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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064042
UUCD1 version UUC-MuM-00903
Ensembl Protein ID ENSMUSP00000092429.3
UniProt Accession Q8BXX2; Q8CID4; Q8K2Z6; ZBT49_MOUSE
Genbank Protein ID BAC31447.1; BAE24420.1; AAH28988.1; AAH29122.1
Protein Name Zinc finger and BTB domain-containing protein 49; Zinc finger protein 509
Genbank Nucleotide ID AK043044; AK140546; BC028988; BC029122
Gene Name Zbtb49; Zfp509; Znf509
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029127.15 ENSMUST00000094833.9 ENSMUSP00000092429.3
ENSMUSG00000029127.15 ENSMUST00000126267.7 ENSMUSP00000122109.1
ENSMUSG00000029127.15 ENSMUST00000143436.7 ENSMUSP00000115513.1
ENSMUSG00000029127.15 ENSMUST00000136475.7 ENSMUSP00000117174.1
ENSMUSG00000029127.15 ENSMUST00000138820.7 ENSMUSP00000117913.1
ENSMUSG00000029127.15 ENSMUST00000146859.1 ENSMUSP00000114955.1
ENSMUSG00000029127.15 ENSMUST00000129161.7 ENSMUSP00000143893.1
ENSMUSG00000029127.15 ENSMUST00000114113.2 ENSMUSP00000109748.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 6.50e-13 50.0 25 90
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +D++lvv g+ f+ahk vLaa S++F++lf++  +++  ++  +++    +   ++l+F+Yt++ld+n
   Q: 25   CDCMLVVRGVCFKAHKNVLAAFSQYFRSLFQNSSSQK--NDVFHLDVTNVSGIGQILDFMYTSRLDLN 90
           8*****************************8876665..56777776899****************98 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription.
 Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription.
Protein Sequence
(Fasta)
MDPVAVHSCH LLQQLREQRI QGLLCDCMLV VRGVCFKAHK NVLAAFSQYF RSLFQNSSSQ 60
KNDVFHLDVT NVSGIGQILD FMYTSRLDLN QDNIQVMLDT AQCLQVQNVL NLCHTFLKSA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064042|E3,BTB_Other|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCGGAAGTT GCCGATGAGC TGCCGAGGGG GCGTTGTCGG AATGGTTCCG AGGCGGTTGG 60
AGTCCTGCAG TTGACACCGA GAGTGCGACG AGAAAGGGTG TCAGGGAGGC GGCCGGGCGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064042|E3,BTB_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR023413--GFP-like
IPR000877--Prot_inh_BBI
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0015630--C:microtubule cytoskeleton
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0001223--F:transcription coactivator binding
GO:0008134--F:transcription factor binding
GO:0007050--P:cell cycle arrest
GO:0008285--P:negative regulation of cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
KEGG mmu:75079
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002380 Ailuropoda melanoleuca 70.14 0.00e+00 1003.00
IUUC-Apl-003402 Anas platyrhynchos 62.60 0.00e+00 961.00
IUUC-Aca-005251 Anolis carolinensis 53.23 0.00e+00 756.00
IUUC-Ame-011624 Astyanax mexicanus 47.16 1.00e-146 514.00
IUUC-Bta-013500 Bos taurus 70.73 0.00e+00 990.00
IUUC-Cja-019265 Callithrix jacchus 72.43 0.00e+00 1053.00
IUUC-Cfa-020468 Canis familiaris 69.23 0.00e+00 996.00
IUUC-Cpo-021937 Cavia porcellus 69.53 0.00e+00 943.00
IUUC-Csa-023216 Chlorocebus sabaeus 73.12 0.00e+00 1074.00
IUUC-Dre-028348 Danio rerio 59.31 2.00e-97 350.00
IUUC-Dno-029339 Dasypus novemcinctus 68.05 0.00e+00 993.00
IUUC-Dor-030277 Dipodomys ordii 75.69 5.00e-90 325.00
IUUC-Dme-032129 Drosophila melanogaster 50.63 5.00e-20 94.00
IUUC-Eca-033669 Equus caballus 70.85 0.00e+00 1040.00
IUUC-Fca-035639 Felis catus 65.29 0.00e+00 894.00
IUUC-Fal-037462 Ficedula albicollis 60.10 0.00e+00 838.00
IUUC-Gmo-039476 Gadus morhua 51.03 8.00e-139 487.00
IUUC-Gac-041549 Gasterosteus aculeatus 52.81 1.00e-160 560.00
IUUC-Ggo-044866 Gorilla gorilla 72.98 0.00e+00 1068.00
IUUC-Hsa-045928 Homo sapiens 73.46 0.00e+00 1077.00
IUUC-Itr-048707 Ictidomys tridecemlineatus 72.77 0.00e+00 1023.00
IUUC-Lch-050388 Latimeria chalumnae 52.87 0.00e+00 781.00
IUUC-Loc-052002 Lepisosteus oculatus 51.10 0.00e+00 674.00
IUUC-Laf-054184 Loxodonta africana 68.45 0.00e+00 980.00
IUUC-Mcc-055715 Macaca mulatta 72.73 0.00e+00 1070.00
IUUC-Mga-059724 Meleagris gallopavo 62.34 0.00e+00 953.00
IUUC-Mdo-062942 Monodelphis domestica 63.71 0.00e+00 920.00
IUUC-Mpu-066682 Mustela putorius furo 61.19 1.00e-135 476.00
IUUC-Mlu-068067 Myotis lucifugus 67.49 0.00e+00 990.00
IUUC-Nle-070108 Nomascus leucogenys 73.37 0.00e+00 1074.00
IUUC-Opr-070475 Ochotona princeps 63.33 0.00e+00 836.00
IUUC-Ont-072124 Oreochromis niloticus 51.69 2.00e-155 543.00
IUUC-Oan-073392 Ornithorhynchus anatinus 57.47 3.00e-64 238.00
IUUC-Ocu-074120 Oryctolagus cuniculus 69.11 0.00e+00 954.00
IUUC-Ola-087133 Oryzias latipes 44.65 2.00e-159 556.00
IUUC-Oga-088105 Otolemur garnettii 71.67 0.00e+00 1058.00
IUUC-Oar-089685 Ovis aries 60.51 8.00e-180 623.00
IUUC-Ptr-090971 Pan troglodytes 73.59 0.00e+00 1079.00
IUUC-Pan-092567 Papio anubis 72.41 0.00e+00 1056.00
IUUC-Psi-093775 Pelodiscus sinensis 62.34 0.00e+00 925.00
IUUC-Pma-094193 Petromyzon marinus 49.17 4.00e-46 178.00
IUUC-Pfo-096353 Poecilia formosa 44.65 1.00e-158 553.00
IUUC-Pab-097617 Pongo abelii 73.53 0.00e+00 1078.00
IUUC-Pva-102633 Pteropus vampyrus 68.89 0.00e+00 982.00
IUUC-Rno-105385 Rattus norvegicus 89.84 0.00e+00 1349.00
IUUC-Sha-107166 Sarcophilus harrisii 60.36 0.00e+00 813.00
IUUC-Sar-113012 Sorex araneus 64.27 0.00e+00 642.00
IUUC-Ssc-116285 Sus scrofa 68.39 0.00e+00 972.00
IUUC-Tgu-117060 Taeniopygia guttata 61.77 0.00e+00 894.00
IUUC-Tru-118102 Takifugu rubripes 50.77 3.00e-153 535.00
IUUC-Tni-120402 Tetraodon nigroviridis 51.80 8.00e-155 540.00
IUUC-Tbe-127463 Tupaia belangeri 63.25 5.00e-136 477.00
IUUC-Ttr-128785 Tursiops truncatus 71.19 0.00e+00 1010.00
IUUC-Vpa-130467 Vicugna pacos 65.38 0.00e+00 631.00
IUUC-Xtr-131986 Xenopus tropicalis 51.64 2.00e-138 486.00
Created Date 25-Jun-2017

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