iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-072958

UUCD1 version

UUC-OrA-00422

Ensembl Protein ID

ENSOANP00000021058.2

UniProt Accession

F7E6V0; F7E6V0_ORNAN

Protein Name

Uncharacterized protein

Gene Name

UBR5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000013340.2	ENSOANT00000021061.2	ENSOANP00000021058.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.20e-79	266.3	2221	2543

Active Site

Position(s)	Description	Evidence
2513	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 17   egldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykll 100
           e+ + +G++r ++++ ++++ + d  ++lf +  +++ +t +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k l
   Q: 2221 ENRKRHGSSRSVVDMELDDTDDGDdnAPLFyQPGKRGFYTPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVL 2303
           456677999999999999999988777888234444777777777765....89********************************* PP
   S: 101  lgkklsledleevdpelyks.lkeikena..esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlke 184
           lg+k++++d++ +dp +y+s  + i++++  ++d   +++dl+f ++ ++ +   ++eL+++G nipVt +N +eYv++++e+r+  
   Q: 2304 LGRKVNWHDFAFFDPVMYESlRQLILASQstDADAVFAAMDLAFAIDLCKEEGGGQVELISNGVNIPVTPQNVYEYVRKYAEHRMLV 2390
           ********************5555666655566889999************************************************ PP
   S: 185  gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLqF 267
             ++ ++a+r+G+ +v+p+++l+ +t+e+++ll++G+ e++v++l ++t+++++  e+ +++    +wFw+++e++s++er++++ F
   Q: 2391 VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLlqfkRWFWSIVEKMSMTERQDLVYF 2477
           ***************************************************9999999999989999******************** PP
   S: 268  vTgssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +T+s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2478 WTSSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2543
           *********999******..799999.99**********************************9.99875 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MSLLDADIHS AHPSVIIDAD AMFSEDISYF GYPSFRRSSL SRLGSSRERD SELLRERESV 60
LRLRERRWLD GASFDNERGS TSKEGEPNLD KKNTPVQSPV SLGEDLQWWP DKDGTKFISI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGACCTCCT ATAGTATTTG GCCTTTAATC TATTGTTTCT ATTTGTAGAA GATCTTATGT 60
CTCTTCTGGA TGCTGATATT CATTCTGCAC ACCCAAGTGT TATTATTGAT GCTGATGCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51309--PABC
PS51157--ZF_UBR

Pfam

PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1

Gene Ontology

GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	98.59	0.00e+00	4190.00
IUUC-Apl-004165	Anas platyrhynchos	97.96	0.00e+00	4180.00
IUUC-Aca-004577	Anolis carolinensis	96.55	0.00e+00	3933.00
IUUC-Ame-010702	Astyanax mexicanus	84.56	0.00e+00	2472.00
IUUC-Bta-012313	Bos taurus	97.61	0.00e+00	4200.00
IUUC-Cel-018165	Caenorhabditis elegans	35.31	6.00e-68	253.00
IUUC-Cja-019858	Callithrix jacchus	97.49	0.00e+00	4218.00
IUUC-Cfa-020973	Canis familiaris	97.76	0.00e+00	4207.00
IUUC-Cpo-022108	Cavia porcellus	97.32	0.00e+00	1899.00
IUUC-Csa-023985	Chlorocebus sabaeus	98.62	0.00e+00	4238.00
IUUC-Cho-025034	Choloepus hoffmanni	88.91	0.00e+00	983.00
IUUC-Cin-025715	Ciona intestinalis	39.72	0.00e+00	810.00
IUUC-Csv-026088	Ciona savignyi	40.02	4.00e-158	551.00
IUUC-Dre-027730	Danio rerio	88.30	0.00e+00	3685.00
IUUC-Dno-029123	Dasypus novemcinctus	94.76	0.00e+00	4026.00
IUUC-Dor-030757	Dipodomys ordii	92.61	0.00e+00	2506.00
IUUC-Dme-032192	Drosophila melanogaster	51.67	3.00e-173	603.00
IUUC-Ete-032292	Echinops telfairi	95.03	0.00e+00	2155.00
IUUC-Eca-034347	Equus caballus	97.45	0.00e+00	4160.00
IUUC-Eeu-034873	Erinaceus europaeus	92.63	0.00e+00	3976.00
IUUC-Fca-036485	Felis catus	96.21	0.00e+00	4102.00
IUUC-Fal-037071	Ficedula albicollis	98.82	0.00e+00	4202.00
IUUC-Gmo-039589	Gadus morhua	89.32	0.00e+00	3715.00
IUUC-Gga-041195	Gallus gallus	96.00	0.00e+00	4083.00
IUUC-Gac-042538	Gasterosteus aculeatus	89.19	0.00e+00	3753.00
IUUC-Ggo-045351	Gorilla gorilla	96.60	0.00e+00	4246.00
IUUC-Hsa-045941	Homo sapiens	97.53	0.00e+00	4242.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	97.41	0.00e+00	4195.00
IUUC-Lch-050480	Latimeria chalumnae	94.20	0.00e+00	4063.00
IUUC-Loc-052664	Lepisosteus oculatus	89.31	0.00e+00	3837.00
IUUC-Laf-053935	Loxodonta africana	98.10	0.00e+00	1575.00
IUUC-Mcc-054703	Macaca mulatta	98.62	0.00e+00	4241.00
IUUC-Meu-056431	Macropus eugenii	88.26	0.00e+00	802.00
IUUC-Mga-059289	Meleagris gallopavo	97.88	0.00e+00	3617.00
IUUC-Mmr-061737	Microcebus murinus	97.10	0.00e+00	4124.00
IUUC-Mdo-062499	Monodelphis domestica	97.84	0.00e+00	4205.00
IUUC-Mmu-063273	Mus musculus	96.51	0.00e+00	4147.00
IUUC-Mpu-066907	Mustela putorius furo	98.58	0.00e+00	4188.00
IUUC-Mlu-067942	Myotis lucifugus	98.24	0.00e+00	4215.00
IUUC-Nle-069527	Nomascus leucogenys	97.53	0.00e+00	4250.00
IUUC-Opr-070626	Ochotona princeps	86.49	0.00e+00	1416.00
IUUC-Ont-071951	Oreochromis niloticus	88.97	0.00e+00	3695.00
IUUC-Ocu-074503	Oryctolagus cuniculus	95.76	0.00e+00	4090.00
IUUC-Ola-086757	Oryzias latipes	88.87	0.00e+00	3772.00
IUUC-Oga-088781	Otolemur garnettii	97.37	0.00e+00	4186.00
IUUC-Oar-089274	Ovis aries	98.51	0.00e+00	4192.00
IUUC-Ptr-090669	Pan troglodytes	98.23	0.00e+00	3978.00
IUUC-Pan-092226	Papio anubis	97.38	0.00e+00	4199.00
IUUC-Psi-093502	Pelodiscus sinensis	97.69	0.00e+00	4180.00
IUUC-Pma-094454	Petromyzon marinus	77.51	0.00e+00	736.00
IUUC-Pfo-096173	Poecilia formosa	87.75	0.00e+00	3747.00
IUUC-Pab-098355	Pongo abelii	97.35	0.00e+00	3024.00
IUUC-Pca-100570	Procavia capensis	98.36	0.00e+00	1153.00
IUUC-Pva-102572	Pteropus vampyrus	94.25	0.00e+00	1337.00
IUUC-Rno-104916	Rattus norvegicus	95.73	0.00e+00	3923.00
IUUC-Sha-106653	Sarcophilus harrisii	97.85	0.00e+00	4199.00
IUUC-Sar-113517	Sorex araneus	97.09	0.00e+00	1117.00
IUUC-Ssc-115470	Sus scrofa	98.54	0.00e+00	2505.00
IUUC-Tgu-116932	Taeniopygia guttata	98.59	0.00e+00	4188.00
IUUC-Tru-117682	Takifugu rubripes	88.19	0.00e+00	2579.00
IUUC-Tsy-119417	Tarsius syrichta	93.89	0.00e+00	2443.00
IUUC-Tni-120442	Tetraodon nigroviridis	83.80	0.00e+00	3405.00
IUUC-Tbe-127456	Tupaia belangeri	85.84	0.00e+00	2096.00
IUUC-Ttr-128606	Tursiops truncatus	95.01	0.00e+00	1252.00
IUUC-Vpa-130112	Vicugna pacos	95.70	0.00e+00	3709.00
IUUC-Xtr-131929	Xenopus tropicalis	94.70	0.00e+00	4081.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence