iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-118410

Ensembl Protein ID

ENSTRUP00000014748.1

UniProt Accession

H2SQR1; H2SQR1_TAKRU

Protein Name

Tyrosine-protein kinase

Gene Name

abl2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000006070.1	ENSTRUT00000014816.1	ENSTRUP00000014748.1
ENSTRUG00000006070.1	ENSTRUT00000014817.1	ENSTRUP00000014749.1
ENSTRUG00000006070.1	ENSTRUT00000014818.1	ENSTRUP00000014750.1
ENSTRUG00000006070.1	ENSTRUT00000014819.1	ENSTRUP00000014751.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.20e-12	46.8	125	182

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++q+++W +     ++ +G +P+n+++ ++
   Q: 125  PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNQNGEWSEV--RSKNGQGWVPSNYITPVN 182
           67899************************.*********98..788899*********997 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MGQQVGRVGE GTSTGLQPPQ PHATQTHQAK GIRGSGAGRR PREPGSITGT PPSRTPAVNV 60
PDPGINIFTQ HSDYSVCVED NTLSTEIPCC PKALHRPFGL DSAALTEAVR WSSKENLLGA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGCAGC AGGTAGGCCG CGTCGGTGAG GGCACGTCGA CCGGACTCCA GCCACCACAG 60
CCCCACGCGA CCCAGACGCA CCAAGCGAAG GGGATCCGGG GGAGCGGCGC CGGGAGAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002263	Ailuropoda melanoleuca	68.57	0.00e+00	1385.00
IUUC-Apl-003389	Anas platyrhynchos	67.65	0.00e+00	1341.00
IUUC-Ame-010629	Astyanax mexicanus	66.09	0.00e+00	1236.00
IUUC-Bta-013370	Bos taurus	65.76	0.00e+00	1402.00
IUUC-Cja-018894	Callithrix jacchus	67.65	0.00e+00	1385.00
IUUC-Cfa-020398	Canis familiaris	82.83	0.00e+00	1082.00
IUUC-Cpo-022367	Cavia porcellus	67.16	0.00e+00	1307.00
IUUC-Csa-023386	Chlorocebus sabaeus	68.24	0.00e+00	1387.00
IUUC-Cho-024714	Choloepus hoffmanni	78.08	0.00e+00	1149.00
IUUC-Dre-027741	Danio rerio	76.03	0.00e+00	1615.00
IUUC-Dno-029246	Dasypus novemcinctus	64.77	0.00e+00	1356.00
IUUC-Dor-030416	Dipodomys ordii	61.19	0.00e+00	1244.00
IUUC-Dme-032098	Drosophila melanogaster	71.64	0.00e+00	741.00
IUUC-Ete-032899	Echinops telfairi	76.40	1.00e-130	461.00
IUUC-Eca-033387	Equus caballus	66.95	0.00e+00	1369.00
IUUC-Eeu-035058	Erinaceus europaeus	60.80	0.00e+00	1293.00
IUUC-Fca-036578	Felis catus	71.69	0.00e+00	1155.00
IUUC-Fal-037491	Ficedula albicollis	68.39	0.00e+00	1413.00
IUUC-Gmo-038509	Gadus morhua	82.96	0.00e+00	1383.00
IUUC-Gga-040638	Gallus gallus	67.59	0.00e+00	1368.00
IUUC-Gac-042550	Gasterosteus aculeatus	83.82	0.00e+00	1754.00
IUUC-Ggo-044487	Gorilla gorilla	65.55	0.00e+00	1410.00
IUUC-Hsa-046636	Homo sapiens	65.71	0.00e+00	1410.00
IUUC-Itr-048685	Ictidomys tridecemlineatus	67.63	0.00e+00	1388.00
IUUC-Lch-049530	Latimeria chalumnae	73.21	0.00e+00	1312.00
IUUC-Loc-051933	Lepisosteus oculatus	76.75	0.00e+00	1564.00
IUUC-Laf-053802	Loxodonta africana	65.90	0.00e+00	1448.00
IUUC-Mcc-054836	Macaca mulatta	66.00	0.00e+00	1412.00
IUUC-Mga-059277	Meleagris gallopavo	68.20	0.00e+00	1379.00
IUUC-Mmr-061206	Microcebus murinus	65.87	0.00e+00	1368.00
IUUC-Mdo-062281	Monodelphis domestica	77.91	0.00e+00	1087.00
IUUC-Mmu-063847	Mus musculus	66.00	0.00e+00	1387.00
IUUC-Mac-064539	Musa acuminata	31.47	8.00e-19	89.40
IUUC-Mpu-066309	Mustela putorius furo	78.88	0.00e+00	1120.00
IUUC-Mlu-068070	Myotis lucifugus	68.19	0.00e+00	1378.00
IUUC-Nle-070062	Nomascus leucogenys	78.11	0.00e+00	1109.00
IUUC-Ont-072440	Oreochromis niloticus	87.29	0.00e+00	1872.00
IUUC-Oan-073526	Ornithorhynchus anatinus	73.25	0.00e+00	1267.00
IUUC-Ocu-074051	Oryctolagus cuniculus	72.55	0.00e+00	1231.00
IUUC-Oni-082734	Oryza nivara	34.55	5.00e-24	106.00
IUUC-Opu-083538	Oryza punctata	35.00	1.00e-23	105.00
IUUC-Ola-086752	Oryzias latipes	98.70	0.00e+00	936.00
IUUC-Oga-088767	Otolemur garnettii	62.54	0.00e+00	1186.00
IUUC-Oar-089800	Ovis aries	68.33	0.00e+00	1377.00
IUUC-Ptr-090857	Pan troglodytes	78.11	0.00e+00	1110.00
IUUC-Pan-092279	Papio anubis	65.33	0.00e+00	1398.00
IUUC-Psi-093573	Pelodiscus sinensis	67.70	0.00e+00	1347.00
IUUC-Pma-094420	Petromyzon marinus	74.34	0.00e+00	858.00
IUUC-Pfo-096543	Poecilia formosa	81.11	0.00e+00	1692.00
IUUC-Pab-097949	Pongo abelii	65.12	0.00e+00	1367.00
IUUC-Pca-100370	Procavia capensis	61.82	0.00e+00	930.00
IUUC-Pva-103220	Pteropus vampyrus	63.19	0.00e+00	1092.00
IUUC-Rno-105924	Rattus norvegicus	65.41	0.00e+00	1370.00
IUUC-Sha-107114	Sarcophilus harrisii	74.23	0.00e+00	1140.00
IUUC-Sit-110444	Setaria italica	33.67	1.00e-20	95.10
IUUC-Ssc-115968	Sus scrofa	68.69	0.00e+00	1297.00
IUUC-Tgu-117301	Taeniopygia guttata	68.72	0.00e+00	1401.00
IUUC-Tni-119991	Tetraodon nigroviridis	94.13	0.00e+00	2129.00
IUUC-Tca-121389	Theobroma cacao	33.85	1.00e-23	105.00
IUUC-Tbe-127362	Tupaia belangeri	64.30	0.00e+00	1351.00
IUUC-Ttr-129291	Tursiops truncatus	67.37	0.00e+00	1385.00
IUUC-Vpa-130800	Vicugna pacos	75.15	0.00e+00	1203.00
IUUC-Xtr-132965	Xenopus tropicalis	66.43	0.00e+00	1172.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence