iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nle-069596

Ensembl Protein ID

ENSNLEP00000016908.2

UniProt Accession

G1RUI1; G1RUI1_NOMLE

Genbank Protein ID

ENSNLEP00000016908

Protein Name

Presenilin

Genbank Nucleotide ID

ADFV01086081

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000013924.2	ENSNLET00000017762.2	ENSNLEP00000016908.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	3.30e-08	33.4	278	316

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 278  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 316
           89********************************99986 PP

Organism

Nomascus leucogenys

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MLTFMASDSE EEVCDERTSL MSAESPTPRS CQEGRQGPED GENTAQWRSQ ENEEDGEEDP 60
DRYVCSGVPG RPPGLEEELT LKYGAKHVIM LFVPVTLCMI VVVATIKSVR FYTEKNGQLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTGAGACTC AGGCCCCAGC TCTGGCTTAG GCCAGGGAGA ACCATCCCCA AGTGGTATGT 60
GTTACTATAT GGGCTGAGAT GGATGGACAG GTGGATGGTC AGCTGGACCA AATACATAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005637--C:nuclear inner membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	87.50	4.00e-165	574.00
IUUC-Apl-003959	Anas platyrhynchos	73.91	1.00e-146	512.00
IUUC-Aca-005160	Anolis carolinensis	71.29	1.00e-144	506.00
IUUC-Ang-009768	Aspergillus niger	51.85	1.50e-01	31.60
IUUC-Ame-010686	Astyanax mexicanus	77.51	2.00e-131	461.00
IUUC-Bta-013097	Bos taurus	96.18	0.00e+00	673.00
IUUC-Cja-018824	Callithrix jacchus	97.45	0.00e+00	694.00
IUUC-Cfa-020253	Canis familiaris	95.41	0.00e+00	687.00
IUUC-Cpo-021401	Cavia porcellus	94.90	0.00e+00	684.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	33.89	4.00e-30	125.00
IUUC-Csa-023369	Chlorocebus sabaeus	99.74	0.00e+00	720.00
IUUC-Dor-031127	Dipodomys ordii	91.14	1.00e-175	608.00
IUUC-Ete-033081	Echinops telfairi	80.53	3.00e-78	285.00
IUUC-Eca-034387	Equus caballus	96.17	0.00e+00	652.00
IUUC-Eeu-034846	Erinaceus europaeus	82.06	2.00e-151	528.00
IUUC-Fca-035396	Felis catus	94.13	0.00e+00	696.00
IUUC-Fal-037457	Ficedula albicollis	73.27	2.00e-144	505.00
IUUC-Gga-040706	Gallus gallus	74.31	7.00e-141	493.00
IUUC-Ggo-045338	Gorilla gorilla	100.00	0.00e+00	721.00
IUUC-Hsa-046455	Homo sapiens	100.00	0.00e+00	721.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	96.94	0.00e+00	701.00
IUUC-Lch-049638	Latimeria chalumnae	66.34	2.00e-130	458.00
IUUC-Loc-052427	Lepisosteus oculatus	72.84	5.00e-142	497.00
IUUC-Laf-053758	Loxodonta africana	87.71	0.00e+00	681.00
IUUC-Mcc-054755	Macaca mulatta	99.74	0.00e+00	718.00
IUUC-Mmr-060890	Microcebus murinus	96.17	0.00e+00	694.00
IUUC-Mdo-062197	Monodelphis domestica	78.36	3.00e-161	561.00
IUUC-Mmu-063823	Mus musculus	95.66	0.00e+00	691.00
IUUC-Mpu-066181	Mustela putorius furo	94.90	0.00e+00	684.00
IUUC-Opr-070344	Ochotona princeps	94.90	0.00e+00	697.00
IUUC-Oan-073378	Ornithorhynchus anatinus	75.49	7.00e-157	546.00
IUUC-Ocu-074652	Oryctolagus cuniculus	94.39	0.00e+00	654.00
IUUC-Obr-076302	Oryza brachyantha	37.68	2.00e-17	83.60
IUUC-Osa-085602	Oryza sativa	37.43	2.00e-17	83.20
IUUC-Ola-086707	Oryzias latipes	71.15	8.00e-107	379.00
IUUC-Oga-088560	Otolemur garnettii	96.46	0.00e+00	663.00
IUUC-Oar-089200	Ovis aries	95.67	0.00e+00	651.00
IUUC-Ptr-090569	Pan troglodytes	99.74	0.00e+00	718.00
IUUC-Pan-091742	Papio anubis	99.74	0.00e+00	718.00
IUUC-Psi-093297	Pelodiscus sinensis	77.10	4.00e-133	467.00
IUUC-Ppa-095431	Physcomitrella patens	31.78	1.00e-27	117.00
IUUC-Pab-098531	Pongo abelii	99.74	0.00e+00	720.00
IUUC-Pca-101120	Procavia capensis	93.11	0.00e+00	673.00
IUUC-Pva-102934	Pteropus vampyrus	84.69	0.00e+00	640.00
IUUC-Rno-106052	Rattus norvegicus	94.90	0.00e+00	703.00
IUUC-Sha-106876	Sarcophilus harrisii	77.21	8.00e-158	550.00
IUUC-Ssc-115380	Sus scrofa	97.70	0.00e+00	727.00
IUUC-Tgu-117280	Taeniopygia guttata	74.01	4.00e-145	507.00
IUUC-Tbe-127632	Tupaia belangeri	98.24	0.00e+00	639.00
IUUC-Ttr-129008	Tursiops truncatus	95.15	0.00e+00	681.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence