iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052427

Ensembl Protein ID

ENSLOCP00000019637.1

UniProt Accession

W5NG78; W5NG78_LEPOC

Genbank Protein ID

ENSLOCP00000019637

Protein Name

Presenilin

Genbank Nucleotide ID

AHAT01001616

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000015948.1	ENSLOCT00000019669.1	ENSLOCP00000019637.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	6.20e-06	26.3	276	303

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeant 29
           +eta+e++++iFP+l+ys+ + +++ ++
   Q: 276  VETAQERNEPIFPALIYSSAMMWMVGMA 303
           89*********************99886 PP

Organism

Lepisosteus oculatus

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

KIPLMNTSDS EEEFCNERTA LVPAESPTVP SYASDVGLPI SSDTEAIRRR PAAGSGERQD 60
GRHVDRDSAL ESEDEELTLK YGAKHVIMLF VPVTLCMVVV VATIKSVSFY TEKNGQLIYT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGATTCCCT TAATGAATAC CTCAGACAGC GAAGAAGAGT TTTGCAATGA GAGGACAGCC 60
TTGGTGCCAG CTGAGAGCCC AACAGTCCCG TCGTATGCTA GTGACGTAGG CCTGCCCATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0034205--P:beta-amyloid formation
GO:0007420--P:brain development
GO:0035556--P:intracellular signal transduction
GO:0030318--P:melanocyte differentiation
GO:0022008--P:neurogenesis
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing
GO:0061053--P:somite development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	32.10	2.00e-26	114.00
IUUC-Aml-002356	Ailuropoda melanoleuca	68.08	3.00e-125	441.00
IUUC-Atr-003039	Amborella trichopoda	30.75	6.00e-38	151.00
IUUC-Apl-003959	Anas platyrhynchos	73.67	8.00e-160	556.00
IUUC-Aca-005160	Anolis carolinensis	74.38	4.00e-163	567.00
IUUC-Aly-005455	Arabidopsis lyrata	51.52	8.00e-17	81.60
IUUC-Ath-006730	Arabidopsis thaliana	30.70	2.00e-17	84.00
IUUC-Ame-010686	Astyanax mexicanus	80.54	3.00e-162	564.00
IUUC-Bta-013097	Bos taurus	74.39	1.00e-150	525.00
IUUC-Bdi-014196	Brachypodium distachyon	32.69	1.00e-31	130.00
IUUC-Bol-015841	Brassica oleracea	30.36	2.00e-27	116.00
IUUC-Bra-017580	Brassica rapa	56.82	4.00e-17	82.40
IUUC-Cel-018553	Caenorhabditis elegans	48.97	3.00e-95	342.00
IUUC-Cja-018824	Callithrix jacchus	74.00	3.00e-149	521.00
IUUC-Cfa-020253	Canis familiaris	74.11	4.00e-151	527.00
IUUC-Cpo-021401	Cavia porcellus	74.72	3.00e-151	528.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	34.56	7.00e-30	125.00
IUUC-Csa-023369	Chlorocebus sabaeus	74.94	1.00e-153	536.00
IUUC-Cho-024735	Choloepus hoffmanni	63.27	2.00e-123	436.00
IUUC-Cin-025780	Ciona intestinalis	62.16	5.00e-125	440.00
IUUC-Csv-025967	Ciona savignyi	61.71	6.00e-125	440.00
IUUC-Dre-028526	Danio rerio	76.05	7.00e-161	560.00
IUUC-Dor-031127	Dipodomys ordii	73.77	7.00e-150	523.00
IUUC-Dme-031929	Drosophila melanogaster	54.18	2.00e-109	389.00
IUUC-Ete-033081	Echinops telfairi	67.96	6.00e-70	258.00
IUUC-Eca-034387	Equus caballus	75.06	2.00e-147	515.00
IUUC-Eeu-034846	Erinaceus europaeus	60.49	6.00e-100	357.00
IUUC-Fca-035396	Felis catus	74.05	8.00e-160	556.00
IUUC-Fal-037457	Ficedula albicollis	74.24	2.00e-156	545.00
IUUC-Gmo-038550	Gadus morhua	70.45	2.00e-135	475.00
IUUC-Gga-040706	Gallus gallus	73.70	1.00e-157	549.00
IUUC-Gac-042511	Gasterosteus aculeatus	70.47	4.00e-143	501.00
IUUC-Gma-043822	Glycine max	35.06	5.00e-23	102.00
IUUC-Ggo-045338	Gorilla gorilla	75.17	2.00e-153	535.00
IUUC-Hsa-046455	Homo sapiens	75.17	2.00e-153	535.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	75.22	2.00e-153	535.00
IUUC-Lch-049638	Latimeria chalumnae	67.74	5.00e-149	520.00
IUUC-Lpe-051132	Leersia perrieri	35.51	5.00e-17	82.00
IUUC-Laf-053758	Loxodonta africana	73.67	2.00e-163	568.00
IUUC-Mcc-054755	Macaca mulatta	75.28	2.00e-153	535.00
IUUC-Mtr-058392	Medicago truncatula	33.60	6.00e-31	128.00
IUUC-Mmr-060890	Microcebus murinus	74.72	3.00e-153	534.00
IUUC-Mdo-062197	Monodelphis domestica	74.08	1.00e-159	556.00
IUUC-Mmu-063823	Mus musculus	74.39	2.00e-154	538.00
IUUC-Mac-064858	Musa acuminata	41.86	9.00e-23	100.00
IUUC-Mpu-066181	Mustela putorius furo	73.63	2.00e-151	528.00
IUUC-Mlu-067079	Myotis lucifugus	71.25	1.00e-138	486.00
IUUC-Nle-069596	Nomascus leucogenys	72.77	1.00e-139	489.00
IUUC-Opr-070344	Ochotona princeps	72.93	2.00e-156	545.00
IUUC-Ont-071867	Oreochromis niloticus	75.06	4.00e-146	511.00
IUUC-Oan-073378	Ornithorhynchus anatinus	72.26	7.00e-146	509.00
IUUC-Ocu-074652	Oryctolagus cuniculus	73.14	3.00e-152	531.00
IUUC-Oba-075256	Oryza barthii	31.12	9.00e-27	114.00
IUUC-Ogl-077097	Oryza glaberrima	31.56	2.00e-30	127.00
IUUC-Ogu-078570	Oryza glumaepatula	31.56	2.00e-30	126.00
IUUC-Oin-079244	Oryza indica	31.84	1.00e-30	127.00
IUUC-Olo-080484	Oryza longistaminata	33.93	2.00e-21	96.30
IUUC-Ome-081814	Oryza meridionalis	31.56	2.00e-31	130.00
IUUC-Oni-082057	Oryza nivara	31.84	1.00e-30	127.00
IUUC-Opu-084176	Oryza punctata	32.77	7.00e-32	131.00
IUUC-Oru-084618	Oryza rufipogon	31.84	1.00e-30	127.00
IUUC-Osa-085602	Oryza sativa	30.45	9.00e-27	114.00
IUUC-Ola-086707	Oryzias latipes	76.16	3.00e-119	421.00
IUUC-Olu-087811	Ostreococcus lucimarinus	36.81	3.00e-44	172.00
IUUC-Oga-088560	Otolemur garnettii	73.88	8.00e-149	520.00
IUUC-Oar-089200	Ovis aries	74.66	3.00e-150	524.00
IUUC-Ptr-090569	Pan troglodytes	75.17	4.00e-154	537.00
IUUC-Pan-091742	Papio anubis	75.28	2.00e-153	535.00
IUUC-Pma-094612	Petromyzon marinus	76.38	7.00e-129	453.00
IUUC-Pab-098531	Pongo abelii	74.94	1.00e-153	536.00
IUUC-Pop-099661	Populus trichocarpa	34.77	2.00e-37	150.00
IUUC-Pca-101120	Procavia capensis	73.15	1.00e-147	516.00
IUUC-Ppe-101495	Prunus persica	32.88	5.00e-22	99.00
IUUC-Pva-102934	Pteropus vampyrus	70.73	8.00e-150	523.00
IUUC-Rno-106052	Rattus norvegicus	74.50	7.00e-158	550.00
IUUC-Sha-106876	Sarcophilus harrisii	71.67	6.00e-156	543.00
IUUC-Smo-109325	Selaginella moellendorffii	37.87	1.00e-33	137.00
IUUC-Sit-110624	Setaria italica	56.52	6.00e-16	78.60
IUUC-Sly-110865	Solanum lycopersicum	57.41	5.00e-07	46.20
IUUC-Stu-112433	Solanum tuberosum	32.62	4.00e-31	128.00
IUUC-Sar-113169	Sorex araneus	65.46	2.00e-103	369.00
IUUC-Ssc-115380	Sus scrofa	74.94	3.00e-158	551.00
IUUC-Tgu-117280	Taeniopygia guttata	74.68	1.00e-157	549.00
IUUC-Tsy-119624	Tarsius syrichta	64.47	8.00e-123	433.00
IUUC-Tca-121865	Theobroma cacao	31.70	1.00e-37	150.00
IUUC-Tae-125925	Triticum aestivum	32.39	1.00e-28	120.00
IUUC-Tur-126237	Triticum urartu	31.82	3.00e-26	112.00
IUUC-Tbe-127632	Tupaia belangeri	73.33	6.00e-126	444.00
IUUC-Ttr-129008	Tursiops truncatus	74.27	6.00e-149	520.00
IUUC-Vpa-130625	Vicugna pacos	60.10	2.00e-103	369.00
IUUC-Vvi-131312	Vitis vinifera	31.65	2.00e-35	143.00
IUUC-Xtr-132756	Xenopus tropicalis	73.68	2.00e-172	598.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence