iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000006439.5	ENSGALT00000010390.3	ENSGALP00000010376.3
ENSGALG00000006439.5	ENSGALT00000051548.1	ENSGALP00000049895.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.30e-15	55.2	156	210

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++ ++++ +n+deL+ +kGd+++v     +++gW++g  +l+gk G fP+n+v++++
   Q: 156  VVKARFNFKQTNEDELSVNKGDIIYVT--RVEEGGWWEG--TLNGKTGWFPSNYVREIK 210
           68999*********************7..999*******..8**************997 PP

Organism

Gallus gallus

Functional Description
(View)

Acts as a RAC1 guanine nucleotide exchange factor (GEF).

Protein Sequence
(Fasta)

MNPEEQVVTW LISLGVLNSP KKIVDDPEEF LKTSLKDGTV LCKLIHRLLP GSAEKYCLEP 60
KNEADCISNI QEFLRGCAVL KVELFEPHDL YSGEQFSKVL STLTAVNKAT EDQPSEGPCS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCAATGAAT CCAGAAGAGC AAGTGGTAAC GTGGCTCATT TCCTTAGGAG TTCTGAACTC 60
CCCTAAGAAA ATAGTTGATG ATCCGGAGGA GTTCCTGAAA ACTTCTCTGA AGGATGGAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0966--Cell projection
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF16523--betaPIX_CC
PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0030027--C:lamellipodium
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0035556--P:intracellular signal transduction
GO:0035023--P:regulation of Rho protein signal transduction

KEGG

gga:422247

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001631	Ailuropoda melanoleuca	65.58	0.00e+00	1036.00
IUUC-Apl-003960	Anas platyrhynchos	95.60	0.00e+00	1434.00
IUUC-Aca-004988	Anolis carolinensis	78.89	0.00e+00	1171.00
IUUC-Aly-005591	Arabidopsis lyrata	40.32	2.00e-09	56.60
IUUC-Ame-011546	Astyanax mexicanus	66.15	0.00e+00	957.00
IUUC-Bta-013527	Bos taurus	73.62	0.00e+00	1113.00
IUUC-Cja-018935	Callithrix jacchus	74.23	0.00e+00	1113.00
IUUC-Cfa-021269	Canis familiaris	73.84	0.00e+00	1111.00
IUUC-Cpo-021620	Cavia porcellus	70.10	0.00e+00	1064.00
IUUC-Csa-023415	Chlorocebus sabaeus	74.45	0.00e+00	1116.00
IUUC-Dre-028580	Danio rerio	66.28	0.00e+00	1003.00
IUUC-Dno-029201	Dasypus novemcinctus	69.47	0.00e+00	1089.00
IUUC-Dor-030868	Dipodomys ordii	61.81	0.00e+00	843.00
IUUC-Eca-033500	Equus caballus	74.01	0.00e+00	1110.00
IUUC-Eeu-035269	Erinaceus europaeus	65.23	1.00e-129	457.00
IUUC-Fca-035683	Felis catus	72.82	0.00e+00	1090.00
IUUC-Fal-037611	Ficedula albicollis	91.98	0.00e+00	1387.00
IUUC-Gmo-038980	Gadus morhua	65.17	0.00e+00	936.00
IUUC-Gac-042203	Gasterosteus aculeatus	64.46	0.00e+00	971.00
IUUC-Ggo-044755	Gorilla gorilla	74.32	0.00e+00	1113.00
IUUC-Hsa-046210	Homo sapiens	74.06	0.00e+00	1110.00
IUUC-Lch-049517	Latimeria chalumnae	74.66	0.00e+00	1091.00
IUUC-Loc-052393	Lepisosteus oculatus	66.33	0.00e+00	1032.00
IUUC-Laf-054196	Loxodonta africana	73.87	0.00e+00	1091.00
IUUC-Mcc-055716	Macaca mulatta	74.32	0.00e+00	1114.00
IUUC-Meu-056285	Macropus eugenii	67.53	3.00e-179	621.00
IUUC-Mtr-058576	Medicago truncatula	46.03	2.00e-11	62.80
IUUC-Mga-060029	Meleagris gallopavo	97.80	0.00e+00	1492.00
IUUC-Mmr-060803	Microcebus murinus	73.75	0.00e+00	1108.00
IUUC-Mdo-062654	Monodelphis domestica	76.45	0.00e+00	1135.00
IUUC-Mmu-063479	Mus musculus	72.98	0.00e+00	1092.00
IUUC-Mpu-066065	Mustela putorius furo	73.75	0.00e+00	1092.00
IUUC-Mlu-068222	Myotis lucifugus	72.81	0.00e+00	1070.00
IUUC-Nle-069379	Nomascus leucogenys	74.32	0.00e+00	1113.00
IUUC-Opr-070687	Ochotona princeps	58.23	0.00e+00	650.00
IUUC-Ont-072240	Oreochromis niloticus	59.73	0.00e+00	929.00
IUUC-Oan-073067	Ornithorhynchus anatinus	80.62	0.00e+00	1219.00
IUUC-Ocu-074852	Oryctolagus cuniculus	72.60	0.00e+00	1088.00
IUUC-Oba-075543	Oryza barthii	34.29	1.70e+00	27.30
IUUC-Ogu-078135	Oryza glumaepatula	34.29	1.60e+00	27.30
IUUC-Oni-082520	Oryza nivara	34.29	6.00e-01	28.10
IUUC-Opu-083443	Oryza punctata	34.29	1.10e+00	27.70
IUUC-Oru-085261	Oryza rufipogon	34.29	1.60e+00	27.30
IUUC-Osa-085322	Oryza sativa	34.29	1.60e+00	27.30
IUUC-Oga-089048	Otolemur garnettii	68.23	0.00e+00	937.00
IUUC-Oar-089339	Ovis aries	73.62	0.00e+00	1112.00
IUUC-Pan-092666	Papio anubis	72.59	0.00e+00	1069.00
IUUC-Psi-093116	Pelodiscus sinensis	85.62	0.00e+00	1314.00
IUUC-Pma-094701	Petromyzon marinus	57.60	1.00e-117	416.00
IUUC-Pfo-097394	Poecilia formosa	63.96	0.00e+00	958.00
IUUC-Pab-098567	Pongo abelii	74.32	0.00e+00	1113.00
IUUC-Pca-100997	Procavia capensis	64.10	0.00e+00	889.00
IUUC-Pva-102500	Pteropus vampyrus	72.47	0.00e+00	1063.00
IUUC-Rno-104974	Rattus norvegicus	73.42	0.00e+00	1068.00
IUUC-Sar-113420	Sorex araneus	72.90	0.00e+00	1064.00
IUUC-Ssc-115679	Sus scrofa	74.71	0.00e+00	979.00
IUUC-Tgu-117069	Taeniopygia guttata	91.10	0.00e+00	1387.00
IUUC-Tru-118488	Takifugu rubripes	59.14	0.00e+00	846.00
IUUC-Tsy-119243	Tarsius syrichta	67.85	0.00e+00	767.00
IUUC-Tni-120584	Tetraodon nigroviridis	62.11	0.00e+00	918.00
IUUC-Tbe-127994	Tupaia belangeri	60.31	0.00e+00	889.00
IUUC-Ttr-128839	Tursiops truncatus	72.22	0.00e+00	1069.00
IUUC-Vpa-130144	Vicugna pacos	68.14	0.00e+00	972.00
IUUC-Xtr-132624	Xenopus tropicalis	71.09	0.00e+00	1091.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence