iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062625

UUCD1 version

UUC-MoD-01101

Ensembl Protein ID

ENSMODP00000014406.2

UniProt Accession

F6RI15; F6RI15_MONDO

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Gene Name

BAP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000011521.3	ENSMODT00000014672.3	ENSMODP00000014406.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	3.90e-168	559.4	3	728

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 6    kewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqv 94
           k+wleLesdPglftllvedfgvk++ qvee+y+L++++    q+pv+g+++lFk++e+r+s+rk+++++++++v+d+di++++ffa+q+
   Q: 3    KGWLELESDPGLFTLLVEDFGVKGV-QVEEIYDLQSKC----QGPVYGFIFLFKWIEERRSRRKVSTLVDETSVIDDDIVNNMFFAHQL 86
           89***********************.************....*********************************************** PP
   S: 95   igNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           i+NsCat+Allsvllnc+++  dlG+tlsr+k++tk++spe+k++a+gn+++l+++hns+ar+e+r++pe+q++ ++++t+eafhfvsy
   Q: 87   IPNSCATHALLSVLLNCSNV--DLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGISAVRTMEAFHFVSY 173
           ******************99..******************************************************************* PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid......... 259
           v+i+grl+eldglk++P+d+g+++e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drr++++ +l+vlk++         
   Q: 174  VPIKGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRIKYESKLHVLKMNrqtvlealq 260
           *************************************..************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 261  qlirvtqpeliqtqksqesqppedskpasckpslvletsktplaseasqtdgpeevagpcqpapthsppskpklmvkppvsslngvptn 349
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 350  pspivqrlpafldnhnyakspmqeeedlaagvgrsrvpvrppqqysddeddydeeeeedvrntnsairykrkgqvkqeplpassdgqlc 438
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 439  vlqpntinvlaeklkesqkdlsiplsiktsggagspavaapshsqpsptpsnestdtaseigsafnsplrspirsanptrpsspvtshi 527
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 528  skvlfgeddgllrvdcmrynravrdlgpvistgllhlsedgvlcpltiteggkgssppirqsqatqisvtieekevpessdrekaglsr 616
           ***************************************************************************************** PP
   S: 260  ............keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgvne 336
                       keLl+Llk++e+e++++ea+l++e+ekrkkfkidd+rRt+nydefic+fi++la+eg+l++lve++is++r++gv++
   Q: 617  ppeqlcgekyspKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSI 705
           ***************************************************************************************** PP
   S: 337  grlakqrkqgrekkirplkrkrk 359
           grl+kqrk++r+k++rp+k+kr+
   Q: 706  GRLHKQRKPDRRKRSRPYKAKRQ 728
           *********************97 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEERRSRR 60
KVSTLVDETS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCSNVDLGP TLSRMKDFTK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATAAAG GCTGGTTAGA GCTGGAGAGT GACCCAGGTG AGGGGCAATA AAGGGGGGGC 60
GGGGCCGGAC GGGGGAGAGG GAAGGAAAAG GAGAGGGGAC CGGGAGAGGG GGAAGGGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0035517--C:PR-DUB complex
GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0061519--P:macrophage homeostasis
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0051726--P:regulation of cell cycle
GO:0001558--P:regulation of cell growth
GO:1900015--P:regulation of cytokine production involved in inflammatory response
GO:0010035--P:response to inorganic substance
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mdo:100030960

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001263	Ailuropoda melanoleuca	87.91	0.00e+00	1159.00
IUUC-Apl-003405	Anas platyrhynchos	70.73	0.00e+00	655.00
IUUC-Aca-004836	Anolis carolinensis	81.32	0.00e+00	1164.00
IUUC-Acl-008231	Aspergillus clavatus	41.67	5.00e-44	171.00
IUUC-Ang-009859	Aspergillus niger	41.37	8.00e-43	167.00
IUUC-Ame-011946	Astyanax mexicanus	65.94	0.00e+00	909.00
IUUC-Bta-013131	Bos taurus	86.15	0.00e+00	1030.00
IUUC-Cja-019599	Callithrix jacchus	90.26	0.00e+00	1251.00
IUUC-Cfa-021003	Canis familiaris	89.71	0.00e+00	1163.00
IUUC-Cpo-022143	Cavia porcellus	89.85	0.00e+00	1234.00
IUUC-Csa-023477	Chlorocebus sabaeus	89.85	0.00e+00	1217.00
IUUC-Cho-024734	Choloepus hoffmanni	75.59	0.00e+00	699.00
IUUC-Csv-025842	Ciona savignyi	58.90	8.00e-96	343.00
IUUC-Dre-027793	Danio rerio	66.84	0.00e+00	934.00
IUUC-Dno-029253	Dasypus novemcinctus	89.14	0.00e+00	1207.00
IUUC-Dor-030891	Dipodomys ordii	83.81	0.00e+00	1149.00
IUUC-Dme-031796	Drosophila melanogaster	61.94	2.00e-93	335.00
IUUC-Ete-032646	Echinops telfairi	81.13	1.00e-164	573.00
IUUC-Eca-033805	Equus caballus	89.30	0.00e+00	1203.00
IUUC-Eeu-035216	Erinaceus europaeus	89.46	1.00e-142	499.00
IUUC-Fca-035611	Felis catus	89.42	0.00e+00	1110.00
IUUC-Fal-037186	Ficedula albicollis	82.80	0.00e+00	1031.00
IUUC-Gmo-038824	Gadus morhua	69.65	0.00e+00	633.00
IUUC-Gga-040875	Gallus gallus	83.13	0.00e+00	1144.00
IUUC-Gac-042226	Gasterosteus aculeatus	68.47	0.00e+00	951.00
IUUC-Ggo-045122	Gorilla gorilla	89.30	0.00e+00	1248.00
IUUC-Hsa-045882	Homo sapiens	89.16	0.00e+00	1244.00
IUUC-Itr-048185	Ictidomys tridecemlineatus	90.40	0.00e+00	1233.00
IUUC-Lch-049960	Latimeria chalumnae	74.66	0.00e+00	1026.00
IUUC-Loc-052408	Lepisosteus oculatus	77.56	0.00e+00	671.00
IUUC-Laf-054187	Loxodonta africana	90.12	0.00e+00	1204.00
IUUC-Mcc-055273	Macaca mulatta	88.48	0.00e+00	1209.00
IUUC-Meu-056267	Macropus eugenii	88.87	0.00e+00	1260.00
IUUC-Mga-059958	Meleagris gallopavo	96.07	3.00e-156	544.00
IUUC-Mmr-061280	Microcebus murinus	89.86	0.00e+00	1206.00
IUUC-Mmu-063853	Mus musculus	88.75	0.00e+00	1217.00
IUUC-Mlu-067771	Myotis lucifugus	89.57	0.00e+00	1187.00
IUUC-Opr-070741	Ochotona princeps	87.79	0.00e+00	1227.00
IUUC-Ont-072172	Oreochromis niloticus	68.28	0.00e+00	966.00
IUUC-Oan-073167	Ornithorhynchus anatinus	82.42	0.00e+00	1179.00
IUUC-Ocu-074176	Oryctolagus cuniculus	88.58	0.00e+00	1176.00
IUUC-Ola-087203	Oryzias latipes	86.74	7.00e-137	479.00
IUUC-Oga-089153	Otolemur garnettii	89.06	0.00e+00	1209.00
IUUC-Oar-090008	Ovis aries	87.38	0.00e+00	1179.00
IUUC-Ptr-091234	Pan troglodytes	89.44	0.00e+00	1249.00
IUUC-Pan-092005	Papio anubis	89.57	0.00e+00	1239.00
IUUC-Psi-093995	Pelodiscus sinensis	84.46	0.00e+00	662.00
IUUC-Pma-094110	Petromyzon marinus	49.24	5.00e-121	428.00
IUUC-Pfo-097418	Poecilia formosa	66.23	0.00e+00	936.00
IUUC-Pab-098267	Pongo abelii	89.16	0.00e+00	1220.00
IUUC-Pca-101084	Procavia capensis	87.88	0.00e+00	1143.00
IUUC-Pva-102292	Pteropus vampyrus	90.29	0.00e+00	860.00
IUUC-Rno-105251	Rattus norvegicus	86.79	0.00e+00	1184.00
IUUC-Sha-107100	Sarcophilus harrisii	97.08	0.00e+00	1409.00
IUUC-Sar-113559	Sorex araneus	81.98	0.00e+00	1022.00
IUUC-Ssc-115688	Sus scrofa	88.89	0.00e+00	1228.00
IUUC-Tgu-117424	Taeniopygia guttata	83.84	0.00e+00	1160.00
IUUC-Tru-118585	Takifugu rubripes	68.92	0.00e+00	939.00
IUUC-Tsy-119299	Tarsius syrichta	78.37	0.00e+00	912.00
IUUC-Tni-120808	Tetraodon nigroviridis	67.96	0.00e+00	941.00
IUUC-Tbe-127705	Tupaia belangeri	90.32	5.00e-175	606.00
IUUC-Ttr-128225	Tursiops truncatus	88.48	0.00e+00	1181.00
IUUC-Vpa-130193	Vicugna pacos	87.00	2.00e-123	436.00
IUUC-Xtr-132449	Xenopus tropicalis	73.04	0.00e+00	954.00
IUUC-Xma-133232	Xiphophorus maculatus	65.71	0.00e+00	927.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence