iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088367

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAQR03016783

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000008473.2	ENSOGAT00000008476.2	ENSOGAP00000007590.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.90e-97	324.6	273	678

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenp.................................... 42
           tGl+NlgNtCYmNSvLQ+Ls++  +r+++l+           ++        +                                    
   Q: 273  TGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKldlnqwlavtaSD--------Ktrssykhppvtdtlvcqmnecqekdtsfvrsrhysl 353
           7******************************8777666654422........1334444568889999999999988899999999999 PP
   S: 43   ......................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk 109
                                 +++  +l+++l++lf+ +w++++  vsp ++l++++++ + f+gy+qqDaqEfl+ lld+++ el  
   Q: 354  ssglsggasksrkmeliqprepSSQYISLCHELHTLFQVMWSGRWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQHEL-- 440
           999999998888888888877777777************************************************************.. PP
   S: 110  eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......slqdcL 191
                  e+++++  +l   +++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +        ++++L
   Q: 441  -------ETTGTSLPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCSGKdaasqpcLVTEML 522
           .......7889999999999************************************************888877668888888****** PP
   S: 192  esftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspe 269
           ++ft++e leg+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++++
   Q: 523  AKFTETEALEGKI-YVCDQCNSKRRrfssksvvlteAQKQLMICHLPQVLRLHLKRFRWSGR-NNREKIGVHVGFEEILNMEPYCCRET 609
           **********965.*******999999999999999***********************998.7778********************99 PP
   S: 270  ekqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
            k+ +  + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++++ev++   ++aY+lfY++
   Q: 610  LKSLRpeCFIYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLSLCTMDEVCK---AQAYILFYTQ 678
           88876779***************************9999********************...********98 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MLTMDKCKHV GQLRLAQDHS ILNPQKWHCV DCNTTESIWA CLSCSHVACG RYIEEHALKH 60
FQESSHPVAL EVNEMYVFCY LCDDYVLNDN ATGDLKLLRS TLSAIKSQNY YCTTRSGRVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAGTTTTCAG ATACTTCAAG TATTGTGAAC AGAGACTGAT TTGGATTATG TGTTTCTCAG 60
CTAGACTAAA TAAATGTTAA CAATGGATAA ATGCAAACAC GTTGGGCAGT TGCGACTTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	93.13	0.00e+00	1323.00
IUUC-Apl-003673	Anas platyrhynchos	76.16	0.00e+00	1066.00
IUUC-Aca-004434	Anolis carolinensis	73.26	0.00e+00	1045.00
IUUC-Ame-010986	Astyanax mexicanus	64.91	0.00e+00	885.00
IUUC-Bta-012774	Bos taurus	90.88	0.00e+00	1284.00
IUUC-Cja-019619	Callithrix jacchus	92.57	0.00e+00	1294.00
IUUC-Cfa-020957	Canis familiaris	92.29	0.00e+00	1335.00
IUUC-Csa-023177	Chlorocebus sabaeus	92.43	0.00e+00	1293.00
IUUC-Cho-024877	Choloepus hoffmanni	90.36	0.00e+00	845.00
IUUC-Cin-025587	Ciona intestinalis	48.97	4.00e-109	389.00
IUUC-Csv-025814	Ciona savignyi	44.89	9.00e-153	533.00
IUUC-Dre-027878	Danio rerio	73.13	0.00e+00	627.00
IUUC-Dno-029832	Dasypus novemcinctus	91.58	0.00e+00	1308.00
IUUC-Ete-032627	Echinops telfairi	87.54	0.00e+00	1239.00
IUUC-Eca-033863	Equus caballus	88.03	0.00e+00	1229.00
IUUC-Eeu-035225	Erinaceus europaeus	86.26	0.00e+00	1191.00
IUUC-Fca-036288	Felis catus	92.57	0.00e+00	1322.00
IUUC-Fal-037207	Ficedula albicollis	74.23	0.00e+00	1014.00
IUUC-Gga-040457	Gallus gallus	74.47	0.00e+00	1030.00
IUUC-Ggo-044926	Gorilla gorilla	92.71	0.00e+00	1291.00
IUUC-Hsa-046079	Homo sapiens	92.15	0.00e+00	1289.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	91.44	0.00e+00	1281.00
IUUC-Lch-050260	Latimeria chalumnae	67.79	0.00e+00	931.00
IUUC-Laf-054491	Loxodonta africana	89.57	0.00e+00	1221.00
IUUC-Mcc-055694	Macaca mulatta	92.85	0.00e+00	1295.00
IUUC-Mga-059523	Meleagris gallopavo	74.44	0.00e+00	1046.00
IUUC-Mmr-060885	Microcebus murinus	94.81	0.00e+00	1345.00
IUUC-Mdo-063018	Monodelphis domestica	80.06	0.00e+00	1124.00
IUUC-Mmu-064012	Mus musculus	81.07	0.00e+00	1101.00
IUUC-Mpu-066207	Mustela putorius furo	91.30	0.00e+00	1330.00
IUUC-Mlu-066929	Myotis lucifugus	88.14	0.00e+00	1191.00
IUUC-Nle-069313	Nomascus leucogenys	82.66	0.00e+00	1113.00
IUUC-Opr-070375	Ochotona princeps	82.91	0.00e+00	1129.00
IUUC-Ont-071637	Oreochromis niloticus	63.57	0.00e+00	867.00
IUUC-Oan-073030	Ornithorhynchus anatinus	79.04	0.00e+00	859.00
IUUC-Ocu-074836	Oryctolagus cuniculus	88.31	0.00e+00	1243.00
IUUC-Oar-089953	Ovis aries	91.88	0.00e+00	1320.00
IUUC-Ptr-090980	Pan troglodytes	92.29	0.00e+00	1291.00
IUUC-Pan-092748	Papio anubis	93.13	0.00e+00	1296.00
IUUC-Pab-098514	Pongo abelii	92.57	0.00e+00	1294.00
IUUC-Pva-102984	Pteropus vampyrus	91.97	0.00e+00	1274.00
IUUC-Rno-106019	Rattus norvegicus	80.17	0.00e+00	1129.00
IUUC-Sha-106965	Sarcophilus harrisii	79.15	0.00e+00	1118.00
IUUC-Ssc-115299	Sus scrofa	91.87	0.00e+00	1324.00
IUUC-Tgu-117160	Taeniopygia guttata	74.74	0.00e+00	1019.00
IUUC-Tru-118156	Takifugu rubripes	61.21	0.00e+00	841.00
IUUC-Tni-119733	Tetraodon nigroviridis	62.21	0.00e+00	857.00
IUUC-Tbe-128084	Tupaia belangeri	85.39	0.00e+00	1233.00
IUUC-Ttr-128928	Tursiops truncatus	93.41	0.00e+00	1330.00
IUUC-Vpa-130706	Vicugna pacos	92.57	0.00e+00	1318.00
IUUC-Xtr-132061	Xenopus tropicalis	72.15	0.00e+00	957.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence