• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP
  • mRNA Expression
    • GEO
    • ArrayExpress
  • DNA & RNA Element
    • miRTarBase
    • TRANSFAC
    • RAID2
  • PPI
    • IID
    • PINA
    • Mentha
  • PTM
    • CPLM
    • PhosphositePlus
  • Proteomics
    • GPMDB

Tag Content
iUUCD ID IUUC-Cne-027087
Ensembl Protein ID AAW43166
UniProt Accession P0CS42; Q55TS8; Q5KIK9; LIS1_CRYNJ
Genbank Protein ID AAW43166.1
Protein Name Nuclear distribution protein PAC1; Lissencephaly-1 homolog; nudF homolog
Genbank Nucleotide ID AE017344
Gene Name PAC1; LIS1; CND02590
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
CND02590 AAW43166 AAW43166
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.10e-52 169.5 324 363
UBD/Beta-Prp 8.10e-78 260.0 88 416
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
    gH +++++l f ++ ++l+s+sdD+tikvWDl g+++k+
   Q: 324 GHDNWIRALVFhPSgKYLLSASDDKTIKVWDLANGRCTKT 363
    8***********666**********************986 PP
   


   UBD/Beta-Prp

   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgd 107
    +h +++t ++f+p +lla++s+d+t+k+wd++ g++ r+l+gh+++v +v+f+p+g +++t+s+D t+k+wd +++ v tl+gh++sv s++f+p+g+
   Q: 88 SHRAPVTRLAFHPTWTLLASASEDATVKLWDWEAGDMERTLKGHTKAVMDVDFDPRGGLMATCSSDLTLKLWDTAnQYTNVKTLHGHDHSVSSVRFMPDGE 188
    68889999****************************************************************76538999********************* PP
   S: 108 klvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng................ 192
    +lvs+s+d+tirvw++++g+c++ t+sgh ++v+ +v ++dg+ lvs+s+D+t r+Wd +tg+ +l+g h++ v++ f +
   Q: 189 TLVSASRDKTIRVWQVSSGYCIK-TFSGHAEWVREAVPSEDGRWLVSASNDQTSRIWDFSTGETKMELRG-HEHVVECAVFAPVNaypairelaglkppap 287
    ***********************.*********************************************9.*********999888999999999999999 PP
   S: 193 .........kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvav............ 272
    + ++gs+d+t+klwd +g+c+rtl gh+++++ + f+p +++l+s+s+D++i++Wdl +g ++kt++ h + v+s++
   Q: 288 rdtrakspgVYAATGSRDKTIKLWDALSGQCLRTLVGHDNWIRALVFHPSGKYLLSASDDKTIKVWDLANGRCTKTIEAHSHFVTSMTWgravgasggiek 388
    999999999************************************************************************99999988777676666666 PP
   S: 273 .....lsfg...dnvlvlgsedskvniw 292
    s + nvl++gs d+++++w
   Q: 389 vngdaSSKEprrINVLATGSVDQTIKVW 416
    555542222445666699999******9 PP
   

Organism Cryptococcus neoformans
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.
Protein Sequence
(Fasta)
MLAYLHAAGM HNAYAALQHD AALADVDPRD RAVGLLEKKW TSVIRLQKKV IDLENRNAAL 60
LAELAAAARP AAPGPFLPRP PPRHTLASHR APVTRLAFHP TWTLLASASE DATVKLWDWE 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Cne-027087|E3,WD_repeat;UBD,Beta-Prp|Cryptococcus neoformans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCTGTCCGA CCGCCAGAAA GACGAGCTGT GAGTGCGCTC AACTCCCCCG CTGACTCCCG 60
CTGACTCCCC CCCCCCCCCA GCCACCGCGC AATGCTCGCC TACCTGCACG CCGCGGGGAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Cne-027087|E3,WD_repeat;UBD,Beta-Prp|Cryptococcus neoformans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005938--C:cell cortex
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0000922--C:spindle pole
GO:0008017--F:microtubule binding
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0031023--P:microtubule organizing center organization
GO:0007067--P:mitotic nuclear division
GO:0007097--P:nuclear migration
GO:2000574--P:regulation of microtubule motor activity
GO:0000003--P:reproduction
GO:0047496--P:vesicle transport along microtubule

KEGG cne:CND02590
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 48.92 2.00e-114 403.00
IUUC-Apl-004024 Anas platyrhynchos 48.92 3.00e-114 403.00
IUUC-Aca-004564 Anolis carolinensis 48.68 4.00e-112 395.00
IUUC-Acl-008360 Aspergillus clavatus 47.91 1.00e-108 384.00
IUUC-Afl-008502 Aspergillus flavus 47.40 2.00e-106 377.00
IUUC-Afu-008848 Aspergillus fumigatus 49.56 2.00e-115 407.00
IUUC-Ani-009173 Aspergillus nidulans 48.99 5.00e-99 352.00
IUUC-Ang-009873 Aspergillus niger 45.96 6.00e-101 358.00
IUUC-Aor-009973 Aspergillus oryzae 46.58 6.00e-103 365.00
IUUC-Ate-010523 Aspergillus terreus 46.91 2.00e-101 360.00
IUUC-Ame-010969 Astyanax mexicanus 49.64 5.00e-116 409.00
IUUC-Bgr-011972 Blumeria graminis 49.11 1.00e-115 407.00
IUUC-Bta-013106 Bos taurus 48.92 2.00e-114 404.00
IUUC-Bci-013615 Botrytis cinerea 51.22 2.00e-118 417.00
IUUC-Cel-018459 Caenorhabditis elegans 43.03 3.00e-94 336.00
IUUC-Cja-018755 Callithrix jacchus 48.92 2.00e-114 404.00
IUUC-Cfa-020749 Canis familiaris 48.92 2.00e-114 404.00
IUUC-Cpo-022371 Cavia porcellus 48.92 2.00e-114 404.00
IUUC-Csa-023524 Chlorocebus sabaeus 51.20 1.00e-103 367.00
IUUC-Cho-024764 Choloepus hoffmanni 44.99 7.00e-93 332.00
IUUC-Cin-025753 Ciona intestinalis 49.04 8.00e-107 378.00
IUUC-Csv-025817 Ciona savignyi 49.16 1.00e-110 391.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 50.67 6.00e-113 399.00
IUUC-Dre-028314 Danio rerio 49.88 2.00e-116 410.00
IUUC-Dno-029050 Dasypus novemcinctus 48.92 3.00e-114 403.00
IUUC-Dor-030222 Dipodomys ordii 44.84 1.00e-99 354.00
IUUC-Dse-031164 Dothistroma septosporum 50.33 1.00e-114 404.00
IUUC-Dme-031745 Drosophila melanogaster 46.39 8.00e-100 355.00
IUUC-Ete-032508 Echinops telfairi 51.50 2.00e-91 327.00
IUUC-Eca-034288 Equus caballus 48.44 3.00e-113 399.00
IUUC-Eeu-034984 Erinaceus europaeus 44.60 2.00e-98 350.00
IUUC-Fca-036498 Felis catus 48.92 2.00e-114 404.00
IUUC-Fal-036920 Ficedula albicollis 48.92 3.00e-114 403.00
IUUC-Fox-037996 Fusarium oxysporum 48.78 1.00e-115 407.00
IUUC-Fso-038160 Fusarium solani 46.67 1.00e-110 391.00
IUUC-Gmo-038983 Gadus morhua 48.92 4.00e-115 405.00
IUUC-Ggr-040051 Gaeumannomyces graminis 47.10 2.00e-110 390.00
IUUC-Gga-040623 Gallus gallus 48.92 3.00e-114 403.00
IUUC-Gac-041613 Gasterosteus aculeatus 47.96 1.00e-113 400.00
IUUC-Ggo-045410 Gorilla gorilla 43.86 4.00e-98 349.00
IUUC-Hsa-046358 Homo sapiens 48.92 2.00e-114 403.00
IUUC-Hvu-047729 Hordeum vulgare 27.38 3.00e-31 127.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 48.92 2.00e-114 404.00
IUUC-Kpa-049351 Komagataella pastoris 28.10 8.00e-36 142.00
IUUC-Lch-049936 Latimeria chalumnae 48.92 2.00e-115 406.00
IUUC-Loc-052476 Lepisosteus oculatus 48.44 4.00e-114 402.00
IUUC-Lma-053170 Leptosphaeria maculans 53.35 3.00e-118 416.00
IUUC-Laf-053713 Loxodonta africana 48.92 1.00e-114 404.00
IUUC-Mcc-054628 Macaca mulatta 48.92 3.00e-114 403.00
IUUC-Meu-055927 Macropus eugenii 43.85 3.00e-72 262.00
IUUC-Mor-056962 Magnaporthe oryzae 47.33 9.00e-109 385.00
IUUC-Mpo-057583 Magnaporthe poae 49.39 2.00e-104 370.00
IUUC-Mla-058819 Melampsora laricipopulina 55.10 1.00e-134 471.00
IUUC-Mga-059945 Meleagris gallopavo 48.68 6.00e-114 402.00
IUUC-Mvi-060403 Microbotryum violaceum 61.61 2.00e-153 533.00
IUUC-Mmr-061289 Microcebus murinus 48.92 2.00e-114 404.00
IUUC-Mdo-061912 Monodelphis domestica 48.92 1.00e-114 404.00
IUUC-Mmu-063253 Mus musculus 48.92 2.00e-114 404.00
IUUC-Mpu-066638 Mustela putorius furo 48.92 2.00e-114 404.00
IUUC-Mlu-067267 Myotis lucifugus 48.92 2.00e-114 403.00
IUUC-Nfi-068571 Neosartorya fischeri 48.57 1.00e-110 391.00
IUUC-Ncr-068895 Neurospora crassa 54.46 7.00e-117 412.00
IUUC-Nle-069087 Nomascus leucogenys 50.00 3.00e-89 319.00
IUUC-Opr-070579 Ochotona princeps 48.92 3.00e-114 403.00
IUUC-Ont-071905 Oreochromis niloticus 48.92 2.00e-115 406.00
IUUC-Oan-073072 Ornithorhynchus anatinus 48.92 2.00e-114 404.00
IUUC-Ocu-074180 Oryctolagus cuniculus 48.92 3.00e-114 403.00
IUUC-Obr-076138 Oryza brachyantha 29.30 5.00e-31 127.00
IUUC-Ola-086815 Oryzias latipes 49.64 5.00e-116 409.00
IUUC-Oga-088219 Otolemur garnettii 48.92 1.00e-114 404.00
IUUC-Oar-090394 Ovis aries 48.92 2.00e-114 404.00
IUUC-Ptr-091517 Pan troglodytes 48.92 2.00e-114 404.00
IUUC-Pan-092421 Papio anubis 48.92 3.00e-114 403.00
IUUC-Psi-093370 Pelodiscus sinensis 48.92 4.00e-114 402.00
IUUC-Pma-094319 Petromyzon marinus 52.10 3.00e-101 359.00
IUUC-Pno-094815 Phaeosphaeria nodorum 50.44 5.00e-118 416.00
IUUC-Pfo-097089 Poecilia formosa 49.40 9.00e-117 411.00
IUUC-Pab-098421 Pongo abelii 48.92 2.00e-114 404.00
IUUC-Pca-100120 Procavia capensis 41.93 5.00e-66 243.00
IUUC-Pva-102960 Pteropus vampyrus 48.68 3.00e-113 399.00
IUUC-Pgr-103538 Puccinia graminis 55.15 8.00e-136 474.00
IUUC-Ptt-103990 Puccinia triticina 44.35 1.00e-39 155.00
IUUC-Pte-104261 Pyrenophora teres 51.00 2.00e-119 421.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 51.00 2.00e-119 420.00
IUUC-Rno-105123 Rattus norvegicus 48.92 2.00e-114 404.00
IUUC-Sce-106208 Saccharomyces cerevisiae 26.42 6.00e-33 133.00
IUUC-Sha-107010 Sarcophilus harrisii 48.92 6.00e-115 405.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 35.59 2.00e-68 250.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 52.80 4.00e-117 412.00
IUUC-Sar-113309 Sorex araneus 48.20 3.00e-112 396.00
IUUC-Sre-115003 Sporisorium reilianum 56.18 3.00e-137 479.00
IUUC-Ssc-116148 Sus scrofa 48.92 2.00e-114 404.00
IUUC-Tgu-117299 Taeniopygia guttata 48.92 2.00e-114 403.00
IUUC-Tru-118179 Takifugu rubripes 48.68 4.00e-114 402.00
IUUC-Tsy-119493 Tarsius syrichta 48.68 8.00e-113 398.00
IUUC-Tni-120355 Tetraodon nigroviridis 48.20 4.00e-112 395.00
IUUC-Tre-121977 Trichoderma reesei 44.83 1.00e-102 364.00
IUUC-Tvi-122661 Trichoderma virens 47.84 8.00e-103 365.00
IUUC-Tur-126181 Triticum urartu 27.08 1.00e-30 126.00
IUUC-Tme-127031 Tuber melanosporum 53.09 6.00e-121 425.00
IUUC-Tbe-127492 Tupaia belangeri 48.26 7.00e-64 235.00
IUUC-Ttr-128929 Tursiops truncatus 48.92 2.00e-114 403.00
IUUC-Uma-129347 Ustilago maydis 57.14 2.00e-145 506.00
IUUC-Vda-129837 Verticillium dahliae 51.86 1.00e-107 381.00
IUUC-Vpa-130532 Vicugna pacos 43.73 1.00e-84 304.00
IUUC-Xtr-131985 Xenopus tropicalis 48.68 5.00e-114 402.00
IUUC-Xma-133314 Xiphophorus maculatus 49.16 3.00e-116 409.00
IUUC-Yli-134403 Yarrowia lipolytica 41.08 9.00e-80 288.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved