iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.90e-11	44.1	305	338

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 4    dsvtclaf..sd.tllvsGsdDgtikvWDlrtgv 34
           +s++ ++f  sd +++++ s+Dg +++++++ + 
   Q: 305  GSIHQFSFsgSDgKMMATVSHDGFLRIFNYHAQE 338
           68999999**999****************88765 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Together with wdr-48, binds to and stimulates the activity of the deubiquitinating enzyme usp-46, leading to deubiquitination and stabilization of the glr-1 glutamate receptor.

Protein Sequence
(Fasta)

MHQHMLGPST SLGGTNNSAL QSSVLSEGVL LSHSQPTREE IKKNFETREG VYRSVPSAEF 60
SRPRPLPQYH MPPGIASAAA SQIAAAGSTV RVSFLNGAEK SVESPEAVAP TSSTYEHHKN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATATTTGACA ATTCTGCTTT ATTGACAAAT TTAAGGATGA GCAGACGGGC TTGAAATGCG 60
GAATGTCGCG AATATTCTCA AAGCTAAGGT TTGTATTAAA GTCATACTTA AATGAAGGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

SMART

SM00320--WD40

Gene Ontology

GO:0010628--P:positive regulation of gene expression
GO:0090326--P:positive regulation of locomotion involved in locomotory behavior
GO:1903003--P:positive regulation of protein deubiquitination
GO:2000010--P:positive regulation of protein localization to cell surface

KEGG

cel:CELE_C08B6.7

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000844	Aegilops tauschii	31.15	1.00e-24	105.00
IUUC-Aml-001749	Ailuropoda melanoleuca	38.57	1.00e-121	428.00
IUUC-Atr-002459	Amborella trichopoda	30.35	7.00e-43	167.00
IUUC-Apl-003710	Anas platyrhynchos	41.87	7.00e-110	389.00
IUUC-Aca-004914	Anolis carolinensis	38.79	1.00e-121	429.00
IUUC-Aly-005833	Arabidopsis lyrata	33.77	2.00e-42	165.00
IUUC-Ath-006649	Arabidopsis thaliana	33.77	3.00e-42	164.00
IUUC-Acl-008348	Aspergillus clavatus	33.20	1.00e-38	153.00
IUUC-Afl-008642	Aspergillus flavus	32.93	2.00e-39	155.00
IUUC-Afu-008994	Aspergillus fumigatus	31.73	3.00e-34	138.00
IUUC-Ani-009266	Aspergillus nidulans	33.20	1.00e-39	156.00
IUUC-Ang-009614	Aspergillus niger	32.21	3.00e-40	158.00
IUUC-Aor-010159	Aspergillus oryzae	32.93	2.00e-39	155.00
IUUC-Ate-010476	Aspergillus terreus	33.74	4.00e-38	151.00
IUUC-Ame-010952	Astyanax mexicanus	45.98	5.00e-89	320.00
IUUC-Bta-013293	Bos taurus	37.79	4.00e-119	420.00
IUUC-Bci-013753	Botrytis cinerea	36.25	1.00e-38	153.00
IUUC-Bdi-014283	Brachypodium distachyon	33.68	1.00e-38	153.00
IUUC-Bol-015990	Brassica oleracea	34.11	8.00e-42	163.00
IUUC-Bra-017842	Brassica rapa	24.37	1.00e-10	60.10
IUUC-Cja-019007	Callithrix jacchus	37.52	4.00e-118	417.00
IUUC-Cfa-020697	Canis familiaris	40.73	7.00e-77	279.00
IUUC-Cpo-022464	Cavia porcellus	37.86	9.00e-84	303.00
IUUC-Csa-023594	Chlorocebus sabaeus	39.25	1.00e-123	435.00
IUUC-Cho-024294	Choloepus hoffmanni	40.94	1.00e-75	275.00
IUUC-Cin-025617	Ciona intestinalis	35.47	3.00e-59	220.00
IUUC-Csv-026120	Ciona savignyi	43.56	1.00e-43	167.00
IUUC-Cgl-026394	Colletotrichum gloeosporioides	35.17	5.00e-39	154.00
IUUC-Cne-026940	Cryptococcus neoformans	26.12	2.00e-22	99.80
IUUC-Cme-027228	Cyanidioschyzon merolae	25.51	7.00e-12	65.50
IUUC-Dre-027892	Danio rerio	37.90	3.00e-119	421.00
IUUC-Dno-029016	Dasypus novemcinctus	38.19	3.00e-119	420.00
IUUC-Dor-030179	Dipodomys ordii	41.73	8.00e-107	379.00
IUUC-Dse-031362	Dothistroma septosporum	32.27	1.00e-35	142.00
IUUC-Dme-031790	Drosophila melanogaster	41.60	3.00e-79	288.00
IUUC-Eca-034209	Equus caballus	48.18	5.00e-77	280.00
IUUC-Eeu-034912	Erinaceus europaeus	40.90	1.00e-70	259.00
IUUC-Fca-036140	Felis catus	38.94	3.00e-124	437.00
IUUC-Fal-037163	Ficedula albicollis	39.10	6.00e-123	433.00
IUUC-Fox-037668	Fusarium oxysporum	34.35	1.00e-13	69.70
IUUC-Fso-038140	Fusarium solani	36.99	3.00e-41	162.00
IUUC-Gmo-039005	Gadus morhua	37.75	5.00e-120	423.00
IUUC-Ggr-039757	Gaeumannomyces graminis	31.56	6.00e-38	150.00
IUUC-Gga-040768	Gallus gallus	39.10	5.00e-123	433.00
IUUC-Gac-042612	Gasterosteus aculeatus	41.54	3.00e-98	350.00
IUUC-Gma-043670	Glycine max	35.79	2.00e-45	175.00
IUUC-Ggo-045322	Gorilla gorilla	37.52	3.00e-118	417.00
IUUC-Hsa-046440	Homo sapiens	37.67	1.00e-118	419.00
IUUC-Hvu-047057	Hordeum vulgare	31.28	1.00e-19	89.00
IUUC-Itr-048055	Ictidomys tridecemlineatus	39.25	2.00e-123	435.00
IUUC-Lch-049678	Latimeria chalumnae	38.88	2.00e-122	431.00
IUUC-Lpe-051650	Leersia perrieri	35.27	3.00e-38	151.00
IUUC-Loc-051970	Lepisosteus oculatus	38.60	3.00e-120	424.00
IUUC-Lma-053071	Leptosphaeria maculans	33.76	2.00e-37	149.00
IUUC-Laf-053660	Loxodonta africana	38.59	7.00e-123	432.00
IUUC-Mcc-055671	Macaca mulatta	41.87	4.00e-109	387.00
IUUC-Meu-056033	Macropus eugenii	45.87	1.00e-61	229.00
IUUC-Mor-057249	Magnaporthe oryzae	32.09	2.00e-36	145.00
IUUC-Mpo-057472	Magnaporthe poae	33.96	4.00e-39	154.00
IUUC-Mtr-058649	Medicago truncatula	35.76	9.00e-44	170.00
IUUC-Mla-059179	Melampsora laricipopulina	30.77	2.00e-24	106.00
IUUC-Mga-059701	Meleagris gallopavo	41.87	9.00e-110	389.00
IUUC-Mvi-060521	Microbotryum violaceum	29.85	2.00e-30	125.00
IUUC-Mmr-060982	Microcebus murinus	37.35	9.00e-119	419.00
IUUC-Mdo-062998	Monodelphis domestica	38.59	8.00e-124	436.00
IUUC-Mmu-064199	Mus musculus	38.94	6.00e-122	429.00
IUUC-Mac-064899	Musa acuminata	31.85	2.00e-38	152.00
IUUC-Mpu-066310	Mustela putorius furo	38.47	1.00e-121	428.00
IUUC-Mlu-068216	Myotis lucifugus	38.85	1.00e-124	439.00
IUUC-Nfi-068256	Neosartorya fischeri	33.33	7.00e-39	154.00
IUUC-Ncr-068904	Neurospora crassa	35.29	3.00e-38	152.00
IUUC-Nle-069233	Nomascus leucogenys	39.41	1.00e-123	435.00
IUUC-Opr-071024	Ochotona princeps	41.76	6.00e-96	343.00
IUUC-Ont-071358	Oreochromis niloticus	40.88	1.00e-95	342.00
IUUC-Oan-073075	Ornithorhynchus anatinus	41.68	2.00e-109	388.00
IUUC-Ocu-073978	Oryctolagus cuniculus	39.10	1.00e-123	435.00
IUUC-Oba-075973	Oryza barthii	31.18	2.00e-41	162.00
IUUC-Obr-076504	Oryza brachyantha	33.57	8.00e-39	153.00
IUUC-Ogl-077048	Oryza glaberrima	33.33	9.00e-37	147.00
IUUC-Ogu-078225	Oryza glumaepatula	33.10	3.00e-34	138.00
IUUC-Oin-079597	Oryza indica	31.28	3.00e-45	176.00
IUUC-Olo-080349	Oryza longistaminata	37.01	1.00e-17	82.40
IUUC-Oni-082556	Oryza nivara	31.18	2.00e-41	162.00
IUUC-Opu-083344	Oryza punctata	29.95	2.00e-39	155.00
IUUC-Oru-085085	Oryza rufipogon	31.82	1.00e-45	176.00
IUUC-Osa-085527	Oryza sativa	30.75	5.00e-44	171.00
IUUC-Ola-086647	Oryzias latipes	41.10	2.00e-96	345.00
IUUC-Olu-087793	Ostreococcus lucimarinus	23.91	1.00e-13	69.70
IUUC-Oga-088879	Otolemur garnettii	38.38	6.00e-121	426.00
IUUC-Oar-089333	Ovis aries	38.50	6.00e-121	426.00
IUUC-Ptr-090538	Pan troglodytes	37.65	6.00e-120	423.00
IUUC-Pan-092473	Papio anubis	38.98	3.00e-124	437.00
IUUC-Psi-094013	Pelodiscus sinensis	39.04	8.00e-123	432.00
IUUC-Ppa-095812	Physcomitrella patens	31.69	2.00e-44	172.00
IUUC-Pfo-096913	Poecilia formosa	41.10	8.00e-97	346.00
IUUC-Pab-098503	Pongo abelii	38.70	1.00e-124	439.00
IUUC-Pop-099670	Populus trichocarpa	33.11	4.00e-41	161.00
IUUC-Pca-100287	Procavia capensis	37.81	1.00e-117	415.00
IUUC-Ppe-101841	Prunus persica	33.64	3.00e-43	168.00
IUUC-Pva-102826	Pteropus vampyrus	38.79	1.00e-122	432.00
IUUC-Pgr-103681	Puccinia graminis	44.86	2.00e-24	106.00
IUUC-Pte-104091	Pyrenophora teres	32.59	2.00e-36	145.00
IUUC-Pyt-104509	Pyrenophora triticirepentis	31.13	4.00e-36	144.00
IUUC-Rno-106076	Rattus norvegicus	38.83	6.00e-124	436.00
IUUC-Sha-107220	Sarcophilus harrisii	38.82	4.00e-125	440.00
IUUC-Sja-107886	Schizosaccharomyces japonicus	29.15	1.00e-24	106.00
IUUC-Spo-108343	Schizosaccharomyces pombe	28.88	9.00e-31	127.00
IUUC-Ssl-108563	Sclerotinia sclerotiorum	35.16	5.00e-28	117.00
IUUC-Smo-108850	Selaginella moellendorffii	33.99	1.00e-43	169.00
IUUC-Sit-109904	Setaria italica	34.15	9.00e-41	160.00
IUUC-Sly-111266	Solanum lycopersicum	33.11	9.00e-42	163.00
IUUC-Stu-112818	Solanum tuberosum	32.78	2.00e-41	162.00
IUUC-Sar-113582	Sorex araneus	49.72	9.00e-51	192.00
IUUC-Sbi-114804	Sorghum bicolor	34.49	5.00e-41	160.00
IUUC-Sre-115177	Sporisorium reilianum	30.84	8.00e-24	104.00
IUUC-Ssc-116048	Sus scrofa	40.09	1.00e-123	435.00
IUUC-Tgu-116514	Taeniopygia guttata	41.49	9.00e-103	365.00
IUUC-Tru-117529	Takifugu rubripes	41.10	1.00e-96	345.00
IUUC-Tsy-119611	Tarsius syrichta	38.62	1.00e-123	435.00
IUUC-Tni-120859	Tetraodon nigroviridis	37.44	7.00e-119	419.00
IUUC-Tca-121339	Theobroma cacao	33.00	3.00e-41	161.00
IUUC-Tre-122206	Trichoderma reesei	31.06	2.00e-29	122.00
IUUC-Tvi-122377	Trichoderma virens	33.19	4.00e-28	118.00
IUUC-Tae-125357	Triticum aestivum	30.96	3.00e-38	152.00
IUUC-Tur-126428	Triticum urartu	31.56	7.00e-24	103.00
IUUC-Tme-126969	Tuber melanosporum	30.94	5.00e-38	150.00
IUUC-Tbe-127985	Tupaia belangeri	39.58	2.00e-105	375.00
IUUC-Ttr-128936	Tursiops truncatus	38.43	3.00e-124	437.00
IUUC-Uma-129485	Ustilago maydis	30.40	4.00e-24	105.00
IUUC-Vda-129875	Verticillium dahliae	31.76	7.00e-40	157.00
IUUC-Vvi-131155	Vitis vinifera	33.89	3.00e-41	161.00
IUUC-Xtr-131864	Xenopus tropicalis	38.53	5.00e-119	420.00
IUUC-Xma-134123	Xiphophorus maculatus	38.64	5.00e-119	420.00
IUUC-Yli-134475	Yarrowia lipolytica	25.45	2.00e-24	105.00
IUUC-Zma-135634	Zea mays	34.15	6.00e-40	157.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence