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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063786
UUCD1 version UUC-MuM-01191
Ensembl Protein ID ENSMUSP00000142708.1
UniProt Accession Q8R5K2; Q3UP32; Q5FWK0; Q8K0I3; Q99K22; UBP33_MOUSE
Genbank Protein ID AAL78316.1; AAH05506.1; AAH31366.1; AAH89315.1; BAE25565.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 33; Deubiquitinating enzyme 33; Ubiquitin thioesterase 33; Ubiquitin-specific-processing protease 33; VHL-interacting deubiquitinating enzyme 1
Genbank Nucleotide ID AF383174; BC005506; BC031366; BC089315; AK143844
Gene Name Usp33; Vdu1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000025437.15 ENSMUST00000117492.8 ENSMUSP00000113265.3
ENSMUSG00000025437.15 ENSMUST00000026507.12 ENSMUSP00000026507.7
ENSMUSG00000025437.15 ENSMUST00000197748.4 ENSMUSP00000142708.1
ENSMUSG00000025437.15 ENSMUST00000123237.7 ENSMUSP00000117590.1
ENSMUSG00000025437.15 ENSMUST00000197600.1 ENSMUSP00000143062.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 3.20e-114 382.8 154 681
Active Site
Position(s) Description Evidence
163 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
640 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tGlkN+gNtCYmN++LQ+Lsn+p+l++++l+     +   +++++k +++ks+ kl++elw ks+ ++v p +l++ +k++++ f+gy+
   Q: 154  TGLKNIGNTCYMNAALQALSNCPPLTQFFLD-----CGGLARTDKKPAICKSYLKLMTELWhKSRPGSVVPANLFQGIKTVNPTFRGYS 237
           7******************************.....999999*******************99************************** PP
   S: 89   qqDaqEflaflldqleeelkk........eknkpkeeeeeedkselsde........................................ 129
           qqDaqEfl++l+d l+eelk+         ++ + ee+ ee+ks++  +                                        
   Q: 238  QQDAQEFLRCLMDLLHEELKEqvmemeeePQTLTSEETVEEEKSQS--Dvdfqscescsssekaenesgskgfpedsnettmliqdedd 324
           *******************887776654433333333333333333..256999*********************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 325  lemakdwqkekvcnkinkanadveldkdrdtvcetvdlnsqetvkvqihgrasesitdvhlndlatsqilpsnesvsprlsasppklgs 413
           ***************************************************************************************** PP
   S: 130  .................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke................ 185
                            +++k++kk++s+isd+F+g++ s+++cl+cd+vs + e+f+dlslp+pgke+ +k+                
   Q: 414  lwpglspphkkaqstsaKRKKQHKKYRSVISDIFDGTVISSVQCLTCDRVSITLETFQDLSLPIPGKEDLAKLhssshptivkagscge 502
           ****************9999************************************************99888**************** PP
   S: 186  ................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfsee 242
                                           +lqdcL++f++++el+g+n+y+cekckk+++ +k +k++k+Pe+L++hLkRf  ++e
   Q: 503  ayapqgwiaffmeyvkrfvvscvpswfwgpvvTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQKFPEILCIHLKRF--RHE 589
           ************************************************************************************..999 PP
   S: 243  qksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgst 329
            ++++ki+++v+fple Ldl+pf+++++ +q   ++Y+L++v++H+G++ssGHY+ay++n+ ++ W++fdD++Vtev+e++v++   ++
   Q: 590  LMFSTKISTHVSFPLEgLDLQPFLAKDSPAQ--IVTYDLLSVICHHGTASSGHYIAYCRNNLNNlWYEFDDQSVTEVSESTVQN---AE 673
           9*************************88777..9**************************88889*******************...** PP
   S: 330  aYvlfYkr 337
           aYvlfY++
   Q: 674  AYVLFYRK 681
           ******98 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
 Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Protein Sequence
(Fasta)
MTTFRNHCPH LDSVGEITKE DLIQKSLGAC QDCKVRGPNL WACLENRCSY VGCGESQVDH 60
STIHSQETKH YLTVNLTTLR VWCYACSKEV FLDRKLGTPP SLPHVRQPQQ TQENSVQDFK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063786|DUB,USP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACGCCCGCA GCGGCCGCGG AGACACCGGA AGGAGCGGCG GCTGCCGAGG GAAGCGTCGG 60
GCAGCGGTCG GGTTCTGCGG GCCGCGCTGC GGAACCGTTT TGCGGCCCTG CGGATCCGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063786|DUB,USP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP
SMART

SM00695--DUSP
SM00290--ZnF_UBP
Gene Ontology

GO:0005776--C:autophagosome
GO:0044297--C:cell body
GO:0005813--C:centrosome
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0004197--F:cysteine-type endopeptidase activity
GO:0001664--F:G-protein coupled receptor binding
GO:0017160--F:Ral GTPase binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0007411--P:axon guidance
GO:0016477--P:cell migration
GO:0009267--P:cellular response to starvation
GO:0051298--P:centrosome duplication
GO:0006897--P:endocytosis
GO:0032091--P:negative regulation of protein binding
GO:0032092--P:positive regulation of protein binding
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:170822
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001742 Ailuropoda melanoleuca 93.01 0.00e+00 1702.00
IUUC-Apl-003987 Anas platyrhynchos 80.50 0.00e+00 1441.00
IUUC-Aca-004713 Anolis carolinensis 75.44 0.00e+00 1382.00
IUUC-Bta-013132 Bos taurus 92.00 0.00e+00 1684.00
IUUC-Cel-018627 Caenorhabditis elegans 33.73 7.00e-38 152.00
IUUC-Cja-018811 Callithrix jacchus 92.32 0.00e+00 1703.00
IUUC-Cfa-021158 Canis familiaris 92.14 0.00e+00 1688.00
IUUC-Cpo-021910 Cavia porcellus 85.98 0.00e+00 1540.00
IUUC-Csa-023130 Chlorocebus sabaeus 92.97 0.00e+00 1714.00
IUUC-Cho-024383 Choloepus hoffmanni 71.12 1.00e-166 580.00
IUUC-Dre-028639 Danio rerio 69.60 0.00e+00 1226.00
IUUC-Dno-029416 Dasypus novemcinctus 91.01 0.00e+00 1636.00
IUUC-Ete-032994 Echinops telfairi 75.18 0.00e+00 795.00
IUUC-Eca-034248 Equus caballus 92.98 0.00e+00 1705.00
IUUC-Eeu-035357 Erinaceus europaeus 74.64 0.00e+00 1240.00
IUUC-Fca-036013 Felis catus 90.48 0.00e+00 1643.00
IUUC-Fal-037509 Ficedula albicollis 80.18 0.00e+00 1439.00
IUUC-Gmo-038944 Gadus morhua 65.81 0.00e+00 1187.00
IUUC-Gga-040647 Gallus gallus 79.08 0.00e+00 1420.00
IUUC-Gac-041752 Gasterosteus aculeatus 69.61 0.00e+00 1253.00
IUUC-Hsa-045694 Homo sapiens 92.43 0.00e+00 1702.00
IUUC-Itr-049041 Ictidomys tridecemlineatus 92.65 0.00e+00 1677.00
IUUC-Lch-050400 Latimeria chalumnae 69.79 0.00e+00 1242.00
IUUC-Loc-052616 Lepisosteus oculatus 71.54 0.00e+00 1303.00
IUUC-Laf-053493 Loxodonta africana 91.36 0.00e+00 1678.00
IUUC-Mcc-055542 Macaca mulatta 93.08 0.00e+00 1716.00
IUUC-Meu-056645 Macropus eugenii 72.92 0.00e+00 1257.00
IUUC-Mga-060019 Meleagris gallopavo 79.71 0.00e+00 1216.00
IUUC-Mmr-061241 Microcebus murinus 89.90 0.00e+00 1662.00
IUUC-Mpu-065772 Mustela putorius furo 92.78 0.00e+00 1410.00
IUUC-Mlu-067732 Myotis lucifugus 91.27 0.00e+00 1671.00
IUUC-Nle-069528 Nomascus leucogenys 91.77 0.00e+00 1704.00
IUUC-Opr-070606 Ochotona princeps 87.27 0.00e+00 1532.00
IUUC-Ont-071495 Oreochromis niloticus 71.27 0.00e+00 1259.00
IUUC-Oan-073695 Ornithorhynchus anatinus 82.53 0.00e+00 993.00
IUUC-Ocu-074457 Oryctolagus cuniculus 89.01 0.00e+00 1647.00
IUUC-Ola-086739 Oryzias latipes 68.80 0.00e+00 1275.00
IUUC-Oga-088720 Otolemur garnettii 92.76 0.00e+00 1707.00
IUUC-Oar-089921 Ovis aries 92.00 0.00e+00 1687.00
IUUC-Ptr-090526 Pan troglodytes 92.32 0.00e+00 1697.00
IUUC-Pan-092396 Papio anubis 92.78 0.00e+00 1707.00
IUUC-Psi-092971 Pelodiscus sinensis 80.85 0.00e+00 1491.00
IUUC-Pfo-097415 Poecilia formosa 70.17 0.00e+00 1257.00
IUUC-Pab-098740 Pongo abelii 92.97 0.00e+00 1733.00
IUUC-Pca-100598 Procavia capensis 82.67 0.00e+00 890.00
IUUC-Pva-102820 Pteropus vampyrus 87.67 0.00e+00 1400.00
IUUC-Rno-104894 Rattus norvegicus 95.05 0.00e+00 1753.00
IUUC-Sha-107244 Sarcophilus harrisii 76.66 0.00e+00 1374.00
IUUC-Sar-113665 Sorex araneus 89.69 0.00e+00 1669.00
IUUC-Ssc-115793 Sus scrofa 90.36 0.00e+00 1622.00
IUUC-Tgu-117487 Taeniopygia guttata 80.88 0.00e+00 1411.00
IUUC-Tru-117694 Takifugu rubripes 69.08 0.00e+00 1271.00
IUUC-Tsy-119598 Tarsius syrichta 81.16 0.00e+00 1416.00
IUUC-Tni-120189 Tetraodon nigroviridis 66.38 0.00e+00 1199.00
IUUC-Tbe-128125 Tupaia belangeri 82.85 3.00e-107 383.00
IUUC-Ttr-128269 Tursiops truncatus 89.02 0.00e+00 1570.00
IUUC-Vpa-130598 Vicugna pacos 90.14 0.00e+00 1645.00
IUUC-Xtr-132044 Xenopus tropicalis 74.07 0.00e+00 1304.00
Created Date 25-Jun-2017

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