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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105573
UUCD1 version UUC-RaN-01093
Ensembl Protein ID ENSRNOP00000010935.4
UniProt Accession Q569C3; UBP1_RAT
Genbank Protein ID AAH92574.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 1; Deubiquitinating enzyme 1; Ubiquitin thioesterase 1; Ubiquitin-specific-processing protease 1
Genbank Nucleotide ID BC092574
Gene Name Usp1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000007890.6 ENSRNOT00000010933.6 ENSRNOP00000010935.4
ENSRNOG00000007890.6 ENSRNOT00000084640.1 ENSRNOP00000069155.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IID
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.00e-88 298.2 81 783
Active Site
Position(s) Description Evidence
90 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
593 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle......kkkeklneenpkepkg..........ellkslqklfeel.......w..... 61
           +Gl+NlgNtCY+NS+LQ+L+++p ++  +++      +kke+l++++ +++kg          el++slq+l+ ++       +     
   Q: 81   VGLNNLGNTCYLNSILQVLYFCPGFKAGVKHlfniisRKKEALKDDSIQKDKGsckedplasyELICSLQSLIISVeqlqasfLlnpek 169
           6******************************999*999999999998888888999999999999999999999995555555144555 PP
   S: 62   kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde..................... 129
           ++++ a++pr+ll++l++++++++gy q+DaqE+l+++l +++e+++  k++++++++e ++ + +++                     
   Q: 170  YTDELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEIKNLTEFSS-KVEEKslqkeetggisstetdstrnl 257
           88888*****************************************5533333333322221.11111345568899999999999*** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 258  ddlkeqlpkgnwkrksdgesgnmkkkvklsresqpleenqrqtrskrkatgdtleaspkiipkcvsenesakpsqkkskvkinwlkpat 346
           ***************************************************************************************** PP
   S: 130  ...................................................................aeekkkkknk.....slisdlF 146
                                                                               ++            +l+++lF
   Q: 347  kqpsilskfcslgkittnqrskgqpkvnegdleedlekdgrdntvngsgpaspgssvtpvdsseaksINKG-----AeqigfELVEKLF 430
           ***********************************************************988544333333.....246666******* PP
   S: 147  qgqlksqikclecdnvssreepfldlslpvpgkeetkke..............slqdcLesftkeeelegenkyycekckkkqeaekkl 221
           qgql  +++clec++ ++r+e+f+d+s+pv+++e +k e              +l++++++f++ e++ ge+ky+ce+c++++eae++l
   Q: 431  QGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEesseispepktemkTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSL 519
           **********************************99998************************************************** PP
   S: 222  klkklPevLilhLkRf.....sfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvkn... 301
            ++k+Pev+++hLk+f     +f+++++  +kin+ + +pl+L+l+++ t+p+     +++Y L+avv+HsG ++ssGHY+a vk    
   Q: 520  LFDKMPEVITIHLKCFaasglEFDCYGGGLSKINTPLLTPLKLSLEEWSTKPT-----NDSYGLFAVVMHSGiTISSGHYTASVKVtdl 603
           ***************************************************99.....678**************************** PP
   S: 302  ......................................................................................... 301
                                                                                                    
   Q: 604  nsleldkgnfvvdqmceigkpeplneeeargtaenyddevsirvggnaqpskvlnkknvegigllggqkskadyelcskasnpekvvgt 692
           ***************************************************************************************** PP
   S: 302  .................................................ekgkWllfdDskVtevkeeevleetg......staYvlfY 335
                                                             +gkWllfdDs+V++++e+++l++ +      st+Y+lfY
   Q: 693  pftdsrnsetndtngtqesdrskessdqtginvsglenkisyvvqslkeYEGKWLLFDDSEVKVTEEKDFLNSLSpstsptSTPYLLFY 781
           *************9999999999999999999999988888888877766999*******************888************** PP
   S: 336  kr 337
           k+
   Q: 782  KK 783
           97 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.
 Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.
Protein Sequence
(Fasta)
MPGVIPSESN GLSRGSPSKK NRLSLKFFQK KETKRALDFT DSQEDEEKAS EYRGSEIDQV 60
VPAAQSSPVS CEKRENLLPF VGLNNLGNTC YLNSILQVLY FCPGFKAGVK HLFNIISRKK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105573|DUB,USP|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGCACTTTC CGTGGACGCC ACCTCCAGCC GCGACGCTGG CGCGGGCGGG GGTTCACTCG 60
CGGGGGTCCT GAGACTGAGG AAAACGCGCC AAGTTCCCCT CGGCAGCTGA GCGGGGACCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105573|DUB,USP|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0068--Autocatalytic cleavage
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR033815--USP1
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006281--P:DNA repair
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0016579--P:protein deubiquitination
GO:0006282--P:regulation of DNA repair
GO:0009411--P:response to UV
GO:0001501--P:skeletal system development
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG rno:313387
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001939 Ailuropoda melanoleuca 88.17 0.00e+00 1329.00
IUUC-Apl-004204 Anas platyrhynchos 72.60 0.00e+00 935.00
IUUC-Aca-004637 Anolis carolinensis 65.74 0.00e+00 919.00
IUUC-Ame-011718 Astyanax mexicanus 48.74 2.00e-169 589.00
IUUC-Bta-012552 Bos taurus 86.11 0.00e+00 1316.00
IUUC-Cja-019588 Callithrix jacchus 88.03 0.00e+00 1360.00
IUUC-Cfa-020211 Canis familiaris 89.17 0.00e+00 1353.00
IUUC-Cpo-021551 Cavia porcellus 80.48 0.00e+00 1221.00
IUUC-Csa-024186 Chlorocebus sabaeus 88.66 0.00e+00 1375.00
IUUC-Cho-024739 Choloepus hoffmanni 75.86 0.00e+00 675.00
IUUC-Dre-028184 Danio rerio 48.90 3.00e-171 595.00
IUUC-Dno-029669 Dasypus novemcinctus 84.50 0.00e+00 1304.00
IUUC-Dor-030168 Dipodomys ordii 82.21 0.00e+00 1196.00
IUUC-Dme-031732 Drosophila melanogaster 28.77 4.00e-18 87.00
IUUC-Ete-032825 Echinops telfairi 81.42 0.00e+00 882.00
IUUC-Eca-033595 Equus caballus 86.26 0.00e+00 1234.00
IUUC-Eeu-034877 Erinaceus europaeus 74.09 6.00e-146 511.00
IUUC-Fca-035381 Felis catus 86.88 0.00e+00 935.00
IUUC-Fal-037592 Ficedula albicollis 69.47 0.00e+00 974.00
IUUC-Gmo-039680 Gadus morhua 44.74 4.00e-150 525.00
IUUC-Gga-041196 Gallus gallus 72.56 0.00e+00 1066.00
IUUC-Gac-042292 Gasterosteus aculeatus 50.08 6.00e-142 498.00
IUUC-Ggo-044671 Gorilla gorilla 88.66 0.00e+00 1370.00
IUUC-Hsa-047020 Homo sapiens 88.66 0.00e+00 1371.00
IUUC-Itr-048800 Ictidomys tridecemlineatus 80.41 0.00e+00 1190.00
IUUC-Lch-050543 Latimeria chalumnae 56.90 0.00e+00 692.00
IUUC-Loc-052338 Lepisosteus oculatus 52.89 0.00e+00 698.00
IUUC-Laf-053707 Loxodonta africana 85.55 0.00e+00 1317.00
IUUC-Mcc-055885 Macaca mulatta 88.66 0.00e+00 1379.00
IUUC-Meu-056573 Macropus eugenii 68.35 0.00e+00 970.00
IUUC-Mga-059346 Meleagris gallopavo 72.33 0.00e+00 1011.00
IUUC-Mmr-061612 Microcebus murinus 87.77 0.00e+00 1306.00
IUUC-Mdo-062887 Monodelphis domestica 73.20 0.00e+00 1053.00
IUUC-Mmu-064044 Mus musculus 93.76 0.00e+00 1460.00
IUUC-Mpu-066847 Mustela putorius furo 88.41 0.00e+00 1338.00
IUUC-Mlu-067684 Myotis lucifugus 86.26 0.00e+00 1333.00
IUUC-Nle-070057 Nomascus leucogenys 88.54 0.00e+00 1371.00
IUUC-Opr-070463 Ochotona princeps 79.82 0.00e+00 1186.00
IUUC-Ont-071975 Oreochromis niloticus 51.02 1.00e-141 497.00
IUUC-Oan-073062 Ornithorhynchus anatinus 86.73 3.00e-47 180.00
IUUC-Ocu-074840 Oryctolagus cuniculus 87.77 0.00e+00 1334.00
IUUC-Ola-087088 Oryzias latipes 46.82 4.00e-172 598.00
IUUC-Oga-088472 Otolemur garnettii 87.52 0.00e+00 1332.00
IUUC-Oar-089498 Ovis aries 86.11 0.00e+00 1315.00
IUUC-Ptr-091395 Pan troglodytes 88.54 0.00e+00 1368.00
IUUC-Pan-092462 Papio anubis 88.79 0.00e+00 1379.00
IUUC-Psi-093583 Pelodiscus sinensis 71.28 0.00e+00 886.00
IUUC-Pma-094644 Petromyzon marinus 36.36 3.00e-28 118.00
IUUC-Pfo-096314 Poecilia formosa 46.75 6.00e-167 581.00
IUUC-Pab-098568 Pongo abelii 88.79 0.00e+00 1377.00
IUUC-Pca-100948 Procavia capensis 77.10 0.00e+00 1165.00
IUUC-Pva-102853 Pteropus vampyrus 86.86 0.00e+00 1325.00
IUUC-Sha-107495 Sarcophilus harrisii 72.60 0.00e+00 909.00
IUUC-Sar-113545 Sorex araneus 72.70 0.00e+00 1028.00
IUUC-Ssc-115962 Sus scrofa 86.82 0.00e+00 1333.00
IUUC-Tgu-116731 Taeniopygia guttata 70.42 0.00e+00 991.00
IUUC-Tru-117893 Takifugu rubripes 46.54 7.00e-158 551.00
IUUC-Tsy-119644 Tarsius syrichta 78.93 0.00e+00 1161.00
IUUC-Tni-119819 Tetraodon nigroviridis 45.33 4.00e-169 588.00
IUUC-Tbe-127272 Tupaia belangeri 82.17 0.00e+00 1156.00
IUUC-Ttr-128404 Tursiops truncatus 87.76 0.00e+00 1343.00
IUUC-Vpa-130205 Vicugna pacos 86.13 0.00e+00 1318.00
IUUC-Xtr-132613 Xenopus tropicalis 55.11 0.00e+00 736.00
Created Date 25-Jun-2017

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