iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046089

UUCD1 version

UUC-HoS-00304

Ensembl Protein ID

ENSP00000292782.4

UniProt Accession

Q96GG9; B2RB37; Q7L3G9; Q8TEX7; Q9H6M1; Q9HCT3; DCNL1_HUMAN

Genbank Protein ID

AAG00606.2; AAL78672.1; AAL78673.1; BAB15235.1; BAG51680.1; BAG37084.1; EAW78342.1; AAH09478.1; AAH13163.2

Protein Name

DCN1-like protein 1; DCUN1 domain-containing protein 1; Defective in cullin neddylation protein 1-like protein 1; Squamous cell carcinoma-related oncogene

Genbank Nucleotide ID

AF292100; AF456425; AF456426; AK025764; AK056335; AK314480; CH471052; BC009478; BC013163

Gene Name

DCUN1D1; DCUN1L1; RP42; SCCRO

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000043093.13	ENST00000292782.8	ENSP00000292782.4
ENSG00000043093.13	ENST00000492563.1	ENSP00000418935.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/DCUN1	DCUN1	19617556
UBD/Alpha-Helix/UBA	UBA	21813641

Classification

Family	E-value	Score	Start	End
E3 activity/DCUN1	3.50e-91	306.1	61	247
UBD/Alpha-Helix/UBA	1.10e-06	30.2	7	45

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/DCUN1

   S: 2    skkkleelferYkdpqed.ligieglekfcedlgvdpediavLvlawkleaatlcefsreefldgltalgcdsieklqeklktleselkdeq 92
           ++kkle+l++rYkdpq++ +igi+g+++fc+dl++dp++i+vL++awk++aat+cefs++ef+dg+t+lgcdsiekl+++++++e+elk+  
   Q: 61   DRKKLEQLYNRYKDPQDEnKIGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQEFMDGMTELGCDSIEKLKAQIPKMEQELKEPG 152
           78**************999************************************************************************* PP
   S: 93   kfkdiYrfafnfakdkgqksldldtaialwkLllaerefklldawlkfLeeekkksiskDtWnllLefskviakdlsnYdeegaWPvliDef 184
           +fkd+Y+f+fnfak++gqk+ldl++aia+w+L+l++r fk+ld+w+kfL e++k+si+kDtWnllL+fs++ia+d+snYdeegaWPvliD+f
   Q: 153  RFKDFYQFTFNFAKNPGQKGLDLEMAIAYWNLVLNGR-FKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIADDMSNYDEEGAWPVLIDDF 243
           ************************************9.****************************************************** PP
   S: 185  veyl 188
           ve++
   Q: 244  VEFA 247
           **97 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlve.MGFdreealqaLraannnleaAveyLl 39
           +++dk++q++  +  ++++a+ +L ++++ l++A+++++
   Q: 7    SQKDKVRQFMIfTQSSEKTAVSCLSQNDWKLDVATDNFF 45
           699********9999999*******************99 PP

Organism

Homo sapiens

Functional Description
(View)

Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates (PubMed:25349211). Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).

Protein Sequence
(Fasta)

MNKLKSSQKD KVRQFMIFTQ SSEKTAVSCL SQNDWKLDVA TDNFFQNPEL YIRESVKGSL 60
DRKKLEQLYN RYKDPQDENK IGIDGIQQFC DDLALDPASI SVLIIAWKFR AATQCEFSKQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGGTCTTG GACAGTTTCT CATTGCTGGG TCTCCACTCC TAGCTGTTAC TGCAAGTCCA 60
TGCCTCTACC ATGAGGGTGG AGGAGTTAAG ATCAACAGAT CCACATGTAC CTTGAGGTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom
IPR009060--UBA-like

PROSITE

PS51229--DCUN1

Pfam

PF03556--Cullin_binding

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation

KEGG

hsa:54165

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001879	Ailuropoda melanoleuca	99.61	9.00e-153	532.00
IUUC-Apl-003451	Anas platyrhynchos	97.70	4.00e-150	523.00
IUUC-Aca-005269	Anolis carolinensis	96.14	3.00e-149	521.00
IUUC-Ago-007806	Ashbya gossypii	23.74	5.00e-20	91.30
IUUC-Acl-008172	Aspergillus clavatus	27.04	3.00e-23	102.00
IUUC-Afl-008569	Aspergillus flavus	28.96	3.00e-29	122.00
IUUC-Ani-009241	Aspergillus nidulans	26.60	4.00e-25	108.00
IUUC-Ang-009664	Aspergillus niger	28.40	6.00e-24	104.00
IUUC-Ate-010414	Aspergillus terreus	30.04	6.00e-31	127.00
IUUC-Ame-011763	Astyanax mexicanus	88.80	3.00e-137	480.00
IUUC-Bgr-011991	Blumeria graminis	32.23	1.00e-25	110.00
IUUC-Bta-013561	Bos taurus	99.59	9.00e-145	505.00
IUUC-Cel-018441	Caenorhabditis elegans	36.73	1.00e-51	196.00
IUUC-Cja-019502	Callithrix jacchus	99.61	1.00e-152	531.00
IUUC-Cfa-020523	Canis familiaris	100.00	3.00e-145	507.00
IUUC-Cpo-022196	Cavia porcellus	98.84	1.00e-151	528.00
IUUC-Cre-022620	Chlamydomonas reinhardtii	36.36	2.00e-50	192.00
IUUC-Csa-023551	Chlorocebus sabaeus	100.00	7.00e-154	536.00
IUUC-Cho-024373	Choloepus hoffmanni	98.06	6.00e-146	509.00
IUUC-Cin-025269	Ciona intestinalis	61.24	9.00e-100	356.00
IUUC-Cne-026950	Cryptococcus neoformans	31.23	5.00e-30	124.00
IUUC-Dre-028247	Danio rerio	88.80	2.00e-137	481.00
IUUC-Dno-028974	Dasypus novemcinctus	100.00	7.00e-154	536.00
IUUC-Dor-030696	Dipodomys ordii	89.15	2.00e-132	464.00
IUUC-Dme-032197	Drosophila melanogaster	63.45	2.00e-92	332.00
IUUC-Ete-032371	Echinops telfairi	99.61	8.00e-153	532.00
IUUC-Eca-033242	Equus caballus	100.00	3.00e-153	533.00
IUUC-Eeu-035317	Erinaceus europaeus	99.61	7.00e-153	532.00
IUUC-Fca-036061	Felis catus	99.61	2.00e-153	534.00
IUUC-Fal-037372	Ficedula albicollis	97.70	4.00e-150	523.00
IUUC-Fox-037884	Fusarium oxysporum	31.54	5.00e-18	84.00
IUUC-Gmo-038885	Gadus morhua	88.42	4.00e-137	480.00
IUUC-Gga-040935	Gallus gallus	98.84	1.00e-152	531.00
IUUC-Gac-041937	Gasterosteus aculeatus	88.03	9.00e-136	475.00
IUUC-Gma-043545	Glycine max	42.91	2.00e-58	219.00
IUUC-Ggo-044468	Gorilla gorilla	98.85	7.00e-151	525.00
IUUC-Lch-050600	Latimeria chalumnae	94.98	3.00e-148	517.00
IUUC-Lpe-051540	Leersia perrieri	44.31	1.00e-61	229.00
IUUC-Loc-052509	Lepisosteus oculatus	94.59	1.00e-145	508.00
IUUC-Laf-053527	Loxodonta africana	99.22	1.00e-152	531.00
IUUC-Mcc-055699	Macaca mulatta	89.93	2.00e-147	514.00
IUUC-Meu-056626	Macropus eugenii	78.29	3.00e-112	397.00
IUUC-Mor-056909	Magnaporthe oryzae	28.72	4.00e-25	108.00
IUUC-Mtr-057964	Medicago truncatula	42.11	6.00e-58	217.00
IUUC-Mla-058990	Melampsora laricipopulina	28.62	9.00e-19	87.80
IUUC-Mga-059379	Meleagris gallopavo	98.71	3.00e-136	477.00
IUUC-Mvi-060312	Microbotryum violaceum	34.09	2.00e-42	166.00
IUUC-Mmr-060851	Microcebus murinus	100.00	7.00e-153	532.00
IUUC-Mdo-063074	Monodelphis domestica	99.61	2.00e-155	543.00
IUUC-Mmu-063954	Mus musculus	99.23	6.00e-153	533.00
IUUC-Mpu-066870	Mustela putorius furo	100.00	3.00e-145	507.00
IUUC-Mlu-067701	Myotis lucifugus	99.61	3.00e-152	530.00
IUUC-Ncr-068780	Neurospora crassa	25.45	1.00e-23	103.00
IUUC-Nle-069291	Nomascus leucogenys	100.00	7.00e-154	536.00
IUUC-Opr-070265	Ochotona princeps	72.87	9.00e-96	342.00
IUUC-Ont-071408	Oreochromis niloticus	88.76	2.00e-135	474.00
IUUC-Oan-073031	Ornithorhynchus anatinus	99.61	1.00e-152	532.00
IUUC-Ocu-074648	Oryctolagus cuniculus	100.00	3.00e-153	533.00
IUUC-Opu-083351	Oryza punctata	43.97	2.00e-57	215.00
IUUC-Ola-086371	Oryzias latipes	84.11	4.00e-134	470.00
IUUC-Olu-087646	Ostreococcus lucimarinus	36.44	2.00e-44	172.00
IUUC-Oga-089015	Otolemur garnettii	99.61	1.00e-152	531.00
IUUC-Oar-090405	Ovis aries	99.61	1.00e-152	531.00
IUUC-Ptr-090735	Pan troglodytes	100.00	3.00e-153	533.00
IUUC-Pan-092186	Papio anubis	99.23	2.00e-150	524.00
IUUC-Psi-093110	Pelodiscus sinensis	99.18	1.00e-143	501.00
IUUC-Pfo-096813	Poecilia formosa	83.78	3.00e-132	464.00
IUUC-Pca-100218	Procavia capensis	96.12	1.00e-149	522.00
IUUC-Ppe-102032	Prunus persica	44.18	2.00e-61	228.00
IUUC-Pva-102983	Pteropus vampyrus	94.19	4.00e-139	486.00
IUUC-Pgr-103633	Puccinia graminis	27.53	1.00e-24	107.00
IUUC-Pyt-104428	Pyrenophora triticirepentis	31.02	1.00e-29	122.00
IUUC-Rno-105554	Rattus norvegicus	98.46	8.00e-153	532.00
IUUC-Sce-106358	Saccharomyces cerevisiae	25.37	5.00e-20	91.30
IUUC-Sha-106888	Sarcophilus harrisii	99.61	5.00e-153	533.00
IUUC-Spo-108207	Schizosaccharomyces pombe	32.46	9.00e-25	107.00
IUUC-Ssl-108410	Sclerotinia sclerotiorum	33.33	1.00e-32	132.00
IUUC-Smo-108750	Selaginella moellendorffii	42.51	1.00e-50	192.00
IUUC-Sly-111489	Solanum lycopersicum	44.72	3.00e-60	224.00
IUUC-Stu-112517	Solanum tuberosum	43.95	5.00e-60	224.00
IUUC-Sar-113509	Sorex araneus	75.58	1.00e-106	379.00
IUUC-Sre-115221	Sporisorium reilianum	27.74	2.00e-25	110.00
IUUC-Ssc-115547	Sus scrofa	100.00	7.00e-154	536.00
IUUC-Tgu-117147	Taeniopygia guttata	98.84	7.00e-152	529.00
IUUC-Tru-117740	Takifugu rubripes	86.05	3.00e-133	467.00
IUUC-Tsy-119599	Tarsius syrichta	99.61	1.00e-152	531.00
IUUC-Tca-121033	Theobroma cacao	44.13	2.00e-59	222.00
IUUC-Tme-126878	Tuber melanosporum	33.60	5.00e-39	155.00
IUUC-Ttr-129086	Tursiops truncatus	89.15	2.00e-132	464.00
IUUC-Uma-129364	Ustilago maydis	29.70	4.00e-34	138.00
IUUC-Vpa-130048	Vicugna pacos	86.82	7.00e-128	449.00
IUUC-Xtr-131888	Xenopus tropicalis	98.45	2.00e-151	527.00
IUUC-Xma-133580	Xiphophorus maculatus	84.17	1.00e-134	471.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence