iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067778

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AAPE02017245

Gene Name

UCHL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000010138.2	ENSMLUT00000010139.2	ENSMLUP00000009241.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.40e-63	214.6	2	222

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvi 95
           ++ ++e +P+++++++ ++gv +++++ ++ +L+++ l++++ pv++llllF+++ ++e++rk+q++    e +++++  +++f+kq+i
   Q: 2    QLKPMEINPEMLNKVLARLGVAGQWRFVDVLGLEEDALSSVPAPVCALLLLFPLTAQHENFRKKQIE----ELKGQEVSPKVYFMKQTI 86
           5789*************************************************************99....99**************** PP
   S: 96   gNsCatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           gNsC+t++l+++++n++dkl ++ G+ l++++++t++ spe++a++++++++++ +h+++a++++++ +          +k +fhf+++
   Q: 87   GNSCGTIGLIHAVANNQDKLeFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQTAHDAVAQEGQCRVD----------DKVNFHFILF 165
           *******************************************************************99..........5679****** PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivad 244
            n++g+lyeldg++pfP+++g + e+  l+d++kv+r+f+er    e++e+rf+++a++++
   Q: 166  NNVDGHLYELDGRMPFPVNHGTSAEDSLLQDAAKVCREFTER----EQGEVRFSAVALCKA 222
           ******************************************....************987 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MQLKPMEINP EMLNKVLARL GVAGQWRFVD VLGLEEDALS SVPAPVCALL LLFPLTAQHE 60
NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTIGLIHAVA NNQDKLEFED GSVLKQFLSE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCAGCTCA AACCCATGGA GATCAACCCC GAGGTGAGCG GCAGGTGCAC GGTGGCCCCG 60
GGAGCGCTTG CCTGGGGGTC AGCCCACGCC AGGCAGCCGG ATCGCTGGCT GGTTTCATTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR030297--UCHL1

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0044306--C:neuron projection terminus
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0016874--F:ligase activity
GO:0008242--F:omega peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007628--P:adult walking behavior
GO:0007412--P:axon target recognition
GO:0019896--P:axonal transport of mitochondrion
GO:0008283--P:cell proliferation
GO:0042755--P:eating behavior
GO:0048747--P:muscle fiber development
GO:0043407--P:negative regulation of MAP kinase activity
GO:0050905--P:neuromuscular process
GO:0016579--P:protein deubiquitination
GO:0002931--P:response to ischemia
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001376	Ailuropoda melanoleuca	79.77	2.00e-112	398.00
IUUC-Apl-003693	Anas platyrhynchos	68.75	4.00e-90	323.00
IUUC-Aca-004716	Anolis carolinensis	75.00	6.00e-101	359.00
IUUC-Ame-011806	Astyanax mexicanus	67.26	2.00e-85	308.00
IUUC-Bta-013521	Bos taurus	81.35	6.00e-114	403.00
IUUC-Cja-018752	Callithrix jacchus	94.64	4.00e-116	410.00
IUUC-Cfa-020442	Canis familiaris	95.98	3.00e-117	414.00
IUUC-Cpo-021723	Cavia porcellus	96.99	9.00e-95	338.00
IUUC-Csa-023626	Chlorocebus sabaeus	94.17	4.00e-116	410.00
IUUC-Cho-024548	Choloepus hoffmanni	84.26	3.00e-40	157.00
IUUC-Dre-027854	Danio rerio	65.18	3.00e-84	304.00
IUUC-Dno-029325	Dasypus novemcinctus	95.07	9.00e-118	415.00
IUUC-Dor-030114	Dipodomys ordii	93.27	2.00e-125	441.00
IUUC-Ete-033092	Echinops telfairi	76.68	2.00e-96	344.00
IUUC-Eca-033854	Equus caballus	97.18	5.00e-80	289.00
IUUC-Eeu-034493	Erinaceus europaeus	91.93	8.00e-113	399.00
IUUC-Fal-036693	Ficedula albicollis	73.21	1.00e-91	328.00
IUUC-Gmo-038848	Gadus morhua	60.85	8.00e-75	272.00
IUUC-Gga-041078	Gallus gallus	73.21	1.00e-99	355.00
IUUC-Gac-042064	Gasterosteus aculeatus	62.73	9.00e-79	286.00
IUUC-Ggo-044827	Gorilla gorilla	94.17	2.00e-116	411.00
IUUC-Hsa-045820	Homo sapiens	94.17	2.00e-116	411.00
IUUC-Itr-048496	Ictidomys tridecemlineatus	96.41	1.00e-118	418.00
IUUC-Lch-050121	Latimeria chalumnae	73.87	3.00e-98	350.00
IUUC-Loc-052342	Lepisosteus oculatus	69.78	6.00e-92	329.00
IUUC-Laf-053916	Loxodonta africana	94.67	1.00e-116	411.00
IUUC-Mcc-054838	Macaca mulatta	94.17	4.00e-116	410.00
IUUC-Meu-056478	Macropus eugenii	87.89	5.00e-120	422.00
IUUC-Mga-059878	Meleagris gallopavo	71.89	2.00e-93	335.00
IUUC-Mdo-062544	Monodelphis domestica	87.33	8.00e-109	385.00
IUUC-Mmu-063300	Mus musculus	94.62	3.00e-126	443.00
IUUC-Mpu-066128	Mustela putorius furo	95.00	2.00e-103	368.00
IUUC-Nle-069686	Nomascus leucogenys	94.17	2.00e-116	410.00
IUUC-Opr-070535	Ochotona princeps	77.58	1.00e-98	352.00
IUUC-Ont-071510	Oreochromis niloticus	62.61	3.00e-80	290.00
IUUC-Ocu-074590	Oryctolagus cuniculus	93.27	7.00e-116	409.00
IUUC-Ola-087552	Oryzias latipes	57.89	3.00e-73	267.00
IUUC-Oga-089013	Otolemur garnettii	80.16	9.00e-112	395.00
IUUC-Oar-089861	Ovis aries	81.35	6.00e-114	403.00
IUUC-Ptr-091536	Pan troglodytes	92.38	5.00e-114	403.00
IUUC-Pan-092909	Papio anubis	94.17	4.00e-116	410.00
IUUC-Psi-093818	Pelodiscus sinensis	79.46	3.00e-104	370.00
IUUC-Pfo-097335	Poecilia formosa	58.22	2.00e-77	281.00
IUUC-Pab-098048	Pongo abelii	94.17	2.00e-116	411.00
IUUC-Pca-100818	Procavia capensis	72.82	2.00e-67	248.00
IUUC-Pva-102954	Pteropus vampyrus	95.52	3.00e-113	400.00
IUUC-Rno-105966	Rattus norvegicus	94.62	3.00e-126	443.00
IUUC-Sha-107111	Sarcophilus harrisii	86.06	2.00e-86	310.00
IUUC-Sar-113190	Sorex araneus	73.68	5.00e-38	149.00
IUUC-Ssc-115908	Sus scrofa	78.67	9.00e-100	355.00
IUUC-Tgu-117465	Taeniopygia guttata	69.67	3.00e-86	310.00
IUUC-Tru-118565	Takifugu rubripes	60.29	1.00e-69	255.00
IUUC-Tsy-119561	Tarsius syrichta	76.68	4.00e-96	343.00
IUUC-Tbe-128048	Tupaia belangeri	94.55	1.00e-92	331.00
IUUC-Ttr-128494	Tursiops truncatus	94.14	6.00e-114	402.00
IUUC-Vda-129850	Verticillium dahliae	33.91	2.00e-28	119.00
IUUC-Xtr-132286	Xenopus tropicalis	69.23	2.00e-91	328.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence