus	59.43	3.00e-88	318.00
IUUC-Ola-087203	Oryzias latipes	51.37	1.00e-90	324.00
IUUC-Oga-089153	Otolemur garnettii	56.60	7.00e-85	306.00
IUUC-Oar-090008	Ovis aries	58.22	4.00e-90	324.00
IUUC-Ptr-091234	Pan troglodytes	58.95	3.00e-89	321.00
IUUC-Pan-092005	Papio anubis	58.95	4.00e-89	320.00
IUUC-Psi-093995	Pelodiscus sinensis	61.15	1.00e-89	322.00
IUUC-Pma-094110	Petromyzon marinus	53.72	6.00e-32	130.00
IUUC-Pfo-097418	Poecilia formosa	65.06	2.00e-93	335.00
IUUC-Pab-098267	Pongo abelii	58.95	4.00e-89	320.00
IUUC-Pca-101084	Procavia capensis	58.22	2.00e-94	338.00
IUUC-Pva-102292	Pteropus vampyrus	57.88	3.00e-89	321.00
IUUC-Rno-105251	Rattus norvegicus	58.42	3.00e-86	311.00
IUUC-Sha-107100	Sarcophilus harrisii	57.69	7.00e-91	326.00
IUUC-Sar-113559	Sorex araneus	60.38	2.00e-68	252.00
IUUC-Ssc-115688	Sus scrofa	60.90	3.00e-88	317.00
IUUC-Tgu-117424	Taeniopygia guttata	61.09	2.00e-89	322.00
IUUC-Tru-118585	Takifugu rubripes	61.28	1.00e-93	335.00
IUUC-Tsy-119299	Tarsius syrichta	51.04	2.00e-59	221.00
IUUC-Tni-120808	Tetraodon nigroviridis	61.28	9.00e-94	336.00
IUUC-Tbe-127705	Tupaia belangeri	60.53	2.00e-82	297.00
IUUC-Ttr-128225	Tursiops truncatus	59.30	2.00e-89	322.00
IUUC-Vpa-130193	Vicugna pacos	45.81	9.00e-47	179.00
IUUC-Xtr-132449	Xenopus tropicalis	59.92	1.00e-87	316.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence