iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000010270.5	ENSGALT00000061159.1	ENSGALP00000046725.1
ENSGALG00000010270.5	ENSGALT00000058902.1	ENSGALP00000045022.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.40e-101	338.4	502	839

Active Site

Position(s)	Description	Evidence
807	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k++ev f++Ee+ld+gG+ re+++l++k+l++++ +lf ++s+n+++ ++pnp + +    +lkl+ef+Grl+gk+l+++     
   Q: 502  SDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTSQLFtRFSDNNQALVHPNPGRPT--YVRLKLYEFAGRLVGKCLYESslgga 588
           7999**************************************788999**********986..48******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ dpe+yks + +i++n   d++e++l ++ ++ ++  +  k++eL++gG+++pVtneNk 
   Q: 589  ykQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSkVCFILNN---DVSEMDLVFAEEKYSKTGQLEKVVELVTGGAQVPVTNENKI 674
           99***********************************99****99...9*********9999999999********************* PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsse 259
            Y +l+++yrl ++++e+v++f +G+ne++p++ll++F+e+elell+cG+ +i+v d+k+++    g ++ ++++++wFw v+++f++e
   Q: 675  FYLNLLAQYRLANQVREEVDHFLKGLNELVPENLLAIFDENELELLMCGTGDISVCDFKAHAvVVGGSWHFREKVMRWFWTVVSSFTQE 763
           **************************************************************555788999****************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           e +++LqF+Tgss+lP+gGfa+l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+++++L++Ai+e+ +gF++
   Q: 764  ELARLLQFTTGSSQLPPGGFAALCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEEVHKMLQLAISEGcEGFGM 839
           ************************99555555.**************************************9***97 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MIDAAVILGC VSHRRDLMFY IIGGITVSVV AFFFTIKFLF ELAARIVSFL QHEDRERRGE 60
RTIYDYVRGN YLDPRSCKIS WDWKDPHEVG HSMAFRVHLF YKNGQPFPAH RPLGLRVHIC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGGCTAGC AAACTACAGG CTACAGGGAG CTGTGCTTCA GGGCAACCTT CTTCCACAAA 60
GAGGAAGAGA TTGCTGTGCT CAGGTCCTCG CCTTTCAGCA GTTTTTCCTG TGATGCAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

gga:423354

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	92.09	0.00e+00	1563.00
IUUC-Apl-004071	Anas platyrhynchos	98.91	0.00e+00	1569.00
IUUC-Aca-005218	Anolis carolinensis	94.54	0.00e+00	1541.00
IUUC-Ame-011871	Astyanax mexicanus	78.65	0.00e+00	1404.00
IUUC-Bta-012978	Bos taurus	91.49	0.00e+00	1555.00
IUUC-Cja-019081	Callithrix jacchus	91.37	0.00e+00	1554.00
IUUC-Cfa-020736	Canis familiaris	90.00	0.00e+00	1474.00
IUUC-Cpo-021581	Cavia porcellus	91.37	0.00e+00	1554.00
IUUC-Csa-024189	Chlorocebus sabaeus	88.94	0.00e+00	862.00
IUUC-Cho-024751	Choloepus hoffmanni	91.25	0.00e+00	1490.00
IUUC-Cin-025773	Ciona intestinalis	43.01	4.00e-149	521.00
IUUC-Csv-026090	Ciona savignyi	40.57	1.00e-172	600.00
IUUC-Dre-027788	Danio rerio	78.83	0.00e+00	1403.00
IUUC-Dno-030022	Dasypus novemcinctus	91.13	0.00e+00	1550.00
IUUC-Dme-031577	Drosophila melanogaster	47.43	0.00e+00	723.00
IUUC-Ete-032402	Echinops telfairi	89.50	0.00e+00	1476.00
IUUC-Eca-033908	Equus caballus	92.10	0.00e+00	1564.00
IUUC-Eeu-034869	Erinaceus europaeus	93.74	0.00e+00	892.00
IUUC-Fca-036023	Felis catus	92.35	0.00e+00	1565.00
IUUC-Fal-037477	Ficedula albicollis	97.26	0.00e+00	1635.00
IUUC-Gmo-039197	Gadus morhua	79.95	0.00e+00	1375.00
IUUC-Gac-041511	Gasterosteus aculeatus	78.61	0.00e+00	1377.00
IUUC-Ggo-044527	Gorilla gorilla	88.11	0.00e+00	1483.00
IUUC-Hsa-046082	Homo sapiens	91.37	0.00e+00	1555.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	92.10	0.00e+00	1561.00
IUUC-Lch-049772	Latimeria chalumnae	77.03	0.00e+00	1261.00
IUUC-Loc-052541	Lepisosteus oculatus	80.83	0.00e+00	1421.00
IUUC-Laf-053852	Loxodonta africana	91.13	0.00e+00	1545.00
IUUC-Mcc-054759	Macaca mulatta	88.91	0.00e+00	778.00
IUUC-Meu-056247	Macropus eugenii	76.01	0.00e+00	819.00
IUUC-Mga-060161	Meleagris gallopavo	98.67	0.00e+00	1606.00
IUUC-Mmr-061447	Microcebus murinus	91.62	0.00e+00	1556.00
IUUC-Mdo-062110	Monodelphis domestica	91.01	0.00e+00	1495.00
IUUC-Mmu-064349	Mus musculus	91.25	0.00e+00	1556.00
IUUC-Mpu-065824	Mustela putorius furo	92.22	0.00e+00	1556.00
IUUC-Mlu-067729	Myotis lucifugus	91.98	0.00e+00	1530.00
IUUC-Nle-069721	Nomascus leucogenys	91.25	0.00e+00	1545.00
IUUC-Opr-070189	Ochotona princeps	92.04	0.00e+00	1553.00
IUUC-Ont-072122	Oreochromis niloticus	79.83	0.00e+00	1368.00
IUUC-Oan-072700	Ornithorhynchus anatinus	83.36	0.00e+00	1212.00
IUUC-Ocu-074057	Oryctolagus cuniculus	91.74	0.00e+00	1559.00
IUUC-Ola-087492	Oryzias latipes	79.10	0.00e+00	1381.00
IUUC-Oga-088084	Otolemur garnettii	91.62	0.00e+00	1552.00
IUUC-Oar-090354	Ovis aries	91.15	0.00e+00	1529.00
IUUC-Ptr-091456	Pan troglodytes	91.37	0.00e+00	1553.00
IUUC-Pan-092596	Papio anubis	90.17	0.00e+00	1526.00
IUUC-Psi-092942	Pelodiscus sinensis	94.78	0.00e+00	1564.00
IUUC-Pma-094662	Petromyzon marinus	63.21	0.00e+00	763.00
IUUC-Pfo-096838	Poecilia formosa	79.31	0.00e+00	1363.00
IUUC-Pab-097849	Pongo abelii	90.89	0.00e+00	1548.00
IUUC-Pca-100498	Procavia capensis	89.58	0.00e+00	889.00
IUUC-Pva-102599	Pteropus vampyrus	92.22	0.00e+00	1544.00
IUUC-Rno-105776	Rattus norvegicus	91.86	0.00e+00	1556.00
IUUC-Sha-106699	Sarcophilus harrisii	91.37	0.00e+00	1502.00
IUUC-Sar-113621	Sorex araneus	90.28	0.00e+00	1502.00
IUUC-Ssc-115742	Sus scrofa	91.62	0.00e+00	1558.00
IUUC-Tgu-116490	Taeniopygia guttata	96.96	0.00e+00	1602.00
IUUC-Tru-117679	Takifugu rubripes	79.59	0.00e+00	1366.00
IUUC-Tsy-119607	Tarsius syrichta	88.12	0.00e+00	1075.00
IUUC-Tni-120376	Tetraodon nigroviridis	75.85	0.00e+00	1285.00
IUUC-Tbe-127348	Tupaia belangeri	63.49	2.00e-174	604.00
IUUC-Ttr-128786	Tursiops truncatus	88.34	0.00e+00	1488.00
IUUC-Vpa-130180	Vicugna pacos	90.53	0.00e+00	1227.00
IUUC-Xtr-132631	Xenopus tropicalis	68.61	0.00e+00	1152.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence