iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000014149.3	ENSXETT00000030896.3	ENSXETP00000030896.3
ENSXETG00000014149.3	ENSXETT00000060698.1	ENSXETP00000062619.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.80e-87	294.0	2261	2528

Active Site

Position(s)	Description	Evidence
2497	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 104  klsledleevdpelykslkeikena........es..........................dieelgldltfsvseeilgetkeeeL 156
            l++ed+e ++p+++++l  i+e+a        ++                          +ie+lgl+++f++s++++g  +++ L
   Q: 2261 ILTWEDFELINPHRARFLRDIRELAvkrrqilgNRclsedekntqlqelmlknpsgsgppvSIEDLGLNFQFCPSSRVYGFSAVD-L 2346
           69**********************976655555006666677788889999999999************************9999.* PP
   S: 157  kpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe..eeidvedlkketkykggyte 241
            p+Ge+++Vt++N+eeYv+l++++++++g+++q+eafr+Gfn+v+p+e+l +F++ee+++++cG+  +++++ed+ + t+ k gyt+
   Q: 2347 RPNGEDEMVTIDNAEEYVDLMFDFCMQTGVQKQMEAFRSGFNKVFPMEKLGSFSPEEVQMILCGNqsPSWSAEDIINYTEPKLGYTR 2433
           *****************************************************************5556666666666666****** PP
   S: 242  dspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAi 327
           +sp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+v+rk da+d+++Ps+nTC++yLkLPeYss+ei++++Ll+A+
   Q: 2434 ESPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKvDATDASYPSVNTCVHYLKLPEYSSEEIMRDRLLAAT 2520
           *************************************************************************************** PP
   S: 328  eetkgFels 336
           +e kgF+l+
   Q: 2521 ME-KGFHLN 2528
           **.****86 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVEGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGACG TAGATCCAGA CACACTACTG GAATGGCTGC AGATGGGGCA GGGGGACGAG 60
AGAGACATGC AGCTCATTGC CTTGGAACAG CTCTGCATGC TGCTGCTCAT GTCGGATAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	85.54	0.00e+00	2539.00
IUUC-Apl-003493	Anas platyrhynchos	85.76	0.00e+00	2540.00
IUUC-Aca-004521	Anolis carolinensis	82.76	0.00e+00	3834.00
IUUC-Ame-011258	Astyanax mexicanus	90.72	0.00e+00	2356.00
IUUC-Bta-012835	Bos taurus	85.19	0.00e+00	2542.00
IUUC-Cel-018153	Caenorhabditis elegans	51.93	1.00e-171	598.00
IUUC-Cja-019174	Callithrix jacchus	83.96	0.00e+00	2460.00
IUUC-Cfa-021115	Canis familiaris	85.13	0.00e+00	2492.00
IUUC-Cpo-022382	Cavia porcellus	79.50	0.00e+00	2298.00
IUUC-Csa-023230	Chlorocebus sabaeus	85.48	0.00e+00	2540.00
IUUC-Cho-024711	Choloepus hoffmanni	74.88	0.00e+00	1271.00
IUUC-Cin-025342	Ciona intestinalis	53.25	0.00e+00	1389.00
IUUC-Csv-026031	Ciona savignyi	51.03	0.00e+00	1354.00
IUUC-Dre-027435	Danio rerio	87.88	0.00e+00	2332.00
IUUC-Dno-029954	Dasypus novemcinctus	85.48	0.00e+00	2513.00
IUUC-Dor-030734	Dipodomys ordii	87.43	0.00e+00	1377.00
IUUC-Dme-031739	Drosophila melanogaster	58.33	0.00e+00	1586.00
IUUC-Ete-033192	Echinops telfairi	83.59	0.00e+00	1134.00
IUUC-Eca-033434	Equus caballus	84.65	0.00e+00	2505.00
IUUC-Eeu-035031	Erinaceus europaeus	76.08	0.00e+00	1027.00
IUUC-Fca-035998	Felis catus	87.96	0.00e+00	2560.00
IUUC-Fal-037468	Ficedula albicollis	82.55	0.00e+00	3802.00
IUUC-Gmo-038495	Gadus morhua	87.23	0.00e+00	1339.00
IUUC-Gga-040736	Gallus gallus	83.33	0.00e+00	3801.00
IUUC-Gac-041777	Gasterosteus aculeatus	89.18	0.00e+00	2265.00
IUUC-Ggo-044677	Gorilla gorilla	81.35	0.00e+00	2356.00
IUUC-Hsa-045879	Homo sapiens	85.48	0.00e+00	2540.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	85.66	0.00e+00	2542.00
IUUC-Lch-050444	Latimeria chalumnae	84.32	0.00e+00	2442.00
IUUC-Loc-051986	Lepisosteus oculatus	86.08	0.00e+00	2533.00
IUUC-Laf-054230	Loxodonta africana	84.99	0.00e+00	2471.00
IUUC-Mcc-054787	Macaca mulatta	85.48	0.00e+00	2540.00
IUUC-Meu-056502	Macropus eugenii	69.46	0.00e+00	1012.00
IUUC-Mga-059409	Meleagris gallopavo	92.70	0.00e+00	1888.00
IUUC-Mmr-061667	Microcebus murinus	84.69	0.00e+00	2504.00
IUUC-Mdo-061960	Monodelphis domestica	85.61	0.00e+00	2521.00
IUUC-Mmu-063941	Mus musculus	84.44	0.00e+00	2494.00
IUUC-Mpu-065939	Mustela putorius furo	85.48	0.00e+00	2538.00
IUUC-Mlu-068112	Myotis lucifugus	85.30	0.00e+00	2536.00
IUUC-Nle-069001	Nomascus leucogenys	85.48	0.00e+00	2539.00
IUUC-Opr-071222	Ochotona princeps	88.08	0.00e+00	2023.00
IUUC-Ont-072101	Oreochromis niloticus	86.71	0.00e+00	2337.00
IUUC-Oan-072814	Ornithorhynchus anatinus	86.12	0.00e+00	2521.00
IUUC-Ocu-074011	Oryctolagus cuniculus	85.54	0.00e+00	2542.00
IUUC-Ola-086412	Oryzias latipes	89.35	0.00e+00	2284.00
IUUC-Oar-089668	Ovis aries	85.13	0.00e+00	2536.00
IUUC-Ptr-090517	Pan troglodytes	84.80	0.00e+00	2494.00
IUUC-Pan-091849	Papio anubis	82.38	0.00e+00	2407.00
IUUC-Psi-093390	Pelodiscus sinensis	84.71	0.00e+00	3855.00
IUUC-Pma-094628	Petromyzon marinus	80.94	0.00e+00	1563.00
IUUC-Pfo-097075	Poecilia formosa	89.71	0.00e+00	2320.00
IUUC-Pab-098176	Pongo abelii	85.48	0.00e+00	2540.00
IUUC-Pca-101123	Procavia capensis	71.91	0.00e+00	1206.00
IUUC-Pva-103008	Pteropus vampyrus	92.56	0.00e+00	1539.00
IUUC-Rno-105885	Rattus norvegicus	85.13	0.00e+00	2529.00
IUUC-Sha-107048	Sarcophilus harrisii	85.15	0.00e+00	2503.00
IUUC-Sar-113071	Sorex araneus	86.39	0.00e+00	1228.00
IUUC-Ssc-115963	Sus scrofa	84.58	0.00e+00	2536.00
IUUC-Tgu-117488	Taeniopygia guttata	91.86	0.00e+00	1305.00
IUUC-Tru-118626	Takifugu rubripes	86.20	0.00e+00	2312.00
IUUC-Tsy-119504	Tarsius syrichta	81.53	0.00e+00	1969.00
IUUC-Tni-119877	Tetraodon nigroviridis	89.13	0.00e+00	2278.00
IUUC-Tbe-127602	Tupaia belangeri	87.12	0.00e+00	1005.00
IUUC-Ttr-128394	Tursiops truncatus	76.74	0.00e+00	1316.00
IUUC-Vpa-130280	Vicugna pacos	85.01	0.00e+00	2514.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence