iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000075702.16	ENST00000401500.6	ENSP00000384792.1
ENSG00000075702.16	ENST00000587391.5	ENSP00000465525.1
ENSG00000075702.16	ENST00000270301.11	ENSP00000270301.6
ENSG00000075702.16	ENST00000427823.2	ENSP00000413475.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.00e-27	93.8	153	190
UBD/Beta-Prp	6.80e-55	188.0	495	752

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGs..dDgtikvWDlrtgv 34
           gH+ +v c+af ++ +++vs +  +D ++ vWD++++ 
   Q: 153  GHKYGVACVAFsPNmKHIVSMGyqHDMVLNVWDWKKDI 190
           89**********888*****9989*********98765 PP

UBD/Beta-Prp

   S: 13   itcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk...ilvtgseDrtikvwdls.tgkcvhtlkghedsvlsl 100
           ++++++spd+++la+g r+g +++++++ ++ l +++ h+aev ++++s+ +    +l+++s+Dr+i+v +++ ++   +tl  h++s++++
   Q: 495  VRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETgltLLASASRDRLIHVLNVEkNYNLEQTLDDHSSSITAI 586
           67899*******************************************99887899**************9997888999************ PP
   S: 101  sfspsg.dklvsGshdrtirvwdletgqclee....tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl...ktgkllrtltgghtdsvy 184
           +f  ++   ++s ++d+ i     ++g+   +        ++ +   + ++ ++++++ ++ Dr vr+++    k++k+ +  +g +++s  
   Q: 587  KFAGNRdIQMISCGADKSIYFRSAQQGSDGLHfvrtHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTvngKQKKCYKGSQG-DEGSLL 677
           ****885789********998666666555544332112222233446677778****************988888888888898.999999 PP
   S: 185  slsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW.......dlr 252
           ++ +d++g++l++   d+++ + d+ +gec+ ++ gh++ ++s++f+ + ++l+++s D  ++iW       ++ 
   Q: 678  KVHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWhlgpeitNCM 752
           999**************************************************************6644444443 PP

Organism

Homo sapiens

Functional Description
(View)

Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20890278, PubMed:20729831). Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806).

Protein Sequence
(Fasta)

MAAVGSGGYA RNDAGEKLPS VMAGVPARRG QSSPPPAPPI CLRRRTRLST ASEETVQNRV 60
SLEKVLGITA QNSSGLTCDP GTGHVAYLAG CVVVILDPKE NKQQHIFNTA RKSLSALAFS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCCCGCGG CTGTTCGCTG TTCCAGTGGG TCGTGGCGGT GGCGGCAGCG GCGGTTAGGG 60
GATGTAACGG TCGCCCGCCT CCGGCGTGAC GATGGCGGCC GTAGGGTCCG GAGGCTATGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0991--Mental retardation
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0905--Primary microcephaly
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR030545--WDR62

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005814--C:centriole
GO:0005813--C:centrosome
GO:0005634--C:nucleus
GO:0071011--C:precatalytic spliceosome
GO:0000922--C:spindle pole
GO:0005682--C:U5 snRNP
GO:0007099--P:centriole replication
GO:0021987--P:cerebral cortex development
GO:0007052--P:mitotic spindle organization
GO:0022008--P:neurogenesis
GO:0008380--P:RNA splicing

KEGG

hsa:284403

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001371	Ailuropoda melanoleuca	82.46	0.00e+00	2383.00
IUUC-Aca-004935	Anolis carolinensis	71.60	0.00e+00	1013.00
IUUC-Afu-008757	Aspergillus fumigatus	21.39	3.00e-28	120.00
IUUC-Bta-013336	Bos taurus	79.92	0.00e+00	2242.00
IUUC-Cel-018592	Caenorhabditis elegans	28.92	1.00e-74	276.00
IUUC-Cja-019094	Callithrix jacchus	90.30	0.00e+00	2604.00
IUUC-Cfa-020529	Canis familiaris	82.48	0.00e+00	2387.00
IUUC-Cpo-021970	Cavia porcellus	87.27	0.00e+00	1667.00
IUUC-Cre-022999	Chlamydomonas reinhardtii	28.38	1.00e-13	72.00
IUUC-Csa-024161	Chlorocebus sabaeus	94.62	0.00e+00	2709.00
IUUC-Cho-024310	Choloepus hoffmanni	84.66	0.00e+00	1166.00
IUUC-Cgl-026454	Colletotrichum gloeosporioides	22.85	3.00e-24	107.00
IUUC-Dre-028678	Danio rerio	56.78	0.00e+00	1001.00
IUUC-Dno-029933	Dasypus novemcinctus	75.61	0.00e+00	2115.00
IUUC-Dor-031147	Dipodomys ordii	77.79	0.00e+00	2131.00
IUUC-Dse-031501	Dothistroma septosporum	30.71	2.00e-23	105.00
IUUC-Eca-033675	Equus caballus	81.08	0.00e+00	2280.00
IUUC-Eeu-034798	Erinaceus europaeus	89.17	0.00e+00	902.00
IUUC-Fca-035826	Felis catus	81.52	0.00e+00	2402.00
IUUC-Gma-043644	Glycine max	31.60	2.00e-101	363.00
IUUC-Ggo-045152	Gorilla gorilla	98.62	0.00e+00	2783.00
IUUC-Itr-048019	Ictidomys tridecemlineatus	91.70	0.00e+00	1548.00
IUUC-Lch-049669	Latimeria chalumnae	58.23	0.00e+00	1016.00
IUUC-Loc-052488	Lepisosteus oculatus	55.81	0.00e+00	1023.00
IUUC-Laf-053992	Loxodonta africana	79.25	0.00e+00	2283.00
IUUC-Mcc-054994	Macaca mulatta	96.52	0.00e+00	2707.00
IUUC-Meu-056815	Macropus eugenii	78.70	0.00e+00	1416.00
IUUC-Mtr-058383	Medicago truncatula	30.43	4.00e-50	192.00
IUUC-Mmr-060693	Microcebus murinus	80.29	0.00e+00	2232.00
IUUC-Mdo-063007	Monodelphis domestica	61.82	0.00e+00	1760.00
IUUC-Mmu-064067	Mus musculus	75.26	0.00e+00	2147.00
IUUC-Mpu-066532	Mustela putorius furo	82.67	0.00e+00	2427.00
IUUC-Mlu-066982	Myotis lucifugus	78.01	0.00e+00	2138.00
IUUC-Nle-070042	Nomascus leucogenys	97.75	0.00e+00	2166.00
IUUC-Opr-070397	Ochotona princeps	79.84	0.00e+00	2303.00
IUUC-Ocu-074274	Oryctolagus cuniculus	80.33	0.00e+00	2216.00
IUUC-Oga-088577	Otolemur garnettii	82.51	0.00e+00	2366.00
IUUC-Oar-090117	Ovis aries	77.37	0.00e+00	2167.00
IUUC-Ptr-090553	Pan troglodytes	98.88	0.00e+00	2830.00
IUUC-Pan-092559	Papio anubis	94.27	0.00e+00	1492.00
IUUC-Psi-093710	Pelodiscus sinensis	63.24	0.00e+00	1384.00
IUUC-Pab-098510	Pongo abelii	95.54	0.00e+00	2646.00
IUUC-Pca-100323	Procavia capensis	71.90	0.00e+00	1337.00
IUUC-Pva-102895	Pteropus vampyrus	81.52	0.00e+00	2320.00
IUUC-Rno-105598	Rattus norvegicus	75.81	0.00e+00	2187.00
IUUC-Sha-107013	Sarcophilus harrisii	67.22	0.00e+00	1807.00
IUUC-Smo-109134	Selaginella moellendorffii	36.95	2.00e-133	470.00
IUUC-Sar-113261	Sorex araneus	74.98	0.00e+00	2073.00
IUUC-Ssc-115317	Sus scrofa	80.88	0.00e+00	2233.00
IUUC-Tsy-118799	Tarsius syrichta	92.34	0.00e+00	869.00
IUUC-Tme-127128	Tuber melanosporum	23.53	7.00e-32	133.00
IUUC-Tbe-127555	Tupaia belangeri	93.42	0.00e+00	1017.00
IUUC-Ttr-128722	Tursiops truncatus	80.03	0.00e+00	2271.00
IUUC-Vda-129957	Verticillium dahliae	22.91	2.00e-29	125.00
IUUC-Vpa-130392	Vicugna pacos	69.09	1.00e-108	387.00
IUUC-Xtr-131789	Xenopus tropicalis	59.88	0.00e+00	994.00
IUUC-Yli-134437	Yarrowia lipolytica	25.68	2.00e-16	81.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence