iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000009168.2	ENSNLET00000032045.1	ENSNLEP00000023669.1
ENSNLEG00000009168.2	ENSNLET00000011746.1	ENSNLEP00000011193.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.30e-31	104.5	403	434
UBD/Beta-Prp	2.70e-48	164.6	401	679

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           gH+++v+cl+  s  +ll sGs D+tikvWD+
   Q: 403  GHQGPVWCLCVySMgDLLFSGSSDKTIKVWDT 434
           8*********778889***************6 PP

UBD/Beta-Prp

   S: 5    lkghhksvitcvkfspdksllatgsrdgtikvwdv.ttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           + gh+   + c+++   ++ll++gs d+tikvwd+ tt k+ ++l+gh++ v a++++     l +gs D ti vwd+++ + v t+++
   Q: 401  FVGHQGP-VWCLCVYSMGDLLFSGSSDKTIKVWDTcTTYKCQKTLEGHDGIVLALCIQGC--KLYSGSADCTIIVWDIQNLQKVNTIRA 486
           5556655.5559999*******************846678899***************99..6************************** PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdl.etgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           h++ v++l +s   + l sGs  + i+vwd+  t+ +l++ l+g +++v+ +v  +  ++l sGs+ +t+++Wd+++ ++++ l+    
   Q: 487  HDNPVCTLVSSH--NMLFSGS-LKAIKVWDIvGTELKLKKELTGLNHWVRALVAAQ--SYLYSGSY-QTIKIWDIRNLECIHVLQT-SG 568
           *******99999..9******.9*******7368888888**************99..*******9.79***************99.** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs..pnderlvsgssDgsiriWdlrsgdllktlqlhnssv 267
           +svys++++    ++v g + + + +wd++++e vrtl+gh  +v+ +++   p+++ + s+s D+s+r+W +++  +++tl +h+ sv
   Q: 569  GSVYSIAVTN--HHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVIstPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSV 655
           *********9..8***********************************99888************************************ PP
   S: 268  isvavlsfgdnvlvlgsedskvniwkl 294
           ++ av   ++  l++g+ ds+v++w +
   Q: 656  TALAV---SRGRLFSGAVDSTVKVWTC 679
           ****9...*****************86 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MKRSGGPAAP GRPRAGDAAQ RTLDASLEHE LRQECPLQPL LRGAQQSSHP RRHHRADGTS 60
TYKQHCRTPS SSSTLAYSPR DEEDSMPPIS TPRRSDSAIS VRSLHSESSM SLRSTFSLPE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGCGTCTA GTCCCTTTCC CGGCCGGCGG CCGAGGGGGG CATCATGAAG AGGTCTGGCG 60
GCCCTGCCGC TCCCGGGCGG CCGCGGGCGG GTGAGTGTCC CCGCGGCGCG CCCGGCCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR020472--G-protein_beta_WD-40_rep
IPR008974--TRAF-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF00400--WD40
PF13445--zf-RING_UBOX

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00184--RING
SM00320--WD40

Gene Ontology

GO:0043231--C:intracellular membrane-bounded organelle
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0000185--P:activation of MAPKKK activity
GO:0006915--P:apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001971	Ailuropoda melanoleuca	98.09	0.00e+00	1199.00
IUUC-Apl-004098	Anas platyrhynchos	95.04	0.00e+00	1170.00
IUUC-Aca-004852	Anolis carolinensis	90.52	0.00e+00	924.00
IUUC-Ame-011275	Astyanax mexicanus	85.64	0.00e+00	893.00
IUUC-Bta-013153	Bos taurus	97.92	0.00e+00	1189.00
IUUC-Cja-019243	Callithrix jacchus	98.19	0.00e+00	1162.00
IUUC-Cfa-020036	Canis familiaris	92.90	0.00e+00	1204.00
IUUC-Cpo-022194	Cavia porcellus	97.59	0.00e+00	1182.00
IUUC-Csa-023363	Chlorocebus sabaeus	99.04	0.00e+00	1210.00
IUUC-Cin-025279	Ciona intestinalis	63.64	0.00e+00	771.00
IUUC-Csv-026163	Ciona savignyi	64.55	0.00e+00	768.00
IUUC-Dre-027998	Danio rerio	91.00	0.00e+00	1099.00
IUUC-Dno-029356	Dasypus novemcinctus	95.09	3.00e-129	453.00
IUUC-Dor-030750	Dipodomys ordii	96.32	0.00e+00	1160.00
IUUC-Eca-033671	Equus caballus	77.13	0.00e+00	913.00
IUUC-Eeu-034765	Erinaceus europaeus	97.04	1.00e-164	573.00
IUUC-Fca-035843	Felis catus	92.31	0.00e+00	1197.00
IUUC-Fal-037237	Ficedula albicollis	94.88	0.00e+00	1171.00
IUUC-Gmo-038779	Gadus morhua	82.79	0.00e+00	989.00
IUUC-Gga-040579	Gallus gallus	94.72	0.00e+00	1168.00
IUUC-Gac-042233	Gasterosteus aculeatus	86.68	0.00e+00	1096.00
IUUC-Gma-042914	Glycine max	26.45	1.00e-18	87.40
IUUC-Ggo-045147	Gorilla gorilla	99.36	0.00e+00	1213.00
IUUC-Hsa-046117	Homo sapiens	99.20	0.00e+00	1211.00
IUUC-Itr-048899	Ictidomys tridecemlineatus	98.08	0.00e+00	1199.00
IUUC-Lch-050593	Latimeria chalumnae	92.64	0.00e+00	1122.00
IUUC-Loc-052444	Lepisosteus oculatus	92.96	0.00e+00	1170.00
IUUC-Laf-053499	Loxodonta africana	90.24	0.00e+00	1130.00
IUUC-Mcc-055038	Macaca mulatta	99.20	0.00e+00	1212.00
IUUC-Meu-056610	Macropus eugenii	96.05	0.00e+00	873.00
IUUC-Mtr-057641	Medicago truncatula	27.73	1.00e-19	90.90
IUUC-Mga-060183	Meleagris gallopavo	94.58	0.00e+00	1164.00
IUUC-Mmr-061133	Microcebus murinus	96.35	0.00e+00	1122.00
IUUC-Mdo-062312	Monodelphis domestica	97.12	0.00e+00	1189.00
IUUC-Mmu-063844	Mus musculus	97.60	0.00e+00	1189.00
IUUC-Mpu-066552	Mustela putorius furo	98.08	0.00e+00	1191.00
IUUC-Mlu-067719	Myotis lucifugus	91.57	0.00e+00	1163.00
IUUC-Opr-070927	Ochotona princeps	96.16	0.00e+00	1170.00
IUUC-Ont-072680	Oreochromis niloticus	89.50	0.00e+00	1114.00
IUUC-Oan-073521	Ornithorhynchus anatinus	94.00	3.00e-52	196.00
IUUC-Ola-087454	Oryzias latipes	89.66	0.00e+00	1151.00
IUUC-Oga-088380	Otolemur garnettii	98.08	0.00e+00	1198.00
IUUC-Oar-089558	Ovis aries	78.66	0.00e+00	925.00
IUUC-Ptr-091606	Pan troglodytes	99.36	0.00e+00	1213.00
IUUC-Pan-092227	Papio anubis	99.20	0.00e+00	1212.00
IUUC-Psi-093853	Pelodiscus sinensis	87.14	0.00e+00	951.00
IUUC-Pma-094541	Petromyzon marinus	81.65	3.00e-153	533.00
IUUC-Pfo-096237	Poecilia formosa	90.94	0.00e+00	1115.00
IUUC-Pab-097589	Pongo abelii	99.52	0.00e+00	1215.00
IUUC-Pca-100375	Procavia capensis	95.81	0.00e+00	1134.00
IUUC-Pva-102434	Pteropus vampyrus	98.08	0.00e+00	1196.00
IUUC-Rno-105443	Rattus norvegicus	97.92	0.00e+00	1196.00
IUUC-Sha-106517	Sarcophilus harrisii	96.80	0.00e+00	1183.00
IUUC-Ssc-115990	Sus scrofa	91.57	0.00e+00	1185.00
IUUC-Tgu-117222	Taeniopygia guttata	94.69	0.00e+00	1160.00
IUUC-Tru-118392	Takifugu rubripes	89.20	0.00e+00	1112.00
IUUC-Tni-120220	Tetraodon nigroviridis	89.18	0.00e+00	1104.00
IUUC-Tca-121793	Theobroma cacao	26.37	1.00e-19	90.50
IUUC-Tur-126339	Triticum urartu	26.69	1.00e-17	84.00
IUUC-Tbe-128045	Tupaia belangeri	98.61	2.00e-160	558.00
IUUC-Ttr-128203	Tursiops truncatus	89.05	0.00e+00	1134.00
IUUC-Xtr-132043	Xenopus tropicalis	93.44	0.00e+00	1179.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence