iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089551

Ensembl Protein ID

ENSOARP00000013182.1

UniProt Accession

W5PRV3; W5PRV3_SHEEP

Genbank Protein ID

ENSOARP00000013182

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01049075

Gene Name

TLE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000012299.1	ENSOART00000013376.1	ENSOARP00000013182.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.90e-21	75.5	615	653

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 615  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 653
           8***********999*********************998 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

LYPTARIPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH 60
YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTATCCAA CCGCCCGCAT CCCGGTCGCT CGGTCCCCCT CGCTGGTCGC CCTTAGACGC 60
CGCACCAGGC TGCAGGCCAG CCCTTCAAGT TCACTATCCC GGAGTCCCTG GACCGGATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0001106--F:RNA polymerase II transcription corepressor activity
GO:2000811--P:negative regulation of anoikis
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0010628--P:positive regulation of gene expression

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001746	Ailuropoda melanoleuca	93.94	0.00e+00	1243.00
IUUC-Apl-003594	Anas platyrhynchos	94.67	0.00e+00	1241.00
IUUC-Aca-005053	Anolis carolinensis	93.34	0.00e+00	1273.00
IUUC-Bta-013380	Bos taurus	90.79	0.00e+00	1161.00
IUUC-Cja-019135	Callithrix jacchus	98.31	0.00e+00	1293.00
IUUC-Cfa-020611	Canis familiaris	98.88	0.00e+00	1186.00
IUUC-Cpo-022495	Cavia porcellus	97.67	0.00e+00	1290.00
IUUC-Csa-024056	Chlorocebus sabaeus	98.18	0.00e+00	1310.00
IUUC-Dre-028144	Danio rerio	69.66	0.00e+00	953.00
IUUC-Dno-029011	Dasypus novemcinctus	97.67	0.00e+00	1288.00
IUUC-Ete-032533	Echinops telfairi	85.73	0.00e+00	1174.00
IUUC-Eca-033351	Equus caballus	98.57	0.00e+00	1296.00
IUUC-Eeu-034666	Erinaceus europaeus	98.79	0.00e+00	1070.00
IUUC-Fal-036696	Ficedula albicollis	97.62	0.00e+00	1255.00
IUUC-Gga-041113	Gallus gallus	97.15	0.00e+00	1343.00
IUUC-Gac-041999	Gasterosteus aculeatus	80.13	0.00e+00	1169.00
IUUC-Ggo-045164	Gorilla gorilla	98.31	0.00e+00	1311.00
IUUC-Hsa-047011	Homo sapiens	98.31	0.00e+00	1311.00
IUUC-Lch-050437	Latimeria chalumnae	94.51	0.00e+00	1117.00
IUUC-Loc-052819	Lepisosteus oculatus	90.28	0.00e+00	1220.00
IUUC-Laf-053862	Loxodonta africana	95.01	0.00e+00	1255.00
IUUC-Mcc-055735	Macaca mulatta	94.16	0.00e+00	1295.00
IUUC-Mmr-061207	Microcebus murinus	94.75	0.00e+00	1246.00
IUUC-Mdo-062493	Monodelphis domestica	97.67	0.00e+00	1342.00
IUUC-Mmu-063795	Mus musculus	92.46	0.00e+00	1249.00
IUUC-Mpu-065819	Mustela putorius furo	98.06	0.00e+00	1321.00
IUUC-Mlu-067047	Myotis lucifugus	98.18	0.00e+00	1280.00
IUUC-Nle-069684	Nomascus leucogenys	98.18	0.00e+00	1306.00
IUUC-Opr-071172	Ochotona princeps	97.15	0.00e+00	1272.00
IUUC-Ont-072102	Oreochromis niloticus	80.59	0.00e+00	1181.00
IUUC-Ocu-074592	Oryctolagus cuniculus	94.55	0.00e+00	1297.00
IUUC-Oga-088629	Otolemur garnettii	95.26	0.00e+00	1251.00
IUUC-Ptr-091207	Pan troglodytes	97.92	0.00e+00	1306.00
IUUC-Pan-091822	Papio anubis	94.16	0.00e+00	1295.00
IUUC-Psi-093594	Pelodiscus sinensis	94.84	0.00e+00	1271.00
IUUC-Pma-094452	Petromyzon marinus	77.81	0.00e+00	1102.00
IUUC-Pfo-096239	Poecilia formosa	79.67	0.00e+00	1173.00
IUUC-Pab-097687	Pongo abelii	98.95	0.00e+00	1305.00
IUUC-Pca-100675	Procavia capensis	98.08	0.00e+00	1047.00
IUUC-Pva-102355	Pteropus vampyrus	94.99	0.00e+00	1196.00
IUUC-Rno-106027	Rattus norvegicus	95.60	0.00e+00	1301.00
IUUC-Sha-107419	Sarcophilus harrisii	95.50	0.00e+00	1268.00
IUUC-Sar-113585	Sorex araneus	86.23	0.00e+00	712.00
IUUC-Ssc-116151	Sus scrofa	98.44	0.00e+00	1297.00
IUUC-Tgu-117387	Taeniopygia guttata	96.50	0.00e+00	1320.00
IUUC-Tsy-119342	Tarsius syrichta	91.63	0.00e+00	1015.00
IUUC-Tbe-127881	Tupaia belangeri	95.20	0.00e+00	1278.00
IUUC-Xtr-131792	Xenopus tropicalis	88.29	0.00e+00	1221.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence