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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063594
Ensembl Protein ID ENSMUSP00000103815.2
UniProt Accession P97303; A2ANU8; A2ANU9; A2RRI0; BACH2_MOUSE
Genbank Protein ID BAA13138.1; CAM26623.1; AAI31643.1
Protein Name Transcription regulator protein BACH2; BTB and CNC homolog 2
Genbank Nucleotide ID D86604; AL732547; BC131642
Gene Name Bach2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000040270.16 ENSMUST00000108180.8 ENSMUSP00000103815.2
ENSMUSG00000040270.16 ENSMUST00000037416.12 ENSMUSP00000043693.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 8.70e-12 46.4 37 100
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgkld 66
           +Dv+l+v+++ef+ah++vLaa+S++F   + ++ ++    l v + + v +  f  ll+F Yt kl 
   Q: 37   CDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKD---DLVVSLPEeVTARGFGPLLQFAYTAKLL 100
           9*****************************888777...489****66****************985 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Transcriptional regulator that acts as repressor or activator (PubMed:8887638). Binds to Maf recognition elements (MARE) (PubMed:8887638). Plays an important role in coordinating transcription activation and repression by MAFK (PubMed:8887638). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (By similarity). Positively regulates the nuclear import of actin (PubMed:26021350).
 Transcriptional regulator that acts as repressor or activator (PubMed:8887638). Binds to Maf recognition elements (MARE) (PubMed:8887638). Plays an important role in coordinating transcription activation and repression by MAFK (PubMed:8887638). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (By similarity). Positively regulates the nuclear import of actin (PubMed:26021350).
Protein Sequence
(Fasta)
MSVDEKPGSP MYVYESTVHC ANILLGLNDQ RKKDILCDVT LIVERKEFRA HRAVLAACSE 60
YFWQALVGQT KDDLVVSLPE EVTARGFGPL LQFAYTAKLL LSRENIREVI RCAEFLRMHN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063594|E3,BTB_Other|Mus musculus
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Nucleotide Sequence
(Fasta)
CGGCCGCGCA CCGGGCTGCG GTCGCCCCTG CGCCCCGCTT CGCCCGCCGC CCCTCCCTCG 60
CGGCCCGCGT CCCCCCTCTC CCCCGTCGCC CCCGCCGCGC GCGCCGCTCC CCTCCCCCTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063594|E3,BTB_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1015--Disulfide bond
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR000210--BTB/POZ_dom
IPR004827--bZIP
IPR004826--bZIP_Maf
IPR011333--SKP1/BTB/POZ
IPR008917--TF_DNA-bd
PROSITE

PS50097--BTB
PS50217--BZIP
PS00036--BZIP_BASIC
Pfam

PF00651--BTB
PF03131--bZIP_Maf
SMART

SM00338--BRLZ
SM00225--BTB
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001206--F:transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination
GO:0006355--P:regulation of transcription, DNA-templated
GO:1902593--P:single-organism nuclear import
GO:0006351--P:transcription, DNA-templated
KEGG mmu:12014
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001451 Ailuropoda melanoleuca 88.10 0.00e+00 1358.00
IUUC-Apl-003617 Anas platyrhynchos 70.50 0.00e+00 1075.00
IUUC-Aca-004829 Anolis carolinensis 73.43 0.00e+00 1120.00
IUUC-Ame-011958 Astyanax mexicanus 51.05 4.00e-176 611.00
IUUC-Bta-013001 Bos taurus 87.41 0.00e+00 1373.00
IUUC-Cja-019232 Callithrix jacchus 89.22 0.00e+00 1365.00
IUUC-Cfa-020872 Canis familiaris 86.59 0.00e+00 1344.00
IUUC-Cpo-022203 Cavia porcellus 82.46 2.00e-175 609.00
IUUC-Csa-023057 Chlorocebus sabaeus 89.07 0.00e+00 1391.00
IUUC-Cho-025090 Choloepus hoffmanni 85.71 0.00e+00 646.00
IUUC-Csv-026178 Ciona savignyi 41.67 1.00e-25 111.00
IUUC-Dre-028449 Danio rerio 56.92 0.00e+00 749.00
IUUC-Dno-029780 Dasypus novemcinctus 89.54 0.00e+00 1372.00
IUUC-Dor-030786 Dipodomys ordii 86.56 0.00e+00 1334.00
IUUC-Eca-033802 Equus caballus 89.30 0.00e+00 1398.00
IUUC-Eeu-035187 Erinaceus europaeus 83.84 0.00e+00 1341.00
IUUC-Fca-036490 Felis catus 79.50 0.00e+00 1227.00
IUUC-Fal-037655 Ficedula albicollis 76.31 0.00e+00 1211.00
IUUC-Gga-041057 Gallus gallus 76.31 0.00e+00 1220.00
IUUC-Gac-041702 Gasterosteus aculeatus 56.80 0.00e+00 743.00
IUUC-Ggo-044982 Gorilla gorilla 89.30 0.00e+00 1377.00
IUUC-Hsa-045852 Homo sapiens 89.42 0.00e+00 1378.00
IUUC-Itr-048706 Ictidomys tridecemlineatus 91.00 0.00e+00 1391.00
IUUC-Lch-049448 Latimeria chalumnae 67.14 0.00e+00 1006.00
IUUC-Loc-052840 Lepisosteus oculatus 59.37 0.00e+00 829.00
IUUC-Laf-054135 Loxodonta africana 84.95 0.00e+00 1307.00
IUUC-Mcc-055251 Macaca mulatta 89.31 0.00e+00 1373.00
IUUC-Meu-056518 Macropus eugenii 71.01 0.00e+00 1063.00
IUUC-Mga-060073 Meleagris gallopavo 76.19 0.00e+00 1216.00
IUUC-Mmr-061770 Microcebus murinus 88.82 0.00e+00 1343.00
IUUC-Mdo-062541 Monodelphis domestica 78.19 0.00e+00 1254.00
IUUC-Mpu-066651 Mustela putorius furo 87.62 0.00e+00 1321.00
IUUC-Mlu-067438 Myotis lucifugus 76.88 0.00e+00 1137.00
IUUC-Nle-069208 Nomascus leucogenys 89.05 0.00e+00 1394.00
IUUC-Ont-072358 Oreochromis niloticus 55.91 0.00e+00 742.00
IUUC-Ola-087475 Oryzias latipes 56.69 0.00e+00 755.00
IUUC-Oga-088512 Otolemur garnettii 84.64 0.00e+00 1248.00
IUUC-Oar-090318 Ovis aries 87.07 0.00e+00 1373.00
IUUC-Ptr-091546 Pan troglodytes 86.07 0.00e+00 1303.00
IUUC-Pan-092159 Papio anubis 89.19 0.00e+00 1371.00
IUUC-Psi-093436 Pelodiscus sinensis 76.43 0.00e+00 1221.00
IUUC-Pfo-097497 Poecilia formosa 56.34 0.00e+00 708.00
IUUC-Pab-097676 Pongo abelii 90.13 0.00e+00 1404.00
IUUC-Pca-100624 Procavia capensis 88.21 4.00e-120 426.00
IUUC-Pva-102757 Pteropus vampyrus 83.87 0.00e+00 1322.00
IUUC-Rno-105060 Rattus norvegicus 97.26 0.00e+00 1533.00
IUUC-Sha-107171 Sarcophilus harrisii 78.21 0.00e+00 1192.00
IUUC-Ssc-116190 Sus scrofa 88.63 0.00e+00 1147.00
IUUC-Tgu-116828 Taeniopygia guttata 76.43 0.00e+00 1214.00
IUUC-Tsy-119088 Tarsius syrichta 83.43 0.00e+00 750.00
IUUC-Tbe-127807 Tupaia belangeri 87.67 0.00e+00 1112.00
IUUC-Ttr-128874 Tursiops truncatus 86.09 0.00e+00 1357.00
Created Date 25-Jun-2017

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