iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.70e-98	329.9	80	540

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...kkkeklneenpkepkgellkslqklfeelw...kskkkavsprellkalkkeaeefsgyeqqDa 92
           +Gl+N+ NtCYmNS+LQ+Lsn+p++++++ +     +   +++++  + g l+ks+++l++e+w   ++ k+ ++pr +l  +++++++f+gy+q+D+
   Q: 80   VGLQNIANTCYMNSALQALSNLPPMTHYFINcsdLVEYIAEQSARRCKPGGLAKSYRRLMQEIWqdvDDPKEFIAPRGILYGIRTVHPMFRGYQQHDT 177
           6******************************99856666667777999****************99999999************************** PP
   S: 93   qEflaflldqleeelkk........eknkpkeeeeeedkselsde..................................................... 129
           qEfl++++dql+eel++        +++ +++++++++ se++de                                                     
   Q: 178  QEFLRCFMDQLHEELTEqvsmlpqtQNQPQYQSLQQQQPSETDDEnddeaapaslshaseseydtcessmsersaevllkteyfvtpcrtngsnsglp 275
           ***************888888888766666667777776666666899999999******************************************** PP
   S: 130  .....................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..................... 185
                                ae+k+ +  +s+isd+F+g+l s+++cl+cd+vs+ree+f+dlslp+p+++  + +                     
   Q: 276  eghsvqlqqaplqhqqknassAEQKPIEAARSIISDVFDGKLLSSVQCLTCDRVSTREETFQDLSLPIPNRDFLNVLhqthslsvqslnaaetsartn 373
           ******************9999999999999*****************************************8877799******************* PP
   S: 186  ....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldls 262
                               +l dc++sf++++el+g+n+y+ce+c+k+++  k  ++ +lPevL++hLkRf  +++ + ++ki++ v+fple +d++
   Q: 374  egwlswmwnmlrswiygpsvTLYDCMASFFSADELKGDNMYSCERCNKLRTGIKYSRVLTLPEVLCIHLKRF--RNDLSYSSKISSDVYFPLEgFDMR 469
           ************************************************************************..78889999**************** PP
   S: 263  pfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           p+ +++++++    +Y+L++v++H+G++++GHY+++++n  +gkW++fdD+ Vtev+ e v++   ++aYvlfY++
   Q: 470  PYIHKDCKSE--VAIYNLSSVICHHGTVGGGHYTCFARNtLNGKWYEFDDQFVTEVSSELVQS---CQAYVLFYHK 540
           *****99887..9**************************55777*******************...********97 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MSLSSNPNPH NPYVEHRNRT IHSSQGHTLA NGYAMGDPRS SRCHDKLFSG SLKSLARRED 60
SNASDSEGTD TAKGSGTGLV GLQNIANTCY MNSALQALSN LPPMTHYFIN CSDLVEYIAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCCGAAATC GCAAACGCCT TTTCTGCGGT CGTTTCCAAT CAAAATTCTC AATTAAAATA 60
TAAAAAAAAA ACAAAATACT GGCAGCTAGG GAACTATAAT GAGTTTGAGT TCCAACCCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007399--P:nervous system development
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG8494

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	43.75	8.00e-136	477.00
IUUC-Apl-003351	Anas platyrhynchos	48.15	5.00e-140	491.00
IUUC-Aca-004713	Anolis carolinensis	48.28	8.00e-132	464.00
IUUC-Ame-011777	Astyanax mexicanus	49.36	6.00e-138	484.00
IUUC-Bta-013063	Bos taurus	48.93	1.00e-139	489.00
IUUC-Cja-019868	Callithrix jacchus	43.57	3.00e-139	488.00
IUUC-Cfa-020761	Canis familiaris	47.73	4.00e-138	484.00
IUUC-Cpo-022267	Cavia porcellus	46.90	2.00e-137	482.00
IUUC-Csa-024251	Chlorocebus sabaeus	43.67	1.00e-138	486.00
IUUC-Cho-024483	Choloepus hoffmanni	54.46	7.00e-70	257.00
IUUC-Dre-028639	Danio rerio	48.54	2.00e-130	459.00
IUUC-Dno-029423	Dasypus novemcinctus	46.90	4.00e-138	484.00
IUUC-Dor-030877	Dipodomys ordii	46.46	5.00e-133	468.00
IUUC-Ete-032802	Echinops telfairi	53.37	1.00e-58	220.00
IUUC-Eca-034248	Equus caballus	51.79	3.00e-28	119.00
IUUC-Eeu-035357	Erinaceus europaeus	39.58	2.00e-86	313.00
IUUC-Fca-036357	Felis catus	47.52	5.00e-139	488.00
IUUC-Fal-037411	Ficedula albicollis	48.35	3.00e-140	491.00
IUUC-Gmo-038563	Gadus morhua	48.68	2.00e-128	452.00
IUUC-Gga-041101	Gallus gallus	48.07	7.00e-139	487.00
IUUC-Gac-041315	Gasterosteus aculeatus	48.94	2.00e-136	479.00
IUUC-Ggo-045600	Gorilla gorilla	47.40	3.00e-135	475.00
IUUC-Hsa-045825	Homo sapiens	47.69	3.00e-138	484.00
IUUC-Itr-049041	Ictidomys tridecemlineatus	41.59	1.00e-157	549.00
IUUC-Lch-050400	Latimeria chalumnae	45.36	3.00e-119	421.00
IUUC-Loc-052574	Lepisosteus oculatus	49.78	6.00e-138	484.00
IUUC-Laf-054428	Loxodonta africana	43.68	2.00e-139	489.00
IUUC-Mcc-055736	Macaca mulatta	43.67	2.00e-138	486.00
IUUC-Meu-056645	Macropus eugenii	36.02	2.00e-121	429.00
IUUC-Mga-059781	Meleagris gallopavo	49.36	1.00e-138	486.00
IUUC-Mmr-061328	Microcebus murinus	46.97	2.00e-127	448.00
IUUC-Mdo-063048	Monodelphis domestica	48.35	5.00e-141	494.00
IUUC-Mmu-064079	Mus musculus	43.59	6.00e-139	487.00
IUUC-Mpu-066616	Mustela putorius furo	47.74	2.00e-138	485.00
IUUC-Mlu-067294	Myotis lucifugus	47.11	8.00e-139	487.00
IUUC-Nle-070015	Nomascus leucogenys	47.48	2.00e-137	482.00
IUUC-Opr-070328	Ochotona princeps	44.02	2.00e-139	489.00
IUUC-Ont-071464	Oreochromis niloticus	49.79	1.00e-137	483.00
IUUC-Oan-073259	Ornithorhynchus anatinus	42.04	9.00e-109	387.00
IUUC-Ocu-074630	Oryctolagus cuniculus	45.90	4.00e-131	461.00
IUUC-Ola-087240	Oryzias latipes	49.05	1.00e-135	476.00
IUUC-Olu-087697	Ostreococcus lucimarinus	32.49	3.00e-32	130.00
IUUC-Oga-088761	Otolemur garnettii	48.35	4.00e-141	494.00
IUUC-Oar-089921	Ovis aries	43.84	2.00e-130	459.00
IUUC-Ptr-091662	Pan troglodytes	47.69	4.00e-138	484.00
IUUC-Pan-092199	Papio anubis	43.52	3.00e-137	482.00
IUUC-Psi-093726	Pelodiscus sinensis	48.55	4.00e-141	494.00
IUUC-Pma-094389	Petromyzon marinus	50.89	2.00e-29	122.00
IUUC-Pfo-097415	Poecilia formosa	44.40	1.00e-124	440.00
IUUC-Pab-098632	Pongo abelii	47.48	2.00e-137	482.00
IUUC-Pca-100614	Procavia capensis	49.34	3.00e-116	412.00
IUUC-Pva-102820	Pteropus vampyrus	44.49	1.00e-109	390.00
IUUC-Rno-105215	Rattus norvegicus	43.85	8.00e-141	493.00
IUUC-Sha-106601	Sarcophilus harrisii	47.73	8.00e-139	487.00
IUUC-Sar-113665	Sorex araneus	47.80	4.00e-130	458.00
IUUC-Ssc-115533	Sus scrofa	47.74	4.00e-138	484.00
IUUC-Tgu-117364	Taeniopygia guttata	48.15	7.00e-139	487.00
IUUC-Tru-117770	Takifugu rubripes	49.24	7.00e-136	477.00
IUUC-Tsy-119598	Tarsius syrichta	40.15	5.00e-108	385.00
IUUC-Tni-120001	Tetraodon nigroviridis	49.68	7.00e-134	470.00
IUUC-Tbe-128125	Tupaia belangeri	40.12	4.00e-30	126.00
IUUC-Ttr-128732	Tursiops truncatus	47.93	1.00e-140	493.00
IUUC-Vpa-130598	Vicugna pacos	39.95	7.00e-150	524.00
IUUC-Xtr-132157	Xenopus tropicalis	48.82	5.00e-139	487.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence