iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063725

UUCD1 version

UUC-MuM-00008

Ensembl Protein ID

ENSMUSP00000146244.1

UniProt Accession

P22682; Q3U527; Q8CEA1; CBL_MOUSE

Genbank Protein ID

CAA40394.1; BAC26087.1; BAE32253.1; AAI25286.1

Protein Name

E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING-type E3 ubiquitin transferase CBL; Signal transduction protein CBL

Genbank Nucleotide ID

X57111; AK028730; AK153915; BC125285

Gene Name

Cbl

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000034342.9	ENSMUST00000206720.1	ENSMUSP00000146244.1
ENSMUSG00000034342.9	ENSMUST00000206147.1	ENSMUSP00000145827.1
ENSMUSG00000034342.9	ENSMUST00000037644.7	ENSMUSP00000041902.7
ENSMUSG00000034342.9	ENSMUST00000205968.1	ENSMUSP00000146287.1
ENSMUSG00000034342.9	ENSMUST00000206258.1	ENSMUSP00000145538.1
ENSMUSG00000034342.9	ENSMUST00000206540.1	ENSMUSP00000145889.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20682791
UBD/Alpha-Helix/UBA	UBA	9653117; 10393178; 20100865

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	4.30e-07	31.5	379	418
UBD/Alpha-Helix/UBA	3.00e-05	25.1	864	899

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl  w    + +s  + CP Cr
   Q: 379  CKICAENDKD-VKIEPCGHLMCTSCLTSW----Q-ESEGQGCPFCR 418
           99********.******************....5.555555****8 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyL 38
           +++ +e l+++G++ +++++aL  a+nn+e+A + L
   Q: 864  LSSEIERLMSQGYSYQDIQKALVIAHNNIEMAKNIL 899
           67889***************************9988 PP

Organism

Mus musculus

Functional Description
(View)

Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-737' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.

Protein Sequence
(Fasta)

MAGNVKKSSG AGGGGSGGSG AGGLIGLMKD AFQPHHHHHH LSPHPPCTVD KKMVEKCWKL 60
MDKVVRLCQN PKLALKNSPP YILDLLPDTY QHLRTVLSRY EGKMETLGEN EYFRVFMENL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCCGCGCTC GCGCCCGCGC AGGGGCGCGC CTCAGGGCGG GCGCCTCCCT CTCACTCCCT 60
GGGCTGCGAG CGCCGGCGGT GGTTGCCGGA GAGGCCCCTC CTTCTCGCCC GGCTCCATTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0106--Calcium
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
PF00627--UBA

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0030424--C:axon
GO:0005913--C:cell-cell adherens junction
GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030426--C:growth cone
GO:0042629--C:mast cell granule
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0098641--F:cadherin binding involved in cell-cell adhesion
GO:0005509--F:calcium ion binding
GO:0046875--F:ephrin receptor binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0045453--P:bone resorption
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071364--P:cellular response to epidermal growth factor stimulus
GO:1990090--P:cellular response to nerve growth factor stimulus
GO:0090650--P:cellular response to oxygen-glucose deprivation
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0008584--P:male gonad development
GO:0043303--P:mast cell degranulation
GO:0043066--P:negative regulation of apoptotic process
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:1901215--P:negative regulation of neuron death
GO:0070997--P:neuron death
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0006513--P:protein monoubiquitination
GO:0006468--P:protein phosphorylation
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006508--P:proteolysis
GO:0014823--P:response to activity
GO:0046677--P:response to antibiotic
GO:0045471--P:response to ethanol
GO:0010332--P:response to gamma radiation
GO:0042594--P:response to starvation
GO:0033574--P:response to testosterone

KEGG

mmu:12402

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002357	Ailuropoda melanoleuca	90.50	0.00e+00	1472.00
IUUC-Apl-004041	Anas platyrhynchos	84.28	0.00e+00	1388.00
IUUC-Aca-004899	Anolis carolinensis	81.67	0.00e+00	1273.00
IUUC-Ame-010746	Astyanax mexicanus	58.95	0.00e+00	630.00
IUUC-Bta-012759	Bos taurus	90.58	0.00e+00	1523.00
IUUC-Cja-019207	Callithrix jacchus	90.63	0.00e+00	1541.00
IUUC-Cfa-020897	Canis familiaris	90.63	0.00e+00	1503.00
IUUC-Cpo-021453	Cavia porcellus	91.55	0.00e+00	1518.00
IUUC-Csa-023136	Chlorocebus sabaeus	90.95	0.00e+00	1524.00
IUUC-Cho-024282	Choloepus hoffmanni	83.30	0.00e+00	1233.00
IUUC-Cin-025574	Ciona intestinalis	71.28	4.00e-178	617.00
IUUC-Csv-025938	Ciona savignyi	69.62	2.00e-173	601.00
IUUC-Dre-027644	Danio rerio	68.54	0.00e+00	1035.00
IUUC-Dno-030025	Dasypus novemcinctus	92.72	0.00e+00	1497.00
IUUC-Dme-032213	Drosophila melanogaster	74.55	0.00e+00	645.00
IUUC-Ete-033118	Echinops telfairi	78.07	0.00e+00	793.00
IUUC-Eca-033900	Equus caballus	93.09	0.00e+00	1500.00
IUUC-Eeu-035142	Erinaceus europaeus	85.91	0.00e+00	957.00
IUUC-Fca-035455	Felis catus	90.33	0.00e+00	1508.00
IUUC-Fal-037182	Ficedula albicollis	94.80	0.00e+00	902.00
IUUC-Gmo-038698	Gadus morhua	86.83	0.00e+00	869.00
IUUC-Gga-040438	Gallus gallus	83.67	0.00e+00	1413.00
IUUC-Gac-042166	Gasterosteus aculeatus	76.53	0.00e+00	888.00
IUUC-Ggo-045618	Gorilla gorilla	90.94	0.00e+00	1537.00
IUUC-Hsa-046177	Homo sapiens	91.16	0.00e+00	1533.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	96.47	0.00e+00	1011.00
IUUC-Lch-050095	Latimeria chalumnae	73.62	0.00e+00	1177.00
IUUC-Loc-052570	Lepisosteus oculatus	71.99	0.00e+00	1117.00
IUUC-Laf-054008	Loxodonta africana	89.93	0.00e+00	1513.00
IUUC-Mcc-054676	Macaca mulatta	90.84	0.00e+00	1521.00
IUUC-Mga-059239	Meleagris gallopavo	83.07	0.00e+00	1411.00
IUUC-Mmr-060907	Microcebus murinus	90.38	0.00e+00	1508.00
IUUC-Mdo-062595	Monodelphis domestica	88.21	0.00e+00	1426.00
IUUC-Mpu-066771	Mustela putorius furo	89.86	0.00e+00	1510.00
IUUC-Mlu-067206	Myotis lucifugus	77.25	0.00e+00	1097.00
IUUC-Nle-069285	Nomascus leucogenys	88.45	0.00e+00	1439.00
IUUC-Opr-071026	Ochotona princeps	91.66	0.00e+00	1484.00
IUUC-Ont-071954	Oreochromis niloticus	69.07	0.00e+00	1042.00
IUUC-Ocu-074657	Oryctolagus cuniculus	91.67	0.00e+00	1468.00
IUUC-Ola-087165	Oryzias latipes	66.70	0.00e+00	1068.00
IUUC-Oga-088198	Otolemur garnettii	81.08	0.00e+00	1320.00
IUUC-Oar-090258	Ovis aries	90.99	0.00e+00	1456.00
IUUC-Ptr-090710	Pan troglodytes	91.16	0.00e+00	1533.00
IUUC-Pan-092785	Papio anubis	90.84	0.00e+00	1522.00
IUUC-Psi-093431	Pelodiscus sinensis	74.55	0.00e+00	721.00
IUUC-Pfo-096990	Poecilia formosa	90.11	0.00e+00	817.00
IUUC-Pab-098526	Pongo abelii	91.69	0.00e+00	1533.00
IUUC-Pca-100984	Procavia capensis	76.26	3.00e-162	565.00
IUUC-Pva-102352	Pteropus vampyrus	95.40	0.00e+00	893.00
IUUC-Rno-105876	Rattus norvegicus	97.70	0.00e+00	1675.00
IUUC-Sha-107588	Sarcophilus harrisii	86.39	0.00e+00	1235.00
IUUC-Sar-112959	Sorex araneus	87.31	0.00e+00	1427.00
IUUC-Ssc-115261	Sus scrofa	91.82	0.00e+00	1536.00
IUUC-Tgu-116580	Taeniopygia guttata	81.37	0.00e+00	1321.00
IUUC-Tru-118731	Takifugu rubripes	67.40	0.00e+00	1030.00
IUUC-Tsy-118982	Tarsius syrichta	84.88	0.00e+00	1032.00
IUUC-Tni-120725	Tetraodon nigroviridis	68.71	0.00e+00	1038.00
IUUC-Tbe-128018	Tupaia belangeri	95.27	0.00e+00	1155.00
IUUC-Ttr-128927	Tursiops truncatus	91.72	0.00e+00	1554.00
IUUC-Vpa-130369	Vicugna pacos	91.32	0.00e+00	1421.00
IUUC-Xtr-132474	Xenopus tropicalis	73.33	0.00e+00	1154.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence