iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000009295.4	ENSCAFT00000046460.2	ENSCAFP00000042791.1
ENSCAFG00000009295.4	ENSCAFT00000014770.3	ENSCAFP00000013663.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.70e-12	45.1	481	510
UBD/Beta-Prp	3.20e-41	141.7	211	513

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlr 31
           H+ +v++++ +d+ +vsG+  g + vWD+r
   Q: 481  HQLGVSAVQMDDWKIVSGGEEGLVSVWDYR 510
           7778999999669***************86 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl.....lrslsgheae....vtavkfspdgkilvtgseDrtikvwdlst 83
           +l++ +++v+++v+   ++ ++++g+++g ++vwd++t+++      ++++++e++    v+ v+++++  + v + eD+++++wdl+t
   Q: 211  ELEHIPDAVLCDVHS--HDGVVIAGYTSGDVRVWDTRTWDYtapflESEYEEDEPGmqpyVSFVRINSS--LAVAAYEDGFLNIWDLRT 295
           567778999998888..9***********************7777433334444449999*********..9***************** PP
   S: 84   gkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkl 171
           gk+ ++  +h++++ +l++s+++ +++++s+ +++++   e+g++  + + + +++v ++++ pd+ ++ v+ ++ + + ++ lk ++ 
   Q: 296  GKYPVHRFEHDARIQALALSQEDATVATASAFDVVMLRPNEEGYWQITAEFEVQKLVDYLEIVPDTgRYPVAVATAGDL-VYLLKAEDS 383
           ***999999**************************************9******************************9.5******** PP
   S: 172  lrtltgghtdsvyslsfdsng.....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrsg 254
            rtl     ++v++l+++ n+     k+l ++ + +++ +++l++++c+ +l +    +++v++  +   ++vsg++D+ +ri+dlr++
   Q: 384  ARTLHYVYGQPVTCLDVSANQaafgvKSLGWVYEGNKILVYSLEAERCLSKLGNALGDFTCVNLRnSPPSLMVSGNMDRRVRIHDLRTD 472
           ****999*********************************************************9778899****************** PP
   S: 255  dllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkkne 298
           ++  +l+ h+  v++v++   +d+++v+g+e++ v +w++++++
   Q: 473  KIALSLSAHQLGVSAVQM---DDWKIVSGGEEGLVSVWDYRMSQ 513
           **********99999999...*******************9876 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MDDHSLDEFR RRWQEELAQA QALRKRRRRR RRPRRRPPRA PAPARLASLP SESENGFPTS 60
AQGLCDLGGG GPPPPPPATA TPPLPPPSRL CGCVTESQVI SGPTLIPSLV LFLNEMDDVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGACC ACAGCCTGGA CGAGTTCCGC CGGCGCTGGC AGGAGGAGCT GGCGCAGGCC 60
CAGGCGCTCC GGAAGCGGCG GCGGCACAAA AATGGACTGA ATAGGTATTA TGATGACACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0060712--P:spongiotrophoblast layer development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001274	Ailuropoda melanoleuca	96.60	0.00e+00	1005.00
IUUC-Apl-003239	Anas platyrhynchos	64.81	0.00e+00	706.00
IUUC-Aca-004756	Anolis carolinensis	61.94	6.00e-141	493.00
IUUC-Ame-011198	Astyanax mexicanus	52.97	1.00e-54	206.00
IUUC-Bta-012430	Bos taurus	56.78	3.00e-150	525.00
IUUC-Cja-019131	Callithrix jacchus	75.87	0.00e+00	874.00
IUUC-Cpo-021898	Cavia porcellus	81.95	0.00e+00	963.00
IUUC-Csa-023452	Chlorocebus sabaeus	79.03	0.00e+00	915.00
IUUC-Cho-024759	Choloepus hoffmanni	72.55	0.00e+00	824.00
IUUC-Dre-028123	Danio rerio	48.83	6.00e-147	514.00
IUUC-Dno-029045	Dasypus novemcinctus	94.48	0.00e+00	899.00
IUUC-Dor-030433	Dipodomys ordii	90.71	0.00e+00	783.00
IUUC-Ete-032465	Echinops telfairi	90.91	0.00e+00	787.00
IUUC-Eca-034134	Equus caballus	95.49	0.00e+00	980.00
IUUC-Eeu-035047	Erinaceus europaeus	83.61	0.00e+00	844.00
IUUC-Fca-036574	Felis catus	95.29	0.00e+00	971.00
IUUC-Fal-037665	Ficedula albicollis	61.69	0.00e+00	628.00
IUUC-Gmo-039137	Gadus morhua	44.40	2.00e-63	236.00
IUUC-Gga-040711	Gallus gallus	64.20	0.00e+00	687.00
IUUC-Gac-041675	Gasterosteus aculeatus	53.76	2.00e-56	211.00
IUUC-Ggo-045331	Gorilla gorilla	87.70	0.00e+00	887.00
IUUC-Hsa-046240	Homo sapiens	78.70	0.00e+00	925.00
IUUC-Itr-048412	Ictidomys tridecemlineatus	94.06	0.00e+00	944.00
IUUC-Loc-052631	Lepisosteus oculatus	54.89	4.00e-170	591.00
IUUC-Laf-054127	Loxodonta africana	81.29	2.00e-62	230.00
IUUC-Mcc-055083	Macaca mulatta	79.53	0.00e+00	921.00
IUUC-Mga-060113	Meleagris gallopavo	64.50	0.00e+00	683.00
IUUC-Mmr-061780	Microcebus murinus	92.14	0.00e+00	958.00
IUUC-Mdo-063066	Monodelphis domestica	68.99	0.00e+00	743.00
IUUC-Mmu-063524	Mus musculus	86.32	0.00e+00	881.00
IUUC-Mpu-066913	Mustela putorius furo	95.61	0.00e+00	995.00
IUUC-Mlu-067924	Myotis lucifugus	82.89	0.00e+00	952.00
IUUC-Nle-069558	Nomascus leucogenys	78.10	0.00e+00	872.00
IUUC-Opr-070506	Ochotona princeps	89.74	0.00e+00	939.00
IUUC-Ont-071514	Oreochromis niloticus	48.05	3.00e-145	508.00
IUUC-Ocu-074477	Oryctolagus cuniculus	90.72	0.00e+00	933.00
IUUC-Ola-087416	Oryzias latipes	48.81	1.00e-144	506.00
IUUC-Oga-088643	Otolemur garnettii	93.21	0.00e+00	979.00
IUUC-Oar-090172	Ovis aries	93.24	0.00e+00	961.00
IUUC-Ptr-090870	Pan troglodytes	79.03	0.00e+00	931.00
IUUC-Pan-092017	Papio anubis	78.54	0.00e+00	906.00
IUUC-Psi-093794	Pelodiscus sinensis	67.21	0.00e+00	700.00
IUUC-Pfo-096192	Poecilia formosa	50.89	2.00e-149	523.00
IUUC-Pab-097882	Pongo abelii	78.20	0.00e+00	914.00
IUUC-Pca-100902	Procavia capensis	72.36	2.00e-135	476.00
IUUC-Pva-103139	Pteropus vampyrus	92.61	0.00e+00	977.00
IUUC-Rno-105798	Rattus norvegicus	85.11	0.00e+00	899.00
IUUC-Sha-106576	Sarcophilus harrisii	69.42	0.00e+00	720.00
IUUC-Ssc-115923	Sus scrofa	75.79	0.00e+00	902.00
IUUC-Tgu-116667	Taeniopygia guttata	57.68	1.00e-122	432.00
IUUC-Tru-118323	Takifugu rubripes	46.67	4.00e-140	491.00
IUUC-Tsy-118818	Tarsius syrichta	77.60	2.00e-109	389.00
IUUC-Tni-120438	Tetraodon nigroviridis	41.95	1.00e-134	473.00
IUUC-Tbe-127784	Tupaia belangeri	95.15	2.00e-114	405.00
IUUC-Ttr-128288	Tursiops truncatus	83.03	0.00e+00	856.00
IUUC-Vpa-130307	Vicugna pacos	89.28	0.00e+00	837.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence