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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046610
Ensembl Protein ID ENSP00000394496.2
UniProt Accession Q9ULV4; A7MAP0; A7MAP1; B3KU12; Q9NSK5; COR1C_HUMAN
Genbank Protein ID BAA83077.1; CAO94662.1; CAO94663.1; BAG53274.1; CAB82406.1; EAW97826.1; AAH02342.1
Protein Name Coronin-1C; Coronin-3; hCRNN4
Genbank Nucleotide ID AB030656; AM849477; AM849478; AK096363; AL162070; AC007569; BC002342
Gene Name CORO1C; CRN2; CRNN4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000110880.10 ENST00000550542.5 ENSP00000448130.1
ENSG00000110880.10 ENST00000551044.1 ENSP00000447049.1
ENSG00000110880.10 ENST00000420959.6 ENSP00000394496.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.60e-15 57.1 131 163
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDl 30
           gHt++v ++++   +d  ++sGs D+t++vW +
   Q: 131  GHTGPVLDIDWcphNDQVIASGSEDCTVMVWQI 163
           8***********977799*************86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Binds F-actin. Isoform 1 and isoform 2 appear as homotrimers, while isoform 3 seems to exist as monomers.
 Binds F-actin. Isoform 1 and isoform 2 appear as homotrimers, while isoform 3 seems to exist as monomers.
Protein Sequence
(Fasta)
MYGPGSQLGK SGNNSWAKER GCSIACQGSL TSARLHAPSI GERPLSHMRW KDTMRRVVRQ 60
SKFRHVFGQA VKNDQCYDDI RVSRVTWDSS FCAVNPRFVA IIIEASGGGA FLVLPLHKTG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046610|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGCGGCGCG GGGGCGGGGC CTACGCGCGG TGGCGGGGGC GGTGGCGGCT GCCCGCGCCC 60
CTCCCCCGCA CGGCGCTCAG TGCCAGGCTG GAGGCGGCAG CGGTTGGAGG CTTCGCCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046610|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR027333--CORO1C
IPR015505--Coronin
IPR015048--DUF1899
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08953--DUF1899
PF00400--WD40
SMART

SM01166--DUF1899
SM00320--WD40
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005737--C:cytoplasm
GO:0016600--C:flotillin complex
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0016328--C:lateral plasma membrane
GO:0051015--F:actin filament binding
GO:0030036--P:actin cytoskeleton organization
GO:0090630--P:activation of GTPase activity
GO:0045184--P:establishment of protein localization
GO:0010633--P:negative regulation of epithelial cell migration
GO:0051895--P:negative regulation of focal adhesion assembly
GO:0044387--P:negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0001933--P:negative regulation of protein phosphorylation
GO:1900025--P:negative regulation of substrate adhesion-dependent cell spreading
GO:0001755--P:neural crest cell migration
GO:0006909--P:phagocytosis
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0010632--P:regulation of epithelial cell migration
GO:0010762--P:regulation of fibroblast migration
GO:0051893--P:regulation of focal adhesion assembly
GO:0001932--P:regulation of protein phosphorylation
GO:1900027--P:regulation of ruffle assembly
GO:1900024--P:regulation of substrate adhesion-dependent cell spreading
GO:0007165--P:signal transduction
KEGG hsa:23603
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002236 Ailuropoda melanoleuca 99.16 0.00e+00 986.00
IUUC-Apl-003861 Anas platyrhynchos 94.53 0.00e+00 949.00
IUUC-Acl-008280 Aspergillus clavatus 43.81 5.00e-98 352.00
IUUC-Afl-008393 Aspergillus flavus 44.06 1.00e-97 350.00
IUUC-Afu-008865 Aspergillus fumigatus 42.07 7.00e-94 338.00
IUUC-Ani-009155 Aspergillus nidulans 43.56 4.00e-99 355.00
IUUC-Ang-009523 Aspergillus niger 41.60 3.00e-88 319.00
IUUC-Aor-010049 Aspergillus oryzae 43.58 2.00e-94 340.00
IUUC-Ate-010368 Aspergillus terreus 43.36 4.00e-94 338.00
IUUC-Ame-011256 Astyanax mexicanus 80.62 0.00e+00 789.00
IUUC-Bta-013225 Bos taurus 93.56 0.00e+00 987.00
IUUC-Bci-013935 Botrytis cinerea 43.03 9.00e-100 357.00
IUUC-Cja-019948 Callithrix jacchus 97.73 0.00e+00 1075.00
IUUC-Cfa-020591 Canis familiaris 96.02 0.00e+00 1050.00
IUUC-Cpo-021480 Cavia porcellus 98.95 0.00e+00 981.00
IUUC-Csa-024152 Chlorocebus sabaeus 99.58 0.00e+00 992.00
IUUC-Cho-024687 Choloepus hoffmanni 98.39 0.00e+00 903.00
IUUC-Csv-026184 Ciona savignyi 42.21 2.00e-87 315.00
IUUC-Cgl-026456 Colletotrichum gloeosporioides 42.93 2.00e-96 346.00
IUUC-Dre-028541 Danio rerio 83.54 0.00e+00 792.00
IUUC-Dno-029552 Dasypus novemcinctus 98.85 0.00e+00 904.00
IUUC-Dse-031378 Dothistroma septosporum 42.46 2.00e-91 330.00
IUUC-Dme-032091 Drosophila melanogaster 53.67 1.00e-153 536.00
IUUC-Ete-032839 Echinops telfairi 89.66 0.00e+00 878.00
IUUC-Eca-034118 Equus caballus 98.32 0.00e+00 982.00
IUUC-Fca-035549 Felis catus 99.37 0.00e+00 982.00
IUUC-Fal-037065 Ficedula albicollis 94.33 0.00e+00 954.00
IUUC-Fox-037737 Fusarium oxysporum 43.28 3.00e-93 335.00
IUUC-Fso-038184 Fusarium solani 43.41 9.00e-99 354.00
IUUC-Gmo-038678 Gadus morhua 77.59 0.00e+00 778.00
IUUC-Ggr-039956 Gaeumannomyces graminis 42.64 2.00e-96 347.00
IUUC-Gga-040842 Gallus gallus 94.74 0.00e+00 956.00
IUUC-Gac-041543 Gasterosteus aculeatus 78.20 0.00e+00 773.00
IUUC-Ggo-044477 Gorilla gorilla 99.43 0.00e+00 1096.00
IUUC-Itr-048583 Ictidomys tridecemlineatus 93.93 0.00e+00 1031.00
IUUC-Lch-050453 Latimeria chalumnae 82.75 0.00e+00 836.00
IUUC-Loc-052911 Lepisosteus oculatus 84.63 0.00e+00 839.00
IUUC-Lma-053160 Leptosphaeria maculans 43.28 3.00e-99 356.00
IUUC-Laf-053416 Loxodonta africana 98.95 0.00e+00 981.00
IUUC-Mcc-055113 Macaca mulatta 99.58 0.00e+00 989.00
IUUC-Meu-056732 Macropus eugenii 82.11 0.00e+00 756.00
IUUC-Mor-056978 Magnaporthe oryzae 39.62 3.00e-99 355.00
IUUC-Mpo-057410 Magnaporthe poae 42.89 3.00e-90 326.00
IUUC-Mla-058883 Melampsora laricipopulina 42.33 2.00e-87 316.00
IUUC-Mga-060143 Meleagris gallopavo 94.71 0.00e+00 948.00
IUUC-Mmr-061130 Microcebus murinus 94.69 0.00e+00 1029.00
IUUC-Mdo-062851 Monodelphis domestica 87.18 0.00e+00 815.00
IUUC-Mmu-063663 Mus musculus 97.47 0.00e+00 964.00
IUUC-Mpu-066179 Mustela putorius furo 98.95 0.00e+00 981.00
IUUC-Mlu-068175 Myotis lucifugus 97.93 0.00e+00 984.00
IUUC-Nfi-068476 Neosartorya fischeri 42.82 2.00e-96 346.00
IUUC-Ncr-068781 Neurospora crassa 42.64 1.00e-97 350.00
IUUC-Nle-070001 Nomascus leucogenys 99.01 0.00e+00 843.00
IUUC-Opr-070617 Ochotona princeps 97.89 0.00e+00 939.00
IUUC-Ont-072629 Oreochromis niloticus 83.30 0.00e+00 840.00
IUUC-Oan-073547 Ornithorhynchus anatinus 95.76 0.00e+00 952.00
IUUC-Ocu-074569 Oryctolagus cuniculus 93.93 0.00e+00 1031.00
IUUC-Ola-086558 Oryzias latipes 80.50 0.00e+00 828.00
IUUC-Oga-089145 Otolemur garnettii 99.16 0.00e+00 986.00
IUUC-Oar-089654 Ovis aries 93.17 0.00e+00 997.00
IUUC-Ptr-090763 Pan troglodytes 99.79 0.00e+00 987.00
IUUC-Pan-091885 Papio anubis 99.56 0.00e+00 946.00
IUUC-Psi-093011 Pelodiscus sinensis 94.11 0.00e+00 945.00
IUUC-Pno-094994 Phaeosphaeria nodorum 44.14 6.00e-98 351.00
IUUC-Pfo-097309 Poecilia formosa 82.66 0.00e+00 846.00
IUUC-Pab-097542 Pongo abelii 91.14 0.00e+00 881.00
IUUC-Pca-100630 Procavia capensis 83.30 0.00e+00 793.00
IUUC-Pte-104194 Pyrenophora teres 42.64 2.00e-98 353.00
IUUC-Pyt-104437 Pyrenophora triticirepentis 42.64 3.00e-98 352.00
IUUC-Rno-105330 Rattus norvegicus 98.31 0.00e+00 973.00
IUUC-Sha-106695 Sarcophilus harrisii 94.63 0.00e+00 774.00
IUUC-Sja-107992 Schizosaccharomyces japonicus 41.96 5.00e-98 352.00
IUUC-Ssc-115348 Sus scrofa 93.37 0.00e+00 1014.00
IUUC-Tgu-116597 Taeniopygia guttata 94.53 0.00e+00 947.00
IUUC-Tru-118425 Takifugu rubripes 81.05 0.00e+00 826.00
IUUC-Tsy-119223 Tarsius syrichta 88.74 0.00e+00 771.00
IUUC-Tni-120610 Tetraodon nigroviridis 80.76 0.00e+00 822.00
IUUC-Tre-122159 Trichoderma reesei 41.50 8.00e-94 337.00
IUUC-Tvi-122480 Trichoderma virens 42.00 3.00e-95 342.00
IUUC-Tbe-127679 Tupaia belangeri 88.14 0.00e+00 642.00
IUUC-Ttr-129226 Tursiops truncatus 88.82 0.00e+00 846.00
IUUC-Vda-129792 Verticillium dahliae 42.14 4.00e-94 338.00
IUUC-Vpa-130339 Vicugna pacos 99.40 0.00e+00 702.00
IUUC-Xtr-132873 Xenopus tropicalis 75.16 0.00e+00 751.00
IUUC-Xma-134047 Xiphophorus maculatus 82.91 0.00e+00 848.00
Created Date 25-Jun-2017

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