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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063823
Ensembl Protein ID ENSMUSP00000106735.1
UniProt Accession Q3U4P5; Q3U4P5_MOUSE
Genbank Protein ID BAE28350.1; BAE32386.1; EDL13156.1; EDL13157.1; EDL13158.1
Protein Name Presenilin
Genbank Nucleotide ID AC132436; AK154119; CH466555; CH466555; CH466555
Gene Name Psen2; mCG_6223
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000010609.15 ENSMUST00000111106.7 ENSMUSP00000106735.1
ENSMUSG00000010609.15 ENSMUST00000111104.1 ENSMUSP00000106733.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
HINT
Post-translational Modifications (PTMs)
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/Alpha-Helix/CUE 7.00e-08 33.5 278 316
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/CUE
   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 278  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 316
           89********************************99986 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
 Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Protein Sequence
(Fasta)
MLAFMASDSE EEVCDERTSL MSAESPTSRS CQEGRPGPED GESTAQWRTQ ESEEDCEEDP 60
DRYACSGAPG RPSGLEEELT LKYGAKHVIM LFVPVTLCMI VVVATIKSVR FYTEKNGQLI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063823|UBD,CUE|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TAAACCAGGC TGGTCTTGAA CCCACAGATT CACTGGCTTC TGCCACCTAT GGACTTAAGG 60
TATGTTCCAC CACACCTAGT GCCTTTAAAC ATTTATAAGC GACTTGTCAA TTTCTACCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063823|UBD,CUE|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP
Pfam

PF01080--Presenilin
PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2
SMART

SM00730--PSN
Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005637--C:nuclear inner membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing
GO:0001666--P:response to hypoxia
KEGG mmu:19165
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002356 Ailuropoda melanoleuca 87.28 1.00e-177 616.00
IUUC-Apl-003959 Anas platyrhynchos 75.91 3.00e-162 565.00
IUUC-Aca-005160 Anolis carolinensis 75.85 8.00e-160 556.00
IUUC-Ame-010686 Astyanax mexicanus 79.17 8.00e-147 513.00
IUUC-Bta-013097 Bos taurus 94.65 0.00e+00 711.00
IUUC-Cja-018824 Callithrix jacchus 94.20 0.00e+00 726.00
IUUC-Cfa-020253 Canis familiaris 93.97 0.00e+00 728.00
IUUC-Cpo-021401 Cavia porcellus 94.64 0.00e+00 734.00
IUUC-Cre-022747 Chlamydomonas reinhardtii 33.74 5.00e-30 125.00
IUUC-Csa-023369 Chlorocebus sabaeus 95.98 0.00e+00 747.00
IUUC-Dre-028526 Danio rerio 70.60 2.00e-145 508.00
IUUC-Dor-031127 Dipodomys ordii 91.52 0.00e+00 687.00
IUUC-Ete-033081 Echinops telfairi 82.62 8.00e-93 333.00
IUUC-Eca-034387 Equus caballus 94.64 0.00e+00 694.00
IUUC-Eeu-034846 Erinaceus europaeus 79.71 4.00e-147 514.00
IUUC-Fca-035396 Felis catus 93.29 0.00e+00 739.00
IUUC-Fal-037457 Ficedula albicollis 75.81 9.00e-161 560.00
IUUC-Gga-040706 Gallus gallus 76.04 4.00e-157 547.00
IUUC-Gac-042511 Gasterosteus aculeatus 66.04 2.00e-130 459.00
IUUC-Gma-043822 Glycine max 37.21 3.00e-23 102.00
IUUC-Ggo-045338 Gorilla gorilla 95.98 0.00e+00 747.00
IUUC-Hsa-046455 Homo sapiens 95.98 0.00e+00 747.00
IUUC-Itr-048731 Ictidomys tridecemlineatus 95.31 0.00e+00 743.00
IUUC-Lch-049638 Latimeria chalumnae 68.31 6.00e-143 500.00
IUUC-Lpe-051132 Leersia perrieri 36.96 5.00e-17 82.40
IUUC-Loc-052427 Lepisosteus oculatus 73.79 3.00e-157 548.00
IUUC-Laf-053758 Loxodonta africana 89.80 0.00e+00 731.00
IUUC-Mcc-054755 Macaca mulatta 95.76 0.00e+00 744.00
IUUC-Mmr-060890 Microcebus murinus 94.87 0.00e+00 732.00
IUUC-Mdo-062197 Monodelphis domestica 80.30 1.00e-178 619.00
IUUC-Mac-064858 Musa acuminata 43.86 4.00e-23 102.00
IUUC-Mpu-066181 Mustela putorius furo 94.20 0.00e+00 731.00
IUUC-Nle-069596 Nomascus leucogenys 95.44 0.00e+00 696.00
IUUC-Opr-070344 Ochotona princeps 93.75 0.00e+00 739.00
IUUC-Ont-071867 Oreochromis niloticus 71.01 9.00e-134 469.00
IUUC-Oan-073378 Ornithorhynchus anatinus 75.30 7.00e-156 543.00
IUUC-Ocu-074652 Oryctolagus cuniculus 94.20 0.00e+00 699.00
IUUC-Oba-075256 Oryza barthii 60.49 2.00e-16 80.10
IUUC-Obr-076302 Oryza brachyantha 36.96 6.00e-17 82.40
IUUC-Ogl-077097 Oryza glaberrima 36.96 1.00e-16 81.30
IUUC-Ogu-078570 Oryza glumaepatula 36.96 1.00e-16 80.90
IUUC-Oin-079244 Oryza indica 37.68 8.00e-17 81.60
IUUC-Ome-081814 Oryza meridionalis 36.31 4.00e-17 82.80
IUUC-Oni-082057 Oryza nivara 37.68 8.00e-17 81.60
IUUC-Opu-084176 Oryza punctata 37.68 1.00e-16 80.90
IUUC-Oru-084618 Oryza rufipogon 37.68 9.00e-17 81.60
IUUC-Osa-085602 Oryza sativa 36.87 4.00e-17 82.80
IUUC-Ola-086707 Oryzias latipes 71.38 3.00e-106 377.00
IUUC-Olu-087811 Ostreococcus lucimarinus 38.73 4.00e-47 181.00
IUUC-Oga-088560 Otolemur garnettii 94.68 0.00e+00 703.00
IUUC-Oar-089200 Ovis aries 94.43 0.00e+00 692.00
IUUC-Ptr-090569 Pan troglodytes 95.76 0.00e+00 745.00
IUUC-Pan-091742 Papio anubis 95.76 0.00e+00 745.00
IUUC-Psi-093297 Pelodiscus sinensis 73.74 3.00e-132 464.00
IUUC-Pma-094612 Petromyzon marinus 76.13 3.00e-126 445.00
IUUC-Ppa-095431 Physcomitrella patens 31.78 7.00e-28 118.00
IUUC-Pab-098531 Pongo abelii 95.98 0.00e+00 747.00
IUUC-Pca-101120 Procavia capensis 91.96 0.00e+00 712.00
IUUC-Pva-102934 Pteropus vampyrus 84.82 0.00e+00 682.00
IUUC-Rno-106052 Rattus norvegicus 97.10 0.00e+00 776.00
IUUC-Sha-106876 Sarcophilus harrisii 79.74 2.00e-175 608.00
IUUC-Sly-110865 Solanum lycopersicum 58.18 2.00e-08 50.80
IUUC-Sbi-114305 Sorghum bicolor 47.83 4.00e-16 79.30
IUUC-Ssc-115380 Sus scrofa 95.98 0.00e+00 765.00
IUUC-Tgu-117280 Taeniopygia guttata 76.03 2.00e-161 561.00
IUUC-Tbe-127632 Tupaia belangeri 94.71 4.00e-179 620.00
IUUC-Ttr-129008 Tursiops truncatus 93.75 0.00e+00 720.00
IUUC-Vvi-131312 Vitis vinifera 38.24 1.00e-19 91.30
Created Date 25-Jun-2017

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